NO752889L - - Google Patents
Info
- Publication number
- NO752889L NO752889L NO752889A NO752889A NO752889L NO 752889 L NO752889 L NO 752889L NO 752889 A NO752889 A NO 752889A NO 752889 A NO752889 A NO 752889A NO 752889 L NO752889 L NO 752889L
- Authority
- NO
- Norway
- Prior art keywords
- arginine
- amoxicillin
- propylene glycol
- mixture
- amino
- Prior art date
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 63
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 229960003022 amoxicillin Drugs 0.000 claims description 24
- 150000001483 arginine derivatives Chemical class 0.000 claims description 24
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 14
- 239000004475 Arginine Substances 0.000 claims description 11
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 11
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- 239000003708 ampul Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 description 13
- 238000003756 stirring Methods 0.000 description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 7
- 229930064664 L-arginine Natural products 0.000 description 7
- 235000014852 L-arginine Nutrition 0.000 description 7
- 235000009697 arginine Nutrition 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 229960004920 amoxicillin trihydrate Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1143374 | 1974-08-21 | ||
| CH658075 | 1975-05-22 | ||
| CH817675 | 1975-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO752889L true NO752889L (fi) | 1976-02-24 |
Family
ID=27175528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO752889A NO752889L (fi) | 1974-08-21 | 1975-08-20 |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5148418A (fi) |
| AR (1) | AR208560A1 (fi) |
| AT (1) | AT338975B (fi) |
| AU (1) | AU8364775A (fi) |
| BR (1) | BR7505337A (fi) |
| CA (1) | CA1055926A (fi) |
| DD (1) | DD121325A5 (fi) |
| DE (1) | DE2536949A1 (fi) |
| DK (1) | DK375775A (fi) |
| ES (1) | ES440337A1 (fi) |
| FI (1) | FI752193A (fi) |
| FR (1) | FR2282270A1 (fi) |
| GB (1) | GB1464065A (fi) |
| IE (1) | IE41514B1 (fi) |
| IL (1) | IL47712A0 (fi) |
| LU (1) | LU73220A1 (fi) |
| NL (1) | NL7509698A (fi) |
| NO (1) | NO752889L (fi) |
| PH (1) | PH13527A (fi) |
| SE (1) | SE7509219L (fi) |
| YU (1) | YU188375A (fi) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2319338A1 (fr) | 1975-08-01 | 1977-02-25 | Synthelabo | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
| JP6746378B2 (ja) | 2016-05-27 | 2020-08-26 | 東洋電装株式会社 | 磁気式回転検出装置 |
-
1975
- 1975-07-15 IL IL7547712A patent/IL47712A0/xx unknown
- 1975-07-24 YU YU01883/75A patent/YU188375A/xx unknown
- 1975-07-31 FI FI752193A patent/FI752193A/fi not_active Application Discontinuation
- 1975-08-04 AU AU83647/75A patent/AU8364775A/en not_active Expired
- 1975-08-08 AR AR259948A patent/AR208560A1/es active
- 1975-08-13 PH PH17466A patent/PH13527A/en unknown
- 1975-08-14 NL NL7509698A patent/NL7509698A/xx unknown
- 1975-08-18 CA CA233,612A patent/CA1055926A/en not_active Expired
- 1975-08-18 SE SE7509219A patent/SE7509219L/xx unknown
- 1975-08-19 DE DE19752536949 patent/DE2536949A1/de active Pending
- 1975-08-19 DD DD187936A patent/DD121325A5/xx unknown
- 1975-08-19 JP JP50099886A patent/JPS5148418A/ja active Pending
- 1975-08-19 LU LU73220A patent/LU73220A1/xx unknown
- 1975-08-19 FR FR7525629A patent/FR2282270A1/fr not_active Withdrawn
- 1975-08-20 NO NO752889A patent/NO752889L/no unknown
- 1975-08-20 AT AT645275A patent/AT338975B/de active
- 1975-08-20 DK DK375775A patent/DK375775A/da unknown
- 1975-08-20 ES ES440337A patent/ES440337A1/es not_active Expired
- 1975-08-20 BR BR7505337*A patent/BR7505337A/pt unknown
- 1975-08-20 IE IE1832/75A patent/IE41514B1/en unknown
- 1975-08-20 GB GB3460775A patent/GB1464065A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI752193A (fi) | 1976-02-22 |
| YU188375A (en) | 1982-02-28 |
| ATA645275A (de) | 1977-01-15 |
| ES440337A1 (es) | 1977-03-16 |
| AT338975B (de) | 1977-09-26 |
| DD121325A5 (fi) | 1976-07-20 |
| IE41514L (en) | 1976-02-21 |
| AR208560A1 (es) | 1977-02-15 |
| FR2282270A1 (fr) | 1976-03-19 |
| DE2536949A1 (de) | 1976-03-04 |
| SE7509219L (sv) | 1976-02-23 |
| IL47712A0 (en) | 1975-10-15 |
| PH13527A (en) | 1980-06-19 |
| NL7509698A (nl) | 1976-02-24 |
| JPS5148418A (fi) | 1976-04-26 |
| DK375775A (da) | 1976-02-22 |
| LU73220A1 (fi) | 1977-04-15 |
| CA1055926A (en) | 1979-06-05 |
| AU8364775A (en) | 1977-02-10 |
| GB1464065A (en) | 1977-02-09 |
| IE41514B1 (en) | 1980-01-16 |
| BR7505337A (pt) | 1976-08-03 |
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