NO923253L - Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser - Google Patents
Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelserInfo
- Publication number
- NO923253L NO923253L NO92923253A NO923253A NO923253L NO 923253 L NO923253 L NO 923253L NO 92923253 A NO92923253 A NO 92923253A NO 923253 A NO923253 A NO 923253A NO 923253 L NO923253 L NO 923253L
- Authority
- NO
- Norway
- Prior art keywords
- group
- membered ring
- compounds
- anion
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Forbindelse med formelen O R1 R2 O R3 l! l l II /^ l G¿D¿C¿N¿CH¿C¿N N¿CH¿Z der G står for en amlnogruppe eller en valgfri cyklisk amlnogruppe, disse blir valgfritt substituert; D står for en avstandsholder som har en 2 til 6 atomkjeder valgfritt bundet gjennom et heteroatom og/eller en 5- tll 6-leddet ring (forutsatt at den 5- til 6-leddede ringen er, avhengig av sin blndingsposlsjon, talt som 2 til 3 atomkjeder); R1 står for hydrogen, benzylgruppe eller en lavere alkylgruppe; R2 og R3 står uavhengig av hverandre for en resterende gruppe dannet ved å fjerne -CH(NE2)COOH fra en a-amlnosyre, eller R1 og R2 kan danne en 5- til 6-leddet ring tatt sammen med den tilgrensende N og C; X står for hydrogen eller en valgfri substituert lavere alkylgruppe; og Z står for en gruppe som har evne til å danne et anion eller en gruppe som kan omdannes til et anion i et levende legeme, eller salter derav og midler for å hemme celleadhesjon, og som er kjennetegnet ved at de inneholder disse forbindelsene. De nye forbindelsene og farmasøytiske midlene er effektive for profylakse og terapi av forskjellige sykdommer ved å regulere eller hemme celleadhesjon.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21239791 | 1991-08-23 | ||
JP12314692 | 1992-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO923253D0 NO923253D0 (no) | 1992-08-19 |
NO923253L true NO923253L (no) | 1993-02-24 |
Family
ID=26460144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92923253A NO923253L (no) | 1991-08-23 | 1992-08-19 | Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser |
Country Status (11)
Country | Link |
---|---|
US (1) | US5294713A (no) |
EP (1) | EP0529858B1 (no) |
KR (1) | KR930004287A (no) |
CN (2) | CN1069730A (no) |
AT (1) | ATE159249T1 (no) |
AU (1) | AU646966B2 (no) |
CA (1) | CA2076619A1 (no) |
DE (1) | DE69222719T2 (no) |
FI (1) | FI923775A (no) |
HU (2) | HUT63154A (no) |
NO (1) | NO923253L (no) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
DE4302485A1 (de) * | 1993-01-29 | 1994-08-04 | Merck Patent Gmbh | Piperazinderivate |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
ZW4194A1 (en) * | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic compounds |
DE69411900T2 (de) * | 1993-03-29 | 1998-12-10 | Zeneca Ltd., London | Heterozyklische derivate als plätchenaggregationsinhibitoren |
HUT70045A (en) * | 1993-06-17 | 1995-09-28 | Takeda Chemical Industries Ltd | 2-piperazinone derivatives parmaceutical compositions containing them and process for producing them |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
WO1996033982A1 (en) * | 1995-04-26 | 1996-10-31 | Takeda Chemical Industries, Ltd. | Piperazinones useful as inhibitors of platelet aggregation |
CA2180206A1 (en) * | 1995-06-30 | 1996-12-31 | Motoya Ohshika | Freeze-dried preparation for pharmaceutical use |
EP0765660A3 (en) * | 1995-09-28 | 1998-09-23 | Takeda Chemical Industries, Ltd. | Microcapsules comprising 2-piperazinone-1-acetic acid compounds |
ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
EP0888344A1 (en) * | 1996-03-15 | 1999-01-07 | The Du Pont Merck Pharmaceutical Company | Spirocycle integrin inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
WO1998039324A1 (en) * | 1997-03-07 | 1998-09-11 | Takeda Chemical Industries, Ltd. | 2-peperazinone-1-acetic acid derivatives and their use |
AU6896298A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
US6133256A (en) * | 1997-04-14 | 2000-10-17 | Cor Therapeutics Inc | Selective factor Xa inhibitors |
AU6896398A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
JP2002513412A (ja) * | 1997-04-14 | 2002-05-08 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
US7109326B2 (en) | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
CA2287292A1 (en) | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6100282A (en) * | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
SI0928790T1 (en) * | 1998-01-02 | 2003-06-30 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
US6403595B1 (en) | 1998-02-05 | 2002-06-11 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, processes for producing the same and utilization thereof |
EP1054871A2 (en) | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
TR200003848T2 (tr) * | 1998-06-30 | 2001-06-21 | Pfizer Products Inc. | VLA-4'e bağlı hücre bağlanmasının peptidil olmayan önleyicileri. |
US6204282B1 (en) | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
WO2000038715A2 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of an integrin antagonist and radiation in the treatment of neoplasia |
JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
KR100464261B1 (ko) * | 2002-01-24 | 2005-01-03 | 주식회사 파나진 | Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3711335A1 (de) * | 1987-04-03 | 1988-10-20 | Merck Patent Gmbh | Aminosaeurederivate |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
DE4007869A1 (de) * | 1990-03-13 | 1991-09-19 | Merck Patent Gmbh | Aminosaeurederivate |
DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1992
- 1992-08-07 US US07/926,171 patent/US5294713A/en not_active Expired - Fee Related
- 1992-08-07 AU AU20908/92A patent/AU646966B2/en not_active Ceased
- 1992-08-10 EP EP92307292A patent/EP0529858B1/en not_active Expired - Lifetime
- 1992-08-10 DE DE69222719T patent/DE69222719T2/de not_active Expired - Fee Related
- 1992-08-10 AT AT92307292T patent/ATE159249T1/de not_active IP Right Cessation
- 1992-08-19 HU HU9202686A patent/HUT63154A/hu unknown
- 1992-08-19 NO NO92923253A patent/NO923253L/no unknown
- 1992-08-21 CA CA002076619A patent/CA2076619A1/en not_active Abandoned
- 1992-08-21 FI FI923775A patent/FI923775A/fi not_active Application Discontinuation
- 1992-08-22 CN CN92109703A patent/CN1069730A/zh active Pending
- 1992-08-22 KR KR1019920015142A patent/KR930004287A/ko not_active Application Discontinuation
-
1993
- 1993-01-01 CN CN 93100005 patent/CN1078968A/zh active Pending
-
1995
- 1995-06-28 HU HU95P/P00497P patent/HU211141A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
NO923253D0 (no) | 1992-08-19 |
EP0529858A1 (en) | 1993-03-03 |
KR930004287A (ko) | 1993-03-22 |
HU211141A9 (en) | 1995-10-30 |
CN1069730A (zh) | 1993-03-10 |
AU646966B2 (en) | 1994-03-10 |
AU2090892A (en) | 1993-02-25 |
EP0529858B1 (en) | 1997-10-15 |
ATE159249T1 (de) | 1997-11-15 |
FI923775A0 (fi) | 1992-08-21 |
DE69222719T2 (de) | 1998-03-19 |
CN1078968A (zh) | 1993-12-01 |
HUT63154A (en) | 1993-07-28 |
US5294713A (en) | 1994-03-15 |
CA2076619A1 (en) | 1993-02-24 |
FI923775A (fi) | 1993-02-24 |
DE69222719D1 (de) | 1997-11-20 |
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