NO853607L - 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-okso-3-kinolin-karboks ylsyre med antibakteriell aktivitet og fremgangsm¨te for f remstilling derav. - Google Patents
7-(pyridinyl)-/-alkyl-1,4-dihydro-4-okso-3-kinolin-karboks ylsyre med antibakteriell aktivitet og fremgangsm¨te for f remstilling derav.Info
- Publication number
- NO853607L NO853607L NO853607A NO853607A NO853607L NO 853607 L NO853607 L NO 853607L NO 853607 A NO853607 A NO 853607A NO 853607 A NO853607 A NO 853607A NO 853607 L NO853607 L NO 853607L
- Authority
- NO
- Norway
- Prior art keywords
- dimethyl
- acid
- pyridinyl
- oxo
- dihydro
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims description 32
- 238000000034 method Methods 0.000 title claims description 23
- 230000000844 anti-bacterial effect Effects 0.000 title description 15
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- -1 6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid Chemical compound 0.000 claims description 22
- YGUOWKBREYDEOC-UHFFFAOYSA-N 4-(2-fluorophenyl)-2,6-dimethylpyridine Chemical compound CC1=NC(C)=CC(C=2C(=CC=CC=2)F)=C1 YGUOWKBREYDEOC-UHFFFAOYSA-N 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 14
- FQVZBJHQWSJCQM-UHFFFAOYSA-N 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine Chemical compound CC1=NC(C)=CC(C=2C(=CC=C(C=2)[N+]([O-])=O)F)=C1 FQVZBJHQWSJCQM-UHFFFAOYSA-N 0.000 claims description 12
- RZCCYPFPALDTNG-UHFFFAOYSA-N 7-(2,6-dimethylpyridin-4-yl)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1C1=CC(C)=NC(C)=C1 RZCCYPFPALDTNG-UHFFFAOYSA-N 0.000 claims description 12
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- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- BJAARRARQJZURR-UHFFFAOYSA-N trimethylazanium;hydroxide Chemical compound O.CN(C)C BJAARRARQJZURR-UHFFFAOYSA-N 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 239000007966 viscous suspension Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65094684A | 1984-09-17 | 1984-09-17 | |
| US06/651,121 US4698350A (en) | 1984-09-17 | 1984-09-17 | 1-ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO853607L true NO853607L (no) | 1986-03-18 |
Family
ID=27095971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO853607A NO853607L (no) | 1984-09-17 | 1985-09-13 | 7-(pyridinyl)-/-alkyl-1,4-dihydro-4-okso-3-kinolin-karboks ylsyre med antibakteriell aktivitet og fremgangsm¨te for f remstilling derav. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0179239A3 (de) |
| KR (1) | KR860002494A (de) |
| AU (1) | AU4748585A (de) |
| DK (1) | DK418885A (de) |
| ES (1) | ES8701168A1 (de) |
| FI (1) | FI853515L (de) |
| GR (1) | GR852237B (de) |
| IL (1) | IL76394A0 (de) |
| NO (1) | NO853607L (de) |
| PT (1) | PT81129B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169853A (en) * | 1987-09-08 | 1992-12-08 | Sterling Drug Inc. | Pyridinyl-quinolone compounds, their preparation and use |
| NZ225926A (en) * | 1987-09-08 | 1990-04-26 | Sterling Drug Inc | 7-pyridinyl-4-oxo-3-quinolinecarboxylic acid derivatives, and pharmaceutical compositions |
| US5075319A (en) * | 1987-09-08 | 1991-12-24 | Sterling Drug Inc. | Pyridinyl-quinolone compounds, their preparation and use |
| US4839355A (en) * | 1987-09-09 | 1989-06-13 | Sterling Drug Inc. | Tricyclic-pyridinylquinoline compounds, their preparation and use |
| CH692199A8 (fr) * | 1997-10-09 | 2002-06-14 | Cermol S.A. | Composes pyridiques et compositions pharmaceutique |
| GB2560903A (en) | 2017-03-27 | 2018-10-03 | Azad Pharmaceutical Ingredients Ag | New synthetic path to pharmaceutically acceptable vismodegib |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
| US3753993A (en) * | 1971-05-17 | 1973-08-21 | Sterling Drug Inc | 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives |
| US3922278A (en) * | 1972-06-12 | 1975-11-25 | Sterling Drug Inc | 4-(3-Nitrophenyl)-3,5-pyridinedicarboxylic acid |
-
1985
- 1985-09-02 EP EP85111049A patent/EP0179239A3/de not_active Withdrawn
- 1985-09-13 KR KR1019850006703A patent/KR860002494A/ko not_active Application Discontinuation
- 1985-09-13 IL IL76394A patent/IL76394A0/xx unknown
- 1985-09-13 FI FI853515A patent/FI853515L/fi not_active Application Discontinuation
- 1985-09-13 NO NO853607A patent/NO853607L/no unknown
- 1985-09-13 PT PT81129A patent/PT81129B/pt unknown
- 1985-09-16 ES ES546998A patent/ES8701168A1/es not_active Expired
- 1985-09-16 AU AU47485/85A patent/AU4748585A/en not_active Abandoned
- 1985-09-16 GR GR852237A patent/GR852237B/el unknown
- 1985-09-16 DK DK418885A patent/DK418885A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL76394A0 (en) | 1986-01-31 |
| EP0179239A2 (de) | 1986-04-30 |
| FI853515L (fi) | 1986-03-18 |
| AU4748585A (en) | 1986-03-27 |
| ES546998A0 (es) | 1986-11-16 |
| KR860002494A (ko) | 1986-04-26 |
| GR852237B (de) | 1986-01-17 |
| DK418885A (da) | 1986-04-24 |
| PT81129A (en) | 1985-10-01 |
| EP0179239A3 (de) | 1986-08-13 |
| PT81129B (en) | 1987-03-17 |
| ES8701168A1 (es) | 1986-11-16 |
| DK418885D0 (da) | 1985-09-16 |
| FI853515A0 (fi) | 1985-09-13 |
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