FI842478A - Foer behandling av oegats inre tryck an- vaendbara 2-sulfamoylbenzo/b/tiofenderivat. - Google Patents

Foer behandling av oegats inre tryck an- vaendbara 2-sulfamoylbenzo/b/tiofenderivat. Download PDF

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Publication number
FI842478A
FI842478A FI842478A FI842478A FI842478A FI 842478 A FI842478 A FI 842478A FI 842478 A FI842478 A FI 842478A FI 842478 A FI842478 A FI 842478A FI 842478 A FI842478 A FI 842478A
Authority
FI
Finland
Prior art keywords
vaendbara
tiofenderivat
oegats
tryck
sulfamoylbenzo
Prior art date
Application number
FI842478A
Other languages
English (en)
Other versions
FI80032C (fi
FI80032B (fi
FI842478A0 (fi
Inventor
Robert F Czaja
David G Melillo
Kenneth L Shepard
Samuel L Graham
Jr Jacob M Hoffmann
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI842478A0 publication Critical patent/FI842478A0/fi
Publication of FI842478A publication Critical patent/FI842478A/fi
Application granted granted Critical
Publication of FI80032B publication Critical patent/FI80032B/fi
Publication of FI80032C publication Critical patent/FI80032C/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI842478A 1983-06-20 1984-06-19 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 2-sulfamoylbenso/b/tiofenderivat. FI80032C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50609283A 1983-06-20 1983-06-20
US50609283 1983-06-20
US54719183A 1983-10-31 1983-10-31
US54719183 1983-10-31

Publications (4)

Publication Number Publication Date
FI842478A0 FI842478A0 (fi) 1984-06-19
FI842478A true FI842478A (fi) 1984-12-21
FI80032B FI80032B (fi) 1989-12-29
FI80032C FI80032C (fi) 1990-04-10

Family

ID=27055356

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842478A FI80032C (fi) 1983-06-20 1984-06-19 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 2-sulfamoylbenso/b/tiofenderivat.

Country Status (15)

Country Link
EP (1) EP0129478B1 (fi)
KR (1) KR890000386B1 (fi)
AU (1) AU558665B2 (fi)
CA (1) CA1253151A (fi)
DE (1) DE3481057D1 (fi)
DK (1) DK298584A (fi)
ES (1) ES533390A0 (fi)
FI (1) FI80032C (fi)
GR (1) GR82372B (fi)
HU (1) HUT37420A (fi)
IE (1) IE57601B1 (fi)
IL (1) IL72070A (fi)
NO (1) NO842467L (fi)
NZ (1) NZ208444A (fi)
PT (1) PT78762A (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE41002T1 (de) * 1984-12-12 1989-03-15 Merck & Co Inc Substituierte aromatische sulfonamide, ihre herstellung und diese enthaltende ophthalmische zubereitungen.
US4820848A (en) * 1984-12-12 1989-04-11 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
EP0271273A3 (en) * 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
US4894390A (en) * 1987-08-03 1990-01-16 Merck & Co., Inc. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents
CA1320487C (en) * 1987-08-03 1993-07-20 George D. Hartman Substituted thieno[2,3-.beta.]thiophene-2-sulfonamides as antiglaucoma agents
US4751231A (en) * 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
US6313309B1 (en) * 1999-04-05 2001-11-06 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl—1H—imidazoles which are usefulα22-adrenoceptoR agonists/ antagonists
NZ561672A (en) 2005-03-28 2010-04-30 Toyama Chemical Co Ltd Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241136A1 (es) * 1981-07-13 1991-11-29 Merck E Co Inc Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
KR850000428A (ko) 1985-02-27
FI80032C (fi) 1990-04-10
IL72070A0 (en) 1984-10-31
NO842467L (no) 1985-12-21
IE57601B1 (en) 1993-01-27
CA1253151A (en) 1989-04-25
EP0129478B1 (en) 1990-01-17
DK298584A (da) 1984-12-21
AU2949684A (en) 1985-06-13
KR890000386B1 (ko) 1989-03-16
AU558665B2 (en) 1987-02-05
ES8600272A1 (es) 1985-10-01
IE841536L (en) 1984-12-20
EP0129478A3 (en) 1987-03-25
PT78762A (en) 1984-07-01
ES533390A0 (es) 1985-10-01
FI80032B (fi) 1989-12-29
NZ208444A (en) 1987-08-31
DK298584D0 (da) 1984-06-19
DE3481057D1 (de) 1990-02-22
HUT37420A (en) 1985-12-28
EP0129478A2 (en) 1984-12-27
FI842478A0 (fi) 1984-06-19
IL72070A (en) 1988-11-30
GR82372B (fi) 1984-12-13

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MM Patent lapsed

Owner name: MERCK & CO., INC.