NO892823L - Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-derivater. - Google Patents
Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-derivater.Info
- Publication number
- NO892823L NO892823L NO89892823A NO892823A NO892823L NO 892823 L NO892823 L NO 892823L NO 89892823 A NO89892823 A NO 89892823A NO 892823 A NO892823 A NO 892823A NO 892823 L NO892823 L NO 892823L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- thiazole
- optionally substituted
- procedure
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- -1 oxy, thio, sulphinyl Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Detergent Compositions (AREA)
- Air Bags (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88401816 | 1988-07-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO892823D0 NO892823D0 (no) | 1989-07-07 |
| NO892823L true NO892823L (no) | 1990-01-15 |
Family
ID=8200404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO89892823A NO892823L (no) | 1988-07-12 | 1989-07-07 | Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-derivater. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5089513A (de) |
| EP (1) | EP0351194B1 (de) |
| JP (1) | JPH0276864A (de) |
| AT (1) | ATE107294T1 (de) |
| AU (1) | AU618610B2 (de) |
| DE (1) | DE68916119T2 (de) |
| DK (1) | DK346089A (de) |
| ES (1) | ES2055791T3 (de) |
| FI (1) | FI893381A7 (de) |
| IE (1) | IE63681B1 (de) |
| NO (1) | NO892823L (de) |
| NZ (1) | NZ229761A (de) |
| PT (1) | PT91123B (de) |
| ZA (1) | ZA894913B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236919A (en) * | 1989-02-28 | 1993-08-17 | Imperial Chemical Industries Plc | Quinoxalinyl derivatives suitable for use in leukotriene mediated disease |
| JPH03173874A (ja) * | 1989-09-29 | 1991-07-29 | Mitsubishi Kasei Corp | 新規複素環化合物 |
| US5254581A (en) * | 1990-06-21 | 1993-10-19 | Imperial Chemical Industries Plc | Pyran derivatives and their use as inhibitors of 5-lipoxygenase |
| IE914005A1 (en) * | 1990-12-14 | 1992-06-17 | Zeneca Ltd | Novel intermediates |
| DE4139751A1 (de) * | 1991-12-03 | 1993-06-09 | Bayer Ag, 5090 Leverkusen, De | Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate |
| US5281720A (en) * | 1991-02-28 | 1994-01-25 | Merck Frosst Canada, Inc. | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis |
| FI943727A0 (fi) * | 1992-02-13 | 1994-08-12 | Merrell Dow Pharma | Piperidinyylitiasyklisiä johdannaisia |
| US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
| US5350744A (en) * | 1992-08-27 | 1994-09-27 | Merck Frosst Canada, Inc. | Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| US5252599A (en) * | 1992-08-27 | 1993-10-12 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
| US5426109A (en) * | 1992-08-27 | 1995-06-20 | Merck Frosst Canada, Inc. | Phenylnaphthalene hydroxy acids |
| US5428060A (en) * | 1992-08-27 | 1995-06-27 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
| US5458793A (en) * | 1993-05-13 | 1995-10-17 | The Lubrizol Corporation | Compositions useful as additives for lubricants and liquid fuels |
| US5981559A (en) * | 1994-10-14 | 1999-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A2 antagonizing activity |
| US5527827A (en) * | 1994-10-27 | 1996-06-18 | Merck Frosst Canada, Inc. | Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis |
| SE9804212D0 (sv) * | 1998-12-04 | 1998-12-04 | Astra Pharma Prod | Compounds |
| CN1468055A (zh) * | 2000-10-03 | 2004-01-14 | �����ɷ� | 苯基丙炔基羟吡啶除草剂 |
| US6825221B2 (en) | 2001-10-18 | 2004-11-30 | Allergan, Inc. | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain |
| WO2010128388A2 (en) * | 2009-05-08 | 2010-11-11 | Aurobindo Pharma Limited | An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet |
| KR20190082985A (ko) | 2009-10-02 | 2019-07-10 | 아벡신 에이에스 | 소염제 2-옥소티아졸 및 2-옥소옥사졸 |
| JPWO2011093352A1 (ja) | 2010-01-27 | 2013-06-06 | 武田薬品工業株式会社 | チアゾール誘導体 |
| AU2014211489A1 (en) | 2013-01-29 | 2015-08-13 | Avexxin As | Antiinflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds |
| US9944664B2 (en) | 2014-04-15 | 2018-04-17 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds as fungicides |
| GB201413695D0 (en) | 2014-08-01 | 2014-09-17 | Avexxin As | Compound |
| GB201604318D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5835178A (ja) * | 1981-08-26 | 1983-03-01 | Santen Pharmaceut Co Ltd | チアゾリジン環を有するカルボン酸類 |
| JPS5841872A (ja) * | 1981-09-04 | 1983-03-11 | Santen Pharmaceut Co Ltd | チアゾリジン環を有するエ−テル類 |
| IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
| US4778931A (en) * | 1982-12-01 | 1988-10-18 | Usv Pharmaceutical Corporation | Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity |
| US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
| US4567184A (en) * | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
| US4644009A (en) * | 1984-10-29 | 1987-02-17 | Usv Pharmaceutical Corporation | Aryl-alkyl heterocyclic compounds |
| NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
| US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4728668A (en) * | 1985-04-16 | 1988-03-01 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
| US4677210A (en) * | 1985-06-19 | 1987-06-30 | Rorer Pharmaceutical Corporation | 1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory or anti-allergic agents |
| JPS62142168A (ja) * | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
| EP0260305B1 (de) * | 1986-03-13 | 1992-12-16 | Rhone-Poulenc Rorer International (Holdings) Inc. | Chinolinyläther tetrazole als mittel zur behandlung von hyperempfindlichen krankheiten |
| US4868193A (en) * | 1986-09-24 | 1989-09-19 | Rorer Pharmaceutical Corporation | Styryl tetrazoles and anti-allergic use thereof |
| US4668694A (en) * | 1986-04-22 | 1987-05-26 | Usv Pharmaceutical Corporation | 1-arylalkoxyphenyl-pyrazolines, ketones or enoles as anti-inflammatory or anti-allergic agents |
| US4874777A (en) * | 1987-04-10 | 1989-10-17 | Eli Lilly And Company | Leukotriene antagonists |
-
1989
- 1989-06-28 ZA ZA894913A patent/ZA894913B/xx unknown
- 1989-06-28 NZ NZ229761A patent/NZ229761A/en unknown
- 1989-07-07 NO NO89892823A patent/NO892823L/no unknown
- 1989-07-11 US US07/378,163 patent/US5089513A/en not_active Expired - Fee Related
- 1989-07-11 PT PT91123A patent/PT91123B/pt not_active IP Right Cessation
- 1989-07-11 AT AT89307041T patent/ATE107294T1/de not_active IP Right Cessation
- 1989-07-11 EP EP89307041A patent/EP0351194B1/de not_active Expired - Lifetime
- 1989-07-11 ES ES89307041T patent/ES2055791T3/es not_active Expired - Lifetime
- 1989-07-11 DE DE68916119T patent/DE68916119T2/de not_active Expired - Fee Related
- 1989-07-11 IE IE223289A patent/IE63681B1/en not_active IP Right Cessation
- 1989-07-11 AU AU38014/89A patent/AU618610B2/en not_active Ceased
- 1989-07-12 FI FI893381A patent/FI893381A7/fi not_active Application Discontinuation
- 1989-07-12 DK DK346089A patent/DK346089A/da not_active Application Discontinuation
- 1989-07-12 JP JP1178206A patent/JPH0276864A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ229761A (en) | 1991-10-25 |
| PT91123A (pt) | 1990-02-08 |
| DE68916119D1 (de) | 1994-07-21 |
| IE892232L (en) | 1990-01-12 |
| ZA894913B (en) | 1990-03-28 |
| EP0351194B1 (de) | 1994-06-15 |
| EP0351194A3 (en) | 1990-06-27 |
| EP0351194A2 (de) | 1990-01-17 |
| DK346089D0 (da) | 1989-07-12 |
| US5089513A (en) | 1992-02-18 |
| FI893381A0 (fi) | 1989-07-12 |
| ES2055791T3 (es) | 1994-09-01 |
| JPH0276864A (ja) | 1990-03-16 |
| NO892823D0 (no) | 1989-07-07 |
| DE68916119T2 (de) | 1994-09-22 |
| PT91123B (pt) | 1995-01-31 |
| AU3801489A (en) | 1990-01-18 |
| AU618610B2 (en) | 1992-01-02 |
| IE63681B1 (en) | 1995-05-31 |
| FI893381A7 (fi) | 1990-01-13 |
| ATE107294T1 (de) | 1994-07-15 |
| DK346089A (da) | 1990-01-13 |
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