NO884324L - Fremgangsmaate til fremstilling av reninhemmende dipeptider og deres anvendelse. - Google Patents

Fremgangsmaate til fremstilling av reninhemmende dipeptider og deres anvendelse.

Info

Publication number
NO884324L
NO884324L NO88884324A NO884324A NO884324L NO 884324 L NO884324 L NO 884324L NO 88884324 A NO88884324 A NO 88884324A NO 884324 A NO884324 A NO 884324A NO 884324 L NO884324 L NO 884324L
Authority
NO
Norway
Prior art keywords
inhibitive
dipeptides
pure
procedure
preparation
Prior art date
Application number
NO88884324A
Other languages
English (en)
Norwegian (no)
Other versions
NO884324D0 (no
Inventor
Adalbert Wagner
Heinz-Werner Kleemann
Dieter Ruppert
Bernward Schoelkens
Hansjoerg Urbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO884324D0 publication Critical patent/NO884324D0/no
Publication of NO884324L publication Critical patent/NO884324L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO88884324A 1987-09-30 1988-09-29 Fremgangsmaate til fremstilling av reninhemmende dipeptider og deres anvendelse. NO884324L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873732971 DE3732971A1 (de) 1987-09-30 1987-09-30 Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (2)

Publication Number Publication Date
NO884324D0 NO884324D0 (no) 1988-09-29
NO884324L true NO884324L (no) 1989-03-31

Family

ID=6337246

Family Applications (1)

Application Number Title Priority Date Filing Date
NO88884324A NO884324L (no) 1987-09-30 1988-09-29 Fremgangsmaate til fremstilling av reninhemmende dipeptider og deres anvendelse.

Country Status (13)

Country Link
EP (1) EP0310015A3 (da)
JP (1) JPH01121258A (da)
KR (1) KR890005146A (da)
AU (1) AU624579B2 (da)
DE (1) DE3732971A1 (da)
DK (1) DK543788A (da)
FI (1) FI884455A (da)
HU (1) HU203118B (da)
IL (1) IL87912A0 (da)
NO (1) NO884324L (da)
NZ (1) NZ226361A (da)
PT (1) PT88622B (da)
ZA (1) ZA887264B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87614A0 (en) * 1987-09-16 1989-01-31 Abbott Lab Peptidylheterocycles
DE3804793A1 (de) * 1988-02-16 1989-08-24 Hoechst Ag Renin-hemmende aminosaeurederivate
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3913290A1 (de) * 1989-04-22 1990-10-25 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
TW225540B (da) * 1990-06-28 1994-06-21 Shionogi & Co
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists
JP4696352B2 (ja) * 2000-11-30 2011-06-08 トヨタ自動車株式会社 車両用電源装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
WO1988003022A1 (en) * 1986-10-31 1988-05-05 Pfizer Inc. Relatively low molecular weight polypeptides as renin inhibitors
NL8800100A (nl) * 1987-01-21 1988-08-16 Sandoz Ag Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.

Also Published As

Publication number Publication date
AU2295988A (en) 1989-06-29
FI884455A0 (fi) 1988-09-28
NZ226361A (en) 1991-12-23
HU203118B (en) 1991-05-28
EP0310015A3 (de) 1992-05-20
AU624579B2 (en) 1992-06-18
JPH01121258A (ja) 1989-05-12
NO884324D0 (no) 1988-09-29
DK543788A (da) 1989-03-31
KR890005146A (ko) 1989-05-13
DK543788D0 (da) 1988-09-29
PT88622A (pt) 1989-07-31
FI884455A (fi) 1989-03-31
EP0310015A2 (de) 1989-04-05
DE3732971A1 (de) 1989-04-20
ZA887264B (en) 1989-06-28
HUT48278A (en) 1989-05-29
PT88622B (pt) 1993-07-30
IL87912A0 (en) 1989-03-31

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