NO922133L - SUBSTITUTED DIAMINOPHALIMIDES AND ANALOGS - Google Patents

SUBSTITUTED DIAMINOPHALIMIDES AND ANALOGS

Info

Publication number
NO922133L
NO922133L NO92922133A NO922133A NO922133L NO 922133 L NO922133 L NO 922133L NO 92922133 A NO92922133 A NO 92922133A NO 922133 A NO922133 A NO 922133A NO 922133 L NO922133 L NO 922133L
Authority
NO
Norway
Prior art keywords
diaminophalimides
analogs
substituted
inhibition
compounds
Prior art date
Application number
NO92922133A
Other languages
Norwegian (no)
Other versions
NO178261C (en
NO178261B (en
NO922133D0 (en
Inventor
Uwe Trinks
Peter Traxler
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO922133D0 publication Critical patent/NO922133D0/en
Publication of NO922133L publication Critical patent/NO922133L/en
Publication of NO178261B publication Critical patent/NO178261B/en
Publication of NO178261C publication Critical patent/NO178261C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Stringed Musical Instruments (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which Ar1, Ar2, A1, A2, R and X have the meanings given in the description, have useful pharmaceutical properties and are particularly active against diseases responsive to the inhibition of protein kinases, for example tumours. They are prepared in a manner known per se.
NO922133A 1991-05-30 1992-05-29 Substituted diaminophthalimides and analogs, pharmaceutical preparations containing them and their use in drugs NO178261C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH160191 1991-05-30

Publications (4)

Publication Number Publication Date
NO922133D0 NO922133D0 (en) 1992-05-29
NO922133L true NO922133L (en) 1992-12-01
NO178261B NO178261B (en) 1995-11-13
NO178261C NO178261C (en) 1996-02-21

Family

ID=4214234

Family Applications (1)

Application Number Title Priority Date Filing Date
NO922133A NO178261C (en) 1991-05-30 1992-05-29 Substituted diaminophthalimides and analogs, pharmaceutical preparations containing them and their use in drugs

Country Status (25)

Country Link
EP (1) EP0516588B1 (en)
JP (1) JP2593273B2 (en)
KR (1) KR920021508A (en)
CN (1) CN1067052A (en)
AT (1) ATE108437T1 (en)
AU (1) AU653024B2 (en)
CA (1) CA2069857A1 (en)
CS (1) CS156792A3 (en)
CY (1) CY1979A (en)
DE (1) DE59200277D1 (en)
DK (1) DK0516588T3 (en)
ES (1) ES2056699T3 (en)
FI (1) FI100530B (en)
HK (1) HK214896A (en)
HU (1) HUT66655A (en)
IE (1) IE65772B1 (en)
IL (1) IL102038A0 (en)
MA (1) MA22540A1 (en)
MX (1) MX9202544A (en)
NO (1) NO178261C (en)
NZ (1) NZ242941A (en)
PL (1) PL170909B1 (en)
RU (1) RU2095349C1 (en)
TW (1) TW204341B (en)
ZA (1) ZA923940B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491144A (en) * 1991-05-30 1996-02-13 Ciba-Geigy Corporation Substituted diaminophthalimides and analogues
EP0600830A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Substituted derivatives of diaminophthalimide as protein-tyrosine kinase inhibitors
EP0600831A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Phtalazinon derivatives
AU691815B2 (en) * 1993-06-25 1998-05-28 Main Camp Marketing Pty. Ltd. Therapeutic agent
CA2165794A1 (en) * 1993-06-25 1995-01-05 Brian Daunter Therapeutic agent
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
GB9325217D0 (en) * 1993-12-09 1994-02-09 Zeneca Ltd Pyrimidine derivatives
WO1995024190A2 (en) 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9600545D0 (en) 1996-01-11 1996-03-13 Ciba Geigy Ag Compositions
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
JP2001524931A (en) * 1996-08-05 2001-12-04 モレキュメティクス リミテッド Use of beta-sheet mimetics as inhibitors of proteases and kinases and as inhibitors of transcription factors
DE60233675D1 (en) * 2001-11-30 2009-10-22 Panasonic Corp BISIMIDINE COMPOUND, ACID GENERATOR AND PROTECTION LACQUER COMPOSITION, WHICH INCLUDE THESE COMPOUNDS, AND METHOD FOR THE FORMATION OF PATTERNS FROM THE COMPOSITION
US20050182061A1 (en) * 2003-10-02 2005-08-18 Jeremy Green Phthalimide compounds useful as protein kinase inhibitors
US20060142591A1 (en) * 2004-10-25 2006-06-29 Susan Lindquist DAPH analogs and inhibition of protein aggregation
US7745641B2 (en) 2005-04-19 2010-06-29 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
DE102009031058A1 (en) * 2009-06-30 2011-01-27 Clariant International Ltd. Continuous process for the preparation of amides of aromatic carboxylic acids
JP5934559B2 (en) * 2012-04-05 2016-06-15 国立大学法人京都工芸繊維大学 Luminescent material and organic EL device
CN105434432B (en) * 2015-12-04 2018-11-13 中国科学院昆明植物研究所 N-Hydroxyphthalimide class compound application in preparation of anti-tumor drugs
IL309666A (en) 2021-07-09 2024-02-01 Plexium Inc Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857947A (en) * 1972-08-14 1974-12-31 Stauffer Chemical Co Fungicidal active phthalimides
GB1581073A (en) * 1976-09-08 1980-12-10 Campbell Chain Co Locking assembly
JPS60161968A (en) * 1984-01-31 1985-08-23 Sankyo Co Ltd Phthalimide derivative and agricultural germicide

Also Published As

Publication number Publication date
KR920021508A (en) 1992-12-18
ATE108437T1 (en) 1994-07-15
RU2095349C1 (en) 1997-11-10
PL170909B1 (en) 1997-02-28
TW204341B (en) 1993-04-21
JP2593273B2 (en) 1997-03-26
AU653024B2 (en) 1994-09-15
NZ242941A (en) 1994-10-26
DE59200277D1 (en) 1994-08-18
FI100530B (en) 1997-12-31
HUT66655A (en) 1994-12-28
FI922459A0 (en) 1992-05-27
IE921770A1 (en) 1992-12-02
HK214896A (en) 1996-12-13
PL294701A1 (en) 1993-02-08
EP0516588A1 (en) 1992-12-02
HU9201789D0 (en) 1992-08-28
MX9202544A (en) 1992-11-01
EP0516588B1 (en) 1994-07-13
ZA923940B (en) 1993-11-15
IE65772B1 (en) 1995-11-15
NO178261C (en) 1996-02-21
CS156792A3 (en) 1992-12-16
CA2069857A1 (en) 1992-12-01
CN1067052A (en) 1992-12-16
CY1979A (en) 1997-09-05
NO178261B (en) 1995-11-13
NO922133D0 (en) 1992-05-29
DK0516588T3 (en) 1994-08-15
ES2056699T3 (en) 1994-10-01
FI922459A (en) 1992-12-01
IL102038A0 (en) 1992-12-30
JPH05163240A (en) 1993-06-29
AU1705392A (en) 1992-12-03
MA22540A1 (en) 1992-12-31

Similar Documents

Publication Publication Date Title
NO922133D0 (en) SUBSTITUTED DIAMINOPHALIMIDES AND ANALOGS
HK1006717A1 (en) Derivatives of amidinophenylalanine procedure for their preparation their utilisation and anticoagulant compositions comprising them
DK0530505T3 (en) hydantoin derivatives
BG92804A (en) 4-BENZOYLISOXAZOLE DERIVATIVES
SE8700499D0 (en) NOVEL PHARMACOLOGICALLY ACTIVE COMPOUNDS
DE69223914D1 (en) 4-substituted-2-deoxy-2,3-didehydro alpha-D-neuraminic acid antiviral derivatives
NO891232D0 (en) ARYLHYDRAZONER.
NO303783B1 (en) Substituted aminophosphonate derivatives and pharmaceutical preparations thereof
DE68906609D1 (en) DOPAMIN PRECURRENT.
DK0387821T3 (en) 2-Alkyl-4-arylmethylquinolines, their uses and drugs prepared therewith
ES2104682T3 (en) FLUORINE-COMPOUNDS.
DK319785A (en) ACETYLENIC PHENOXYPROPANOLE DERIVATIVES
ATE92070T1 (en) AZACHROMAN DERIVATIVES.
ES2062214T3 (en) DERIVATIVES OF AMINOOLIGOHIDROXI RENINA INHIBITORS.
SE9203824D0 (en) BENZOFURANY LIMIDAZOLE DERIVATIVES AND PROCESS FOR THE PREPARATION AND THERAPEUTICAL COMPOSITIONS CONTAINING THE SAME
DK0418990T3 (en) 13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals
ES2073919T3 (en) 1,3-TRISUBSTITUTED PIPERIDINE DERIVATIVES, THEIR OBTAINING AND EMPLOYMENT.
DK0580624T3 (en) New Cytarabine Derivatives, Preparation and Use thereof
DK1105388T3 (en) N-substituted azabicycloheptane derivatives, preparation and use thereof