NO864206L - Derivat av interleukin-2, dets fremstilling og anvendelse. - Google Patents
Derivat av interleukin-2, dets fremstilling og anvendelse.Info
- Publication number
- NO864206L NO864206L NO864206A NO864206A NO864206L NO 864206 L NO864206 L NO 864206L NO 864206 A NO864206 A NO 864206A NO 864206 A NO864206 A NO 864206A NO 864206 L NO864206 L NO 864206L
- Authority
- NO
- Norway
- Prior art keywords
- protein
- derivatives
- production
- amino acid
- dna
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title claims description 23
- 102000000588 Interleukin-2 Human genes 0.000 title claims description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000004071 biological effect Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 102000055277 human IL2 Human genes 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000013613 expression plasmid Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 101000702488 Rattus norvegicus High affinity cationic amino acid transporter 1 Proteins 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- -1 indolyl-acrylacetic acid Chemical compound 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853537461 DE3537461A1 (de) | 1985-10-22 | 1985-10-22 | Derivat des interleukin-2, seine herstellung und verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
NO864206D0 NO864206D0 (no) | 1986-10-21 |
NO864206L true NO864206L (no) | 1987-04-23 |
Family
ID=6284108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO864206A NO864206L (no) | 1985-10-22 | 1986-10-21 | Derivat av interleukin-2, dets fremstilling og anvendelse. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0219839A3 (fr) |
JP (1) | JPS62100299A (fr) |
KR (1) | KR870004142A (fr) |
AU (1) | AU6422986A (fr) |
DE (1) | DE3537461A1 (fr) |
DK (1) | DK504286A (fr) |
FI (1) | FI864235A (fr) |
HU (1) | HUT43109A (fr) |
IL (1) | IL80366A0 (fr) |
NO (1) | NO864206L (fr) |
NZ (1) | NZ217994A (fr) |
PT (1) | PT83591B (fr) |
ZA (1) | ZA867968B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
JPS62185098A (ja) * | 1986-02-10 | 1987-08-13 | Otsuka Pharmaceut Co Ltd | インタ−ロイキン−2活性を有するポリペプチド |
ZA898139B (en) * | 1988-11-17 | 1990-08-29 | Hoffmann La Roche | Recombinant interleukin-2 hybrid proteins |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2559782B1 (fr) * | 1984-02-16 | 1986-07-18 | Transgene Sa | Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2 |
JPS61500790A (ja) * | 1984-03-28 | 1986-04-24 | シタス コ−ポレイシヨン | 微生物的に製造されたインターロイキン―2を含有する組成物 |
DE3419995A1 (de) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens |
-
1985
- 1985-10-22 DE DE19853537461 patent/DE3537461A1/de not_active Withdrawn
-
1986
- 1986-10-18 EP EP86114468A patent/EP0219839A3/fr not_active Withdrawn
- 1986-10-20 NZ NZ217994A patent/NZ217994A/xx unknown
- 1986-10-20 IL IL80366A patent/IL80366A0/xx unknown
- 1986-10-20 FI FI864235A patent/FI864235A/fi not_active Application Discontinuation
- 1986-10-21 AU AU64229/86A patent/AU6422986A/en not_active Abandoned
- 1986-10-21 HU HU864371A patent/HUT43109A/hu unknown
- 1986-10-21 DK DK504286A patent/DK504286A/da not_active Application Discontinuation
- 1986-10-21 NO NO864206A patent/NO864206L/no unknown
- 1986-10-21 PT PT83591A patent/PT83591B/pt unknown
- 1986-10-21 ZA ZA867968A patent/ZA867968B/xx unknown
- 1986-10-22 KR KR1019860008846A patent/KR870004142A/ko not_active Application Discontinuation
- 1986-10-22 JP JP61249806A patent/JPS62100299A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS62100299A (ja) | 1987-05-09 |
FI864235A0 (fi) | 1986-10-20 |
DK504286D0 (da) | 1986-10-21 |
NO864206D0 (no) | 1986-10-21 |
NZ217994A (en) | 1988-09-29 |
EP0219839A2 (fr) | 1987-04-29 |
KR870004142A (ko) | 1987-05-07 |
DK504286A (da) | 1987-04-23 |
FI864235A (fi) | 1987-04-23 |
DE3537461A1 (de) | 1987-04-23 |
PT83591B (de) | 1988-11-10 |
AU6422986A (en) | 1987-04-30 |
EP0219839A3 (fr) | 1988-05-04 |
PT83591A (de) | 1986-11-01 |
IL80366A0 (en) | 1987-01-30 |
ZA867968B (en) | 1987-06-24 |
HUT43109A (en) | 1987-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3043803B2 (ja) | 融合タンパク質、その調製及び用途 | |
Patra et al. | Optimization of inclusion body solubilization and renaturation of recombinant human growth hormone from Escherichia coli | |
US4355104A (en) | Bacteriolytic proteins | |
US4520016A (en) | Bacteriolytic proteins | |
SK171492A3 (en) | Polypeptide, method of its preparation its use and pharmaceutical agent | |
JPS63267292A (ja) | 新規ポリペプチド | |
JPS60501391A (ja) | ポリペプチドおよび蛋白質生成物、ならびにその製造方法および使用 | |
JPH01502638A (ja) | グラム陽性及びグラム陰性菌に対する活性を有するポリペプチド類 | |
JPH03503596A (ja) | 蛋白質若しくはポリペプチドの調製方法、該ポリペプチドをコードするdna配列、該dna配列およびポリペプチドを有する微生物および該ポリペプチドの薬学的製剤としての利用 | |
NO864206L (no) | Derivat av interleukin-2, dets fremstilling og anvendelse. | |
KR100754235B1 (ko) | 수성 용매에 저장하는 동안 복합 혼합물중 단백질을안정화시키는 방법 | |
AU618011B2 (en) | Preparation of novel protein sweeteners-monellin type | |
RU2325440C1 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pGG-1, КОДИРУЮЩАЯ ПОЛИПЕПТИД ПРОИНСУЛИНА GLARGIN ЧЕЛОВЕКА И ШТАММ БАКТЕРИЙ ESCHERICHIA COLI BGG18 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ПРОИНСУЛИНА GLARGIN | |
RU2337964C2 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pAS-2, КОДИРУЮЩАЯ ПОЛИПЕПТИД ПРОИНСУЛИНА Aspart ЧЕЛОВЕКА, И ШТАММ БАКТЕРИЙ Escherichia coli BAS2 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ПРОИНСУЛИНА Aspart | |
AU619193B2 (en) | Preparation of novel protein sweeteners - monellin type | |
JPH03503002A (ja) | 蛋白質甘味料の酵母中における発現 | |
JP2845558B2 (ja) | メチオニンアミノペプチダーゼのdna配列 | |
JPH06306100A (ja) | Vipアナログ調製用融合蛋白、vipアナログの製法並びにそのための遺伝子組換えプラスミド及び形質転換微生物 | |
KR0149955B1 (ko) | 융합단백질을 이용한 인간 글루카곤의 제조방법 | |
KR0132003B1 (ko) | 스트렙토마이세스 써모니트리피컨스 아미노펩티다제를 이용한 천연형 재조합 단백질의 제조방법 | |
JP4252299B2 (ja) | 新規ジスルフィド酸化還元酵素、および、該酵素を用いたタンパク質の活性化方法 | |
RU2263147C1 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pHINS05, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ПРОИНСУЛИН ЧЕЛОВЕКА, КЛЕТКА ESCHERICHIA COLI, ТРАНСФОРМИРОВАННАЯ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pHINS05, И ШТАММ БАКТЕРИЙ ESCHERICHIA COLI JM109/pHINS05 - ПРОДУЦЕНТ ГИБРИДНОГО ПОЛИПЕПТИДА, СОДЕРЖАЩЕГО ПРОИНСУЛИН ЧЕЛОВЕКА | |
WO2018216841A1 (fr) | Protéine de fusion de protéine de choc thermique 10 et de protéine de type brazzéine, qui augmente l'activité antioxydante et l'effet de prolifération de cellules cutanées, et composition cosmétique pour réduire les rides de la peau, qui la contient en tant que principe actif | |
KR900004942B1 (ko) | 펩티드(peptide)의 제조방법 | |
KR920007684B1 (ko) | 신규한 발현 벡터와 그의 제조방법 |