NO341815B1 - New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy - Google Patents

New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy Download PDF

Info

Publication number
NO341815B1
NO341815B1 NO20160680A NO20160680A NO341815B1 NO 341815 B1 NO341815 B1 NO 341815B1 NO 20160680 A NO20160680 A NO 20160680A NO 20160680 A NO20160680 A NO 20160680A NO 341815 B1 NO341815 B1 NO 341815B1
Authority
NO
Norway
Prior art keywords
compound
bacterium
bacterial
mbl
culture
Prior art date
Application number
NO20160680A
Other languages
English (en)
Norwegian (no)
Other versions
NO20160680A1 (en
Inventor
Håvard Sletta
Geir Klinkenberg
Degnes Kristin Fløgstad
Trond Erling Ellingsen
Anna Nordborg
Sigrid Hakvåg
Original Assignee
Marbileads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marbileads filed Critical Marbileads
Priority to NO20160680A priority Critical patent/NO341815B1/en
Priority to US16/095,143 priority patent/US10494375B2/en
Priority to CN201780024990.4A priority patent/CN109195971B/zh
Priority to PT177223930T priority patent/PT3445766T/pt
Priority to JP2018555117A priority patent/JP6964600B2/ja
Priority to DK17722393.0T priority patent/DK3445766T3/da
Priority to PCT/EP2017/059521 priority patent/WO2017182632A1/en
Priority to PL17722393T priority patent/PL3445766T3/pl
Priority to EP17722393.0A priority patent/EP3445766B1/en
Priority to ES17722393T priority patent/ES2909248T3/es
Priority to HRP20220350TT priority patent/HRP20220350T1/hr
Publication of NO20160680A1 publication Critical patent/NO20160680A1/en
Publication of NO341815B1 publication Critical patent/NO341815B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20160680A 2016-04-22 2016-04-22 New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy NO341815B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NO20160680A NO341815B1 (en) 2016-04-22 2016-04-22 New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy
US16/095,143 US10494375B2 (en) 2016-04-22 2017-04-21 Antimicrobial compound
CN201780024990.4A CN109195971B (zh) 2016-04-22 2017-04-21 抗微生物化合物
PT177223930T PT3445766T (pt) 2016-04-22 2017-04-21 Novo composto antimicrobiano
JP2018555117A JP6964600B2 (ja) 2016-04-22 2017-04-21 新たな抗菌化合物
DK17722393.0T DK3445766T3 (da) 2016-04-22 2017-04-21 Ny antimikrobiel forbindelse
PCT/EP2017/059521 WO2017182632A1 (en) 2016-04-22 2017-04-21 New antimicrobial compound
PL17722393T PL3445766T3 (pl) 2016-04-22 2017-04-21 Nowy związek przeciwdrobnoustrojowy
EP17722393.0A EP3445766B1 (en) 2016-04-22 2017-04-21 New antimicrobial compound
ES17722393T ES2909248T3 (es) 2016-04-22 2017-04-21 Nuevo compuesto antimicrobiano
HRP20220350TT HRP20220350T1 (hr) 2016-04-22 2017-04-21 Novi antimikrobni spoj

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20160680A NO341815B1 (en) 2016-04-22 2016-04-22 New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy

Publications (2)

Publication Number Publication Date
NO20160680A1 NO20160680A1 (en) 2017-10-23
NO341815B1 true NO341815B1 (en) 2018-01-29

Family

ID=58692467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20160680A NO341815B1 (en) 2016-04-22 2016-04-22 New antimicrobial compound, a method of producing it, pharmaceutical compositions and uses in therapy

Country Status (11)

Country Link
US (1) US10494375B2 (cg-RX-API-DMAC7.html)
EP (1) EP3445766B1 (cg-RX-API-DMAC7.html)
JP (1) JP6964600B2 (cg-RX-API-DMAC7.html)
CN (1) CN109195971B (cg-RX-API-DMAC7.html)
DK (1) DK3445766T3 (cg-RX-API-DMAC7.html)
ES (1) ES2909248T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220350T1 (cg-RX-API-DMAC7.html)
NO (1) NO341815B1 (cg-RX-API-DMAC7.html)
PL (1) PL3445766T3 (cg-RX-API-DMAC7.html)
PT (1) PT3445766T (cg-RX-API-DMAC7.html)
WO (1) WO2017182632A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109280692A (zh) * 2018-10-31 2019-01-29 广东药科大学 一种蜚蠊内生放线菌的抗真菌活性筛选方法及其发酵方法
KR102112570B1 (ko) * 2019-01-28 2020-05-19 한국해양과학기술원 신규 람노리피드 화합물 및 이의 용도
CN109956951B (zh) * 2019-04-11 2021-01-01 中国医学科学院医药生物技术研究所 鹿色霉素(cervinomycin)C1、C2、C3、C4及其生产方法及应用
CN120478324B (zh) * 2025-04-28 2025-12-26 暨南大学 泛酸或其药学上可接受的盐在制备增强病原菌对达托霉素的敏感性的药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006002427A1 (de) * 2006-01-09 2007-07-12 Combinature Biopharm Ag Neue Lysolipin Derivate
WO2007095696A1 (en) * 2006-02-27 2007-08-30 The University Of Queensland Polyketide xanthones and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494913A (en) * 1994-12-13 1996-02-27 Schering Corporation Antifungal compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006002427A1 (de) * 2006-01-09 2007-07-12 Combinature Biopharm Ag Neue Lysolipin Derivate
WO2007095696A1 (en) * 2006-02-27 2007-08-30 The University Of Queensland Polyketide xanthones and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ENGELHARDT K. et al "Production of a New Thiopeptide Antibiotic, TP-1161, by a marine Nocardiopsis Species", Applied and Environmental Microbiology, 2010, vol. 76 (15), p. 4969-4976, Dated: 01.01.0001 *
TERUI, Y et al "Xantholipin, a novel inhibitor of HSP47 gene expression produced by Streptomyces sp", Tetrahedron Letters, 2003, vol 44(29), page 5427-5430, Dated: 01.01.0001 *
WEIKE ZHANG et al "Unveiling the Post-PKS Redox Tailoring Steps in Biosynthesis of the Type II Polyketide Antitumor Antibiotic Xantholipin", CHEMISTRY AND BIOLOGY, 2012, vol. 19 (3), page 422-432, Dated: 01.01.0001 *
WINTER, DANA K. et al. "Polycyclic xanthone natural products: structure, biological activity and chemical synthesis", Nat. Prod. Rep., 2013, 30, page 382-391, DOI: 10.1039/C3NP20122Hy, Dated: 01.01.0001 *

Also Published As

Publication number Publication date
PT3445766T (pt) 2022-03-21
ES2909248T3 (es) 2022-05-05
NO20160680A1 (en) 2017-10-23
EP3445766B1 (en) 2021-12-15
JP6964600B2 (ja) 2021-11-10
US20190135822A1 (en) 2019-05-09
HRP20220350T1 (hr) 2022-05-13
DK3445766T3 (da) 2022-03-21
CN109195971A (zh) 2019-01-11
US10494375B2 (en) 2019-12-03
CN109195971B (zh) 2021-08-27
EP3445766A1 (en) 2019-02-27
WO2017182632A1 (en) 2017-10-26
PL3445766T3 (pl) 2022-04-04
JP2019521078A (ja) 2019-07-25

Similar Documents

Publication Publication Date Title
EP3445766B1 (en) New antimicrobial compound
US6218398B1 (en) Nocathiacin antibiotics
Charousová et al. Streptomyces globosus DK15 and Streptomyces ederensis ST13 as new producers of factumycin and tetrangomycin antibiotics
US20150376676A1 (en) Method to generate novel bioactive molecules
RU2536587C2 (ru) Антибиотические соединения
Yoon et al. Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341
Lee et al. Metabolomics-based chemotaxonomic classification of Streptomyces spp. and its correlation with antibacterial activity
EP1285928B1 (en) Antibiotics tripropeptins and process for producing the same
KR101764349B1 (ko) 펩티드 디포밀라제 저해 및 항균 활성을 갖는 신규한 프라비마이신 화합물
CN109280034B (zh) 一种具有抑菌活性的苯并氮氧杂卓类化合物及其制备方法与应用
KR101344083B1 (ko) 폴리사이클릭 펩타이드 화합물을 포함하는 항균용 조성물 및 이의 생산방법
Carrano et al. A novel microbisporicin producer identified by early dereplication during lantibiotic screening
EP2327789B1 (en) Signamycin, method for production thereof, and use thereof
US20140228278A1 (en) Antibiotics and methods for manufacturing the same
US12018305B2 (en) Process for production of nigericin from Streptomyces sp. MCC-0151
RU2798207C1 (ru) Штамм Streptomyces rochei MP21 - продуцент антибиотика кирромицина
US20230181684A1 (en) Novel antibiotic compositions and methods of making or using the same
WO2025235845A9 (en) Antibiotic compositions and methods of use thereof
WO2025235845A1 (en) Antibiotic compositions and methods of use thereof
WO2025212845A1 (en) Phosphonopeptides and methods of making and use thereof
Quezada Iniguez Microbial biodiscovery: Exploring venomous animal associated microbes as sources of new chemical diversity
Bertholtz Antibiotics from the nature-culturing of genetically talented bacterial isolates
ZA200006693B (en) Nocathiacin antibiotics.
KR20050078182A (ko) 신규한 후사리움 비020115 균주 및 그 균주가 생산하는에노일 리덕타아제 저해에 의한 항균활성 물질

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: SINTEF TTO AS, NO