NO763361L - - Google Patents
Info
- Publication number
- NO763361L NO763361L NO763361A NO763361A NO763361L NO 763361 L NO763361 L NO 763361L NO 763361 A NO763361 A NO 763361A NO 763361 A NO763361 A NO 763361A NO 763361 L NO763361 L NO 763361L
- Authority
- NO
- Norway
- Prior art keywords
- pregnancy
- glycoprotein
- specific
- protein
- proteins
- Prior art date
Links
- 230000035935 pregnancy Effects 0.000 claims abstract description 67
- 238000000034 method Methods 0.000 claims abstract description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 36
- 102000004169 proteins and genes Human genes 0.000 claims description 35
- 238000006243 chemical reaction Methods 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 15
- 229940124452 immunizing agent Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000003647 oxidation Effects 0.000 claims description 6
- 238000007254 oxidation reaction Methods 0.000 claims description 6
- 230000010933 acylation Effects 0.000 claims description 4
- 238000005917 acylation reaction Methods 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 229920001817 Agar Polymers 0.000 claims description 3
- 230000029936 alkylation Effects 0.000 claims description 3
- 238000005804 alkylation reaction Methods 0.000 claims description 3
- 239000002054 inoculum Substances 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 238000006722 reduction reaction Methods 0.000 claims description 3
- 108010017384 Blood Proteins Proteins 0.000 claims description 2
- 102000004506 Blood Proteins Human genes 0.000 claims description 2
- 230000008033 biological extinction Effects 0.000 claims description 2
- 238000002523 gelfiltration Methods 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 2
- 235000018102 proteins Nutrition 0.000 description 32
- 239000000126 substance Substances 0.000 description 16
- 230000003053 immunization Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 241000282693 Cercopithecidae Species 0.000 description 9
- HVBSAKJJOYLTQU-UHFFFAOYSA-N 4-aminobenzenesulfonic acid Chemical compound NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 7
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- -1 benzoyl- Chemical group 0.000 description 7
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- 239000011630 iodine Substances 0.000 description 7
- 229910052740 iodine Inorganic materials 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000003277 amino group Chemical group 0.000 description 6
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 150000001718 carbodiimides Chemical class 0.000 description 4
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- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
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- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
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- 241000282412 Homo Species 0.000 description 2
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- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
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- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 2
- 239000012954 diazonium Substances 0.000 description 2
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical class C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 2
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- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- ABBAHMOUCAIMOQ-UHFFFAOYSA-N (4-azidophenyl)arsonic acid Chemical compound O[As](O)(=O)C1=CC=C(N=[N+]=[N-])C=C1 ABBAHMOUCAIMOQ-UHFFFAOYSA-N 0.000 description 1
- UQZOMPUVIQNBPY-HJQSKNPRSA-N 1-hydroxy-2-[(e)-(1-hydroxy-4-imino-5,5-dimethylimidazol-2-yl)diazenyl]-5,5-dimethylimidazol-4-imine Chemical compound N=C1C(C)(C)N(O)C(\N=N\C=2N(C(C)(C)C(=N)N=2)O)=N1 UQZOMPUVIQNBPY-HJQSKNPRSA-N 0.000 description 1
- IORISFYTXJVNFE-UHFFFAOYSA-N 2,3-dinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC([N+]([O-])=O)=C1[N+]([O-])=O IORISFYTXJVNFE-UHFFFAOYSA-N 0.000 description 1
- GTQFGAJYMBBUSO-UHFFFAOYSA-N 2-diazoacetamide Chemical compound NC(=O)C=[N+]=[N-] GTQFGAJYMBBUSO-UHFFFAOYSA-N 0.000 description 1
- MIVRMHJOEYRXQB-UHFFFAOYSA-N 2-diazonio-1-methoxyethenolate Chemical compound COC(=O)C=[N+]=[N-] MIVRMHJOEYRXQB-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- UEUIKXVPXLWUDU-UHFFFAOYSA-N 4-diazoniobenzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=C([N+]#N)C=C1 UEUIKXVPXLWUDU-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2543994A DE2543994C3 (de) | 1975-10-02 | 1975-10-02 | Proteinmodifizierte Verbindungen des schwangerschaftsspezifischen ß, -Glykoproteins und deren Verwendung als Bestandteil von immunisierenden Mitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO763361L true NO763361L (de) | 1977-04-05 |
Family
ID=5958064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO763361A NO763361L (de) | 1975-10-02 | 1976-10-01 |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5290613A (de) |
| AT (1) | AT352756B (de) |
| AU (1) | AU511175B2 (de) |
| BE (1) | BE846928A (de) |
| DE (1) | DE2543994C3 (de) |
| DK (1) | DK444576A (de) |
| FI (1) | FI762790A7 (de) |
| FR (1) | FR2326203A1 (de) |
| GB (1) | GB1560633A (de) |
| IL (1) | IL50589A (de) |
| IT (1) | IT1070582B (de) |
| LU (1) | LU75913A1 (de) |
| NL (1) | NL7610688A (de) |
| NO (1) | NO763361L (de) |
| NZ (1) | NZ182193A (de) |
| SE (1) | SE7610892L (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191533A (en) * | 1971-09-29 | 1980-03-04 | Behringwerke Aktiengesellschaft | Pregnancy-specific β1 -glycoprotein and process for isolating it |
| DE3525926A1 (de) | 1985-07-19 | 1987-01-29 | Boehringer Mannheim Gmbh | Verfahren und reagenz zur spezifischen bestimmung von pankreas-alpha-amylase |
| WO2013123423A1 (en) * | 2012-02-17 | 2013-08-22 | Castech Laboratories, Llc | Purification method |
-
1975
- 1975-10-02 DE DE2543994A patent/DE2543994C3/de not_active Expired
-
1976
- 1976-09-27 NL NL7610688A patent/NL7610688A/xx not_active Application Discontinuation
- 1976-09-30 IL IL50589A patent/IL50589A/xx unknown
- 1976-09-30 NZ NZ182193A patent/NZ182193A/xx unknown
- 1976-09-30 SE SE7610892A patent/SE7610892L/xx unknown
- 1976-09-30 LU LU75913A patent/LU75913A1/xx unknown
- 1976-09-30 FI FI762790A patent/FI762790A7/fi not_active Application Discontinuation
- 1976-09-30 IT IT27866/76A patent/IT1070582B/it active
- 1976-10-01 DK DK444576A patent/DK444576A/da not_active Application Discontinuation
- 1976-10-01 AT AT731176A patent/AT352756B/de not_active IP Right Cessation
- 1976-10-01 AU AU18318/76A patent/AU511175B2/en not_active Expired
- 1976-10-01 NO NO763361A patent/NO763361L/no unknown
- 1976-10-02 JP JP11795476A patent/JPS5290613A/ja active Pending
- 1976-10-04 BE BE171227A patent/BE846928A/xx unknown
- 1976-10-04 FR FR7629798A patent/FR2326203A1/fr active Granted
- 1976-10-04 GB GB41042/76A patent/GB1560633A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7610688A (nl) | 1977-04-05 |
| AU511175B2 (en) | 1980-07-31 |
| DK444576A (da) | 1977-04-03 |
| FR2326203A1 (fr) | 1977-04-29 |
| BE846928A (fr) | 1977-04-04 |
| LU75913A1 (de) | 1977-05-11 |
| JPS5290613A (en) | 1977-07-30 |
| FI762790A7 (de) | 1977-04-03 |
| GB1560633A (en) | 1980-02-06 |
| ATA731176A (de) | 1979-03-15 |
| SE7610892L (sv) | 1977-04-03 |
| IT1070582B (it) | 1985-03-29 |
| AU1831876A (en) | 1978-04-06 |
| DE2543994A1 (de) | 1977-04-07 |
| DE2543994B2 (de) | 1979-02-15 |
| FR2326203B1 (de) | 1980-10-31 |
| NZ182193A (en) | 1979-03-28 |
| IL50589A0 (en) | 1976-11-30 |
| IL50589A (en) | 1980-10-26 |
| AT352756B (de) | 1979-10-10 |
| DE2543994C3 (de) | 1979-10-11 |
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