NO810702L - Fremgangsmaate til fremstilling av terapeutisk virksomme heterocykliske forbindelser - Google Patents
Fremgangsmaate til fremstilling av terapeutisk virksomme heterocykliske forbindelserInfo
- Publication number
- NO810702L NO810702L NO810702A NO810702A NO810702L NO 810702 L NO810702 L NO 810702L NO 810702 A NO810702 A NO 810702A NO 810702 A NO810702 A NO 810702A NO 810702 L NO810702 L NO 810702L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- acid
- compounds
- pyrazolidone
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 17
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 150000002391 heterocyclic compounds Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 48
- 239000002253 acid Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 9
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims 1
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- -1 n-octyl Chemical group 0.000 description 15
- 241000700159 Rattus Species 0.000 description 14
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- 230000037396 body weight Effects 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 13
- NDGRWYRVNANFNB-UHFFFAOYSA-N pyrazolidin-3-one Chemical class O=C1CCNN1 NDGRWYRVNANFNB-UHFFFAOYSA-N 0.000 description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
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- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8007201 | 1980-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO810702L true NO810702L (no) | 1981-09-04 |
Family
ID=10511827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO810702A NO810702L (no) | 1980-03-03 | 1981-03-02 | Fremgangsmaate til fremstilling av terapeutisk virksomme heterocykliske forbindelser |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0035270A3 (es) |
| JP (1) | JPS56133269A (es) |
| KR (1) | KR830005151A (es) |
| AU (1) | AU6795981A (es) |
| DK (1) | DK94181A (es) |
| ES (1) | ES8300709A1 (es) |
| FI (1) | FI810641L (es) |
| GR (1) | GR73583B (es) |
| IL (1) | IL62247A0 (es) |
| IT (1) | IT1170772B (es) |
| MC (1) | MC1378A1 (es) |
| NO (1) | NO810702L (es) |
| PT (1) | PT72604B (es) |
| ZA (1) | ZA811358B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459298A (en) * | 1982-09-28 | 1984-07-10 | Ciba-Geigy Corporation | Method of suppressing appetite |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL29944A (en) * | 1968-05-06 | 1973-08-29 | Polak G | 3-pyrazolidinone derivatives and processes for their preparation |
-
1981
- 1981-03-02 ZA ZA00811358A patent/ZA811358B/xx unknown
- 1981-03-02 DK DK94181A patent/DK94181A/da unknown
- 1981-03-02 IL IL62247A patent/IL62247A0/xx unknown
- 1981-03-02 KR KR1019810000684A patent/KR830005151A/ko unknown
- 1981-03-02 IT IT47925/81A patent/IT1170772B/it active
- 1981-03-02 AU AU67959/81A patent/AU6795981A/en not_active Abandoned
- 1981-03-02 NO NO810702A patent/NO810702L/no unknown
- 1981-03-02 ES ES499965A patent/ES8300709A1/es not_active Expired
- 1981-03-02 JP JP2978381A patent/JPS56133269A/ja active Pending
- 1981-03-02 MC MC811505A patent/MC1378A1/xx unknown
- 1981-03-02 FI FI810641A patent/FI810641L/fi not_active Application Discontinuation
- 1981-03-02 PT PT72604A patent/PT72604B/pt unknown
- 1981-03-02 GR GR64288A patent/GR73583B/el unknown
- 1981-03-02 EP EP81101497A patent/EP0035270A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR830005151A (ko) | 1983-08-03 |
| PT72604A (en) | 1981-04-01 |
| IT8147925A0 (it) | 1981-03-02 |
| FI810641L (fi) | 1981-09-04 |
| PT72604B (fr) | 1982-12-30 |
| IT1170772B (it) | 1987-06-03 |
| ES499965A0 (es) | 1982-11-01 |
| IT8147925A1 (it) | 1982-09-02 |
| GR73583B (es) | 1984-03-21 |
| EP0035270A3 (en) | 1981-10-14 |
| DK94181A (da) | 1981-09-04 |
| ZA811358B (en) | 1982-10-27 |
| EP0035270A2 (en) | 1981-09-09 |
| IL62247A0 (en) | 1981-05-20 |
| AU6795981A (en) | 1981-09-10 |
| MC1378A1 (fr) | 1982-01-19 |
| ES8300709A1 (es) | 1982-11-01 |
| JPS56133269A (en) | 1981-10-19 |
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