IL102038A0 - Substituted diaminophthalimides and analogues - Google Patents

Substituted diaminophthalimides and analogues

Info

Publication number
IL102038A0
IL102038A0 IL102038A IL10203892A IL102038A0 IL 102038 A0 IL102038 A0 IL 102038A0 IL 102038 A IL102038 A IL 102038A IL 10203892 A IL10203892 A IL 10203892A IL 102038 A0 IL102038 A0 IL 102038A0
Authority
IL
Israel
Prior art keywords
analogues
diaminophthalimides
substituted
substituted diaminophthalimides
inhibition
Prior art date
Application number
IL102038A
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL102038A0 publication Critical patent/IL102038A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Compounds of the formula I <IMAGE> in which Ar1, Ar2, A1, A2, R and X have the meanings given in the description, have useful pharmaceutical properties and are particularly active against diseases responsive to the inhibition of protein kinases, for example tumours. They are prepared in a manner known per se.
IL102038A 1991-05-30 1992-05-28 Substituted diaminophthalimides and analogues IL102038A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH160191 1991-05-30

Publications (1)

Publication Number Publication Date
IL102038A0 true IL102038A0 (en) 1992-12-30

Family

ID=4214234

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102038A IL102038A0 (en) 1991-05-30 1992-05-28 Substituted diaminophthalimides and analogues

Country Status (25)

Country Link
EP (1) EP0516588B1 (en)
JP (1) JP2593273B2 (en)
KR (1) KR920021508A (en)
CN (1) CN1067052A (en)
AT (1) ATE108437T1 (en)
AU (1) AU653024B2 (en)
CA (1) CA2069857A1 (en)
CS (1) CS156792A3 (en)
CY (1) CY1979A (en)
DE (1) DE59200277D1 (en)
DK (1) DK0516588T3 (en)
ES (1) ES2056699T3 (en)
FI (1) FI100530B (en)
HK (1) HK214896A (en)
HU (1) HUT66655A (en)
IE (1) IE65772B1 (en)
IL (1) IL102038A0 (en)
MA (1) MA22540A1 (en)
MX (1) MX9202544A (en)
NO (1) NO178261C (en)
NZ (1) NZ242941A (en)
PL (1) PL170909B1 (en)
RU (1) RU2095349C1 (en)
TW (1) TW204341B (en)
ZA (1) ZA923940B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491144A (en) * 1991-05-30 1996-02-13 Ciba-Geigy Corporation Substituted diaminophthalimides and analogues
EP0600830A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Substituted derivatives of diaminophthalimide as protein-tyrosine kinase inhibitors
EP0600831A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Phtalazinon derivatives
AU691815B2 (en) * 1993-06-25 1998-05-28 Main Camp Marketing Pty. Ltd. Therapeutic agent
ES2140541T3 (en) * 1993-06-25 2000-03-01 Main Camp Marketing Pty Ltd THERAPEUTIC AGENT.
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
GB9325217D0 (en) * 1993-12-09 1994-02-09 Zeneca Ltd Pyrimidine derivatives
AU2096895A (en) * 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9600545D0 (en) 1996-01-11 1996-03-13 Ciba Geigy Ag Compositions
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
AU732174B2 (en) * 1996-08-05 2001-04-12 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US7374857B2 (en) * 2001-11-30 2008-05-20 Wako Pure Chemical Industries Ltd. Bismide compound, acid generator and resist composition each containing the same, and method of forming pattern from the composition
US20050182061A1 (en) * 2003-10-02 2005-08-18 Jeremy Green Phthalimide compounds useful as protein kinase inhibitors
US20060142591A1 (en) * 2004-10-25 2006-06-29 Susan Lindquist DAPH analogs and inhibition of protein aggregation
AU2006237920A1 (en) * 2005-04-19 2006-10-26 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
DE102009031058A1 (en) * 2009-06-30 2011-01-27 Clariant International Ltd. Continuous process for the preparation of amides of aromatic carboxylic acids
JP5934559B2 (en) * 2012-04-05 2016-06-15 国立大学法人京都工芸繊維大学 Luminescent material and organic EL device
CN105434432B (en) * 2015-12-04 2018-11-13 中国科学院昆明植物研究所 N-Hydroxyphthalimide class compound application in preparation of anti-tumor drugs
WO2023283425A1 (en) 2021-07-09 2023-01-12 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857947A (en) * 1972-08-14 1974-12-31 Stauffer Chemical Co Fungicidal active phthalimides
GB1581073A (en) * 1976-09-08 1980-12-10 Campbell Chain Co Locking assembly
JPS60161968A (en) * 1984-01-31 1985-08-23 Sankyo Co Ltd Phthalimide derivative and agricultural germicide

Also Published As

Publication number Publication date
CN1067052A (en) 1992-12-16
ES2056699T3 (en) 1994-10-01
HK214896A (en) 1996-12-13
MX9202544A (en) 1992-11-01
DE59200277D1 (en) 1994-08-18
IE65772B1 (en) 1995-11-15
FI922459A (en) 1992-12-01
ATE108437T1 (en) 1994-07-15
KR920021508A (en) 1992-12-18
DK0516588T3 (en) 1994-08-15
NO922133L (en) 1992-12-01
FI922459A0 (en) 1992-05-27
CY1979A (en) 1997-09-05
AU1705392A (en) 1992-12-03
JP2593273B2 (en) 1997-03-26
EP0516588B1 (en) 1994-07-13
TW204341B (en) 1993-04-21
FI100530B (en) 1997-12-31
ZA923940B (en) 1993-11-15
IE921770A1 (en) 1992-12-02
NO178261B (en) 1995-11-13
HU9201789D0 (en) 1992-08-28
HUT66655A (en) 1994-12-28
CS156792A3 (en) 1992-12-16
NZ242941A (en) 1994-10-26
AU653024B2 (en) 1994-09-15
NO922133D0 (en) 1992-05-29
JPH05163240A (en) 1993-06-29
PL170909B1 (en) 1997-02-28
NO178261C (en) 1996-02-21
PL294701A1 (en) 1993-02-08
CA2069857A1 (en) 1992-12-01
MA22540A1 (en) 1992-12-31
EP0516588A1 (en) 1992-12-02
RU2095349C1 (en) 1997-11-10

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