NO811667L - Fremgangsmaate ved fremstilling av substituerte pyrazinyl-1,2,4-oxadiazoler - Google Patents

Fremgangsmaate ved fremstilling av substituerte pyrazinyl-1,2,4-oxadiazoler

Info

Publication number
NO811667L
NO811667L NO811667A NO811667A NO811667L NO 811667 L NO811667 L NO 811667L NO 811667 A NO811667 A NO 811667A NO 811667 A NO811667 A NO 811667A NO 811667 L NO811667 L NO 811667L
Authority
NO
Norway
Prior art keywords
carbon atoms
lower alkyl
hydrogen
formula
amino
Prior art date
Application number
NO811667A
Other languages
English (en)
Norwegian (no)
Inventor
Mark G Bock
Edward J Cragoe Jr
Robert L Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/151,494 external-priority patent/US4309540A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO811667L publication Critical patent/NO811667L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO811667A 1980-05-19 1981-05-15 Fremgangsmaate ved fremstilling av substituerte pyrazinyl-1,2,4-oxadiazoler NO811667L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/151,494 US4309540A (en) 1980-05-19 1980-05-19 Substituted pyrazinyl-1,2,4-oxadiazoles
US06/244,509 US4362724A (en) 1980-05-19 1981-03-16 Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic

Publications (1)

Publication Number Publication Date
NO811667L true NO811667L (no) 1981-11-20

Family

ID=26848697

Family Applications (1)

Application Number Title Priority Date Filing Date
NO811667A NO811667L (no) 1980-05-19 1981-05-15 Fremgangsmaate ved fremstilling av substituerte pyrazinyl-1,2,4-oxadiazoler

Country Status (12)

Country Link
US (1) US4362724A (enEXAMPLES)
EP (1) EP0040422B1 (enEXAMPLES)
AU (1) AU536493B2 (enEXAMPLES)
DE (1) DE3161767D1 (enEXAMPLES)
DK (1) DK214681A (enEXAMPLES)
ES (1) ES8207528A1 (enEXAMPLES)
FI (1) FI811421A7 (enEXAMPLES)
GR (1) GR74903B (enEXAMPLES)
IE (1) IE51288B1 (enEXAMPLES)
NO (1) NO811667L (enEXAMPLES)
NZ (1) NZ197055A (enEXAMPLES)
PT (1) PT73016B (enEXAMPLES)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
NZ709197A (en) 2012-12-17 2020-06-26 Parion Sciences Inc 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
SMT201700107T1 (it) 2012-12-17 2017-03-08 Parion Sciences Inc Derivati di cloro-pirazina carbossammide utili per il trattamento di patologie favorite da idratazione insufficiente della mucosa
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639386A (enEXAMPLES) * 1962-10-30
MC641A1 (fr) * 1967-03-08 1967-12-05 Mauvernay Roland Yves Nouveaux composés chimiques et procédé pour leur préparation
US4196292A (en) * 1977-06-29 1980-04-01 Merck & Co., Inc. 6-Substituted amiloride derivatives
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same

Also Published As

Publication number Publication date
AU536493B2 (en) 1984-05-10
ES502282A0 (es) 1982-10-01
US4362724A (en) 1982-12-07
EP0040422B1 (en) 1983-12-28
FI811421L (fi) 1981-11-20
DK214681A (da) 1981-11-20
NZ197055A (en) 1984-07-31
ES8207528A1 (es) 1982-10-01
AU7018081A (en) 1981-11-26
IE51288B1 (en) 1986-11-26
DE3161767D1 (en) 1984-02-02
PT73016A (en) 1981-06-01
FI811421A7 (fi) 1981-11-20
IE811102L (en) 1981-11-19
PT73016B (en) 1983-08-08
GR74903B (enEXAMPLES) 1984-07-12
EP0040422A1 (en) 1981-11-25

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