NO922133D0 - SUBSTITUTED DIAMINOPHALIMIDES AND ANALOGS - Google Patents

SUBSTITUTED DIAMINOPHALIMIDES AND ANALOGS

Info

Publication number
NO922133D0
NO922133D0 NO922133A NO922133A NO922133D0 NO 922133 D0 NO922133 D0 NO 922133D0 NO 922133 A NO922133 A NO 922133A NO 922133 A NO922133 A NO 922133A NO 922133 D0 NO922133 D0 NO 922133D0
Authority
NO
Norway
Prior art keywords
diaminophalimides
analogs
substituted
inhibition
compounds
Prior art date
Application number
NO922133A
Other languages
Norwegian (no)
Other versions
NO178261B (en
NO178261C (en
NO922133L (en
Inventor
Uwe Trinks
Peter Traxler
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO922133D0 publication Critical patent/NO922133D0/en
Publication of NO922133L publication Critical patent/NO922133L/en
Publication of NO178261B publication Critical patent/NO178261B/en
Publication of NO178261C publication Critical patent/NO178261C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Stringed Musical Instruments (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pyridine Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)

Abstract

Compounds of the formula I <IMAGE> in which Ar1, Ar2, A1, A2, R and X have the meanings given in the description, have useful pharmaceutical properties and are particularly active against diseases responsive to the inhibition of protein kinases, for example tumours. They are prepared in a manner known per se.
NO922133A 1991-05-30 1992-05-29 Substituted diaminophthalimides and analogs, pharmaceutical preparations containing them and their use in drugs NO178261C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH160191 1991-05-30

Publications (4)

Publication Number Publication Date
NO922133D0 true NO922133D0 (en) 1992-05-29
NO922133L NO922133L (en) 1992-12-01
NO178261B NO178261B (en) 1995-11-13
NO178261C NO178261C (en) 1996-02-21

Family

ID=4214234

Family Applications (1)

Application Number Title Priority Date Filing Date
NO922133A NO178261C (en) 1991-05-30 1992-05-29 Substituted diaminophthalimides and analogs, pharmaceutical preparations containing them and their use in drugs

Country Status (25)

Country Link
EP (1) EP0516588B1 (en)
JP (1) JP2593273B2 (en)
KR (1) KR920021508A (en)
CN (1) CN1067052A (en)
AT (1) ATE108437T1 (en)
AU (1) AU653024B2 (en)
CA (1) CA2069857A1 (en)
CS (1) CS156792A3 (en)
CY (1) CY1979A (en)
DE (1) DE59200277D1 (en)
DK (1) DK0516588T3 (en)
ES (1) ES2056699T3 (en)
FI (1) FI100530B (en)
HK (1) HK214896A (en)
HU (1) HUT66655A (en)
IE (1) IE65772B1 (en)
IL (1) IL102038A0 (en)
MA (1) MA22540A1 (en)
MX (1) MX9202544A (en)
NO (1) NO178261C (en)
NZ (1) NZ242941A (en)
PL (1) PL170909B1 (en)
RU (1) RU2095349C1 (en)
TW (1) TW204341B (en)
ZA (1) ZA923940B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491144A (en) * 1991-05-30 1996-02-13 Ciba-Geigy Corporation Substituted diaminophthalimides and analogues
EP0600830A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Substituted derivatives of diaminophthalimide as protein-tyrosine kinase inhibitors
EP0600831A1 (en) * 1992-11-27 1994-06-08 Ciba-Geigy Ag Phtalazinon derivatives
AU691815B2 (en) * 1993-06-25 1998-05-28 Main Camp Marketing Pty. Ltd. Therapeutic agent
NZ267567A (en) * 1993-06-25 1997-10-24 Main Camp Marketing Pty Ltd Su Treatment of inflammatory conditions using various indole, benzoquinone and benzofuran derivatives; method of plant material extraction; celery seed extract
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
GB9325217D0 (en) * 1993-12-09 1994-02-09 Zeneca Ltd Pyrimidine derivatives
AU2096895A (en) 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9600545D0 (en) 1996-01-11 1996-03-13 Ciba Geigy Ag Compositions
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
DE69735545T2 (en) * 1996-08-05 2006-08-10 Myriad Genetics, Inc., Salt Lake City USE OF BETA LEAF MIMETIKA AS A PROTEASE AND KINASE INHIBITOR AND ALSHEMMER OF A TRANSCRIPTION FACTOR
US7374857B2 (en) * 2001-11-30 2008-05-20 Wako Pure Chemical Industries Ltd. Bismide compound, acid generator and resist composition each containing the same, and method of forming pattern from the composition
US20050182061A1 (en) * 2003-10-02 2005-08-18 Jeremy Green Phthalimide compounds useful as protein kinase inhibitors
WO2006047514A2 (en) * 2004-10-25 2006-05-04 Whitehead Institute For Biomedical Research Daph analogs and inhibition of protein aggregation
CN101163675A (en) * 2005-04-19 2008-04-16 协和发酵工业株式会社 Nitrogen-containing heterocyclic compound
DE102009031058A1 (en) * 2009-06-30 2011-01-27 Clariant International Ltd. Continuous process for the preparation of amides of aromatic carboxylic acids
JP5934559B2 (en) * 2012-04-05 2016-06-15 国立大学法人京都工芸繊維大学 Luminescent material and organic EL device
CN105434432B (en) * 2015-12-04 2018-11-13 中国科学院昆明植物研究所 N-Hydroxyphthalimide class compound application in preparation of anti-tumor drugs
EP4367112A1 (en) 2021-07-09 2024-05-15 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857947A (en) * 1972-08-14 1974-12-31 Stauffer Chemical Co Fungicidal active phthalimides
GB1581073A (en) * 1976-09-08 1980-12-10 Campbell Chain Co Locking assembly
JPS60161968A (en) * 1984-01-31 1985-08-23 Sankyo Co Ltd Phthalimide derivative and agricultural germicide

Also Published As

Publication number Publication date
NZ242941A (en) 1994-10-26
DK0516588T3 (en) 1994-08-15
MA22540A1 (en) 1992-12-31
NO178261B (en) 1995-11-13
KR920021508A (en) 1992-12-18
ZA923940B (en) 1993-11-15
IL102038A0 (en) 1992-12-30
DE59200277D1 (en) 1994-08-18
HU9201789D0 (en) 1992-08-28
IE921770A1 (en) 1992-12-02
FI922459A0 (en) 1992-05-27
PL170909B1 (en) 1997-02-28
CA2069857A1 (en) 1992-12-01
NO178261C (en) 1996-02-21
FI100530B (en) 1997-12-31
NO922133L (en) 1992-12-01
FI922459A (en) 1992-12-01
CS156792A3 (en) 1992-12-16
TW204341B (en) 1993-04-21
IE65772B1 (en) 1995-11-15
AU653024B2 (en) 1994-09-15
MX9202544A (en) 1992-11-01
HUT66655A (en) 1994-12-28
EP0516588A1 (en) 1992-12-02
PL294701A1 (en) 1993-02-08
ATE108437T1 (en) 1994-07-15
CN1067052A (en) 1992-12-16
CY1979A (en) 1997-09-05
EP0516588B1 (en) 1994-07-13
ES2056699T3 (en) 1994-10-01
JPH05163240A (en) 1993-06-29
JP2593273B2 (en) 1997-03-26
RU2095349C1 (en) 1997-11-10
AU1705392A (en) 1992-12-03
HK214896A (en) 1996-12-13

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