NO744591L - - Google Patents
Info
- Publication number
- NO744591L NO744591L NO744591A NO744591A NO744591L NO 744591 L NO744591 L NO 744591L NO 744591 A NO744591 A NO 744591A NO 744591 A NO744591 A NO 744591A NO 744591 L NO744591 L NO 744591L
- Authority
- NO
- Norway
- Prior art keywords
- stated
- reaction
- mmol
- solution
- carboxylic acid
- Prior art date
Links
- 238000000034 method Methods 0.000 claims abstract description 14
- 230000002255 enzymatic effect Effects 0.000 claims abstract description 5
- 229930182555 Penicillin Natural products 0.000 claims abstract description 4
- 229930186147 Cephalosporin Natural products 0.000 claims abstract description 3
- 229940124587 cephalosporin Drugs 0.000 claims abstract description 3
- 150000001780 cephalosporins Chemical class 0.000 claims abstract description 3
- 150000002960 penicillins Chemical class 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 239000000835 fiber Substances 0.000 claims description 17
- 238000003786 synthesis reaction Methods 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 108010073038 Penicillin Amidase Proteins 0.000 claims description 5
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 4
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical group C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 3
- 229960003022 amoxicillin Drugs 0.000 claims description 3
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- NVIAYEIXYQCDAN-UHFFFAOYSA-N 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)C(N)C12 NVIAYEIXYQCDAN-UHFFFAOYSA-N 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 5
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 4
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 108700023418 Amidases Proteins 0.000 description 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108010087702 Penicillinase Proteins 0.000 description 1
- 102000005922 amidase Human genes 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- CVWJDUUVFSVART-UHFFFAOYSA-N ethyl 2-amino-2-(4-hydroxyphenyl)acetate Chemical compound CCOC(=O)C(N)C1=CC=C(O)C=C1 CVWJDUUVFSVART-UHFFFAOYSA-N 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT54486/73A IT1045797B (it) | 1973-12-20 | 1973-12-20 | Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO744591L true NO744591L (enrdf_load_stackoverflow) | 1975-07-14 |
Family
ID=11287339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO744591A NO744591L (enrdf_load_stackoverflow) | 1973-12-20 | 1974-12-19 |
Country Status (20)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1243800B (it) * | 1990-08-28 | 1994-06-28 | Sclavo Spa | Procedimento migliorato per la preparazione di cefalosporine |
| CZ69593A3 (en) * | 1992-04-24 | 1993-12-15 | Lilly Co Eli | Process for preparing cephalosporins |
| IT1274658B (it) * | 1995-02-28 | 1997-07-18 | Acs Dobfar Spa | Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine |
-
1973
- 1973-12-20 IT IT54486/73A patent/IT1045797B/it active
-
1974
- 1974-11-28 IL IL46151A patent/IL46151A0/xx unknown
- 1974-12-02 AU AU75938/74A patent/AU7593874A/en not_active Expired
- 1974-12-05 FR FR7439837A patent/FR2255379B1/fr not_active Expired
- 1974-12-10 CH CH1640174A patent/CH606432A5/xx not_active IP Right Cessation
- 1974-12-11 ZA ZA00747896A patent/ZA747896B/xx unknown
- 1974-12-13 LU LU71482A patent/LU71482A1/xx unknown
- 1974-12-16 GB GB54337/74A patent/GB1482481A/en not_active Expired
- 1974-12-16 FI FI3621/74A patent/FI362174A7/fi unknown
- 1974-12-16 BE BE151539A patent/BE823393A/xx not_active IP Right Cessation
- 1974-12-17 YU YU03355/74A patent/YU335574A/xx unknown
- 1974-12-18 DK DK661074A patent/DK661074A/da unknown
- 1974-12-18 NL NL7416548A patent/NL7416548A/xx unknown
- 1974-12-19 HU HU74SA00002732A patent/HU172712B/hu unknown
- 1974-12-19 NO NO744591A patent/NO744591L/no unknown
- 1974-12-19 SE SE7416078A patent/SE7416078L/xx unknown
- 1974-12-20 JP JP49145851A patent/JPS5095487A/ja active Pending
- 1974-12-20 DD DD183278A patent/DD115683A5/xx unknown
- 1974-12-20 CS CS748820A patent/CS190459B2/cs unknown
- 1974-12-20 DE DE19742460649 patent/DE2460649A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA747896B (en) | 1975-12-31 |
| CH606432A5 (enrdf_load_stackoverflow) | 1978-10-31 |
| NL7416548A (nl) | 1975-06-24 |
| YU335574A (en) | 1982-05-31 |
| IL46151A0 (en) | 1975-02-10 |
| AU7593874A (en) | 1976-06-03 |
| HU172712B (hu) | 1978-11-28 |
| DK661074A (enrdf_load_stackoverflow) | 1975-08-25 |
| SE7416078L (enrdf_load_stackoverflow) | 1975-06-23 |
| GB1482481A (en) | 1977-08-10 |
| FR2255379B1 (enrdf_load_stackoverflow) | 1977-10-28 |
| LU71482A1 (enrdf_load_stackoverflow) | 1975-06-17 |
| FR2255379A1 (enrdf_load_stackoverflow) | 1975-07-18 |
| DE2460649A1 (de) | 1975-06-26 |
| FI362174A7 (enrdf_load_stackoverflow) | 1975-06-21 |
| JPS5095487A (enrdf_load_stackoverflow) | 1975-07-29 |
| IT1045797B (it) | 1980-06-10 |
| DD115683A5 (enrdf_load_stackoverflow) | 1975-10-12 |
| BE823393A (fr) | 1975-04-16 |
| CS190459B2 (en) | 1979-05-31 |
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