NO892271L - Fremgangsmaate for fremstilling av bicykliske carboxamider. - Google Patents

Fremgangsmaate for fremstilling av bicykliske carboxamider.

Info

Publication number
NO892271L
NO892271L NO89892271A NO892271A NO892271L NO 892271 L NO892271 L NO 892271L NO 89892271 A NO89892271 A NO 89892271A NO 892271 A NO892271 A NO 892271A NO 892271 L NO892271 L NO 892271L
Authority
NO
Norway
Prior art keywords
cycloalkyl
radical
alkenyl
alkyl
hydrogen
Prior art date
Application number
NO89892271A
Other languages
English (en)
Other versions
NO892271D0 (no
Inventor
Wolfgang Von Der Saal
Alfred Mertens
Erwin Boehm
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO892271D0 publication Critical patent/NO892271D0/no
Publication of NO892271L publication Critical patent/NO892271L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser av generell. formel I. hvori. A og B kan være like eller forskjel-lige og betegne et hydrogenatom,. en alkyl-, alkenyl-, alkynyl-,. benzyl- eller cykloalkylgruppe,. Rbetegner et -hydrogenatom, en. alkyl-, alkenyl- eller cykloalkylgruppe ,. R 2 betegner et hydrogenatom, en. alkyl-, alkenyl-, cykloalkyl-,. alkylcarbonyl-, alkoxycarbonyl-,. aminocarbonyl- eller hydrazino-carbonylgruppe, eller hvor og. Rsammen med C-atomet, til. hvilket de er bundet, danner en. cykloalkylring,. n betegner 0 eller 1,. X betegner en binding eller en. alkylengruppe,. Rbetegner en aromatisk hetero-cyklisk, substituert eller usubstituert 5- eller 6-ring, hvorved 5- eller 6-ringen kan være kondensert med en fenylring eller en ytterligere aromatisk 5-eller 6-ring til en bicyklisk for-bindelse som kan være substituert med alkyl-, alkoxy-, alkoxycarbonyl-, carboxyl-, alkylmercapto-, hydroxy-, nitro-, amino-, halogen-eller cyangruppen, eller hvor R 3 betegner en substituert eller usubstituert fenyl- eller nafthyl-rest,. utviser terapeutisk aktivitet. Frem-stilling av forbindelsene er beskrevet.
NO89892271A 1988-06-03 1989-06-02 Fremgangsmaate for fremstilling av bicykliske carboxamider. NO892271L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3818830A DE3818830A1 (de) 1988-06-03 1988-06-03 Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
NO892271D0 NO892271D0 (no) 1989-06-02
NO892271L true NO892271L (no) 1989-12-04

Family

ID=6355728

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89892271A NO892271L (no) 1988-06-03 1989-06-02 Fremgangsmaate for fremstilling av bicykliske carboxamider.

Country Status (18)

Country Link
US (1) US5019587A (no)
EP (1) EP0344634B1 (no)
JP (1) JPH0225464A (no)
KR (1) KR900000339A (no)
CN (1) CN1038640A (no)
AT (1) ATE103593T1 (no)
AU (1) AU616521B2 (no)
DD (1) DD283809A5 (no)
DE (2) DE3818830A1 (no)
DK (1) DK268789A (no)
FI (1) FI892730A (no)
HU (1) HUT53074A (no)
IL (1) IL90447A0 (no)
MX (1) MX16283A (no)
NO (1) NO892271L (no)
NZ (1) NZ229335A (no)
PT (1) PT90744B (no)
ZA (1) ZA894236B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE3935514A1 (de) * 1989-10-25 1991-05-02 Boehringer Mannheim Gmbh Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5076835A (en) * 1990-05-31 1991-12-31 America Cyanamid Company Aryloxyspiroalkylindolinone herbicides
BR9200951A (pt) * 1991-03-21 1992-11-17 Hoffmann La Roche Compostos, processo para sua producao,preparacoes farmaceuticas e uso
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
WO2004073634A2 (en) 2003-02-20 2004-09-02 Encysive Pharmaceuticals Inc. Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists
US7288538B2 (en) 2003-02-20 2007-10-30 Encysive Pharmaceuticals, Inc. Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
RU2009119394A (ru) * 2006-12-07 2011-01-20 Ф. Хоффманн-Ля Рош Аг (Ch) Производные спиро-пиперидина в качестве антагонистов рецептора v1a
BRPI0721138A2 (pt) * 2006-12-22 2014-04-01 Hoffmann La Roche Derivados de espiro-piperidina
KR101706877B1 (ko) 2012-09-13 2017-02-15 에프. 호프만-라 로슈 아게 Cns 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌
AR101196A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
WO2018086703A1 (en) 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas
US20200172483A1 (en) * 2017-06-22 2020-06-04 Curadev Pharma Limited Heterocyclic small molecule modulators of human sting
GB2572526A (en) * 2017-06-22 2019-10-09 Curadev Pharma Ltd Heterocyclic small molecule modulators of human STING
CA3089754A1 (en) 2018-01-31 2019-08-08 Bayer Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
AU2019289228A1 (en) * 2018-06-22 2021-01-21 Ucl Business Ltd Novel compounds
WO2021013693A1 (en) 2019-07-23 2021-01-28 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
FR2584713B1 (fr) * 1985-07-11 1988-09-09 Roussel Uclaf Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
EP0255134B1 (en) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same

Also Published As

Publication number Publication date
FI892730A (fi) 1989-12-04
NZ229335A (en) 1990-09-26
FI892730A0 (fi) 1989-06-02
AU616521B2 (en) 1991-10-31
HUT53074A (en) 1990-09-28
DE58907324D1 (de) 1994-05-05
EP0344634B1 (de) 1994-03-30
ATE103593T1 (de) 1994-04-15
DD283809A5 (de) 1990-10-24
IL90447A0 (en) 1990-01-18
JPH0225464A (ja) 1990-01-26
DK268789D0 (da) 1989-06-01
ZA894236B (en) 1990-03-28
EP0344634A1 (de) 1989-12-06
MX16283A (es) 1993-11-01
DE3818830A1 (de) 1989-12-14
PT90744A (pt) 1989-12-29
DK268789A (da) 1989-12-04
US5019587A (en) 1991-05-28
NO892271D0 (no) 1989-06-02
PT90744B (pt) 1994-10-31
CN1038640A (zh) 1990-01-10
KR900000339A (ko) 1990-01-30
AU3528389A (en) 1989-12-07

Similar Documents

Publication Publication Date Title
NO892271D0 (no) Fremgangsmaate for fremstilling av bicykliske carboxamider.
DE69432611D1 (de) Herstellung einer substituierten 2,5-Diamino-3-hydroxyhexan
KR970069985A (ko) 1,2-디페닐피롤 유도체,그의 제법 및 그의 치료학적 용도
BR9401484A (pt) Hidrazida de ácido 1h-indol-3-acético e formulação farmacêutica
DE69617788D1 (de) Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung
ATE39483T1 (de) Kondensierte pyrrolinon-derivate, und ihre herstellung.
ATE80378T1 (de) Substituierte crotonsaeureester und diese enthalende fungizide.
FI831388A0 (fi) 2-/2'-hydroxi-3'-(1,1-dimetylpropylamino)-propoxi/- -fenylpropionfenon, syreadditionssalter av denna foerfarande foer framstaellning av denna och farmaceutiska sammansaettningar
ATE131478T1 (de) 4-((2-benzothiazolyl)methylamino>-alpha-(3,4- difluorphenoxy)methyl-1-piperidenethanol
NO893482L (no) Fremgangsmaate for fremstilling av sulfonamider med tetrazolylrest.
NO177351C (no) Analogifremgangsmåte for fremstilling av renin-hemmende aminodiolderivater
DE3887102D1 (de) Substituierte Derivate von 20,21-Dinoreburnamenin, Verfahren zur Herstellung und so hergestellte Zwischenprodukte, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammenstellungen.
ATE22289T1 (de) N-(3-trifluormethylphenyl)-n'-propargylpiperazi , seine herstellung und verwendung.
NO921558D0 (no) Soetningsmidler som stammer fra l-glutaminsyre; fremgangsmaate for fremstilling av et soetningsmiddel
ATE114309T1 (de) N-azabicyclo(3.3.0>octanamide von aromatischen säuren.
DE3863682D1 (de) N-benzoyl-n'-trihalogen-halogenalkoxy-phenylharnstoffe, ihre herstellung und verwendung bei der kontrolle von schaedlingen.
DE59403903D1 (de) Verfahren zur Herstellung von gegebenfalls 2-substituierten 5-Chlorimidazolen
ES2070932T3 (es) Derivado de imidazolilpropilguanidina, procedimiento para su preparacion y medicamentos que lo contienen.
EP0337765A3 (en) Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists