HUT64296A - Method for producing 1,4-bis (amino-hydroxi-alkyl-amino)-anthraquinone and medical preparatives containing them - Google Patents
Method for producing 1,4-bis (amino-hydroxi-alkyl-amino)-anthraquinone and medical preparatives containing themInfo
- Publication number
- HUT64296A HUT64296A HU9202207A HU220792A HUT64296A HU T64296 A HUT64296 A HU T64296A HU 9202207 A HU9202207 A HU 9202207A HU 220792 A HU220792 A HU 220792A HU T64296 A HUT64296 A HU T64296A
- Authority
- HU
- Hungary
- Prior art keywords
- amino
- hydroxi
- anthraquinone
- bis
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
- C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
- C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
- C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
- C07C225/34—Amino anthraquinones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60824890A | 1990-11-02 | 1990-11-02 | |
US07/609,416 US5141957A (en) | 1990-11-02 | 1990-11-05 | 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9202207D0 HU9202207D0 (en) | 1992-12-28 |
HUT64296A true HUT64296A (en) | 1993-12-28 |
Family
ID=27085707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9202207A HUT64296A (en) | 1990-11-02 | 1991-10-30 | Method for producing 1,4-bis (amino-hydroxi-alkyl-amino)-anthraquinone and medical preparatives containing them |
Country Status (11)
Country | Link |
---|---|
US (1) | US5141957A (hu) |
EP (1) | EP0509088A4 (hu) |
JP (1) | JPH05505829A (hu) |
KR (1) | KR920703512A (hu) |
AU (1) | AU641581B2 (hu) |
BR (1) | BR9106117A (hu) |
CA (1) | CA2072884A1 (hu) |
FI (1) | FI923031A0 (hu) |
HU (1) | HUT64296A (hu) |
NO (1) | NO922601D0 (hu) |
WO (1) | WO1992007558A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA936396B (en) * | 1992-09-08 | 1994-06-13 | Univ Vermont | 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
WO1995034307A1 (en) * | 1994-06-14 | 1995-12-21 | Sloan-Kettering Institute For Cancer Research | Ceramide-activated protein kinase and methods of use of effectors |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
US6376467B1 (en) * | 1998-10-09 | 2002-04-23 | The Regents Of The University Of California | Use of inhibitors of protein kinase C epsilon to treat pain |
US6717030B2 (en) * | 1998-07-06 | 2004-04-06 | The Regents Of The University Of California | Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse |
CA2336709A1 (en) * | 1998-07-06 | 2000-01-13 | Robert O. Messing | Use of inhibitors of protein kinase c epsilon to treat pain |
EP1572115B1 (en) * | 2002-11-27 | 2015-01-21 | Ampio Pharmaceuticals, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
US20040175384A1 (en) * | 2003-12-12 | 2004-09-09 | Mohapatra Shyam S. | Protein kinase C as a target for the treatment of respiratory syncytial virus |
EP2228069A1 (en) | 2003-09-16 | 2010-09-15 | Garvan Institute Of Medical Research | Antagonists of protein kinase c-epsilon (pkcepsilon) and their use for the treatment of aberrant glucose metabolism associated therewith. |
US8592368B2 (en) | 2003-12-19 | 2013-11-26 | University Of South Florida | JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection |
WO2006108270A1 (en) * | 2005-04-11 | 2006-10-19 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
WO2007033374A2 (en) | 2005-09-16 | 2007-03-22 | Schering Corporation | Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor |
JP2010516709A (ja) * | 2007-01-19 | 2010-05-20 | カイ ファーマシューティカルズ インコーポレーティッド | 疼痛減弱のためのイプシロン阻害化合物の使用方法 |
US20120208750A1 (en) | 2009-09-29 | 2012-08-16 | Joslin Diabetes Center, Inc. | Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis |
US9980936B2 (en) | 2014-05-05 | 2018-05-29 | Emory University | BH4 antagonists and methods related thereto |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1540733A (en) * | 1923-10-25 | 1925-06-02 | British Dyestuffs Corp Ltd | Dyestuffs of the anthraquinone series |
US2411148A (en) * | 1943-10-23 | 1946-11-19 | Eastman Kodak Co | Anthraquinone dyestuffs |
US3960751A (en) * | 1973-09-19 | 1976-06-01 | Matsushita Electric Industrial Co., Ltd. | Electro-optical display element |
US4197249A (en) * | 1977-08-15 | 1980-04-08 | American Cyanamid Company | 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
US4310666A (en) * | 1978-04-10 | 1982-01-12 | United States Of America | Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones |
US4526989A (en) * | 1978-07-11 | 1985-07-02 | American Cyanamid Company | 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof |
EP0079862B1 (de) * | 1981-11-18 | 1986-01-15 | Ciba-Geigy Ag | 1,4-Diaminoanthrachinonverbindungen |
US4540788A (en) * | 1983-07-14 | 1985-09-10 | American Cyanamid Company | Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones |
DE3331296A1 (de) * | 1983-08-31 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | Mono- und bisfunktionelle anthrachinon-(oxy-2,3-oxidopropane), verfahren zu ihrer herstellung und ihre verwendung |
US4894451A (en) * | 1985-04-01 | 1990-01-16 | The University Of Vermont | Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives |
JPS6315853A (ja) * | 1986-07-07 | 1988-01-22 | Dainippon Printing Co Ltd | 熱転写シ−ト用染料 |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
JPH0219818A (ja) * | 1988-07-07 | 1990-01-23 | Nec Corp | 暗視双眼鏡 |
DE3827974A1 (de) * | 1988-08-18 | 1990-02-22 | Boehringer Mannheim Gmbh | Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen |
GB8923075D0 (en) * | 1989-10-13 | 1989-11-29 | Patterson Laurence H | Anti-cancer compounds |
HUT64295A (en) * | 1990-11-02 | 1993-12-28 | Sphinx Pharma Corp | Method for producing bis-(hydroxy-alkyl-amino)-anthraquinone derivatives as well as pharmaceutical preparatives containing them |
-
1990
- 1990-11-05 US US07/609,416 patent/US5141957A/en not_active Expired - Fee Related
-
1991
- 1991-10-30 JP JP92501843A patent/JPH05505829A/ja active Pending
- 1991-10-30 WO PCT/US1991/008030 patent/WO1992007558A1/en not_active Application Discontinuation
- 1991-10-30 KR KR1019920701571A patent/KR920703512A/ko not_active Application Discontinuation
- 1991-10-30 BR BR919106117A patent/BR9106117A/pt unknown
- 1991-10-30 HU HU9202207A patent/HUT64296A/hu unknown
- 1991-10-30 AU AU90862/91A patent/AU641581B2/en not_active Ceased
- 1991-10-30 CA CA002072884A patent/CA2072884A1/en not_active Abandoned
- 1991-10-30 EP EP19920900630 patent/EP0509088A4/en not_active Withdrawn
-
1992
- 1992-06-30 FI FI923031A patent/FI923031A0/fi not_active Application Discontinuation
- 1992-07-01 NO NO922601A patent/NO922601D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI923031A (fi) | 1992-06-30 |
KR920703512A (ko) | 1992-12-18 |
EP0509088A1 (en) | 1992-10-21 |
CA2072884A1 (en) | 1992-05-03 |
HU9202207D0 (en) | 1992-12-28 |
AU641581B2 (en) | 1993-09-23 |
NO922601L (no) | 1992-07-01 |
AU9086291A (en) | 1992-05-26 |
JPH05505829A (ja) | 1993-08-26 |
US5141957A (en) | 1992-08-25 |
WO1992007558A1 (en) | 1992-05-14 |
EP0509088A4 (en) | 1993-03-24 |
NO922601D0 (no) | 1992-07-01 |
FI923031A0 (fi) | 1992-06-30 |
BR9106117A (pt) | 1993-03-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFD9 | Temporary protection cancelled due to non-payment of fee |