NO910191L - Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike. - Google Patents
Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike.Info
- Publication number
- NO910191L NO910191L NO91910191A NO910191A NO910191L NO 910191 L NO910191 L NO 910191L NO 91910191 A NO91910191 A NO 91910191A NO 910191 A NO910191 A NO 910191A NO 910191 L NO910191 L NO 910191L
- Authority
- NO
- Norway
- Prior art keywords
- meaning
- group
- numbers
- hydrogen atom
- ring
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 125000000524 functional group Chemical group 0.000 abstract 2
- 229920002521 macromolecule Polymers 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxymethylene Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical class [H]N=* 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4001655A DE4001655A1 (de) | 1990-01-18 | 1990-01-18 | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO910191D0 NO910191D0 (no) | 1991-01-17 |
| NO910191L true NO910191L (no) | 1991-07-19 |
Family
ID=6398485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO91910191A NO910191L (no) | 1990-01-18 | 1991-01-17 | Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0438206B1 (cs) |
| JP (1) | JPH05112567A (cs) |
| KR (1) | KR910014377A (cs) |
| AT (1) | ATE141602T1 (cs) |
| AU (1) | AU6981291A (cs) |
| CA (1) | CA2034242A1 (cs) |
| DE (2) | DE4001655A1 (cs) |
| DK (1) | DK0438206T3 (cs) |
| ES (1) | ES2091865T3 (cs) |
| FI (1) | FI94758C (cs) |
| GR (1) | GR3020973T3 (cs) |
| HU (1) | HUT56569A (cs) |
| IE (1) | IE75898B1 (cs) |
| IL (1) | IL96840A0 (cs) |
| NO (1) | NO910191L (cs) |
| NZ (1) | NZ236803A (cs) |
| PT (1) | PT96505B (cs) |
| TW (1) | TW233298B (cs) |
| ZA (1) | ZA91389B (cs) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| ATE160943T1 (de) * | 1991-12-10 | 1997-12-15 | Dow Chemical Co | Bicycloazamakrocyclophosphon-säure, komplexe, konjugate, kontrastmittel und herstellung |
| US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5480990A (en) * | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
| WO1994026313A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| CA2103554C (en) * | 1991-12-10 | 2002-07-30 | Garry E. Kiefer | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
| AU3275293A (en) * | 1991-12-10 | 1993-07-19 | Dow Chemical Company, The | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates processes for their preparation, and use as radiopharmaceuticals |
| US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| WO1994026315A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals |
| US5358704A (en) * | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
| US5417959A (en) * | 1993-10-04 | 1995-05-23 | Mallinckrodt Medical, Inc. | Functionalized aza-crytand ligands for diagnostic imaging applications |
| ES2123167T3 (es) * | 1994-02-21 | 1999-01-01 | Pliva Pharm & Chem Works | Sulfonamidodioxepanos con una actividad hipoglicemica, metodos para su preparacion, sus intermediarios y sus sales. |
| US6207826B1 (en) | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
| US6107482A (en) | 1995-03-27 | 2000-08-22 | Isis Pharmaceuticals, Inc. | Nitrogenous macrocyclic compounds |
| KR20000010533A (ko) * | 1996-04-19 | 2000-02-15 | 텍사스 테크 유니버시티 | 시각적 조직 특이성 조영제로서의 형광 킬레이트 |
| IT1291624B1 (it) * | 1997-04-18 | 1999-01-11 | Bracco Spa | Chelati complessi di metalli paramagnetici a bassa tossicita' |
| AU7066698A (en) * | 1997-04-22 | 1998-11-13 | Nycomed Imaging As | Nmr image compounds |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| JP5368099B2 (ja) | 2005-10-07 | 2013-12-18 | ゲルベ | ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物 |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US8198101B2 (en) * | 2006-03-10 | 2012-06-12 | Nordion (Canada) Inc. | Bifunctional polyazamacrocyclic chelating agents |
| BR112015026473B1 (pt) | 2013-04-26 | 2020-12-01 | Guerbet | composições farmacêuticas líquidas e processo de preparação das mesmas e meio de contraste para imagiologia médica |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| RU2755181C2 (ru) | 2016-11-28 | 2021-09-14 | Байер Фарма Акциенгезельшафт | Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации |
| MY208484A (en) | 2018-11-23 | 2025-05-13 | Bayer Pharma AG | Formulation of contrast media and process of preparation thereof |
| FR3091872B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| CN116209661A (zh) | 2020-07-17 | 2023-06-02 | 法国加栢 | 用于制备基于pcta的螯合配体的方法 |
| CN114105983B (zh) * | 2021-11-09 | 2023-08-11 | 国科温州研究院(温州生物材料与工程研究所) | 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| DE3150917A1 (de) | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung" |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
| DE3417413A1 (de) | 1984-05-11 | 1985-11-14 | Dr. Karl Thomae Gmbh, 7950 Biberach | Dicarbonsaeure-monohydrazid-derivate, ihre herstellung und ihre verwendung als kopplungskomponenten |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| EP0232751B1 (en) | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| IT1224416B (it) | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
| DE3713842A1 (de) | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| EP0299795B1 (en) | 1987-07-16 | 1992-03-18 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
-
1990
- 1990-01-18 DE DE4001655A patent/DE4001655A1/de not_active Withdrawn
- 1990-12-31 IL IL96840A patent/IL96840A0/xx unknown
-
1991
- 1991-01-14 JP JP3002602A patent/JPH05112567A/ja active Pending
- 1991-01-16 DK DK91250008.9T patent/DK0438206T3/da active
- 1991-01-16 AT AT91250008T patent/ATE141602T1/de not_active IP Right Cessation
- 1991-01-16 DE DE59108091T patent/DE59108091D1/de not_active Expired - Lifetime
- 1991-01-16 CA CA002034242A patent/CA2034242A1/en not_active Abandoned
- 1991-01-16 EP EP91250008A patent/EP0438206B1/de not_active Expired - Lifetime
- 1991-01-16 ES ES91250008T patent/ES2091865T3/es not_active Expired - Lifetime
- 1991-01-17 NZ NZ236803A patent/NZ236803A/xx unknown
- 1991-01-17 PT PT96505A patent/PT96505B/pt not_active IP Right Cessation
- 1991-01-17 HU HU91156A patent/HUT56569A/hu unknown
- 1991-01-17 NO NO91910191A patent/NO910191L/no unknown
- 1991-01-18 IE IE16291A patent/IE75898B1/en not_active IP Right Cessation
- 1991-01-18 ZA ZA91389A patent/ZA91389B/xx unknown
- 1991-01-18 FI FI910276A patent/FI94758C/fi active
- 1991-01-18 AU AU69812/91A patent/AU6981291A/en not_active Abandoned
- 1991-01-18 KR KR1019910000816A patent/KR910014377A/ko not_active Withdrawn
- 1991-08-06 TW TW080108935A patent/TW233298B/zh active
-
1996
- 1996-09-06 GR GR960402335T patent/GR3020973T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR910014377A (ko) | 1991-08-31 |
| FI910276A0 (fi) | 1991-01-18 |
| EP0438206B1 (de) | 1996-08-21 |
| TW233298B (cs) | 1994-11-01 |
| IE910162A1 (en) | 1991-07-31 |
| FI94758C (fi) | 1995-10-25 |
| ATE141602T1 (de) | 1996-09-15 |
| FI910276A7 (fi) | 1991-07-19 |
| DE4001655A1 (de) | 1991-07-25 |
| JPH05112567A (ja) | 1993-05-07 |
| CA2034242A1 (en) | 1991-07-19 |
| NZ236803A (en) | 1993-08-26 |
| EP0438206A1 (de) | 1991-07-24 |
| GR3020973T3 (en) | 1996-12-31 |
| PT96505B (pt) | 1998-07-31 |
| ES2091865T3 (es) | 1996-11-16 |
| ZA91389B (en) | 1991-10-30 |
| DK0438206T3 (cs) | 1997-01-20 |
| DE59108091D1 (de) | 1996-09-26 |
| HUT56569A (en) | 1991-09-30 |
| PT96505A (pt) | 1991-10-15 |
| AU6981291A (en) | 1991-08-22 |
| NO910191D0 (no) | 1991-01-17 |
| IL96840A0 (en) | 1991-09-16 |
| FI94758B (fi) | 1995-07-14 |
| IE75898B1 (en) | 1997-09-24 |
| HU910156D0 (en) | 1991-08-28 |
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