BR9106118A - Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto - Google Patents

Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto

Info

Publication number
BR9106118A
BR9106118A BR919106118A BR9106118A BR9106118A BR 9106118 A BR9106118 A BR 9106118A BR 919106118 A BR919106118 A BR 919106118A BR 9106118 A BR9106118 A BR 9106118A BR 9106118 A BR9106118 A BR 9106118A
Authority
BR
Brazil
Prior art keywords
famaceutic
anthraquinone
replaced
compound
composition
Prior art date
Application number
BR919106118A
Other languages
English (en)
Inventor
Jack B Jiang
Mary George Johnson
Original Assignee
Sphinx Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/609,252 external-priority patent/US5204370A/en
Application filed by Sphinx Pharma Corp filed Critical Sphinx Pharma Corp
Publication of BR9106118A publication Critical patent/BR9106118A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C07C225/36—Amino anthraquinones the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/68—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C229/72—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C07C229/74—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by doubly-bound oxygen atoms the condensed ring system being formed by at least three rings, e.g. amino anthraquinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR919106118A 1990-11-02 1991-10-30 Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto BR9106118A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60917990A 1990-11-02 1990-11-02
US07/609,252 US5204370A (en) 1990-11-05 1990-11-05 Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase C
PCT/US1991/008026 WO1992007557A1 (en) 1990-11-02 1991-10-30 Bis-(hydroxyalkylamino)-anthraquinone inhibitors of protein kinase c

Publications (1)

Publication Number Publication Date
BR9106118A true BR9106118A (pt) 1993-03-02

Family

ID=27085973

Family Applications (1)

Application Number Title Priority Date Filing Date
BR919106118A BR9106118A (pt) 1990-11-02 1991-10-30 Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto

Country Status (9)

Country Link
US (1) US5344841A (pt)
EP (1) EP0507938A4 (pt)
JP (1) JPH05503721A (pt)
KR (1) KR920703513A (pt)
AU (1) AU637014B2 (pt)
BR (1) BR9106118A (pt)
CA (1) CA2072889A1 (pt)
HU (1) HUT64295A (pt)
WO (1) WO1992007557A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141957A (en) * 1990-11-02 1992-08-25 Sphinx Pharmaceuticals Corporation 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
GB9205859D0 (en) * 1992-03-18 1992-04-29 Imp Cancer Res Tech Compounds
US5519035A (en) * 1993-07-02 1996-05-21 Cornell Research Foundation, Inc. Treatment of stroke or in anticipation of the occurrence of brain ischemia
GB9320191D0 (en) * 1993-09-30 1993-11-17 Univ Napier Compounds
US5436243A (en) * 1993-11-17 1995-07-25 Research Triangle Institute Duke University Aminoanthraquinone derivatives to combat multidrug resistance
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
US6717030B2 (en) * 1998-07-06 2004-04-06 The Regents Of The University Of California Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse
US6376467B1 (en) 1998-10-09 2002-04-23 The Regents Of The University Of California Use of inhibitors of protein kinase C epsilon to treat pain
US7598418B2 (en) 2002-04-18 2009-10-06 Institute Of Medicinal Molecular Design, Inc. Amide derivatives
DE10244453A1 (de) * 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
CN1980948B (zh) 2002-11-27 2011-08-10 Dmi生物科学公司 治疗由增强磷酸化介导的疾病和病况
EP2228069A1 (en) 2003-09-16 2010-09-15 Garvan Institute Of Medical Research Antagonists of protein kinase c-epsilon (pkcepsilon) and their use for the treatment of aberrant glucose metabolism associated therewith.
US8158586B2 (en) * 2005-04-11 2012-04-17 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
CN101678063B (zh) 2007-01-19 2012-12-19 凯制药公司 使用ε抑制剂化合物减轻疼痛的方法
DE102007063056A1 (de) * 2007-12-28 2009-07-02 Universität Leipzig Verwendung von 4-Amino-1,3,8-trihydroxyanthracen-9,10-dionderivaten zur Inhibierung von Proteinkinasen
WO2011041385A2 (en) 2009-09-29 2011-04-07 Joslin Diabetes Center, Inc. Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis
WO2013028543A1 (en) 2011-08-19 2013-02-28 Emory University Bax agonist, compositions, and methods related thereto
US9980936B2 (en) * 2014-05-05 2018-05-29 Emory University BH4 antagonists and methods related thereto
CN104491889B (zh) * 2014-12-05 2017-05-24 江苏省中医药研究院 放射性同位素标记的单蒽核蒽醌类化合物在制备用于检测心肌活性的药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1540733A (en) * 1923-10-25 1925-06-02 British Dyestuffs Corp Ltd Dyestuffs of the anthraquinone series
US2411148A (en) * 1943-10-23 1946-11-19 Eastman Kodak Co Anthraquinone dyestuffs
US3960751A (en) * 1973-09-19 1976-06-01 Matsushita Electric Industrial Co., Ltd. Electro-optical display element
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4310666A (en) * 1978-04-10 1982-01-12 United States Of America Anti-neoplastic 1,4-bis-(substituted aminoalkyl amino)-anthraquinones
US4526989A (en) * 1978-07-11 1985-07-02 American Cyanamid Company 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4598155A (en) * 1981-11-18 1986-07-01 Ciba-Geigy Corporation 3(5-tetrazolyl)1,4-diaminoanthraquinones
US4540788A (en) * 1983-07-14 1985-09-10 American Cyanamid Company Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones
DE3331296A1 (de) * 1983-08-31 1985-03-14 Hoechst Ag, 6230 Frankfurt Mono- und bisfunktionelle anthrachinon-(oxy-2,3-oxidopropane), verfahren zu ihrer herstellung und ihre verwendung
US4894451A (en) * 1985-04-01 1990-01-16 The University Of Vermont Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives
JPS6315853A (ja) * 1986-07-07 1988-01-22 Dainippon Printing Co Ltd 熱転写シ−ト用染料
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
JPH0219819A (ja) * 1988-07-08 1990-01-23 Nikon Corp 角度制御装置
DE3827974A1 (de) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen

Also Published As

Publication number Publication date
EP0507938A4 (en) 1993-03-10
US5344841A (en) 1994-09-06
KR920703513A (ko) 1992-12-18
EP0507938A1 (en) 1992-10-14
AU637014B2 (en) 1993-05-13
AU9039891A (en) 1992-05-26
WO1992007557A1 (en) 1992-05-14
JPH05503721A (ja) 1993-06-17
HUT64295A (en) 1993-12-28
CA2072889A1 (en) 1992-05-03

Similar Documents

Publication Publication Date Title
BR9106118A (pt) Antraquinona substituida,composicao famaceutica e processo para inibir quinase c de proteina e,uso de um composto
BR8503490A (pt) Composto,processo para preparar o composto,composicao,processo para exterminar ervas daninhas e uso de um composto
BR1100323A (pt) Composto, uso de um composto, composição farmacêutica e processo para preparar um composto
BR9107219A (pt) Composicao de revestimento e processo para preparar a mesma
BR9103195A (pt) Composto e processo para sua preparacao
DE69032116D1 (de) Beschichtungszusammensetzung
BR9505107A (pt) Composto composiçao farmacêutica processo para a preparaçao de um composto e seu uso
BR9004852A (pt) Composto,processo para sua preparacao,sua aplicacao e composicao farmaceutica
BR1100979A (pt) Derivado de carboidrato, processo para preparar um derivado de carboidrato, composição farmacêutica de carboidrato e uso de derivado de carboidrato
BR8905837A (pt) Composto,processo para sua preparacao e composicao fotocuravel
BR9102489A (pt) Aminobenzo diazepinas,benzodiaze pinotionas,processo para preparar um composto,medicamento,uso e composto
BR9106117A (pt) Antraquinona substituida,composicao farmaceutica para inibir quinase c de proteina,processo para tal inibicao e uso de um composto
BR8500565A (pt) Corantes,processo para sua preparacao,utilizacao,compostos,processo para sua preparacao
BR9005793A (pt) Composicao de fluoreto estanoso aquoso estabilizada e processo para preparacao da mesma
BR8702278A (pt) Processo para a preparacao de um composto e composicao
BR9202446A (pt) Composicao de dentifricio,dentifricio e processo para a preparacao de um dentifricio
BR9602025A (pt) Composto composição farmacêutica uso e processo para a preparação de um composto
BR8702907A (pt) Processo para preparacao de composto herbicida e composicao herbicida
BR9005094A (pt) Composto,processo para preparar o mesmo,composicao herbicida,processo para exterminar ervas daninhas e uso de tal composto
BR9106781A (pt) Xilanase,processo para produzir xilanese e uso da mesma
BR8702908A (pt) Processo para preparacao de composto herbicida e composicao herbicida
BR8702902A (pt) Processo para preparacao de composto,e composicao herbicida
BR8803768A (pt) Composicao odorante,processo para producao de compostos e uso dos ditos compostos
BR9002315A (pt) Composto,composicao e processo para tingir cabelo
BR9103479A (pt) Composto,estereoisomero,composicao farmaceutica e processo para a preparacao de um composto