NO923539L - Nye umettede acykliske fosfonatderivater av purin og pyrimidin - Google Patents
Nye umettede acykliske fosfonatderivater av purin og pyrimidinInfo
- Publication number
- NO923539L NO923539L NO92923539A NO923539A NO923539L NO 923539 L NO923539 L NO 923539L NO 92923539 A NO92923539 A NO 92923539A NO 923539 A NO923539 A NO 923539A NO 923539 L NO923539 L NO 923539L
- Authority
- NO
- Norway
- Prior art keywords
- unsatured
- purin
- pyrimidine
- new
- phosphonate derivatives
- Prior art date
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91402427A EP0531597A1 (fr) | 1991-09-12 | 1991-09-12 | Dérivés acycliques insaturés d'acides phosphoniques puriniques ou pyrimidimiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO923539D0 NO923539D0 (no) | 1992-09-11 |
| NO923539L true NO923539L (no) | 1993-03-15 |
Family
ID=8208612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92923539A NO923539L (no) | 1991-09-12 | 1992-09-11 | Nye umettede acykliske fosfonatderivater av purin og pyrimidin |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0531597A1 (fr) |
| JP (1) | JPH05247070A (fr) |
| KR (1) | KR930006036A (fr) |
| AU (1) | AU646758B2 (fr) |
| CA (1) | CA2078030A1 (fr) |
| FI (1) | FI924077A (fr) |
| HU (1) | HUT62009A (fr) |
| IL (1) | IL103125A0 (fr) |
| NO (1) | NO923539L (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0618214A1 (fr) * | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Dérivés phosphonates insaturés de purines et de pyrimidines |
| US5817647A (en) * | 1993-04-01 | 1998-10-06 | Merrell Pharmaceuticals Inc. | Unsaturated acetylene phosphonate derivatives of purines |
| CA2171868A1 (fr) * | 1993-09-17 | 1995-03-23 | Petr Alexander | Methode pour le dosage de composes therapeutiques |
| US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| US5994321A (en) * | 1993-12-20 | 1999-11-30 | Aronex Pharmaceuticals, Inc. | Antiviral guanine analogs |
| US5446045A (en) * | 1993-12-20 | 1995-08-29 | Revankar; Ganapathi R. | Antiviral guanine analogs |
| WO2001044260A2 (fr) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Nouvelles purines |
| IL150062A0 (en) | 1999-12-17 | 2002-12-01 | Ariad Pharma Inc | Proton pump inhibitors |
| TR200302288T2 (tr) * | 2001-06-29 | 2004-12-21 | Institute Of Organic Chemistry And Biochemistry Academy Of | Terapi için yeni bileşikler ve metotlar. |
| TWI332956B (en) | 2002-04-26 | 2010-11-11 | Gilead Sciences Inc | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7300924B2 (en) | 2003-04-25 | 2007-11-27 | Gilead Sciences, Inc. | Anti-infective phosphonate analogs |
| WO2005002626A2 (fr) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Composes de phosphonate therapeutiques |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| MXPA05011296A (es) | 2003-04-25 | 2006-01-24 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de la cinasa. |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| ATE490788T1 (de) | 2003-04-25 | 2010-12-15 | Gilead Sciences Inc | Antivirale phosphonate analoge |
| AU2004260789B2 (en) | 2003-07-30 | 2011-06-30 | Gilead Sciences, Inc. | Nucleobase phosphonate analogs for antiviral treatment |
| WO2005044308A1 (fr) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Analogues phosphonates d'antimetabolites |
| WO2005044279A1 (fr) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Conjugues phosphonate / inhibiteur de purine nucleoside phosphorylase |
| JP2007508843A (ja) | 2003-10-24 | 2007-04-12 | ギリアード サイエンシーズ， インコーポレイテッド | 治療用化合物の同定のための方法および組成物 |
| US20080287471A1 (en) | 2003-12-22 | 2008-11-20 | Maria Fardis | 4'-Substituted Carbovir And Abacavir-Derivatives As Well As Related Compounds With Hiv And Hcv Antiviral Activity |
| ES2720618T3 (es) | 2004-07-27 | 2019-07-23 | Gilead Sciences Inc | Análogos de fosfonato de compuestos de inhibidores de VIH |
| ATE534652T1 (de) * | 2005-04-01 | 2011-12-15 | Univ California | Phosphono-pent-2-en-1-yl-nukleoside und analoga |
| CA2616314A1 (fr) * | 2005-07-27 | 2007-02-01 | Gilead Sciences, Inc. | Composes antiviraux |
| WO2008100447A2 (fr) | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Analogues nucléosidiques pour traitement antiviral |
| UA103329C2 (ru) | 2008-07-08 | 2013-10-10 | Гилиад Сайенсиз, Инк. | Соли соединений-ингибиторов вич |
| WO2013095684A1 (fr) | 2011-12-22 | 2013-06-27 | Geron Corporation | Analogues de guanine en tant que substrats de télomérase et affecteurs de la longueur de télomères |
| PL3661937T3 (pl) | 2017-08-01 | 2021-12-20 | Gilead Sciences, Inc. | Formy krystaliczne ((s)-((((2r,5r)-5-(6-amino-9h-puryn-9-ylo)-4-fluoro-2,5-dihydrofuran-2-ylo)oksy)metylo)(fenoksy)fosforylo)-l-alaninianu etylu (gs-9131) do leczenia zakażeń wirusowych |
| CN111655268B (zh) | 2017-10-04 | 2024-03-26 | 艾维迪提生物科学公司 | 核酸-多肽组合物及其用途 |
| WO2019136180A2 (fr) * | 2018-01-04 | 2019-07-11 | Avidity Biosciences Llc | Molécules d'acide nucléique hétéroduplex et leurs utilisations |
| CA3097255A1 (fr) | 2018-04-23 | 2019-10-31 | Centre National De La Recherche Scientifique | Nouveaux analogues d'acyclonucleosides antiviraux |
| AU2020287880A1 (en) | 2019-06-06 | 2022-01-20 | Avidity Biosciences, Inc. | UNA amidites and uses thereof |
| WO2020247782A1 (fr) | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Compositions d'acide nucléique-polypeptide et utilisations de celles-ci |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0353955A3 (fr) * | 1988-08-02 | 1991-08-14 | Beecham Group Plc | Composés chimiques |
| DK0465297T3 (da) * | 1990-07-04 | 1996-02-19 | Merrell Pharma Inc | 9-Purinylphosphonsyre-derivater |
| EP0539487A1 (fr) * | 1990-07-19 | 1993-05-05 | Beecham Group Plc | Derives phosphono-alceniques antiviraux de purine |
-
1991
- 1991-09-12 EP EP91402427A patent/EP0531597A1/fr not_active Withdrawn
-
1992
- 1992-09-08 AU AU22197/92A patent/AU646758B2/en not_active Ceased
- 1992-09-09 KR KR1019920016534A patent/KR930006036A/ko not_active Application Discontinuation
- 1992-09-10 IL IL103125A patent/IL103125A0/xx unknown
- 1992-09-11 NO NO92923539A patent/NO923539L/no unknown
- 1992-09-11 JP JP4267791A patent/JPH05247070A/ja active Pending
- 1992-09-11 EP EP92402487A patent/EP0532423A1/fr not_active Withdrawn
- 1992-09-11 CA CA002078030A patent/CA2078030A1/fr not_active Abandoned
- 1992-09-11 HU HU9202924A patent/HUT62009A/hu unknown
- 1992-09-11 FI FI924077A patent/FI924077A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL103125A0 (en) | 1993-02-21 |
| EP0532423A1 (fr) | 1993-03-17 |
| FI924077A0 (fi) | 1992-09-11 |
| FI924077A (fi) | 1993-03-13 |
| HUT62009A (en) | 1993-03-29 |
| AU2219792A (en) | 1993-03-18 |
| KR930006036A (ko) | 1993-04-20 |
| AU646758B2 (en) | 1994-03-03 |
| CA2078030A1 (fr) | 1993-03-13 |
| JPH05247070A (ja) | 1993-09-24 |
| HU9202924D0 (en) | 1992-11-30 |
| NO923539D0 (no) | 1992-09-11 |
| EP0531597A1 (fr) | 1993-03-17 |
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