NO842467L - Fremgangsmaate ved fremstilling av 2-sulfamoylbenzo(b)thiofenderivater - Google Patents

Fremgangsmaate ved fremstilling av 2-sulfamoylbenzo(b)thiofenderivater

Info

Publication number
NO842467L
NO842467L NO842467A NO842467A NO842467L NO 842467 L NO842467 L NO 842467L NO 842467 A NO842467 A NO 842467A NO 842467 A NO842467 A NO 842467A NO 842467 L NO842467 L NO 842467L
Authority
NO
Norway
Prior art keywords
thiophene
sulfamoylbenzo
alkyl
compound
hydroxy
Prior art date
Application number
NO842467A
Other languages
English (en)
Norwegian (no)
Inventor
Kenneth L Shepard
Samuel L Graham
Robert F Czaja
David G Melillo
Jacob M Hoffman Jr
Original Assignee
Merk & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merk & Co Ltd filed Critical Merk & Co Ltd
Publication of NO842467L publication Critical patent/NO842467L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO842467A 1983-06-20 1984-06-19 Fremgangsmaate ved fremstilling av 2-sulfamoylbenzo(b)thiofenderivater NO842467L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50609283A 1983-06-20 1983-06-20
US54719183A 1983-10-31 1983-10-31

Publications (1)

Publication Number Publication Date
NO842467L true NO842467L (no) 1985-12-21

Family

ID=27055356

Family Applications (1)

Application Number Title Priority Date Filing Date
NO842467A NO842467L (no) 1983-06-20 1984-06-19 Fremgangsmaate ved fremstilling av 2-sulfamoylbenzo(b)thiofenderivater

Country Status (15)

Country Link
EP (1) EP0129478B1 (sv)
KR (1) KR890000386B1 (sv)
AU (1) AU558665B2 (sv)
CA (1) CA1253151A (sv)
DE (1) DE3481057D1 (sv)
DK (1) DK298584A (sv)
ES (1) ES8600272A1 (sv)
FI (1) FI80032C (sv)
GR (1) GR82372B (sv)
HU (1) HUT37420A (sv)
IE (1) IE57601B1 (sv)
IL (1) IL72070A (sv)
NO (1) NO842467L (sv)
NZ (1) NZ208444A (sv)
PT (1) PT78762A (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189690B1 (en) * 1984-12-12 1989-03-01 Merck & Co. Inc. Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4820848A (en) * 1984-12-12 1989-04-11 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
EP0271273A3 (en) * 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
US4894390A (en) * 1987-08-03 1990-01-16 Merck & Co., Inc. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents
CA1320487C (en) * 1987-08-03 1993-07-20 George D. Hartman Substituted thieno[2,3-.beta.]thiophene-2-sulfonamides as antiglaucoma agents
US4751231A (en) * 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
US6313309B1 (en) * 1999-04-05 2001-11-06 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl—1H—imidazoles which are usefulα22-adrenoceptoR agonists/ antagonists
NZ561672A (en) 2005-03-28 2010-04-30 Toyama Chemical Co Ltd Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241136A1 (es) * 1981-07-13 1991-11-29 Merck E Co Inc Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
EP0129478B1 (en) 1990-01-17
AU2949684A (en) 1985-06-13
FI80032C (sv) 1990-04-10
KR890000386B1 (ko) 1989-03-16
AU558665B2 (en) 1987-02-05
PT78762A (en) 1984-07-01
KR850000428A (ko) 1985-02-27
DK298584A (da) 1984-12-21
ES533390A0 (es) 1985-10-01
GR82372B (sv) 1984-12-13
IL72070A0 (en) 1984-10-31
EP0129478A3 (en) 1987-03-25
DK298584D0 (da) 1984-06-19
EP0129478A2 (en) 1984-12-27
NZ208444A (en) 1987-08-31
IE841536L (en) 1984-12-20
FI80032B (fi) 1989-12-29
FI842478A0 (fi) 1984-06-19
FI842478A (fi) 1984-12-21
HUT37420A (en) 1985-12-28
IE57601B1 (en) 1993-01-27
DE3481057D1 (de) 1990-02-22
ES8600272A1 (es) 1985-10-01
IL72070A (en) 1988-11-30
CA1253151A (en) 1989-04-25

Similar Documents

Publication Publication Date Title
US4668697A (en) Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
Graham et al. Topically active carbonic anhydrase inhibitors. 2. Benzo [b] thiophenesulfonamide derivatives with ocular hypotensive activity
DK175886B1 (da) Fremgangsmåde til fremstilling af ikke-solvatiseret krystallinsk 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophenhydrochlorid
US5292736A (en) Morpholinoalkylindenes as antiglaucoma agents
NO842467L (no) Fremgangsmaate ved fremstilling av 2-sulfamoylbenzo(b)thiofenderivater
US4677115A (en) Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof
US4436748A (en) Benzo[b]thiophenes
US3070606A (en) Xchxn
CA2445010A1 (en) Heteroaryloxy 3-substituted propanamines s serotonin and norepinephrine reuptake inhibitors
US4847289A (en) Thiophene sulfonamide antiglaucoma agents
EP0189690B1 (en) Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
EP0152340B1 (en) 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure
KR100322943B1 (ko) 항염증제로서유용한디히드로벤조푸란및관련화합물
US4788192A (en) 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
US4665090A (en) Substituted thiophene-2-sulfonamide antiglaucoma agents
US4820848A (en) Substituted aromatic sulfonamides as antiglaucoma agents
US4824968A (en) Substituted aromatic sulfonamides as antiglaucoma agents
JPH0219837B2 (sv)
EP0182691B1 (en) Substituted thiophene-2-sulfonamides and their preparation
US5175284A (en) Tricyclic thienothiopyrans as pharmaceutical intermediates
PL145950B1 (en) Method of obtaining 1,3-diacyl-2-ketoindoles
NO771032L (no) Dibenzotiofen-derivater.
Charonnat et al. The synthesis of four isomeric bisthienothiepinones
NO115439B (sv)