NO923253L - Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser - Google Patents

Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser

Info

Publication number
NO923253L
NO923253L NO92923253A NO923253A NO923253L NO 923253 L NO923253 L NO 923253L NO 92923253 A NO92923253 A NO 92923253A NO 923253 A NO923253 A NO 923253A NO 923253 L NO923253 L NO 923253L
Authority
NO
Norway
Prior art keywords
group
membered ring
compounds
anion
lower alkyl
Prior art date
Application number
NO92923253A
Other languages
English (en)
Other versions
NO923253D0 (no
Inventor
Hirosada Sugihara
Zenichi Terashita
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO923253D0 publication Critical patent/NO923253D0/no
Publication of NO923253L publication Critical patent/NO923253L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Forbindelse med formelen O R1 R2 O R3 l! l l II /^ l G¿D¿C¿N¿CH¿C¿N N¿CH¿Z der G står for en amlnogruppe eller en valgfri cyklisk amlnogruppe, disse blir valgfritt substituert; D står for en avstandsholder som har en 2 til 6 atomkjeder valgfritt bundet gjennom et heteroatom og/eller en 5- tll 6-leddet ring (forutsatt at den 5- til 6-leddede ringen er, avhengig av sin blndingsposlsjon, talt som 2 til 3 atomkjeder); R1 står for hydrogen, benzylgruppe eller en lavere alkylgruppe; R2 og R3 står uavhengig av hverandre for en resterende gruppe dannet ved å fjerne -CH(NE2)COOH fra en a-amlnosyre, eller R1 og R2 kan danne en 5- til 6-leddet ring tatt sammen med den tilgrensende N og C; X står for hydrogen eller en valgfri substituert lavere alkylgruppe; og Z står for en gruppe som har evne til å danne et anion eller en gruppe som kan omdannes til et anion i et levende legeme, eller salter derav og midler for å hemme celleadhesjon, og som er kjennetegnet ved at de inneholder disse forbindelsene. De nye forbindelsene og farmasøytiske midlene er effektive for profylakse og terapi av forskjellige sykdommer ved å regulere eller hemme celleadhesjon.
NO92923253A 1991-08-23 1992-08-19 Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser NO923253L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21239791 1991-08-23
JP12314692 1992-05-15

Publications (2)

Publication Number Publication Date
NO923253D0 NO923253D0 (no) 1992-08-19
NO923253L true NO923253L (no) 1993-02-24

Family

ID=26460144

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923253A NO923253L (no) 1991-08-23 1992-08-19 Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser

Country Status (11)

Country Link
US (1) US5294713A (no)
EP (1) EP0529858B1 (no)
KR (1) KR930004287A (no)
CN (2) CN1069730A (no)
AT (1) ATE159249T1 (no)
AU (1) AU646966B2 (no)
CA (1) CA2076619A1 (no)
DE (1) DE69222719T2 (no)
FI (1) FI923775A (no)
HU (2) HUT63154A (no)
NO (1) NO923253L (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
DE4302485A1 (de) * 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
ZW4194A1 (en) * 1993-03-29 1994-12-21 Zeneca Ltd Heterocyclic compounds
DE69411900T2 (de) * 1993-03-29 1998-12-10 Zeneca Ltd., London Heterozyklische derivate als plätchenaggregationsinhibitoren
HUT70045A (en) * 1993-06-17 1995-09-28 Takeda Chemical Industries Ltd 2-piperazinone derivatives parmaceutical compositions containing them and process for producing them
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
WO1996033982A1 (en) * 1995-04-26 1996-10-31 Takeda Chemical Industries, Ltd. Piperazinones useful as inhibitors of platelet aggregation
CA2180206A1 (en) * 1995-06-30 1996-12-31 Motoya Ohshika Freeze-dried preparation for pharmaceutical use
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
ZA972195B (en) * 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
EP0888344A1 (en) * 1996-03-15 1999-01-07 The Du Pont Merck Pharmaceutical Company Spirocycle integrin inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998039324A1 (en) * 1997-03-07 1998-09-11 Takeda Chemical Industries, Ltd. 2-peperazinone-1-acetic acid derivatives and their use
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6133256A (en) * 1997-04-14 2000-10-17 Cor Therapeutics Inc Selective factor Xa inhibitors
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
JP2002513412A (ja) * 1997-04-14 2002-05-08 シーオーアール セラピューティクス インコーポレイテッド 選択的Xa因子阻害剤
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
CA2287292A1 (en) 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6100282A (en) * 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
SI0928790T1 (en) * 1998-01-02 2003-06-30 F. Hoffmann-La Roche Ag Thiazole derivatives
US6403595B1 (en) 1998-02-05 2002-06-11 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, processes for producing the same and utilization thereof
EP1054871A2 (en) 1998-04-01 2000-11-29 Du Pont Pharmaceuticals Company Pyrimidines and triazines as integrin antagonists
TR200003848T2 (tr) * 1998-06-30 2001-06-21 Pfizer Products Inc. VLA-4'e bağlı hücre bağlanmasının peptidil olmayan önleyicileri.
US6204282B1 (en) 1998-11-30 2001-03-20 Schering Corporation Benzimidazole compounds that are vitronectin receptor antagonists
WO2000038715A2 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Use of an integrin antagonist and radiation in the treatment of neoplasia
JP2003519697A (ja) 1999-12-28 2003-06-24 ファイザー・プロダクツ・インク 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬
KR100464261B1 (ko) * 2002-01-24 2005-01-03 주식회사 파나진 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3711335A1 (de) * 1987-04-03 1988-10-20 Merck Patent Gmbh Aminosaeurederivate
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
DE4007869A1 (de) * 1990-03-13 1991-09-19 Merck Patent Gmbh Aminosaeurederivate
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NO923253D0 (no) 1992-08-19
EP0529858A1 (en) 1993-03-03
KR930004287A (ko) 1993-03-22
HU211141A9 (en) 1995-10-30
CN1069730A (zh) 1993-03-10
AU646966B2 (en) 1994-03-10
AU2090892A (en) 1993-02-25
EP0529858B1 (en) 1997-10-15
ATE159249T1 (de) 1997-11-15
FI923775A0 (fi) 1992-08-21
DE69222719T2 (de) 1998-03-19
CN1078968A (zh) 1993-12-01
HUT63154A (en) 1993-07-28
US5294713A (en) 1994-03-15
CA2076619A1 (en) 1993-02-24
FI923775A (fi) 1993-02-24
DE69222719D1 (de) 1997-11-20

Similar Documents

Publication Publication Date Title
NO923253L (no) Fremgangsmaate for fremstilling og anvendelse av 2-piperazinonforbindelser
ES8605806A1 (es) Procedimiento de preparacion de nuevos derivados de la xan- tina y de sus sales de adicion con acidos apropiados
DK359289A (da) 4-oxoquinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf samt deres anvendelse
DK160877C (da) Fremgangsmaade til fremstilling af 2-penemforbindelser
DK114783D0 (da) Hidtil ukendte forbindelser, fremgangsmader til deres fremstilling samt deres anvendelse som laegemidler
SE8304465D0 (sv) Forfarande for framstellning av cefemforeningar
ATE103812T1 (de) Zusammensetzung zur behandlung von ischaemischen stoerungen in organen.
KR880007461A (ko) 헤테로 사이클-치환 디포스포네이트화합물 및 이의 약제학적 조성물
ZA82111B (en) Carboxylic acid amides, their preparation and use as pharmaceutical compositions
ES467543A1 (es) Metodo de provocar esterilidad macho en una planta de grano de cereal y procedimiento de preparar una composicion regu- ladora del crecimiento de plantas.
DK0526313T3 (da) Nye ureaderivater, deres fremstilling og terapeutiske anvendelse
GB1342520A (en) Alpha-alkyl-substituted benzyl or thenyl-benzyloxy derivatives of amines
HUP9802194A1 (hu) Indanolszármazékok, eljárás előállításukra, és ezeket tartalmazó gyógyászati készítmények
ES481855A1 (es) Procedimiento para la preparacion de nuevos revidados de 6- metoxi-2-acetilnaftaleno oxima con actividad analgesica.
ES477076A1 (es) Un procedimiento de preparacion de derivados de acido 1-naf-til-acetico.
ES8103056A1 (es) Un procedimiento para la preparacion de derivados de hidan- toina
ES8100282A1 (es) Procedimiento para la obtencion de nuevos derivados de la piperacina metanimina
GB1505849A (en) 9,10-dihydroanthracen-9,10-imine derivatives
GB1164496A (en) 0-Oxaphenanthridine Derivatives and Method for the Preparation
DK95081A (da) Carboxylsyreamidiner samt deres fremstilling og anvendelse i farmaceutiske praeparater
ES272324A1 (es) Procedimiento para la preparaciën de nuevos derivados de piperidina
GB807618A (en) Improvements in or relating to therapeutically useful diamines
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
TH1819B (th) การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน
ES8301230A1 (es) Un procedimiento para la preparacion de 1-fenil-5-amidotetrazoles.