NO840113L - Anvendelse av nafazatrom ved terapien av hjerterytmeforstyrrelser og ischemier, hud- og oeyenbetennelser, samt av reumatiske, allergiske og astmatiske sykdommer, oedemer, lungeembolier, pulmonal hypertensjon, sjokklunge, o.s.v. - Google Patents
Anvendelse av nafazatrom ved terapien av hjerterytmeforstyrrelser og ischemier, hud- og oeyenbetennelser, samt av reumatiske, allergiske og astmatiske sykdommer, oedemer, lungeembolier, pulmonal hypertensjon, sjokklunge, o.s.v.Info
- Publication number
- NO840113L NO840113L NO840113A NO840113A NO840113L NO 840113 L NO840113 L NO 840113L NO 840113 A NO840113 A NO 840113A NO 840113 A NO840113 A NO 840113A NO 840113 L NO840113 L NO 840113L
- Authority
- NO
- Norway
- Prior art keywords
- nafazatrom
- rheumatic
- allergic
- effective amount
- therapeutically effective
- Prior art date
Links
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- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000005246 left atrium Anatomy 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-M leukotriene B4(1-) Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC([O-])=O VNYSSYRCGWBHLG-AMOLWHMGSA-M 0.000 description 1
- 230000000936 membranestabilizing effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- CMCWWLVWPDLCRM-UHFFFAOYSA-N phenidone Chemical compound N1C(=O)CCN1C1=CC=CC=C1 CMCWWLVWPDLCRM-UHFFFAOYSA-N 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 description 1
- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002336 repolarization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- XNRNNGPBEPRNAR-JQBLCGNGSA-N thromboxane B2 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O XNRNNGPBEPRNAR-JQBLCGNGSA-N 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833302811 DE3302811A1 (de) | 1983-01-28 | 1983-01-28 | Verwendung von nafazatrom bei der therapie von herzrhythmusstoerungen und myokardischaemien, arzneimittel hierfuer und verfahren zu deren herstellung |
| DE19833308880 DE3308880A1 (de) | 1983-03-12 | 1983-03-12 | Verwendung von nafazatrom als lipoxygenasehemmer, bei der therapie von herzrhythmusstoerungen und ischaemien, sowie von rheumatischen, allergischen und asthmatischen erkrankungen, oedemen, lungenembolien, pulmonaler hypertension, sauerstoffintoxikation und ulcerationen, arzneimittel hierfuer und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO840113L true NO840113L (no) | 1984-07-30 |
Family
ID=25807873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO840113A NO840113L (no) | 1983-01-28 | 1984-01-12 | Anvendelse av nafazatrom ved terapien av hjerterytmeforstyrrelser og ischemier, hud- og oeyenbetennelser, samt av reumatiske, allergiske og astmatiske sykdommer, oedemer, lungeembolier, pulmonal hypertensjon, sjokklunge, o.s.v. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US4540707A (hu) |
| EP (1) | EP0115789B1 (hu) |
| DE (1) | DE3481403D1 (hu) |
| DK (1) | DK39584A (hu) |
| ES (1) | ES529236A0 (hu) |
| FI (1) | FI840327A (hu) |
| GR (1) | GR81959B (hu) |
| HU (1) | HU197213B (hu) |
| IL (1) | IL70771A0 (hu) |
| NO (1) | NO840113L (hu) |
| PH (1) | PH20369A (hu) |
| PT (1) | PT77971B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169185A (en) * | 1991-01-25 | 1992-12-08 | Republic Industries, Inc. | Panic exit device featuring improved bar movement and fail safe dogging |
| WO2004002422A2 (en) * | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4372887A (en) * | 1970-06-18 | 1983-02-08 | Mead Johnson & Company | Iminopyrrolidinylindoles |
| DE2427272C3 (de) * | 1974-06-06 | 1981-10-01 | Bayer Ag, 5090 Leverkusen | 1-(2-(β-Naphthyloxy)-äthyl)-3-methyl -pyrazolon-(5), Verfahren sowie Verwendung als Antithrombotikum |
| DE3118126A1 (de) * | 1981-05-07 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Sulfenamide zur verwendung in arzneimitteln |
| US4432991A (en) * | 1981-07-13 | 1984-02-21 | American Cyanamid Company | Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines |
-
1983
- 1983-04-18 US US06/486,175 patent/US4540707A/en not_active Expired - Fee Related
-
1984
- 1984-01-12 NO NO840113A patent/NO840113L/no unknown
- 1984-01-13 DE DE8484100305T patent/DE3481403D1/de not_active Expired - Lifetime
- 1984-01-13 EP EP84100305A patent/EP0115789B1/de not_active Expired - Lifetime
- 1984-01-18 PT PT77971A patent/PT77971B/pt unknown
- 1984-01-25 PH PH30164A patent/PH20369A/en unknown
- 1984-01-25 IL IL70771A patent/IL70771A0/xx unknown
- 1984-01-26 GR GR73625A patent/GR81959B/el unknown
- 1984-01-26 FI FI840327A patent/FI840327A/fi not_active Application Discontinuation
- 1984-01-27 ES ES529236A patent/ES529236A0/es active Granted
- 1984-01-27 DK DK39584A patent/DK39584A/da not_active Application Discontinuation
- 1984-01-27 HU HU84375A patent/HU197213B/hu not_active IP Right Cessation
-
1985
- 1985-03-25 US US06/715,438 patent/US4657924A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES8500055A1 (es) | 1984-10-01 |
| DK39584D0 (da) | 1984-01-27 |
| DK39584A (da) | 1984-07-29 |
| US4540707A (en) | 1985-09-10 |
| EP0115789B1 (de) | 1990-02-28 |
| EP0115789A2 (de) | 1984-08-15 |
| FI840327A0 (fi) | 1984-01-26 |
| GR81959B (hu) | 1984-12-12 |
| IL70771A0 (en) | 1984-04-30 |
| PT77971B (en) | 1986-07-15 |
| FI840327A (fi) | 1984-07-29 |
| US4657924A (en) | 1987-04-14 |
| HU197213B (en) | 1989-03-28 |
| HUT34886A (en) | 1985-05-28 |
| DE3481403D1 (de) | 1990-04-05 |
| PT77971A (en) | 1984-02-01 |
| ES529236A0 (es) | 1984-10-01 |
| PH20369A (en) | 1986-12-04 |
| EP0115789A3 (en) | 1987-07-15 |
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