NO783976L - Fremgangsmaate ved fremstilling av et renset kapsulaert polysaccharid av streptococcus pneumoniae - Google Patents
Fremgangsmaate ved fremstilling av et renset kapsulaert polysaccharid av streptococcus pneumoniaeInfo
- Publication number
- NO783976L NO783976L NO783976A NO783976A NO783976L NO 783976 L NO783976 L NO 783976L NO 783976 A NO783976 A NO 783976A NO 783976 A NO783976 A NO 783976A NO 783976 L NO783976 L NO 783976L
- Authority
- NO
- Norway
- Prior art keywords
- polysaccharide
- hours
- added
- stirring
- isopropanol
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title claims description 241
- 229920001282 polysaccharide Polymers 0.000 title claims description 240
- 239000005017 polysaccharide Substances 0.000 title claims description 240
- 238000000034 method Methods 0.000 title claims description 14
- 241000193998 Streptococcus pneumoniae Species 0.000 title description 13
- 229940031000 streptococcus pneumoniae Drugs 0.000 title description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 316
- 239000007788 liquid Substances 0.000 claims description 135
- 238000000855 fermentation Methods 0.000 claims description 52
- 230000004151 fermentation Effects 0.000 claims description 52
- 102000004142 Trypsin Human genes 0.000 claims description 22
- 108090000631 Trypsin Proteins 0.000 claims description 22
- 239000012588 trypsin Substances 0.000 claims description 22
- 241000194017 Streptococcus Species 0.000 claims description 18
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 13
- 229960000800 cetrimonium bromide Drugs 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 239000003093 cationic surfactant Substances 0.000 claims description 4
- 101710163270 Nuclease Proteins 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 232
- 238000003756 stirring Methods 0.000 description 170
- 239000000203 mixture Substances 0.000 description 154
- 229960004592 isopropanol Drugs 0.000 description 116
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 111
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 109
- 239000002609 medium Substances 0.000 description 107
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 86
- 239000006228 supernatant Substances 0.000 description 77
- 239000002244 precipitate Substances 0.000 description 73
- 239000000243 solution Substances 0.000 description 69
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 63
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 56
- 229960000583 acetic acid Drugs 0.000 description 54
- 239000012362 glacial acetic acid Substances 0.000 description 53
- 239000007787 solid Substances 0.000 description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 49
- 229910001868 water Inorganic materials 0.000 description 49
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 44
- 235000017557 sodium bicarbonate Nutrition 0.000 description 43
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 42
- 239000000843 powder Substances 0.000 description 42
- 239000001632 sodium acetate Substances 0.000 description 42
- 235000017281 sodium acetate Nutrition 0.000 description 42
- 239000008280 blood Substances 0.000 description 39
- 210000004369 blood Anatomy 0.000 description 39
- 238000005119 centrifugation Methods 0.000 description 34
- 235000013372 meat Nutrition 0.000 description 28
- 239000000284 extract Substances 0.000 description 27
- 235000015097 nutrients Nutrition 0.000 description 27
- 238000011534 incubation Methods 0.000 description 26
- 229960003742 phenol Drugs 0.000 description 23
- 238000012360 testing method Methods 0.000 description 23
- 239000000725 suspension Substances 0.000 description 22
- 238000001556 precipitation Methods 0.000 description 21
- 102000016911 Deoxyribonucleases Human genes 0.000 description 20
- 108010053770 Deoxyribonucleases Proteins 0.000 description 20
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 20
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 20
- 102000006382 Ribonucleases Human genes 0.000 description 19
- 108010083644 Ribonucleases Proteins 0.000 description 19
- 238000003556 assay Methods 0.000 description 19
- 230000004520 agglutination Effects 0.000 description 18
- 229940075894 denatured ethanol Drugs 0.000 description 17
- 238000005352 clarification Methods 0.000 description 16
- 238000001914 filtration Methods 0.000 description 16
- 238000004090 dissolution Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 14
- 239000006161 blood agar Substances 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 14
- 238000003306 harvesting Methods 0.000 description 14
- 230000001105 regulatory effect Effects 0.000 description 14
- 238000005406 washing Methods 0.000 description 14
- 239000008103 glucose Substances 0.000 description 13
- 238000010408 sweeping Methods 0.000 description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 239000012528 membrane Substances 0.000 description 12
- 230000029087 digestion Effects 0.000 description 11
- 239000011521 glass Substances 0.000 description 11
- 238000001802 infusion Methods 0.000 description 11
- 239000012466 permeate Substances 0.000 description 11
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
- 238000000502 dialysis Methods 0.000 description 10
- 239000008188 pellet Substances 0.000 description 10
- 230000035899 viability Effects 0.000 description 10
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 9
- 239000002054 inoculum Substances 0.000 description 9
- 239000012465 retentate Substances 0.000 description 9
- 238000000108 ultra-filtration Methods 0.000 description 9
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 8
- 239000011928 denatured alcohol Substances 0.000 description 8
- 239000008363 phosphate buffer Substances 0.000 description 8
- 239000013587 production medium Substances 0.000 description 8
- 239000007691 rabbit blood agar Substances 0.000 description 8
- 238000013019 agitation Methods 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 229960003666 liquefied phenol Drugs 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 6
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 description 5
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 239000011344 liquid material Substances 0.000 description 5
- 229910001629 magnesium chloride Inorganic materials 0.000 description 5
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 4
- 230000001476 alcoholic effect Effects 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 239000002198 insoluble material Substances 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 3
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 3
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 229930182830 galactose Natural products 0.000 description 3
- 229960002442 glucosamine Drugs 0.000 description 3
- 229940031348 multivalent vaccine Drugs 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 2
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 235000011132 calcium sulphate Nutrition 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007974 sodium acetate buffer Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 101710186708 Agglutinin Proteins 0.000 description 1
- 229910018626 Al(OH) Inorganic materials 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 238000003794 Gram staining Methods 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- -1 KHCO^ ^ 2C0^ Chemical compound 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 241001233242 Lontra Species 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- FLEAADSSUQORCN-WIYIBBIWSA-N N-[(2S,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]acetamide N-[(3S,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O FLEAADSSUQORCN-WIYIBBIWSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- MBLBDJOUHNCFQT-WCTZXXKLSA-N aldehydo-N-acetyl-D-mannosamine Chemical compound CC(=O)N[C@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-WCTZXXKLSA-N 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000001175 calcium sulphate Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000012869 germination medium Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 235000012254 magnesium hydroxide Nutrition 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85549177A | 1977-11-28 | 1977-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO783976L true NO783976L (no) | 1979-05-29 |
Family
ID=25321387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO783976A NO783976L (no) | 1977-11-28 | 1978-11-27 | Fremgangsmaate ved fremstilling av et renset kapsulaert polysaccharid av streptococcus pneumoniae |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0002404A1 (es) |
| JP (1) | JPS5495724A (es) |
| AU (1) | AU529128B2 (es) |
| CA (1) | CA1115210A (es) |
| DK (1) | DK527078A (es) |
| ES (1) | ES475509A1 (es) |
| FI (1) | FI783620A (es) |
| IT (1) | IT1109450B (es) |
| NO (1) | NO783976L (es) |
| NZ (1) | NZ188966A (es) |
| PT (1) | PT68831A (es) |
| YU (1) | YU283378A (es) |
| ZA (1) | ZA786664B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| US4287173A (en) * | 1979-09-24 | 1981-09-01 | Merck & Co., Inc. | Vaccine for dental caries |
| FR2510606A1 (fr) * | 1981-07-30 | 1983-02-04 | Berri Balzac | Procede d'obtention de polyosides capsulaires, polyosides capsulaires ainsi obtenus et leur application a la preparation de vaccins |
| BE889979A (fr) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| NL8202527A (nl) * | 1982-06-22 | 1984-01-16 | Univ Utrecht | Vaccins tegen door bacterien met kapsel-polysacchariden verwekte ziekten en werkwijze voor het bereiden daarvan. |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| US6224880B1 (en) | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
| IL308456A (en) | 2005-04-08 | 2024-01-01 | Wyeth Llc | A multivalent pneumomuroral protein-polysaccharide conjugate preparation |
| BRPI0607026B1 (pt) * | 2005-04-08 | 2022-02-15 | Wyeth | Processos para redução do teor de proteína e preservação do teor de polissacarídeo capsular em um caldo de lisado celular de streptococcus pneumoniae complexo antes da purificação |
| MY150927A (en) * | 2007-03-23 | 2014-03-14 | Wyeth Corp | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| SI2385981T1 (sl) | 2008-12-18 | 2019-11-29 | Wyeth Llc | Postopek za nadzorovanje molekulske mase polisaharida streptococcus pneumoniae z uporabo ogljika |
| KR20110091546A (ko) | 2008-12-18 | 2011-08-11 | 와이어쓰 엘엘씨 | 스트렙토코커스 뉴모니에 혈청형 19ａ 폴리사카라이드 분자량을 조절하는 방법 |
| US20140106030A1 (en) * | 2011-05-02 | 2014-04-17 | Friesland Brands B.V. | Probiotics with Enhanced Survival Properties |
| CN106460062A (zh) | 2014-05-05 | 2017-02-22 | 美敦力公司 | 用于scd、crt、crt‑d或sca治疗识别和/或选择的方法和组合物 |
| CN114853917A (zh) * | 2022-04-22 | 2022-08-05 | 兰州生物制品研究所有限责任公司 | 制备肺炎球菌荚膜多糖和肺炎球菌疫苗的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2388563A1 (fr) * | 1977-04-29 | 1978-11-24 | Fabre Sa Pierre | Vaccins acellulaires perfectionnes contenant des polysaccharides capsulaires |
-
1978
- 1978-10-24 CA CA314,028A patent/CA1115210A/en not_active Expired
- 1978-11-16 EP EP78400185A patent/EP0002404A1/en not_active Withdrawn
- 1978-11-20 AU AU41728/78A patent/AU529128B2/en not_active Expired
- 1978-11-21 NZ NZ188966A patent/NZ188966A/xx unknown
- 1978-11-27 NO NO783976A patent/NO783976L/no unknown
- 1978-11-27 DK DK527078A patent/DK527078A/da not_active Application Discontinuation
- 1978-11-27 FI FI783620A patent/FI783620A/fi unknown
- 1978-11-27 IT IT52075/78A patent/IT1109450B/it active
- 1978-11-27 ZA ZA786664A patent/ZA786664B/xx unknown
- 1978-11-27 PT PT68831A patent/PT68831A/pt unknown
- 1978-11-28 JP JP14614478A patent/JPS5495724A/ja active Pending
- 1978-11-28 ES ES475509A patent/ES475509A1/es not_active Expired
- 1978-12-04 YU YU02833/78A patent/YU283378A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0002404A1 (en) | 1979-06-13 |
| IT1109450B (it) | 1985-12-16 |
| JPS5495724A (en) | 1979-07-28 |
| AU4172878A (en) | 1979-06-07 |
| NZ188966A (en) | 1982-03-23 |
| DK527078A (da) | 1979-07-04 |
| IT7852075A0 (it) | 1978-11-27 |
| FI783620A (fi) | 1979-05-29 |
| ZA786664B (en) | 1980-07-30 |
| YU283378A (en) | 1983-04-30 |
| ES475509A1 (es) | 1980-07-16 |
| CA1115210A (en) | 1981-12-29 |
| PT68831A (en) | 1978-12-01 |
| AU529128B2 (en) | 1983-05-26 |
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