NO922601D0 - 1,4-bis-(amino-hydroksyalkylamino)-antraquinoner for hemming av proteinkinase c - Google Patents

1,4-bis-(amino-hydroksyalkylamino)-antraquinoner for hemming av proteinkinase c

Info

Publication number
NO922601D0
NO922601D0 NO922601A NO922601A NO922601D0 NO 922601 D0 NO922601 D0 NO 922601D0 NO 922601 A NO922601 A NO 922601A NO 922601 A NO922601 A NO 922601A NO 922601 D0 NO922601 D0 NO 922601D0
Authority
NO
Norway
Prior art keywords
antraquinones
proteinkinase
hydroxyalkylamino
inhibition
bis
Prior art date
Application number
NO922601A
Other languages
English (en)
Other versions
NO922601L (no
Inventor
Jack B Jiang
Mary George Johnson
Original Assignee
Sphinx Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphinx Pharma Corp filed Critical Sphinx Pharma Corp
Publication of NO922601D0 publication Critical patent/NO922601D0/no
Publication of NO922601L publication Critical patent/NO922601L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO92922601A 1990-11-02 1992-07-01 1,4-bis-(amino-hydroksyalkylamino)-antraquinoner for hemming av proteinkinase c NO922601L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60824890A 1990-11-02 1990-11-02
US07/609,416 US5141957A (en) 1990-11-02 1990-11-05 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
PCT/US1991/008030 WO1992007558A1 (en) 1990-11-02 1991-10-30 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c

Publications (2)

Publication Number Publication Date
NO922601D0 true NO922601D0 (no) 1992-07-01
NO922601L NO922601L (no) 1992-07-01

Family

ID=27085707

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922601A NO922601L (no) 1990-11-02 1992-07-01 1,4-bis-(amino-hydroksyalkylamino)-antraquinoner for hemming av proteinkinase c

Country Status (11)

Country Link
US (1) US5141957A (no)
EP (1) EP0509088A4 (no)
JP (1) JPH05505829A (no)
KR (1) KR920703512A (no)
AU (1) AU641581B2 (no)
BR (1) BR9106117A (no)
CA (1) CA2072884A1 (no)
FI (1) FI923031A (no)
HU (1) HUT64296A (no)
NO (1) NO922601L (no)
WO (1) WO1992007558A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA936396B (en) * 1992-09-08 1994-06-13 Univ Vermont 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en) 1993-01-28 2006-09-19 Virginia Commonwealth University Medical College Of Virginia Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
WO1995034307A1 (en) * 1994-06-14 1995-12-21 Sloan-Kettering Institute For Cancer Research Ceramide-activated protein kinase and methods of use of effectors
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
US6376467B1 (en) * 1998-10-09 2002-04-23 The Regents Of The University Of California Use of inhibitors of protein kinase C epsilon to treat pain
US6717030B2 (en) * 1998-07-06 2004-04-06 The Regents Of The University Of California Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse
WO2000001415A2 (en) * 1998-07-06 2000-01-13 Messing Robert O Use of inhibitors of protein kinase c epsilon to treat pain
AU2003299568B2 (en) * 2002-11-27 2010-07-22 Ampio Pharmaceuticals, Inc. Treatment of diseases and conditions mediated by increased phosphorylation
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US8598146B2 (en) 2003-09-16 2013-12-03 Garvan Institute Of Medical Research Methods for identifying modulators of protein kinase C-epsilon (PKCε) and method of treatment of aberrant glucose metabolism associated therewith
US8592368B2 (en) 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
EP1877424A4 (en) * 2005-04-11 2010-09-29 Pharmagap Inc INHIBITORS OF PROTEIN KINASES AND USES THEREOF
PE20070435A1 (es) 2005-09-16 2007-06-13 Schering Corp Formulacion farmaceutica que comprende temozolomida y un inhibidor de la proteina quinasa
JP2010516709A (ja) * 2007-01-19 2010-05-20 カイ ファーマシューティカルズ インコーポレーティッド 疼痛減弱のためのイプシロン阻害化合物の使用方法
EP2482837A4 (en) 2009-09-29 2013-05-22 Joslin Diabetes Center Inc USE OF INHIBITORS OF PROTEIN KINASE C DELTA (PKCD) FOR THE TREATMENT OF DIABETES, OBESITY AND HEPATIC STEATOSIS
US9980936B2 (en) 2014-05-05 2018-05-29 Emory University BH4 antagonists and methods related thereto

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1540733A (en) * 1923-10-25 1925-06-02 British Dyestuffs Corp Ltd Dyestuffs of the anthraquinone series
US2411148A (en) * 1943-10-23 1946-11-19 Eastman Kodak Co Anthraquinone dyestuffs
US3960751A (en) * 1973-09-19 1976-06-01 Matsushita Electric Industrial Co., Ltd. Electro-optical display element
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4310666A (en) * 1978-04-10 1982-01-12 United States Of America Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones
US4526989A (en) * 1978-07-11 1985-07-02 American Cyanamid Company 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4598155A (en) * 1981-11-18 1986-07-01 Ciba-Geigy Corporation 3(5-tetrazolyl)1,4-diaminoanthraquinones
US4540788A (en) * 1983-07-14 1985-09-10 American Cyanamid Company Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones
DE3331296A1 (de) * 1983-08-31 1985-03-14 Hoechst Ag, 6230 Frankfurt Mono- und bisfunktionelle anthrachinon-(oxy-2,3-oxidopropane), verfahren zu ihrer herstellung und ihre verwendung
US4894451A (en) * 1985-04-01 1990-01-16 The University Of Vermont Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives
JPS6315853A (ja) * 1986-07-07 1988-01-22 Dainippon Printing Co Ltd 熱転写シ−ト用染料
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
JPH0219818A (ja) * 1988-07-07 1990-01-23 Nec Corp 暗視双眼鏡
DE3827974A1 (de) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen
GB8923075D0 (en) * 1989-10-13 1989-11-29 Patterson Laurence H Anti-cancer compounds
BR9106118A (pt) * 1990-11-02 1993-03-02 Sphinx Pharma Corp Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto

Also Published As

Publication number Publication date
FI923031A0 (fi) 1992-06-30
KR920703512A (ko) 1992-12-18
US5141957A (en) 1992-08-25
AU9086291A (en) 1992-05-26
AU641581B2 (en) 1993-09-23
EP0509088A4 (en) 1993-03-24
HUT64296A (en) 1993-12-28
JPH05505829A (ja) 1993-08-26
BR9106117A (pt) 1993-03-09
WO1992007558A1 (en) 1992-05-14
EP0509088A1 (en) 1992-10-21
HU9202207D0 (en) 1992-12-28
CA2072884A1 (en) 1992-05-03
FI923031A (fi) 1992-06-30
NO922601L (no) 1992-07-01

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