NO904808L - Nye insulinderivater, fremgangsmaate for fremstilling og anvendelse derav. - Google Patents

Nye insulinderivater, fremgangsmaate for fremstilling og anvendelse derav.

Info

Publication number
NO904808L
NO904808L NO90904808A NO904808A NO904808L NO 904808 L NO904808 L NO 904808L NO 90904808 A NO90904808 A NO 90904808A NO 904808 A NO904808 A NO 904808A NO 904808 L NO904808 L NO 904808L
Authority
NO
Norway
Prior art keywords
residue
atoms
insulin derivatives
chain
amino acid
Prior art date
Application number
NO90904808A
Other languages
English (en)
Norwegian (no)
Other versions
NO904808D0 (no
Inventor
Laszlo Vertesy
Karl Geisen
Richard Bicker
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO904808D0 publication Critical patent/NO904808D0/no
Publication of NO904808L publication Critical patent/NO904808L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO90904808A 1989-11-06 1990-11-05 Nye insulinderivater, fremgangsmaate for fremstilling og anvendelse derav. NO904808L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3936876A DE3936876A1 (de) 1989-11-06 1989-11-06 Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (2)

Publication Number Publication Date
NO904808D0 NO904808D0 (no) 1990-11-05
NO904808L true NO904808L (no) 1991-05-07

Family

ID=6392948

Family Applications (1)

Application Number Title Priority Date Filing Date
NO90904808A NO904808L (no) 1989-11-06 1990-11-05 Nye insulinderivater, fremgangsmaate for fremstilling og anvendelse derav.

Country Status (18)

Country Link
US (1) US5149716A (hu)
EP (1) EP0427162B1 (hu)
JP (1) JP3131215B2 (hu)
KR (1) KR910009930A (hu)
AT (1) ATE137765T1 (hu)
AU (1) AU6577290A (hu)
CA (1) CA2029289A1 (hu)
DE (2) DE3936876A1 (hu)
DK (1) DK0427162T3 (hu)
ES (1) ES2087879T3 (hu)
FI (1) FI905439A0 (hu)
GR (1) GR3020095T3 (hu)
HU (1) HU205773B (hu)
IE (1) IE903978A1 (hu)
IL (1) IL96239A0 (hu)
NO (1) NO904808L (hu)
PT (1) PT95788A (hu)
ZA (1) ZA908842B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
JP3406244B2 (ja) * 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
SK2432004A3 (sk) * 2001-12-20 2005-04-01 Eli Lilly And Company Inzulínová zlúčenina s protrahovaným účinkom
AU2004234345A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US8343914B2 (en) * 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
ES2554773T3 (es) * 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
NZ588857A (en) * 2008-04-22 2012-07-27 Univ Case Western Reserve Isoform-specific insulin analogue for control blood sugar levels
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
CN102762589A (zh) 2009-12-11 2012-10-31 卡斯西部储备大学 带有氯化氨基酸的胰岛素类似物
RU2447149C1 (ru) * 2011-03-24 2012-04-10 Винсорт Менеджемент Инк РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА
CN110354255B (zh) 2013-04-03 2024-05-14 赛诺菲 通过长效胰岛素制剂治疗糖尿病
JP6829928B2 (ja) 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3837273A1 (de) * 1987-05-05 1990-05-10 Hoechst Ag Verfahren zur herstellung eines insulin-vorprodukts in streptomyceten
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Also Published As

Publication number Publication date
DK0427162T3 (da) 1996-09-16
US5149716A (en) 1992-09-22
ES2087879T3 (es) 1996-08-01
IE903978A1 (en) 1991-05-08
ZA908842B (en) 1991-08-28
AU6577290A (en) 1991-05-09
DE59010316D1 (de) 1996-06-13
FI905439A0 (fi) 1990-11-02
JPH03169895A (ja) 1991-07-23
ATE137765T1 (de) 1996-05-15
HUT55804A (en) 1991-06-28
GR3020095T3 (en) 1996-08-31
EP0427162B1 (de) 1996-05-08
HU205773B (en) 1992-06-29
DE3936876A1 (de) 1991-05-23
EP0427162A1 (de) 1991-05-15
JP3131215B2 (ja) 2001-01-31
CA2029289A1 (en) 1991-05-07
IL96239A0 (en) 1991-08-16
NO904808D0 (no) 1990-11-05
HU907026D0 (en) 1991-05-28
KR910009930A (ko) 1991-06-28
PT95788A (pt) 1991-09-13

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DK669889D0 (da) Insulinderivater, deres fremstilling og anvendelse
NO904808L (no) Nye insulinderivater, fremgangsmaate for fremstilling og anvendelse derav.
ES2059676T3 (es) Nuevos derivados de insulina, su empleo y un preparado farmaceutico que los contiene.