NO792968L - Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer - Google Patents
Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stofferInfo
- Publication number
- NO792968L NO792968L NO792968A NO792968A NO792968L NO 792968 L NO792968 L NO 792968L NO 792968 A NO792968 A NO 792968A NO 792968 A NO792968 A NO 792968A NO 792968 L NO792968 L NO 792968L
- Authority
- NO
- Norway
- Prior art keywords
- allergen
- product
- pollen
- formaldehyde
- aldehyde
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 80
- 230000002009 allergenic effect Effects 0.000 title claims description 28
- 239000000126 substance Substances 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 155
- 239000013566 allergen Substances 0.000 claims description 155
- 150000001299 aldehydes Chemical class 0.000 claims description 53
- 239000000463 material Substances 0.000 claims description 46
- 238000006243 chemical reaction Methods 0.000 claims description 44
- 229960004784 allergens Drugs 0.000 claims description 37
- 208000010668 atopic eczema Diseases 0.000 claims description 24
- 230000000172 allergic effect Effects 0.000 claims description 23
- 101001094887 Ambrosia artemisiifolia Pectate lyase 1 Proteins 0.000 claims description 19
- 101001123576 Ambrosia artemisiifolia Pectate lyase 2 Proteins 0.000 claims description 19
- 101001123572 Ambrosia artemisiifolia Pectate lyase 3 Proteins 0.000 claims description 19
- 101000573177 Ambrosia artemisiifolia Pectate lyase 5 Proteins 0.000 claims description 19
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 17
- 230000003053 immunization Effects 0.000 claims description 17
- 208000024891 symptom Diseases 0.000 claims description 17
- 230000008569 process Effects 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000654 additive Substances 0.000 claims description 11
- 230000000903 blocking effect Effects 0.000 claims description 11
- 239000006286 aqueous extract Substances 0.000 claims description 10
- 239000008098 formaldehyde solution Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 230000000996 additive effect Effects 0.000 claims description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 5
- 241000233866 Fungi Species 0.000 claims description 4
- 241000238631 Hexapoda Species 0.000 claims description 4
- 230000006872 improvement Effects 0.000 claims description 4
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims description 4
- 239000009342 ragweed pollen Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 230000009257 reactivity Effects 0.000 claims description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- GVNWZKBFMFUVNX-UHFFFAOYSA-N Adipamide Chemical compound NC(=O)CCCCC(N)=O GVNWZKBFMFUVNX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 239000005700 Putrescine Substances 0.000 claims description 2
- 241000238711 Pyroglyphidae Species 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000013568 food allergen Substances 0.000 claims description 2
- 229940046528 grass pollen Drugs 0.000 claims description 2
- 239000013574 grass pollen allergen Substances 0.000 claims description 2
- 229940046533 house dust mites Drugs 0.000 claims description 2
- 235000004400 serine Nutrition 0.000 claims description 2
- 229940046536 tree pollen allergenic extract Drugs 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 43
- 239000000243 solution Substances 0.000 description 36
- 239000010267 Allergoid Substances 0.000 description 33
- 238000002347 injection Methods 0.000 description 30
- 239000007924 injection Substances 0.000 description 30
- 239000000284 extract Substances 0.000 description 29
- 210000002966 serum Anatomy 0.000 description 28
- 239000000872 buffer Substances 0.000 description 23
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 22
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 19
- 238000000502 dialysis Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 16
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 15
- 235000003484 annual ragweed Nutrition 0.000 description 14
- 239000000427 antigen Substances 0.000 description 14
- 235000006263 bur ragweed Nutrition 0.000 description 14
- 235000003488 common ragweed Nutrition 0.000 description 14
- 238000011534 incubation Methods 0.000 description 14
- 235000009736 ragweed Nutrition 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 229940074608 allergen extract Drugs 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 230000009885 systemic effect Effects 0.000 description 11
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 238000009169 immunotherapy Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- 244000281762 Chenopodium ambrosioides Species 0.000 description 7
- 235000000509 Chenopodium ambrosioides Nutrition 0.000 description 7
- 235000005490 Chenopodium botrys Nutrition 0.000 description 7
- 206010020751 Hypersensitivity Diseases 0.000 description 7
- 230000005875 antibody response Effects 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 239000007975 buffered saline Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 244000025254 Cannabis sativa Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 238000002649 immunization Methods 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 5
- 241000700198 Cavia Species 0.000 description 5
- 230000007815 allergy Effects 0.000 description 5
- 229960001340 histamine Drugs 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 238000000108 ultra-filtration Methods 0.000 description 5
- 244000037005 Ambrosia artemisiifolia var. elatior Species 0.000 description 4
- 241000234645 Festuca pratensis Species 0.000 description 4
- 206010024769 Local reaction Diseases 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 238000007792 addition Methods 0.000 description 4
- -1 aliphatic diamines Chemical class 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 230000036512 infertility Effects 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000012064 sodium phosphate buffer Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 241000209049 Poa pratensis Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960005139 epinephrine Drugs 0.000 description 3
- 238000002523 gelfiltration Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000012510 hollow fiber Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 238000002562 urinalysis Methods 0.000 description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 241000208841 Ambrosia trifida Species 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 240000006891 Artemisia vulgaris Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101100453921 Caenorhabditis elegans kin-29 gene Proteins 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 241000234642 Festuca Species 0.000 description 2
- 208000032912 Local swelling Diseases 0.000 description 2
- 240000004296 Lolium perenne Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 241000746983 Phleum pratense Species 0.000 description 2
- 241000209504 Poaceae Species 0.000 description 2
- 244000124765 Salsola kali Species 0.000 description 2
- 235000007658 Salsola kali Nutrition 0.000 description 2
- 244000082988 Secale cereale Species 0.000 description 2
- 235000007238 Secale cereale Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241001106462 Ulmus Species 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000000984 immunochemical effect Effects 0.000 description 2
- 238000000760 immunoelectrophoresis Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 240000007241 Agrostis stolonifera Species 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 108700032051 Ambrosia artemisiifolia Amb a I Proteins 0.000 description 1
- 240000004178 Anthoxanthum odoratum Species 0.000 description 1
- 235000014251 Anthoxanthum odoratum Nutrition 0.000 description 1
- 235000003826 Artemisia Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 235000002992 Betula pubescens Nutrition 0.000 description 1
- 241001520764 Betula pubescens Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 235000013175 Crataegus laevigata Nutrition 0.000 description 1
- 241000371644 Curvularia ravenelii Species 0.000 description 1
- 241000209210 Dactylis Species 0.000 description 1
- 240000004585 Dactylis glomerata Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 241000238710 Dermatophagoides Species 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000295146 Gallionellaceae Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241000758789 Juglans Species 0.000 description 1
- 244000026839 Juglans californica Species 0.000 description 1
- 235000014053 Juglans californica Nutrition 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 241001490312 Lithops pseudotruncatella Species 0.000 description 1
- 241000209082 Lolium Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 229920002274 Nalgene Polymers 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000219098 Parthenocissus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000746981 Phleum Species 0.000 description 1
- 241001127637 Plantago Species 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 244000274906 Quercus alba Species 0.000 description 1
- 235000009137 Quercus alba Nutrition 0.000 description 1
- 241000245165 Rhododendron ponticum Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 244000197975 Solidago virgaurea Species 0.000 description 1
- 235000000914 Solidago virgaurea Nutrition 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 241000256856 Vespidae Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 150000007824 aliphatic compounds Chemical class 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 235000009052 artemisia Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003659 bee venom Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000003508 chemical denaturation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000002357 guanidines Chemical class 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000011034 membrane dialysis Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000003541 multi-stage reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 239000013573 pollen allergen Substances 0.000 description 1
- 230000010152 pollination Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- MKWYFZFMAMBPQK-UHFFFAOYSA-J sodium feredetate Chemical compound [Na+].[Fe+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O MKWYFZFMAMBPQK-UHFFFAOYSA-J 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000006150 trypticase soy agar Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/948,409 US4234569A (en) | 1978-10-04 | 1978-10-04 | Production of aldehyde-treated allergen-containing substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO792968L true NO792968L (no) | 1980-04-09 |
Family
ID=25487805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO792968A NO792968L (no) | 1978-10-04 | 1979-09-13 | Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4234569A (fr) |
| JP (1) | JPS55115826A (fr) |
| AR (1) | AR225616A1 (fr) |
| AT (1) | AT368006B (fr) |
| AU (1) | AU523526B2 (fr) |
| BE (1) | BE879173A (fr) |
| CA (1) | CA1122525A (fr) |
| CH (1) | CH648757A5 (fr) |
| DE (1) | DE2939557C2 (fr) |
| DK (1) | DK415279A (fr) |
| ES (1) | ES484702A1 (fr) |
| FI (1) | FI793017A (fr) |
| FR (1) | FR2437837A1 (fr) |
| GB (1) | GB2034585B (fr) |
| GR (1) | GR69120B (fr) |
| IL (1) | IL58238A (fr) |
| IT (1) | IT1193763B (fr) |
| NL (1) | NL7907365A (fr) |
| NO (1) | NO792968L (fr) |
| PH (1) | PH15825A (fr) |
| PT (1) | PT70244A (fr) |
| SE (1) | SE7908199L (fr) |
| ZA (1) | ZA794485B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58110240A (ja) * | 1981-12-24 | 1983-06-30 | いすゞ自動車株式会社 | アスフアルトシ−ト及びその使用方法 |
| EP0083497A3 (fr) * | 1982-01-06 | 1985-11-06 | Beecham Group Plc | Procédé de préparation d'allergènes modifiés et leur usage pour le traitement d'états allergiques |
| US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US5543145A (en) * | 1984-09-17 | 1996-08-06 | Baxter International, Inc. | Pharmaceutical composition and method for the suppression of factor VIII inhibitor production |
| US5026545A (en) * | 1984-09-17 | 1991-06-25 | Baxter International, Inc. | Treatment of allergy and composition therefor |
| US4740371A (en) * | 1984-09-17 | 1988-04-26 | International Institute Of Cellular And Molecular Pathology | Treatment of allergy |
| US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
| NL8900652A (nl) * | 1989-03-16 | 1990-10-16 | Leti Lab | Primair-toxische stoffen of allergenen, isoleerbaar uit plantaardig materiaal, alsmede werkwijzen ter bereiding ervan en de toepassing ervan. |
| IT1237475B (it) * | 1989-10-06 | 1993-06-07 | Allergeni modificati chimicamente e procedimento per la loro preparazione | |
| CA2015515C (fr) | 1990-01-03 | 1999-12-07 | Jean-Marie Saint-Remy | Composes pharmaceutiques contenant des complexes antigene-anticorps et leur utilisation |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| AU676668B2 (en) * | 1991-10-16 | 1997-03-20 | Merck Patent Gmbh | T cell epitopes of the major allergens from dermatophagoides(house dust mite) |
| US20020090381A1 (en) * | 1999-04-09 | 2002-07-11 | H. Kim Bottomly | System for controlling immune system response to antigen |
| GB0326439D0 (en) * | 2003-11-13 | 2003-12-17 | Imp College Innovations Ltd | Methods |
| ES2316909T3 (es) * | 2004-09-18 | 2009-04-16 | Protectimmun Gmbh | Extracto de polvo de establo para proteccion contra alergias. |
| EP2258391A1 (fr) * | 2009-06-05 | 2010-12-08 | Stallergenes S.A. | Diminution de la génotoxicité in vitro d'extraits de pollen par élimination de flavonoïdes |
| CN104371016B (zh) | 2010-02-12 | 2018-05-15 | 过敏症研究实验室有限公司 | 过敏原提取物 |
| GB201106802D0 (en) * | 2011-04-21 | 2011-06-01 | Allergy Therapeutics Ltd | Process for preparing vaccine composition |
| ES2439617B1 (es) * | 2012-07-20 | 2015-03-13 | Diater Lab De Diagnostico Y Aplicaciones Terapeuticas S A | Composicion para la administracion intradermica de alergoides |
| US20140170727A1 (en) * | 2012-12-19 | 2014-06-19 | Nanomr, Inc. | Affinity medium using fixed whole cells |
| US11617789B2 (en) | 2018-11-09 | 2023-04-04 | Jubilant HollisterStier LLC | Process for the preparation of allergenic extracts |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2019808A (en) * | 1932-10-08 | 1935-11-05 | Abbott Lab | Detoxified pollen extract |
| US3057775A (en) * | 1959-02-04 | 1962-10-09 | Champion Co | Embalming composition |
| US3135662A (en) * | 1961-01-05 | 1964-06-02 | Burroughs Wellcome Co | Diphtheria toxoid preparation and its production |
| CH453269A4 (fr) * | 1968-03-29 | 1973-01-31 | ||
| FR1604982A (en) * | 1968-03-29 | 1972-06-26 | Active protein product - with polymeric carrier | |
| FR2035774A2 (en) * | 1969-03-19 | 1970-12-24 | Anvar | Active protein product - with polymeric carrier |
| NO132132C (fr) * | 1968-10-10 | 1975-09-24 | David George Marsh | |
| GB1282163A (en) * | 1969-08-06 | 1972-07-19 | Beecham Group Ltd | Modified allergens and a process for their preparation |
| BE754523A (fr) * | 1969-08-06 | 1971-02-08 | Beecham Group Ltd | Vaccins |
| JPS4935413A (fr) * | 1972-08-09 | 1974-04-02 | ||
| DE2310964A1 (de) * | 1973-03-02 | 1974-09-05 | Schering Ag | Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation |
| FR2227861B1 (fr) * | 1973-05-04 | 1976-07-02 | Anvar | |
| GB1444652A (en) * | 1973-05-08 | 1976-08-04 | Abbott Lab | Polymerized gagweed antigen e |
| US4070455A (en) * | 1974-02-16 | 1978-01-24 | Beecham Group Limited | Process for preparing injectable desensitizing compositions and products thereof in microparticle form |
| GB1492973A (en) * | 1974-02-16 | 1977-11-23 | Beecham Group Ltd | Process for preparing injectable compositions |
-
1978
- 1978-10-04 US US05/948,409 patent/US4234569A/en not_active Expired - Lifetime
-
1979
- 1979-08-24 ZA ZA00794485A patent/ZA794485B/xx unknown
- 1979-09-01 GR GR59946A patent/GR69120B/el unknown
- 1979-09-12 IL IL58238A patent/IL58238A/xx unknown
- 1979-09-13 NO NO792968A patent/NO792968L/no unknown
- 1979-09-24 AU AU51119/79A patent/AU523526B2/en not_active Ceased
- 1979-09-24 PH PH23056A patent/PH15825A/en unknown
- 1979-09-27 GB GB7933549A patent/GB2034585B/en not_active Expired
- 1979-09-27 FI FI793017A patent/FI793017A/fi not_active Application Discontinuation
- 1979-09-28 AR AR278268A patent/AR225616A1/es active
- 1979-09-28 DE DE2939557A patent/DE2939557C2/de not_active Expired
- 1979-09-28 PT PT70244A patent/PT70244A/pt unknown
- 1979-10-03 BE BE0/197457A patent/BE879173A/fr not_active IP Right Cessation
- 1979-10-03 SE SE7908199A patent/SE7908199L/xx not_active Application Discontinuation
- 1979-10-03 ES ES484702A patent/ES484702A1/es not_active Expired
- 1979-10-03 AT AT0646179A patent/AT368006B/de not_active IP Right Cessation
- 1979-10-03 NL NL7907365A patent/NL7907365A/nl not_active Application Discontinuation
- 1979-10-03 CH CH8922/79A patent/CH648757A5/fr not_active IP Right Cessation
- 1979-10-03 DK DK415279A patent/DK415279A/da not_active Application Discontinuation
- 1979-10-04 JP JP12742979A patent/JPS55115826A/ja active Pending
- 1979-10-04 FR FR7924725A patent/FR2437837A1/fr active Granted
- 1979-10-04 IT IT50450/79A patent/IT1193763B/it active
- 1979-10-04 CA CA336,952A patent/CA1122525A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2034585A (en) | 1980-06-11 |
| GR69120B (fr) | 1982-05-03 |
| AU523526B2 (en) | 1982-07-29 |
| CH648757A5 (fr) | 1985-04-15 |
| FI793017A (fi) | 1980-04-05 |
| FR2437837A1 (fr) | 1980-04-30 |
| CA1122525A (fr) | 1982-04-27 |
| SE7908199L (sv) | 1980-04-05 |
| DK415279A (da) | 1980-04-05 |
| DE2939557C2 (de) | 1986-10-09 |
| AT368006B (de) | 1982-08-25 |
| BE879173A (fr) | 1980-02-01 |
| IL58238A (en) | 1982-07-30 |
| IT1193763B (it) | 1988-08-24 |
| JPS55115826A (en) | 1980-09-06 |
| US4234569A (en) | 1980-11-18 |
| ES484702A1 (es) | 1980-06-16 |
| IL58238A0 (en) | 1979-12-30 |
| IT7950450A0 (it) | 1979-10-04 |
| FR2437837B1 (fr) | 1983-10-21 |
| PH15825A (en) | 1983-04-08 |
| PT70244A (en) | 1979-10-01 |
| AU5111979A (en) | 1980-04-17 |
| NL7907365A (nl) | 1980-04-09 |
| GB2034585B (en) | 1983-05-11 |
| ZA794485B (en) | 1980-08-27 |
| ATA646179A (de) | 1982-01-15 |
| DE2939557A1 (de) | 1980-04-24 |
| AR225616A1 (es) | 1982-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO792968L (no) | Fremgangsmaate til fremstilling av aldehydbehandlede allergenholdige stoffer | |
| Solley et al. | The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies. | |
| Worm et al. | Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy | |
| BENNETT JR et al. | The properties and biologic effects of bacterial pyrogens | |
| Binder et al. | Individual hymenoptera venom compounds induce upregulation of the basophil activation marker ectonucleotide pyrophosphatase/phosphodiesterase 3 (CD203c) in sensitized patients | |
| Dessaint et al. | Quantitative determination of specific IgE antibodies to Echinococcus granulosus and IgE levels in sera from patients with hydatid disease. | |
| US4338297A (en) | Polypeptide active pollen immunosuppressant fraction | |
| DE2804457A1 (de) | Immunsuppressive mittel | |
| CN102258780B (zh) | 一种螨变应原冻干疫苗及其制备方法 | |
| US4226853A (en) | Formalinized allergen-containing substances and production thereof | |
| Bruynzeel et al. | IgE and IgG4 antibodies in specific human allergies | |
| Paley et al. | Dermal reactions to insulin therapy | |
| JPS63277634A (ja) | アレルギーの治療およびそのための組成物 | |
| Franklin et al. | Comparison of honeybee venoms and their components from various sources | |
| US4163778A (en) | Asthma immunotherapy | |
| EP4190351A1 (fr) | Préparation d'allergène | |
| REISMAN et al. | Clinical and immunological studies of venom immunotherapy | |
| Friedlaender et al. | Observations on basophil degranulation as an indicator of antigen-antibody reaction | |
| Weiss et al. | Hemorrhagic disease in rodents caused by chikungunya virus. 1. Studies of hemostasis | |
| Walzer et al. | Passive transfer of atopic hypersensitiveness in man by means of leucocytes. | |
| Pegelow et al. | Immunotherapy with alginate-conjugated and alum-precipitated grass pollen extracts in patients with allergic rhinoconjunctivitis. | |
| Panzani et al. | Results of skin test and RAST in allergy to a clinically potent allergen (castor bean) | |
| Burrell et al. | Mediators of experimental hypersensitivity pneumonitis | |
| Sickles et al. | Studies of antipneumococcal serum: I. The development of reactivity with bacterial fractions and with agar in the serum of horses and rabbits | |
| Grasset et al. | The Preparation and Comparison of Different Types of Anti-Typhoid Sera.(Agglutinins—Mouse Protection and Preliminary Clinical Trials.) |