NO338853B1 - Isolert spesifikt bindingsmedlem for humant IL-13, isolert antistoff VH og VL domene, sammensetning inneholdende disse og fremgangsmåter for å fremstille disse og anvendelse, samt isolert nukleinsyre og vertscelle. - Google Patents

Isolert spesifikt bindingsmedlem for humant IL-13, isolert antistoff VH og VL domene, sammensetning inneholdende disse og fremgangsmåter for å fremstille disse og anvendelse, samt isolert nukleinsyre og vertscelle. Download PDF

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Publication number
NO338853B1
NO338853B1 NO20060730A NO20060730A NO338853B1 NO 338853 B1 NO338853 B1 NO 338853B1 NO 20060730 A NO20060730 A NO 20060730A NO 20060730 A NO20060730 A NO 20060730A NO 338853 B1 NO338853 B1 NO 338853B1
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NO
Norway
Prior art keywords
domain
antibody
seq
human
amino acid
Prior art date
Application number
NO20060730A
Other languages
English (en)
Norwegian (no)
Other versions
NO20060730L (no
Inventor
Phillip David Monk
Celia Patricia Shorrock
Original Assignee
Cambridge Antibody Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0407315.1A external-priority patent/GB0407315D0/en
Application filed by Cambridge Antibody Tech Ltd filed Critical Cambridge Antibody Tech Ltd
Publication of NO20060730L publication Critical patent/NO20060730L/no
Publication of NO338853B1 publication Critical patent/NO338853B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20060730A 2003-07-15 2006-02-15 Isolert spesifikt bindingsmedlem for humant IL-13, isolert antistoff VH og VL domene, sammensetning inneholdende disse og fremgangsmåter for å fremstille disse og anvendelse, samt isolert nukleinsyre og vertscelle. NO338853B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48751203P 2003-07-15 2003-07-15
US55821604P 2004-03-31 2004-03-31
GBGB0407315.1A GB0407315D0 (en) 2003-07-15 2004-03-31 Human antibody molecules
US57379104P 2004-05-24 2004-05-24
PCT/GB2004/003059 WO2005007699A2 (en) 2003-07-15 2004-07-15 Human antibody molecules for il-13

Publications (2)

Publication Number Publication Date
NO20060730L NO20060730L (no) 2006-04-10
NO338853B1 true NO338853B1 (no) 2016-10-24

Family

ID=44535047

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20060730A NO338853B1 (no) 2003-07-15 2006-02-15 Isolert spesifikt bindingsmedlem for humant IL-13, isolert antistoff VH og VL domene, sammensetning inneholdende disse og fremgangsmåter for å fremstille disse og anvendelse, samt isolert nukleinsyre og vertscelle.
NO20160707A NO342727B1 (no) 2003-07-15 2016-04-27 Isolert spesifikt antistoffmolekyl mot humant IL-13, sammensetning inneholdende disse, fremgangsmåter for fremstilling og anvendelse, samt isolert nukleinsyre og 30 vertscelle.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20160707A NO342727B1 (no) 2003-07-15 2016-04-27 Isolert spesifikt antistoffmolekyl mot humant IL-13, sammensetning inneholdende disse, fremgangsmåter for fremstilling og anvendelse, samt isolert nukleinsyre og 30 vertscelle.

Country Status (8)

Country Link
JP (3) JP5519567B2 (ja)
KR (1) KR101073590B1 (ja)
AU (1) AU2011200308B2 (ja)
CY (1) CY1111467T1 (ja)
HK (3) HK1097853A1 (ja)
MX (1) MXPA06000258A (ja)
NO (2) NO338853B1 (ja)
RU (1) RU2009148270A (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952241A1 (en) * 2014-06-18 2015-12-23 Medimmune, Llc Cell culture methods and media comprising n-acetylcysteine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004680A1 (en) * 1992-08-21 1994-03-03 Schering Corporation Human interleukin-13
WO2003035847A2 (en) * 2001-10-26 2003-05-01 Centocor, Inc. Il-13 mutein proteins, antibodies, compositions, methods and uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030235555A1 (en) * 2002-04-05 2003-12-25 David Shealey Asthma-related anti-IL-13 immunoglobulin derived proteins, compositions, methods and uses
AU2002359568B2 (en) * 2001-12-03 2008-02-21 Alexion Pharmaceuticals, Inc. Hybrid antibodies
AU2003260748A1 (en) * 2002-08-30 2004-03-19 Glaxo Group Limited Il-14 vaccine for the treatment of asthma and atopic disorders
GB0407315D0 (en) * 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
TWI307630B (en) * 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004680A1 (en) * 1992-08-21 1994-03-03 Schering Corporation Human interleukin-13
WO2003035847A2 (en) * 2001-10-26 2003-05-01 Centocor, Inc. Il-13 mutein proteins, antibodies, compositions, methods and uses

Also Published As

Publication number Publication date
RU2009148270A (ru) 2011-06-27
JP5519567B2 (ja) 2014-06-11
MXPA06000258A (es) 2006-07-03
JP2014101372A (ja) 2014-06-05
HK1097853A1 (en) 2007-07-06
KR101073590B1 (ko) 2011-10-14
AU2011200308B2 (en) 2011-07-28
KR20060054312A (ko) 2006-05-22
NO20160707A1 (no) 2016-04-27
HK1216427A1 (zh) 2016-11-11
AU2011200308A1 (en) 2011-02-17
CY1111467T1 (el) 2015-08-05
JP2011147454A (ja) 2011-08-04
JP5922686B2 (ja) 2016-05-24
HK1155185A1 (zh) 2012-05-11
JP2016047843A (ja) 2016-04-07
NO20060730L (no) 2006-04-10
NO342727B1 (no) 2018-07-30

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