BR9106117A - Antraquinona substituida,composicao farmaceutica para inibir quinase c de proteina,processo para tal inibicao e uso de um composto - Google Patents
Antraquinona substituida,composicao farmaceutica para inibir quinase c de proteina,processo para tal inibicao e uso de um compostoInfo
- Publication number
- BR9106117A BR9106117A BR919106117A BR9106117A BR9106117A BR 9106117 A BR9106117 A BR 9106117A BR 919106117 A BR919106117 A BR 919106117A BR 9106117 A BR9106117 A BR 9106117A BR 9106117 A BR9106117 A BR 9106117A
- Authority
- BR
- Brazil
- Prior art keywords
- antraquinone
- inhibition
- replaced
- compound
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
- C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60824890A | 1990-11-02 | 1990-11-02 | |
US07/609,416 US5141957A (en) | 1990-11-02 | 1990-11-05 | 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c |
PCT/US1991/008030 WO1992007558A1 (en) | 1990-11-02 | 1991-10-30 | 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9106117A true BR9106117A (pt) | 1993-03-09 |
Family
ID=27085707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR919106117A BR9106117A (pt) | 1990-11-02 | 1991-10-30 | Antraquinona substituida,composicao farmaceutica para inibir quinase c de proteina,processo para tal inibicao e uso de um composto |
Country Status (11)
Country | Link |
---|---|
US (1) | US5141957A (pt) |
EP (1) | EP0509088A4 (pt) |
JP (1) | JPH05505829A (pt) |
KR (1) | KR920703512A (pt) |
AU (1) | AU641581B2 (pt) |
BR (1) | BR9106117A (pt) |
CA (1) | CA2072884A1 (pt) |
FI (1) | FI923031A (pt) |
HU (1) | HUT64296A (pt) |
NO (1) | NO922601D0 (pt) |
WO (1) | WO1992007558A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA936396B (en) * | 1992-09-08 | 1994-06-13 | Univ Vermont | 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
AU2771395A (en) * | 1994-06-14 | 1996-01-05 | Sloan-Kettering Institute For Cancer Research | Ceramide-activated protein kinase and methods of use of effectors |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
US6376467B1 (en) * | 1998-10-09 | 2002-04-23 | The Regents Of The University Of California | Use of inhibitors of protein kinase C epsilon to treat pain |
US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
ATE350032T1 (de) * | 1998-07-06 | 2007-01-15 | Univ California | Verwendung der protein-kinase-c-epsilon- inhibitoren zur behandlung von schmerzen |
NZ540767A (en) | 2002-11-27 | 2009-03-31 | Dmi Biosciences Inc | Treatment of diseases and conditions mediated by increased phosphorylation |
US20040175384A1 (en) * | 2003-12-12 | 2004-09-09 | Mohapatra Shyam S. | Protein kinase C as a target for the treatment of respiratory syncytial virus |
WO2005025602A1 (en) | 2003-09-16 | 2005-03-24 | Garvan Institute Of Medical Research | METHODS FOR IDENTIFYING MODULATORS OF PROTEIN KINASE C-EPSILON (PKCϵ) AND METHOD OF TREATMENT OF ABERRANT GLUCOSE METABOLISM ASSOCIATED THEREWITH |
US8592368B2 (en) | 2003-12-19 | 2013-11-26 | University Of South Florida | JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection |
EP1877424A4 (en) * | 2005-04-11 | 2010-09-29 | Pharmagap Inc | INHIBITORS OF PROTEIN KINASES AND USES THEREOF |
JP2009508868A (ja) | 2005-09-16 | 2009-03-05 | シェーリング コーポレイション | テモゾロミドおよびプロテインキナーゼインヒビターを用いる薬学的組成物および方法 |
JP2010516709A (ja) | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | 疼痛減弱のためのイプシロン阻害化合物の使用方法 |
EP2482837A4 (en) | 2009-09-29 | 2013-05-22 | Joslin Diabetes Center Inc | USE OF INHIBITORS OF PROTEIN KINASE C DELTA (PKCD) FOR THE TREATMENT OF DIABETES, OBESITY AND HEPATIC STEATOSIS |
EP3140275B1 (en) | 2014-05-05 | 2020-07-08 | Emory University | Combination of a bh4 antagonist and a mtor inhibitor for lung cancer therapy |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1540733A (en) * | 1923-10-25 | 1925-06-02 | British Dyestuffs Corp Ltd | Dyestuffs of the anthraquinone series |
US2411148A (en) * | 1943-10-23 | 1946-11-19 | Eastman Kodak Co | Anthraquinone dyestuffs |
US3960751A (en) * | 1973-09-19 | 1976-06-01 | Matsushita Electric Industrial Co., Ltd. | Electro-optical display element |
US4197249A (en) * | 1977-08-15 | 1980-04-08 | American Cyanamid Company | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
US4310666A (en) * | 1978-04-10 | 1982-01-12 | United States Of America | Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones |
US4526989A (en) * | 1978-07-11 | 1985-07-02 | American Cyanamid Company | 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof |
EP0079862B1 (de) * | 1981-11-18 | 1986-01-15 | Ciba-Geigy Ag | 1,4-Diaminoanthrachinonverbindungen |
US4540788A (en) * | 1983-07-14 | 1985-09-10 | American Cyanamid Company | Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones |
DE3331296A1 (de) * | 1983-08-31 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | Mono- und bisfunktionelle anthrachinon-(oxy-2,3-oxidopropane), verfahren zu ihrer herstellung und ihre verwendung |
US4894451A (en) * | 1985-04-01 | 1990-01-16 | The University Of Vermont | Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives |
JPS6315853A (ja) * | 1986-07-07 | 1988-01-22 | Dainippon Printing Co Ltd | 熱転写シ−ト用染料 |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
JPH0219818A (ja) * | 1988-07-07 | 1990-01-23 | Nec Corp | 暗視双眼鏡 |
DE3827974A1 (de) * | 1988-08-18 | 1990-02-22 | Boehringer Mannheim Gmbh | Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen |
GB8923075D0 (en) * | 1989-10-13 | 1989-11-29 | Patterson Laurence H | Anti-cancer compounds |
KR920703513A (ko) * | 1990-11-02 | 1992-12-18 | 클레이턴 아이. 턴칸 | 단백질 활성효소 c(protein kinase c)를 방해하는 비스-(하이드록시알킬아미노)-안트라퀴논 |
-
1990
- 1990-11-05 US US07/609,416 patent/US5141957A/en not_active Expired - Fee Related
-
1991
- 1991-10-30 KR KR1019920701571A patent/KR920703512A/ko not_active Application Discontinuation
- 1991-10-30 BR BR919106117A patent/BR9106117A/pt unknown
- 1991-10-30 JP JP92501843A patent/JPH05505829A/ja active Pending
- 1991-10-30 HU HU9202207A patent/HUT64296A/hu unknown
- 1991-10-30 WO PCT/US1991/008030 patent/WO1992007558A1/en not_active Application Discontinuation
- 1991-10-30 CA CA002072884A patent/CA2072884A1/en not_active Abandoned
- 1991-10-30 AU AU90862/91A patent/AU641581B2/en not_active Ceased
- 1991-10-30 EP EP19920900630 patent/EP0509088A4/en not_active Withdrawn
-
1992
- 1992-06-30 FI FI923031A patent/FI923031A/fi not_active Application Discontinuation
- 1992-07-01 NO NO922601A patent/NO922601D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1992007558A1 (en) | 1992-05-14 |
NO922601L (no) | 1992-07-01 |
US5141957A (en) | 1992-08-25 |
HU9202207D0 (en) | 1992-12-28 |
EP0509088A4 (en) | 1993-03-24 |
FI923031A0 (fi) | 1992-06-30 |
JPH05505829A (ja) | 1993-08-26 |
KR920703512A (ko) | 1992-12-18 |
AU641581B2 (en) | 1993-09-23 |
CA2072884A1 (en) | 1992-05-03 |
HUT64296A (en) | 1993-12-28 |
NO922601D0 (no) | 1992-07-01 |
FI923031A (fi) | 1992-06-30 |
EP0509088A1 (en) | 1992-10-21 |
AU9086291A (en) | 1992-05-26 |
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