NO861139L - Stabilt gamma-interferonpreparat. - Google Patents
Stabilt gamma-interferonpreparat.Info
- Publication number
- NO861139L NO861139L NO861139A NO861139A NO861139L NO 861139 L NO861139 L NO 861139L NO 861139 A NO861139 A NO 861139A NO 861139 A NO861139 A NO 861139A NO 861139 L NO861139 L NO 861139L
- Authority
- NO
- Norway
- Prior art keywords
- solution
- interferon
- preparation
- preparation according
- gif
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 36
- 229940044627 gamma-interferon Drugs 0.000 title claims description 6
- 108010074328 Interferon-gamma Proteins 0.000 title description 2
- 102000008070 Interferon-gamma Human genes 0.000 title description 2
- 239000000243 solution Substances 0.000 claims description 47
- 229940079322 interferon Drugs 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 239000000872 buffer Substances 0.000 claims description 10
- 230000007935 neutral effect Effects 0.000 claims description 10
- 239000003963 antioxidant agent Substances 0.000 claims description 9
- 235000006708 antioxidants Nutrition 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 7
- 235000018417 cysteine Nutrition 0.000 claims description 7
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 6
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 239000004471 Glycine Substances 0.000 claims description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 4
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- 238000007710 freezing Methods 0.000 claims description 4
- 230000008014 freezing Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 102000006992 Interferon-alpha Human genes 0.000 claims description 3
- 108010047761 Interferon-alpha Proteins 0.000 claims description 3
- 102000003996 Interferon-beta Human genes 0.000 claims description 3
- 108090000467 Interferon-beta Proteins 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000007853 buffer solution Substances 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 150000005846 sugar alcohols Chemical class 0.000 claims description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 239000003349 gelling agent Substances 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 230000002378 acidificating effect Effects 0.000 description 8
- 239000008364 bulk solution Substances 0.000 description 8
- 108010050904 Interferons Proteins 0.000 description 7
- 102000014150 Interferons Human genes 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000008176 lyophilized powder Substances 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000001028 anti-proliverative effect Effects 0.000 description 3
- 229960002433 cysteine Drugs 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940047124 interferons Drugs 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 101800000263 Acidic protein Proteins 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000120 cytopathologic effect Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- -1 glucose) Chemical class 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 230000004957 immunoregulator effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 150000001945 cysteines Chemical class 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- UVZICZIVKIMRNE-UHFFFAOYSA-N thiodiacetic acid Chemical compound OC(=O)CSCC(O)=O UVZICZIVKIMRNE-UHFFFAOYSA-N 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000006208 topical dosage form Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71585185A | 1985-03-25 | 1985-03-25 | |
| US74093285A | 1985-06-03 | 1985-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO861139L true NO861139L (no) | 1986-09-26 |
Family
ID=27109430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO861139A NO861139L (no) | 1985-03-25 | 1986-03-21 | Stabilt gamma-interferonpreparat. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0196203A3 (es) |
| KR (1) | KR900004799B1 (es) |
| CN (1) | CN86101878A (es) |
| AU (1) | AU592552B2 (es) |
| DK (1) | DK131986A (es) |
| ES (1) | ES8705761A1 (es) |
| FI (1) | FI861193A (es) |
| GR (1) | GR860758B (es) |
| HU (1) | HU200278B (es) |
| IL (1) | IL78231A (es) |
| MA (1) | MA20647A1 (es) |
| MY (1) | MY101973A (es) |
| NO (1) | NO861139L (es) |
| NZ (1) | NZ215563A (es) |
| OA (1) | OA08269A (es) |
| PT (1) | PT82249B (es) |
| TN (1) | TNSN86042A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5183746A (en) * | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
| US5037644A (en) * | 1986-10-27 | 1991-08-06 | Cetus Corporation | Pharmaceutical compositions of recombinant interleukin-2 and formulation processes |
| EP0284249A1 (en) * | 1987-03-13 | 1988-09-28 | Interferon Sciences, Inc. | Lyophilized lymphokine composition |
| US5151265A (en) * | 1987-11-03 | 1992-09-29 | Genentech, Inc. | Gamma interferon formulation |
| US5004605A (en) * | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
| CA2024046A1 (en) * | 1989-09-28 | 1991-03-29 | Alberto Ferro | Stabilized leukocyte-interferons |
| FR2690340B1 (fr) * | 1992-04-24 | 1995-02-24 | Scr Newmed | Nouveau procédé de stabilisation des préparations pharmaceutiques liquides et les compositions pharmaceutiques ainsi stabilisées en résultant. |
| TW249202B (es) * | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
| US20030147850A1 (en) * | 2001-09-27 | 2003-08-07 | Pomytkin Igor Anatolievich | Composition and methods for potentiating therapeutic effects of interferons |
| CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
| CN109819650A (zh) * | 2017-09-25 | 2019-05-28 | 春布里泽·格奥尔基·格奥尔基耶维奇 | 具有抗病毒和抗细菌活性的热稳定组合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4480032A (en) * | 1980-11-13 | 1984-10-30 | Yabrov Alexander A | Natural mixture of Type I and Type II interferons |
| EP0080879B1 (en) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| ZA83768B (en) * | 1982-03-01 | 1983-10-26 | Hoffmann La Roche | Homogeneous human immune interferon and process therefor |
| DE3484374D1 (de) * | 1983-08-04 | 1991-05-08 | Green Cross Corp | Gamma-interferonzusammensetzung. |
| EP0168008A3 (en) * | 1984-07-10 | 1986-12-30 | Takeda Chemical Industries, Ltd. | Stable composition of gamma-interferon |
-
1986
- 1986-03-21 FI FI861193A patent/FI861193A/fi not_active Application Discontinuation
- 1986-03-21 EP EP86302104A patent/EP0196203A3/en not_active Ceased
- 1986-03-21 NZ NZ215563A patent/NZ215563A/xx unknown
- 1986-03-21 AU AU55028/86A patent/AU592552B2/en not_active Ceased
- 1986-03-21 IL IL78231A patent/IL78231A/xx unknown
- 1986-03-21 TN TNTNSN86042A patent/TNSN86042A1/fr unknown
- 1986-03-21 GR GR860758A patent/GR860758B/el unknown
- 1986-03-21 ES ES553232A patent/ES8705761A1/es not_active Expired
- 1986-03-21 OA OA58817A patent/OA08269A/xx unknown
- 1986-03-21 DK DK131986A patent/DK131986A/da not_active Application Discontinuation
- 1986-03-21 MA MA20872A patent/MA20647A1/fr unknown
- 1986-03-21 NO NO861139A patent/NO861139L/no unknown
- 1986-03-21 PT PT82249A patent/PT82249B/pt unknown
- 1986-03-24 HU HU861217A patent/HU200278B/hu not_active IP Right Cessation
- 1986-03-24 CN CN198686101878A patent/CN86101878A/zh active Pending
- 1986-03-24 KR KR1019860002163A patent/KR900004799B1/ko not_active Application Discontinuation
-
1987
- 1987-08-10 MY MYPI87001253A patent/MY101973A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0196203A2 (en) | 1986-10-01 |
| OA08269A (fr) | 1987-10-30 |
| HUT40577A (en) | 1987-01-28 |
| IL78231A (en) | 1990-07-26 |
| ES553232A0 (es) | 1987-05-16 |
| CN86101878A (zh) | 1986-10-29 |
| FI861193A (fi) | 1986-09-26 |
| FI861193A0 (fi) | 1986-03-21 |
| DK131986A (da) | 1986-09-26 |
| AU592552B2 (en) | 1990-01-18 |
| NZ215563A (en) | 1989-06-28 |
| ES8705761A1 (es) | 1987-05-16 |
| PT82249A (en) | 1986-04-01 |
| KR860006982A (ko) | 1986-10-06 |
| IL78231A0 (en) | 1986-07-31 |
| DK131986D0 (da) | 1986-03-21 |
| EP0196203A3 (en) | 1987-09-30 |
| MY101973A (en) | 1992-02-29 |
| PT82249B (en) | 1988-01-07 |
| TNSN86042A1 (fr) | 1990-01-01 |
| MA20647A1 (fr) | 1986-10-01 |
| AU5502886A (en) | 1986-10-02 |
| HU200278B (en) | 1990-05-28 |
| GR860758B (en) | 1986-07-21 |
| KR900004799B1 (ko) | 1990-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0618807B1 (en) | A stabilized pharmaceutical formulation comprising growth hormone and histidine | |
| US4847079A (en) | Biologically stable interferon compositions comprising thimerosal | |
| JP3898221B2 (ja) | トレハロースを含む乾燥血液因子組成物 | |
| JP4405666B2 (ja) | 安定化テリパラチド溶液剤 | |
| JP3031570B2 (ja) | 安定化されたゴナドトロピンを含有する調製品 | |
| EP0618806B1 (en) | A stabilized pharmaceutical formulation comprising growth hormone and asparagine | |
| US20020077461A1 (en) | Pharmaceutical formulation | |
| EP0839049A1 (en) | A stabilized pharmaceutical formulation comprising a growth hormone pre-treated with zinc and optionally lysine or calcium ions | |
| EP1082133A2 (en) | Pharmaceutical formulations for igf/igfbp | |
| AU738413B2 (en) | Human growth hormone-containing aqueous pharmaceutical composition | |
| US20060074011A1 (en) | Compositions providing for increased IGF-I solubility | |
| JP2002511103A (ja) | アミリン作動薬ペプチド用製剤 | |
| NO861139L (no) | Stabilt gamma-interferonpreparat. | |
| US20050163752A1 (en) | Human interferon-beta formulations | |
| US8841252B2 (en) | Pharmaceutical formulation | |
| EP1706150B1 (en) | Stable growth hormone liquid formulation | |
| JPH0925241A (ja) | Ｈｇｆ凍結乾燥製剤 | |
| JP2002512973A (ja) | タンパク質製剤 | |
| JPH11515002A (ja) | 副甲状腺ホルモンを含む安定な医薬投与形態 | |
| EP0804223B1 (en) | Hgh containing pharmaceutical compositions | |
| KR880002037B1 (ko) | 인터페론 조성물 및 이의 제조방법 | |
| JP2001524360A (ja) | ０．５ｍｌ未満の容量を投与するための凍結乾燥タンパク質組成物を含む１回量注射器 | |
| EP0189673A1 (en) | Stable growth hormone releasing factor preparation | |
| US5169834A (en) | Compositions and method for reducing vial breakage during lyophilization | |
| US9387233B2 (en) | Long-term storage of non-glycosylated recombinant human G-CSF |