NO770373L - Fremgangsm}te ved bestemmelse av paracetamol. - Google Patents
Fremgangsm}te ved bestemmelse av paracetamol.Info
- Publication number
- NO770373L NO770373L NO770373A NO770373A NO770373L NO 770373 L NO770373 L NO 770373L NO 770373 A NO770373 A NO 770373A NO 770373 A NO770373 A NO 770373A NO 770373 L NO770373 L NO 770373L
- Authority
- NO
- Norway
- Prior art keywords
- paracetamol
- sample
- acid
- blood
- nitric acid
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims description 66
- 229960005489 paracetamol Drugs 0.000 title claims description 65
- 238000000034 method Methods 0.000 title claims description 47
- 210000004369 blood Anatomy 0.000 claims description 43
- 239000008280 blood Substances 0.000 claims description 43
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 20
- 229910017604 nitric acid Inorganic materials 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 13
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 12
- 239000003513 alkali Substances 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 8
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- 235000010288 sodium nitrite Nutrition 0.000 claims description 6
- 230000003544 deproteinization Effects 0.000 claims description 5
- 230000009635 nitrosylation Effects 0.000 claims description 5
- -1 alkali metal nitrite Chemical class 0.000 claims description 4
- 239000003086 colorant Substances 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 3
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims description 2
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000008188 pellet Substances 0.000 description 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007866 hepatic necrosis Effects 0.000 description 2
- 206010019692 hepatic necrosis Diseases 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical group OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001030 gas--liquid chromatography Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9486—Analgesics, e.g. opiates, aspirine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4489/76A GB1510071A (en) | 1976-02-05 | 1976-02-05 | Assay method for paracetamol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO770373L true NO770373L (no) | 1977-08-08 |
Family
ID=9778144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO770373A NO770373L (no) | 1976-02-05 | 1977-02-04 | Fremgangsm}te ved bestemmelse av paracetamol. |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE851110A (enExample) |
| DE (1) | DE2704194A1 (enExample) |
| DK (1) | DK47577A (enExample) |
| FI (1) | FI770380A7 (enExample) |
| FR (1) | FR2340550A1 (enExample) |
| GB (1) | GB1510071A (enExample) |
| LU (1) | LU76701A1 (enExample) |
| NL (1) | NL7701133A (enExample) |
| NO (1) | NO770373L (enExample) |
| SE (1) | SE7701266L (enExample) |
-
1976
- 1976-02-05 GB GB4489/76A patent/GB1510071A/en not_active Expired
-
1977
- 1977-02-01 LU LU76701A patent/LU76701A1/xx unknown
- 1977-02-02 DE DE19772704194 patent/DE2704194A1/de active Pending
- 1977-02-03 NL NL7701133A patent/NL7701133A/xx not_active Application Discontinuation
- 1977-02-03 FI FI770380A patent/FI770380A7/fi not_active Application Discontinuation
- 1977-02-04 SE SE7701266A patent/SE7701266L/xx unknown
- 1977-02-04 DK DK47577A patent/DK47577A/da unknown
- 1977-02-04 NO NO770373A patent/NO770373L/no unknown
- 1977-02-04 BE BE174681A patent/BE851110A/xx unknown
- 1977-02-07 FR FR7703365A patent/FR2340550A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2704194A1 (de) | 1977-08-11 |
| LU76701A1 (enExample) | 1977-06-28 |
| SE7701266L (sv) | 1977-09-16 |
| DK47577A (da) | 1977-08-06 |
| GB1510071A (en) | 1978-05-10 |
| BE851110A (fr) | 1977-05-31 |
| FI770380A7 (enExample) | 1977-08-06 |
| NL7701133A (nl) | 1977-08-09 |
| FR2340550A1 (fr) | 1977-09-02 |
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