NO760537L - - Google Patents
Info
- Publication number
- NO760537L NO760537L NO760537A NO760537A NO760537L NO 760537 L NO760537 L NO 760537L NO 760537 A NO760537 A NO 760537A NO 760537 A NO760537 A NO 760537A NO 760537 L NO760537 L NO 760537L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- formula
- halogen
- alkoxy
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 51
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 23
- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 11
- 150000002431 hydrogen Chemical class 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- PQTABYXQQFTCEC-UHFFFAOYSA-N 1-(5-chloro-2,3-dihydroindol-1-yl)-2-cyclopropylguanidine Chemical compound C1CC2=CC(Cl)=CC=C2N1NC(=N)NC1CC1 PQTABYXQQFTCEC-UHFFFAOYSA-N 0.000 claims description 2
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 230000008020 evaporation Effects 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WKMJCQCRQLPLNH-UHFFFAOYSA-N methyl n'-(5-chloro-2,3-dihydroindol-1-yl)carbamimidothioate;hydrochloride Chemical compound Cl.ClC1=CC=C2N(NC(=N)SC)CCC2=C1 WKMJCQCRQLPLNH-UHFFFAOYSA-N 0.000 description 3
- -1 phenoxyethyl Chemical group 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 125000004036 acetal group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000004103 aminoalkyl group Chemical group 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- CPEKAXYCDKETEN-UHFFFAOYSA-N benzoyl isothiocyanate Chemical compound S=C=NC(=O)C1=CC=CC=C1 CPEKAXYCDKETEN-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LDUCDHHSTPRPKF-UHFFFAOYSA-N (5-chloro-2,3-dihydroindol-1-yl)thiourea Chemical compound ClC1=CC=C2N(NC(=S)N)CCC2=C1 LDUCDHHSTPRPKF-UHFFFAOYSA-N 0.000 description 1
- OETXTUGXJWWGQO-UHFFFAOYSA-N 1-(5-chloro-2,3-dihydroindol-1-yl)-2-(2,2-diethoxyethyl)guanidine Chemical compound ClC1=CC=C2N(NC(=N)NCC(OCC)OCC)CCC2=C1 OETXTUGXJWWGQO-UHFFFAOYSA-N 0.000 description 1
- QZQJVPGOPWBQDO-UHFFFAOYSA-N 2-(2,3-dihydroindol-1-yl)-1-hydroxyguanidine Chemical compound C1=CC=C2N(NC(=N)NO)CCC2=C1 QZQJVPGOPWBQDO-UHFFFAOYSA-N 0.000 description 1
- LYIIBVSRGJSHAV-UHFFFAOYSA-N 2-aminoacetaldehyde Chemical compound NCC=O LYIIBVSRGJSHAV-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- GHVZOJONCUEWAV-UHFFFAOYSA-N [K].CCO Chemical compound [K].CCO GHVZOJONCUEWAV-UHFFFAOYSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 150000002357 guanidines Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940071870 hydroiodic acid Drugs 0.000 description 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- AKDLCSAFFNGUNI-UHFFFAOYSA-N methyl n'-(2,3-dihydroindol-1-yl)carbamimidothioate;hydrochloride Chemical compound Cl.C1=CC=C2N(NC(=N)SC)CCC2=C1 AKDLCSAFFNGUNI-UHFFFAOYSA-N 0.000 description 1
- IYMKYZQOGKMRRZ-UHFFFAOYSA-N methyl n'-(5-chloro-2,3-dihydroindol-1-yl)carbamimidothioate;hydroiodide Chemical compound I.ClC1=CC=C2N(NC(=N)SC)CCC2=C1 IYMKYZQOGKMRRZ-UHFFFAOYSA-N 0.000 description 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 1
- XTEGVFVZDVNBPF-UHFFFAOYSA-L naphthalene-1,5-disulfonate(2-) Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1S([O-])(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-L 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000054 salidiuretic effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH244075A CH613691A5 (en) | 1975-02-26 | 1975-02-26 | Process for the preparation of novel 1-indolinylguanidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO760537L true NO760537L (fr) | 1976-08-27 |
Family
ID=4233860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO760537A NO760537L (fr) | 1975-02-26 | 1976-02-18 |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS51110562A (fr) |
| AT (1) | AT358062B (fr) |
| AU (1) | AU505134B2 (fr) |
| BE (1) | BE838903A (fr) |
| CA (1) | CA1071640A (fr) |
| CH (1) | CH613691A5 (fr) |
| DD (1) | DD123883A5 (fr) |
| DE (1) | DE2605981A1 (fr) |
| DK (1) | DK62676A (fr) |
| ES (1) | ES445477A1 (fr) |
| FI (1) | FI760385A (fr) |
| FR (1) | FR2302090A1 (fr) |
| GB (1) | GB1531611A (fr) |
| IE (1) | IE42644B1 (fr) |
| IL (1) | IL49097A (fr) |
| NL (1) | NL7601728A (fr) |
| NO (1) | NO760537L (fr) |
| NZ (1) | NZ180109A (fr) |
| PT (1) | PT64838B (fr) |
| SE (1) | SE411119B (fr) |
| SU (1) | SU655307A3 (fr) |
| YU (1) | YU47076A (fr) |
| ZA (1) | ZA761155B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2737064A1 (de) * | 1976-08-27 | 1978-03-09 | Sandoz Ag | Indolin-1-ylguanidin-derivate, ihre verwendung und herstellung |
| JP4943715B2 (ja) * | 2006-02-27 | 2012-05-30 | 株式会社タダノ | 移動式クレーンのカウンタウエイト装置 |
-
1975
- 1975-02-26 CH CH244075A patent/CH613691A5/xx not_active IP Right Cessation
-
1976
- 1976-02-14 DE DE19762605981 patent/DE2605981A1/de not_active Ceased
- 1976-02-17 FI FI760385A patent/FI760385A/fi not_active Application Discontinuation
- 1976-02-17 DK DK62676*#A patent/DK62676A/da not_active Application Discontinuation
- 1976-02-18 NO NO760537A patent/NO760537L/no unknown
- 1976-02-19 SE SE7602000A patent/SE411119B/xx unknown
- 1976-02-20 NL NL7601728A patent/NL7601728A/xx unknown
- 1976-02-23 GB GB7002/76A patent/GB1531611A/en not_active Expired
- 1976-02-24 ES ES445477A patent/ES445477A1/es not_active Expired
- 1976-02-24 CA CA246,492A patent/CA1071640A/fr not_active Expired
- 1976-02-24 IL IL49097A patent/IL49097A/xx unknown
- 1976-02-24 DD DD191457A patent/DD123883A5/xx unknown
- 1976-02-24 PT PT64838A patent/PT64838B/fr unknown
- 1976-02-24 FR FR7605036A patent/FR2302090A1/fr active Granted
- 1976-02-24 BE BE164609A patent/BE838903A/fr unknown
- 1976-02-24 NZ NZ180109A patent/NZ180109A/xx unknown
- 1976-02-25 AT AT136476A patent/AT358062B/de not_active IP Right Cessation
- 1976-02-25 SU SU762324510A patent/SU655307A3/ru active
- 1976-02-25 IE IE371/76A patent/IE42644B1/en unknown
- 1976-02-25 YU YU00470/76A patent/YU47076A/xx unknown
- 1976-02-25 JP JP51019038A patent/JPS51110562A/ja active Pending
- 1976-02-26 ZA ZA761155A patent/ZA761155B/xx unknown
- 1976-02-26 AU AU11461/76A patent/AU505134B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2302090B1 (fr) | 1979-09-21 |
| FR2302090A1 (fr) | 1976-09-24 |
| ES445477A1 (es) | 1977-10-16 |
| SE7602000L (sv) | 1976-08-27 |
| IE42644B1 (en) | 1980-09-24 |
| DE2605981A1 (de) | 1976-09-09 |
| FI760385A (fr) | 1976-08-27 |
| CH613691A5 (en) | 1979-10-15 |
| DD123883A5 (fr) | 1977-01-19 |
| YU47076A (en) | 1982-02-28 |
| BE838903A (fr) | 1976-08-24 |
| CA1071640A (fr) | 1980-02-12 |
| JPS51110562A (fr) | 1976-09-30 |
| IL49097A (en) | 1979-01-31 |
| SE411119B (sv) | 1979-12-03 |
| ATA136476A (de) | 1980-01-15 |
| DK62676A (da) | 1976-08-27 |
| PT64838A (pt) | 1976-03-01 |
| AU1146176A (en) | 1977-09-01 |
| GB1531611A (en) | 1978-11-08 |
| NL7601728A (nl) | 1976-08-30 |
| SU655307A3 (ru) | 1979-03-30 |
| NZ180109A (en) | 1978-06-20 |
| ZA761155B (en) | 1977-09-28 |
| AU505134B2 (en) | 1979-11-08 |
| IE42644L (en) | 1976-08-26 |
| IL49097A0 (en) | 1976-04-30 |
| PT64838B (fr) | 1977-09-06 |
| AT358062B (de) | 1980-08-25 |
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