NO770650L - Fremgangsm}te til fremstilling av en forbindelse mellom en polyhydroksylpolymer og et prim{rt aminogruppeholdig stoff. - Google Patents
Fremgangsm}te til fremstilling av en forbindelse mellom en polyhydroksylpolymer og et prim{rt aminogruppeholdig stoff.Info
- Publication number
- NO770650L NO770650L NO770650A NO770650A NO770650L NO 770650 L NO770650 L NO 770650L NO 770650 A NO770650 A NO 770650A NO 770650 A NO770650 A NO 770650A NO 770650 L NO770650 L NO 770650L
- Authority
- NO
- Norway
- Prior art keywords
- polymer
- compound
- biologically active
- compounds
- reaction
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title description 33
- 229920000642 polymer Polymers 0.000 title description 29
- 239000000126 substance Substances 0.000 title description 19
- 238000000034 method Methods 0.000 title description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 19
- 239000007800 oxidant agent Substances 0.000 description 15
- 230000003647 oxidation Effects 0.000 description 14
- 238000007254 oxidation reaction Methods 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- -1 polyvinylene Polymers 0.000 description 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 229940088623 biologically active substance Drugs 0.000 description 10
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 10
- 229920001197 polyacetylene Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000013543 active substance Substances 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- 239000007795 chemical reaction product Substances 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000003172 aldehyde group Chemical group 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000012876 carrier material Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 230000001588 bifunctional effect Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 239000012636 effector Substances 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000007809 chemical reaction catalyst Substances 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 239000002262 Schiff base Substances 0.000 description 2
- 150000004753 Schiff bases Chemical class 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- HAXFWIACAGNFHA-UHFFFAOYSA-N aldrithiol Chemical compound C=1C=CC=NC=1SSC1=CC=CC=N1 HAXFWIACAGNFHA-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 239000012954 diazonium Substances 0.000 description 2
- 150000001989 diazonium salts Chemical class 0.000 description 2
- 238000006193 diazotization reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- JMCRDEBJJPRTPV-UHFFFAOYSA-N 1,2-Ethenediol Chemical compound OC=CO JMCRDEBJJPRTPV-UHFFFAOYSA-N 0.000 description 1
- QWVCIORZLNBIIC-UHFFFAOYSA-N 2,3-dibromopropan-1-ol Chemical compound OCC(Br)CBr QWVCIORZLNBIIC-UHFFFAOYSA-N 0.000 description 1
- LGKDEBYYRWXEDL-UHFFFAOYSA-N 2-aminobenzenecarboximidamide Chemical compound NC(=N)C1=CC=CC=C1N LGKDEBYYRWXEDL-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 239000007868 Raney catalyst Substances 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 125000001769 aryl amino group Chemical group 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical class C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- ANORDWOIBSUYBN-UHFFFAOYSA-N n-chloro-1-phenylmethanamine Chemical compound ClNCC1=CC=CC=C1 ANORDWOIBSUYBN-UHFFFAOYSA-N 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
- C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
Landscapes
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyamides (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2607766A DE2607766C3 (de) | 1976-02-26 | 1976-02-26 | Verfahren zur Herstellung von trägergebundenen biologisch aktiven Substanzen |
Publications (1)
Publication Number | Publication Date |
---|---|
NO770650L true NO770650L (no) | 1977-08-29 |
Family
ID=5970898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO770650A NO770650L (no) | 1976-02-26 | 1977-02-25 | Fremgangsm}te til fremstilling av en forbindelse mellom en polyhydroksylpolymer og et prim{rt aminogruppeholdig stoff. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4066581A (de) |
JP (1) | JPS52103490A (de) |
AU (1) | AU2262977A (de) |
BE (1) | BE851917A (de) |
DE (1) | DE2607766C3 (de) |
DK (1) | DK83877A (de) |
ES (1) | ES456118A1 (de) |
FI (1) | FI770600A (de) |
FR (1) | FR2342305A1 (de) |
IL (1) | IL51529A0 (de) |
IT (1) | IT1075122B (de) |
LU (1) | LU76836A1 (de) |
NL (1) | NL7701830A (de) |
NO (1) | NO770650L (de) |
SE (1) | SE7702125L (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4530974A (en) * | 1981-03-19 | 1985-07-23 | Board Of Regents, The University Of Texas System | Nonthrombogenic articles having enhanced albumin affinity |
AU4660789A (en) * | 1988-11-23 | 1990-06-12 | Genentech Inc. | Polypeptide derivatives |
US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA667451A (en) * | 1963-07-23 | S. Newman Melvin | Vinylene carbonate and related products and processes | |
CA667985A (en) * | 1963-08-06 | W. Gluesenkamp Earl | Polymerization of vinylene carbonate | |
US2722525A (en) * | 1953-05-07 | 1955-11-01 | American Cyanamid Co | Polymerizable compositions containing an unsaturated carbonate and polymerization products thereof |
DE1040789B (de) * | 1953-05-18 | 1958-10-09 | Monsanto Chemicals | Verfahren zur Herstellung von Polymerisaten und Mischpolymerisaten |
US2847398A (en) * | 1953-05-18 | 1958-08-12 | Monsanto Chemicals | Vinylene carbonate-ethylene copolymer and method of producing same |
US2794013A (en) * | 1953-12-23 | 1957-05-28 | American Cyanamid Co | Reaction products of vinylene carbonate and ammonia or primary amine |
US2847402A (en) * | 1955-12-05 | 1958-08-12 | Monsanto Chemicals | High pressure homopolymerization and interpolymerization of vinylene carbonate |
US2993030A (en) * | 1957-08-19 | 1961-07-18 | George E Ham | Process for polymerizing vinylene carbonate |
US3037965A (en) * | 1958-04-14 | 1962-06-05 | Polaroid Corp | Water-insoluble hydrolyzed copolymer of vinylene carbonate and vinyl acetate |
US3020290A (en) * | 1959-10-14 | 1962-02-06 | Jefferson Chem Co Inc | Preparation of unsaturated compounds |
US3069391A (en) * | 1960-02-05 | 1962-12-18 | Du Pont | Polyhydroxymethylene polymers |
NL286954A (de) * | 1962-01-03 | |||
BE666318A (de) * | 1964-07-07 | 1966-01-03 | ||
DE1494576A1 (de) * | 1965-02-03 | 1969-04-24 | Dynamit Nobel Ag | Verfahren zur Herstellung von Filmen,Folien und Fasern auf der Basis von Polyoxymethylenen |
US3553310A (en) * | 1967-12-28 | 1971-01-05 | Miles Lab | Immunologically reactive particles |
US3616229A (en) * | 1968-09-27 | 1971-10-26 | Monsanto Co | Polymer-enzyme products comprising plurality of enzymes covalently bound to polymer |
US4011377A (en) * | 1971-02-11 | 1977-03-08 | Peter Duncan Goodearl Dean | Enzyme separation |
US3847743A (en) * | 1971-08-24 | 1974-11-12 | American Cyanamid Co | Enzymes bound to carbonyl polymers |
US4013514A (en) * | 1972-01-04 | 1977-03-22 | Monsanto Company | Preparing a reactor containing enzymes attached to dialdehyde cellulose |
US3753861A (en) * | 1972-03-13 | 1973-08-21 | American Cyanamid Co | Binding enzymes to carbonyl polymers |
US3944525A (en) * | 1973-10-03 | 1976-03-16 | Ciba-Geigy Corporation | Crosslinked resins prepared from an N,N'-bis-imide and a schiff base |
GB1492937A (en) * | 1973-12-28 | 1977-11-23 | Beecham Group Ltd | Enzyme complexes and their use |
US4025391A (en) * | 1974-06-15 | 1977-05-24 | Director Of National Food Research Institute | Preparation of bead-shaped immobilized enzyme |
US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
-
1976
- 1976-02-26 DE DE2607766A patent/DE2607766C3/de not_active Expired
-
1977
- 1977-02-21 NL NL7701830A patent/NL7701830A/xx not_active Application Discontinuation
- 1977-02-21 ES ES456118A patent/ES456118A1/es not_active Expired
- 1977-02-24 AU AU22629/77A patent/AU2262977A/en not_active Expired
- 1977-02-24 IT IT20627/77A patent/IT1075122B/it active
- 1977-02-24 LU LU76836A patent/LU76836A1/xx unknown
- 1977-02-24 IL IL51529A patent/IL51529A0/xx unknown
- 1977-02-24 FI FI770600A patent/FI770600A/fi not_active Application Discontinuation
- 1977-02-24 US US05/771,766 patent/US4066581A/en not_active Expired - Lifetime
- 1977-02-25 SE SE7702125A patent/SE7702125L/xx unknown
- 1977-02-25 DK DK83877A patent/DK83877A/da unknown
- 1977-02-25 NO NO770650A patent/NO770650L/no unknown
- 1977-02-26 JP JP1982977A patent/JPS52103490A/ja active Pending
- 1977-02-28 BE BE175340A patent/BE851917A/xx unknown
- 1977-02-28 FR FR7705828A patent/FR2342305A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2262977A (en) | 1978-08-31 |
LU76836A1 (de) | 1977-09-12 |
JPS52103490A (en) | 1977-08-30 |
US4066581A (en) | 1978-01-03 |
DE2607766A1 (de) | 1977-09-01 |
SE7702125L (sv) | 1977-08-27 |
FI770600A (de) | 1977-08-27 |
NL7701830A (nl) | 1977-08-30 |
FR2342305A1 (fr) | 1977-09-23 |
IL51529A0 (en) | 1977-04-29 |
ES456118A1 (es) | 1978-02-01 |
DE2607766C3 (de) | 1978-12-07 |
BE851917A (de) | 1977-08-29 |
DE2607766B2 (de) | 1978-04-20 |
DK83877A (da) | 1977-08-27 |
IT1075122B (it) | 1985-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5053133A (en) | Affinity separation with activated polyamide microporous membranes | |
US4925921A (en) | Products of coupling biological substances by covalent bonds | |
JP4198468B2 (ja) | 生細胞および有機分子をカプセル封入するための方法およびゲル組成物 | |
AU755968B2 (en) | Method for preparing water-soluble cross-linked conjugates | |
DK141533B (da) | Polykondensationsprodukt til binding af proteiner eller enzymer. | |
JP2001503131A (ja) | 医薬ライブラリーをスクリーニングするための組成物および方法 | |
Hsiao et al. | Immobilization of glycoenzymes through carbohydrate side chains | |
NO763975L (de) | ||
EP0154315A2 (de) | Diazonium-Matrizen für Affinitätschromatographie | |
CA1084860A (en) | Immobilized biologically active proteins | |
NO770650L (no) | Fremgangsm}te til fremstilling av en forbindelse mellom en polyhydroksylpolymer og et prim{rt aminogruppeholdig stoff. | |
JP4006523B2 (ja) | タンパク質アレイ及びその作製方法 | |
TWI353880B (en) | Verfahren zur selektiven bindung eines substrats a | |
KR0175724B1 (ko) | 표면 개질된 폴리아크릴로니트릴 기질 및 이의 제조방법 | |
US4448764A (en) | Direct-acting iodinating reagent | |
JPH05501762A (ja) | ペプチド及び蛋白質の連続c末端分解 | |
US4440903A (en) | Dihaloisocyanide derivatives of polymers for coupling nucleophiles | |
CA1063049A (en) | Preparation of water insoluble immobilized bio-active compounds | |
EP0991944A1 (de) | Verfahren zur kovalenten immobilisierung von biomolekülen an einem träger mittels eines his-tags | |
GB1449471A (en) | Process for the manufacture of activated carriers for fixing amino compounds and carrier-bonded materials derived therefrom | |
JPS6325555A (ja) | アミノ酸配列の決定法および該方法に用いられる装置 | |
JPS62500596A (ja) | 塩化スルフリル−ポリアミド誘導体 | |
EP0206779A1 (de) | Nachweis antinuklearer Antikörper | |
JPH05261281A (ja) | 生理活性物質固定化担体とその製法 | |
EP1072688B1 (de) | Verfahren zur bestimmung des gens eines zielproteins mit hilfe eines medikamentes |