NO922291L - 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater - Google Patents

7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater

Info

Publication number
NO922291L
NO922291L NO92922291A NO922291A NO922291L NO 922291 L NO922291 L NO 922291L NO 92922291 A NO92922291 A NO 92922291A NO 922291 A NO922291 A NO 922291A NO 922291 L NO922291 L NO 922291L
Authority
NO
Norway
Prior art keywords
hydroxy
amino
methyl
acid derivatives
methylamino
Prior art date
Application number
NO92922291A
Other languages
English (en)
Norwegian (no)
Other versions
NO922291D0 (no
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Hans-Joachim Zeiler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO922291D0 publication Critical patent/NO922291D0/no
Publication of NO922291L publication Critical patent/NO922291L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO92922291A 1991-06-27 1992-06-11 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater NO922291L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4121214A DE4121214A1 (de) 1991-06-27 1991-06-27 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate

Publications (2)

Publication Number Publication Date
NO922291D0 NO922291D0 (no) 1992-06-11
NO922291L true NO922291L (no) 1992-12-28

Family

ID=6434855

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922291A NO922291L (no) 1991-06-27 1992-06-11 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater

Country Status (17)

Country Link
US (2) US5312823A (es)
EP (1) EP0520277A3 (es)
JP (1) JPH05213947A (es)
KR (1) KR930000514A (es)
CN (1) CN1068114A (es)
AU (2) AU647627B2 (es)
CA (1) CA2072207A1 (es)
CZ (1) CZ192892A3 (es)
DE (1) DE4121214A1 (es)
FI (1) FI922953A (es)
HU (1) HUT61545A (es)
IE (1) IE922099A1 (es)
IL (1) IL102288A0 (es)
MX (1) MX9203228A (es)
NO (1) NO922291L (es)
TW (1) TW209218B (es)
ZA (1) ZA924743B (es)

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DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4339134A1 (de) * 1993-11-16 1995-05-18 Bayer Ag 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE4435479A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19500792A1 (de) * 1995-01-13 1996-07-18 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6951863B2 (en) 2001-02-07 2005-10-04 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods
EP2305697A3 (en) 2005-07-25 2011-07-27 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
FR2891274B1 (fr) * 2005-09-27 2007-11-23 Pierre Fabre Medicament Sa Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
CN102443015A (zh) * 2010-10-13 2012-05-09 南京明生医药技术有限公司 一种7-取代喹啉羧酸衍生物及其制备方法和在抗菌抗结核上的应用
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN103351348A (zh) * 2013-07-15 2013-10-16 黄河三角洲京博化工研究院有限公司 一种2-甲胺基嘧啶盐酸盐的合成方法
MX2016005186A (es) 2013-11-26 2016-07-08 Hoffmann La Roche Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo.
PL3102576T3 (pl) 2014-02-03 2019-12-31 Vitae Pharmaceuticals, Llc Dihydropirolopirydynowe inhibitory ror-gamma
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
WO2016046837A1 (en) * 2014-09-22 2016-03-31 Cadila Healthcare Limited An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
MX2020004504A (es) 2015-09-04 2021-11-10 Hoffmann La Roche Derivados de fenoximetilo.
WO2017050791A1 (en) * 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
CN115124538A (zh) 2015-09-24 2022-09-30 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
CN107614505B (zh) 2015-09-24 2021-05-07 豪夫迈·罗氏有限公司 作为双重atx/ca抑制剂的新型二环化合物
MA53943A (fr) 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
CN110392679B (zh) 2017-03-16 2023-04-07 豪夫迈·罗氏有限公司 可用作双重atx/ca抑制剂的杂环化合物
RS59306B1 (sr) 2017-03-20 2019-10-31 Forma Therapeutics Inc Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr)
CN115716826A (zh) 2017-07-24 2023-02-28 生命医药有限责任公司 RORγ的抑制剂
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
US12122778B2 (en) 2018-09-19 2024-10-22 Novo Nordisk Health Care Ag Activating pyruvate kinase R
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

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DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
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DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) * 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
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Also Published As

Publication number Publication date
KR930000514A (ko) 1993-01-15
CZ192892A3 (en) 1993-01-13
IE922099A1 (en) 1992-12-30
HU9202145D0 (en) 1992-10-28
CA2072207A1 (en) 1992-12-28
EP0520277A3 (en) 1993-01-13
FI922953A0 (fi) 1992-06-25
FI922953A (fi) 1992-12-28
JPH05213947A (ja) 1993-08-24
IL102288A0 (en) 1993-01-14
NO922291D0 (no) 1992-06-11
DE4121214A1 (de) 1993-01-14
AU647627B2 (en) 1994-03-24
AU1803092A (en) 1993-01-07
HUT61545A (en) 1993-01-28
AU5304094A (en) 1994-03-03
CN1068114A (zh) 1993-01-20
US5312823A (en) 1994-05-17
US5371090A (en) 1994-12-06
ZA924743B (en) 1993-03-31
EP0520277A2 (de) 1992-12-30
MX9203228A (es) 1992-12-01
TW209218B (es) 1993-07-11

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