NO821174L - Fremgangsmaate ved fremstilling av natriumamoxillin - Google Patents
Fremgangsmaate ved fremstilling av natriumamoxillinInfo
- Publication number
- NO821174L NO821174L NO821174A NO821174A NO821174L NO 821174 L NO821174 L NO 821174L NO 821174 A NO821174 A NO 821174A NO 821174 A NO821174 A NO 821174A NO 821174 L NO821174 L NO 821174L
- Authority
- NO
- Norway
- Prior art keywords
- sodium
- solution
- procedure
- preparation
- amoxillin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title description 2
- 238000002360 preparation method Methods 0.000 title description 2
- 229910052708 sodium Inorganic materials 0.000 title description 2
- 239000011734 sodium Substances 0.000 title description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 12
- BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 229960003022 amoxicillin Drugs 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 3
- 229960004920 amoxicillin trihydrate Drugs 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- VOUGEZYPVGAPBB-UHFFFAOYSA-N penicillin acid Natural products OC(=O)C=C(OC)C(=O)C(C)=C VOUGEZYPVGAPBB-UHFFFAOYSA-N 0.000 description 2
- 238000012503 pharmacopoeial method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 150000004684 trihydrates Chemical class 0.000 description 2
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical compound C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- VYPDUQYOLCLEGS-UHFFFAOYSA-M sodium;2-ethylhexanoate Chemical compound [Na+].CCCCC(CC)C([O-])=O VYPDUQYOLCLEGS-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8107247A FR2503710B1 (fr) | 1981-04-10 | 1981-04-10 | Procede de production du sel de sodium de l'amoxicilline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO821174L true NO821174L (no) | 1982-10-11 |
Family
ID=9257255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO821174A NO821174L (no) | 1981-04-10 | 1982-04-06 | Fremgangsmaate ved fremstilling av natriumamoxillin |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS57179191A (es) |
| KR (1) | KR880001410B1 (es) |
| AU (1) | AU559766B2 (es) |
| BE (1) | BE892451A (es) |
| CA (1) | CA1182108A (es) |
| CH (1) | CH651836A5 (es) |
| DE (1) | DE3213308A1 (es) |
| DK (1) | DK157382A (es) |
| ES (1) | ES8304138A1 (es) |
| FI (1) | FI821247L (es) |
| FR (1) | FR2503710B1 (es) |
| GB (1) | GB2096599B (es) |
| GR (1) | GR76106B (es) |
| IE (1) | IE52939B1 (es) |
| IT (1) | IT1148165B (es) |
| LU (1) | LU84007A1 (es) |
| NL (1) | NL8201467A (es) |
| NO (1) | NO821174L (es) |
| NZ (1) | NZ200281A (es) |
| PT (1) | PT74727B (es) |
| SE (1) | SE8202269L (es) |
| YU (1) | YU43132B (es) |
| ZA (1) | ZA822400B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3474023D1 (en) * | 1983-06-10 | 1988-10-20 | Beecham Group Plc | Crystalline amoxycillin salt |
| IT1255716B (it) * | 1992-10-05 | 1995-11-10 | Procedimento per la preparazione di antibiotici beta-lattamici sterili | |
| AT412213B (de) * | 2000-05-30 | 2004-11-25 | Sandoz Ag | Verfahren zur trocknung von amoxicillin oder amoxicillin-hältigen, oralen, festen pharmazeutischen zusammensetzungen unter verwendung eines gases mit einer definierten gasfeuchte |
| CN105055169B (zh) * | 2015-07-11 | 2019-01-22 | 鲁南制药集团股份有限公司 | 一种制备亚胺培南西司他丁钠无菌粉末的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1471235A (en) * | 1974-09-18 | 1977-04-21 | Beecham Group Ltd | Amoxycillin derivatives |
| GB1527557A (en) * | 1976-07-07 | 1978-10-04 | Beecham Group Ltd | Process for preparing solid sodium amoxycillin |
| GB1576731A (en) * | 1976-08-10 | 1980-10-15 | Beecham Group Ltd | Process for the preparation of sodium amoxycillin |
| EP0012496B1 (en) * | 1978-12-08 | 1983-07-20 | Beecham Group Plc | A process for the preparation of a solid sodium amoxycillin and aqueous solutions thereof |
-
1981
- 1981-04-10 FR FR8107247A patent/FR2503710B1/fr not_active Expired
-
1982
- 1982-02-12 AU AU80455/82A patent/AU559766B2/en not_active Expired
- 1982-02-16 GR GR67339A patent/GR76106B/el unknown
- 1982-02-26 YU YU432/82A patent/YU43132B/xx unknown
- 1982-03-02 GB GB8206075A patent/GB2096599B/en not_active Expired
- 1982-03-10 BE BE0/207536A patent/BE892451A/fr not_active IP Right Cessation
- 1982-03-12 LU LU84007A patent/LU84007A1/fr unknown
- 1982-04-06 NL NL8201467A patent/NL8201467A/nl not_active Application Discontinuation
- 1982-04-06 KR KR8201511A patent/KR880001410B1/ko active
- 1982-04-06 NO NO821174A patent/NO821174L/no unknown
- 1982-04-06 DK DK157382A patent/DK157382A/da not_active IP Right Cessation
- 1982-04-07 IT IT48188/82A patent/IT1148165B/it active
- 1982-04-07 ES ES511295A patent/ES8304138A1/es not_active Expired
- 1982-04-07 FI FI821247A patent/FI821247L/fi not_active Application Discontinuation
- 1982-04-07 ZA ZA822400A patent/ZA822400B/xx unknown
- 1982-04-08 CH CH2211/82A patent/CH651836A5/fr not_active IP Right Cessation
- 1982-04-08 CA CA000400753A patent/CA1182108A/en not_active Expired
- 1982-04-08 PT PT74727A patent/PT74727B/pt unknown
- 1982-04-08 SE SE8202269A patent/SE8202269L/xx not_active Application Discontinuation
- 1982-04-08 JP JP57057416A patent/JPS57179191A/ja active Granted
- 1982-04-08 IE IE844/82A patent/IE52939B1/en not_active IP Right Cessation
- 1982-04-08 DE DE19823213308 patent/DE3213308A1/de not_active Withdrawn
- 1982-04-08 NZ NZ200281A patent/NZ200281A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT8248188A0 (it) | 1982-04-07 |
| JPS57179191A (en) | 1982-11-04 |
| ES511295A0 (es) | 1983-02-16 |
| AU559766B2 (en) | 1987-03-19 |
| IE820844L (en) | 1983-10-10 |
| DK157382A (da) | 1982-10-11 |
| PT74727A (en) | 1982-05-01 |
| LU84007A1 (fr) | 1983-02-22 |
| NL8201467A (nl) | 1982-11-01 |
| FI821247A0 (fi) | 1982-04-07 |
| GB2096599B (en) | 1985-01-23 |
| YU43132B (en) | 1989-04-30 |
| AU8045582A (en) | 1982-10-14 |
| IE52939B1 (en) | 1988-04-13 |
| ES8304138A1 (es) | 1983-02-16 |
| CH651836A5 (fr) | 1985-10-15 |
| JPH0219119B2 (es) | 1990-04-27 |
| FR2503710A1 (fr) | 1982-10-15 |
| GB2096599A (en) | 1982-10-20 |
| NZ200281A (en) | 1984-12-14 |
| GR76106B (es) | 1984-08-03 |
| FI821247L (fi) | 1982-10-11 |
| YU43282A (en) | 1985-06-30 |
| PT74727B (en) | 1985-01-08 |
| DE3213308A1 (de) | 1982-11-11 |
| FR2503710B1 (fr) | 1985-07-05 |
| KR880001410B1 (ko) | 1988-08-01 |
| KR830010116A (ko) | 1983-12-26 |
| BE892451A (fr) | 1982-09-10 |
| CA1182108A (en) | 1985-02-05 |
| ZA822400B (en) | 1983-02-23 |
| SE8202269L (sv) | 1982-10-11 |
| IT1148165B (it) | 1986-11-26 |
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