NO330392B1 - Imidazolderivater med affinitet for alfa 2-reseptoraktivitet og anvendelser derav, samt farmasoytisk preparat omfattende imidazolderivat - Google Patents
Imidazolderivater med affinitet for alfa 2-reseptoraktivitet og anvendelser derav, samt farmasoytisk preparat omfattende imidazolderivat Download PDFInfo
- Publication number
- NO330392B1 NO330392B1 NO20053302A NO20053302A NO330392B1 NO 330392 B1 NO330392 B1 NO 330392B1 NO 20053302 A NO20053302 A NO 20053302A NO 20053302 A NO20053302 A NO 20053302A NO 330392 B1 NO330392 B1 NO 330392B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- ylmethyl
- imidazol
- pharmaceutically acceptable
- imidazole derivatives
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
- 230000000694 effects Effects 0.000 title description 6
- 150000002460 imidazoles Chemical class 0.000 title 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 2
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 150000004677 hydrates Chemical class 0.000 claims abstract description 7
- 208000019901 Anxiety disease Diseases 0.000 claims description 6
- 230000036506 anxiety Effects 0.000 claims description 6
- QOGPGHSEZPBKFX-UHFFFAOYSA-N [3-(1h-imidazol-1-ium-4-ylmethyl)-2,3-dihydro-1h-inden-5-yl] 2,2-dimethylpropanoate;chloride Chemical compound [Cl-].C12=CC(OC(=O)C(C)(C)C)=CC=C2CCC1CC1=C[NH2+]C=N1 QOGPGHSEZPBKFX-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 206010020772 Hypertension Diseases 0.000 claims description 4
- 206010002091 Anaesthesia Diseases 0.000 claims description 3
- 206010012735 Diarrhoea Diseases 0.000 claims description 3
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 208000019695 Migraine disease Diseases 0.000 claims description 3
- 208000023178 Musculoskeletal disease Diseases 0.000 claims description 3
- IJVDZNZQEUKGJI-UHFFFAOYSA-N [3-(1h-imidazol-1-ium-4-ylmethyl)-2,3-dihydro-1h-inden-5-yl] acetate;chloride Chemical compound [Cl-].C12=CC(OC(=O)C)=CC=C2CCC1CC1=C[NH2+]C=N1 IJVDZNZQEUKGJI-UHFFFAOYSA-N 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 3
- 230000037005 anaesthesia Effects 0.000 claims description 3
- 238000001949 anaesthesia Methods 0.000 claims description 3
- 208000010877 cognitive disease Diseases 0.000 claims description 3
- 208000028867 ischemia Diseases 0.000 claims description 3
- 206010027599 migraine Diseases 0.000 claims description 3
- 239000000133 nasal decongestant Substances 0.000 claims description 3
- 230000000926 neurological effect Effects 0.000 claims description 3
- 208000020016 psychiatric disease Diseases 0.000 claims description 3
- 239000000932 sedative agent Substances 0.000 claims description 3
- 230000001624 sedative effect Effects 0.000 claims description 3
- 208000012902 Nervous system disease Diseases 0.000 claims description 2
- 208000025966 Neurological disease Diseases 0.000 claims description 2
- QMDUNEFOOFZIPI-UHFFFAOYSA-N [3-(1h-imidazol-1-ium-4-ylmethyl)-2,3-dihydro-1h-inden-5-yl] butanoate;chloride Chemical compound [Cl-].C12=CC(OC(=O)CCC)=CC=C2CCC1CC1=C[NH2+]C=N1 QMDUNEFOOFZIPI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000730 antalgic agent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 26
- OYKZVKWXOWICFI-UHFFFAOYSA-N 3-(1h-imidazol-1-ium-4-ylmethyl)-2,3-dihydro-1h-inden-5-ol;chloride Chemical compound Cl.C12=CC(O)=CC=C2CCC1CC1=CN=CN1 OYKZVKWXOWICFI-UHFFFAOYSA-N 0.000 abstract description 18
- 239000002243 precursor Substances 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 8
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 description 12
- 229940002612 prodrug Drugs 0.000 description 10
- 239000000651 prodrug Substances 0.000 description 10
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 8
- -1 pivaloyl ester Chemical class 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000008363 phosphate buffer Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 230000007071 enzymatic hydrolysis Effects 0.000 description 5
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000001508 eye Anatomy 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 2
- 238000002680 cardiopulmonary resuscitation Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000002144 chemical decomposition reaction Methods 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 1
- JVSFQJZRHXAUGT-UHFFFAOYSA-N 2,2-dimethylpropanoyl chloride Chemical compound CC(C)(C)C(Cl)=O JVSFQJZRHXAUGT-UHFFFAOYSA-N 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010048010 Withdrawal syndrome Diseases 0.000 description 1
- PMFMOTWELHDYFE-UHFFFAOYSA-N [Cl-].OC1=CC=C2CCC(C2=C1)CC=1N=C[NH2+]C1.[Cl-].CC(C(=O)OC1=CC=C2CCC(C2=C1)CC=1N=C[NH2+]C1)(C)C Chemical compound [Cl-].OC1=CC=C2CCC(C2=C1)CC=1N=C[NH2+]C1.[Cl-].CC(C(=O)OC1=CC=C2CCC(C2=C1)CC=1N=C[NH2+]C1)(C)C PMFMOTWELHDYFE-UHFFFAOYSA-N 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 description 1
- 230000003502 anti-nociceptive effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- DVECBJCOGJRVPX-UHFFFAOYSA-N butyryl chloride Chemical compound CCCC(Cl)=O DVECBJCOGJRVPX-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000007073 chemical hydrolysis Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- YIAPLDFPUUJILH-UHFFFAOYSA-N indan-1-ol Chemical compound C1=CC=C2C(O)CCC2=C1 YIAPLDFPUUJILH-UHFFFAOYSA-N 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 description 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 description 1
- 229960003502 oxybuprocaine Drugs 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20022159A FI20022159A0 (fi) | 2002-12-05 | 2002-12-05 | Uusia farmaseuttisia yhdisteitä |
| PCT/FI2003/000933 WO2004050635A2 (en) | 2002-12-05 | 2003-12-05 | Imidazol derivatives having affinity for alpha 2 receptors activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20053302L NO20053302L (no) | 2005-07-05 |
| NO20053302D0 NO20053302D0 (no) | 2005-07-05 |
| NO330392B1 true NO330392B1 (no) | 2011-04-04 |
Family
ID=8565048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053302A NO330392B1 (no) | 2002-12-05 | 2005-07-05 | Imidazolderivater med affinitet for alfa 2-reseptoraktivitet og anvendelser derav, samt farmasoytisk preparat omfattende imidazolderivat |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7759496B2 (ko) |
| EP (1) | EP1572198B1 (ko) |
| JP (1) | JP4667042B2 (ko) |
| KR (1) | KR20050114603A (ko) |
| CN (1) | CN100560070C (ko) |
| AT (1) | ATE323484T1 (ko) |
| BR (1) | BR0317024A (ko) |
| CA (1) | CA2508335C (ko) |
| CY (1) | CY1105699T1 (ko) |
| DE (1) | DE60304741T2 (ko) |
| DK (1) | DK1572198T3 (ko) |
| EA (1) | EA008251B1 (ko) |
| ES (1) | ES2262031T3 (ko) |
| FI (1) | FI20022159A0 (ko) |
| HR (1) | HRP20050617B1 (ko) |
| IL (1) | IL168882A (ko) |
| IS (1) | IS2282B (ko) |
| ME (1) | ME00521B (ko) |
| MX (1) | MXPA05005963A (ko) |
| NO (1) | NO330392B1 (ko) |
| NZ (1) | NZ540466A (ko) |
| PL (1) | PL216530B1 (ko) |
| PT (1) | PT1572198E (ko) |
| RS (1) | RS52571B (ko) |
| SI (1) | SI1572198T1 (ko) |
| WO (1) | WO2004050635A2 (ko) |
| ZA (1) | ZA200504533B (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2348997T3 (es) | 2005-08-25 | 2010-12-21 | Schering Corporation | Compuestos de 3,4-dihidro-2h-benzo[1,4]oxazina y 3,4-dihidro-2h-benzo[1,4]tiazina como agonistas del adrenorreceptor alfa2c. |
| US7700592B2 (en) | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
| US8003624B2 (en) | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
| AR073628A1 (es) | 2008-10-07 | 2010-11-17 | Schering Corp | Analogos de biaril espiroaminooxazolina y espiroaminodiazolina moduladores de receptores adrenergicos alfa2c, composiciones farmaceuticas que los comprenden y uso de los mismos en rinitis alergica,trastornos cardiacos y otras enfermedades |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| GB9425211D0 (en) * | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| JPH10195056A (ja) * | 1996-11-12 | 1998-07-28 | Takeda Chem Ind Ltd | 縮合ベンゼン誘導体、その製造法および剤 |
| CZ299918B6 (cs) | 1998-09-28 | 2008-12-29 | Orion Corporation | Lécivo pro dosahování analgézie nebo asistenci pri dosahování anestézie u savcu intraspinálním podáváním |
| NZ518447A (en) | 1999-10-29 | 2004-10-29 | Orion Corp | Treatment or prevention of hypotension and shock |
| US6388090B2 (en) * | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
| FI20000073A0 (fi) | 2000-01-14 | 2000-01-14 | Orion Yhtymae Oy | Uusia imidatsolijohdannaisia |
| US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
| US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
-
2002
- 2002-12-05 FI FI20022159A patent/FI20022159A0/fi unknown
-
2003
- 2003-12-05 WO PCT/FI2003/000933 patent/WO2004050635A2/en active IP Right Grant
- 2003-12-05 BR BR0317024-1A patent/BR0317024A/pt unknown
- 2003-12-05 JP JP2004556387A patent/JP4667042B2/ja not_active Expired - Fee Related
- 2003-12-05 EP EP03812203A patent/EP1572198B1/en not_active Expired - Lifetime
- 2003-12-05 DK DK03812203T patent/DK1572198T3/da active
- 2003-12-05 EA EA200500922A patent/EA008251B1/ru not_active IP Right Cessation
- 2003-12-05 ES ES03812203T patent/ES2262031T3/es not_active Expired - Lifetime
- 2003-12-05 ME MEP-2008-864A patent/ME00521B/me unknown
- 2003-12-05 SI SI200330300T patent/SI1572198T1/sl unknown
- 2003-12-05 AT AT03812203T patent/ATE323484T1/de active
- 2003-12-05 PT PT03812203T patent/PT1572198E/pt unknown
- 2003-12-05 CA CA2508335A patent/CA2508335C/en not_active Expired - Lifetime
- 2003-12-05 NZ NZ540466A patent/NZ540466A/en not_active IP Right Cessation
- 2003-12-05 MX MXPA05005963A patent/MXPA05005963A/es active IP Right Grant
- 2003-12-05 KR KR1020057009983A patent/KR20050114603A/ko active Search and Examination
- 2003-12-05 RS YU20050428A patent/RS52571B/en unknown
- 2003-12-05 CN CNB2003801051320A patent/CN100560070C/zh not_active Expired - Lifetime
- 2003-12-05 US US10/537,622 patent/US7759496B2/en active Active
- 2003-12-05 DE DE60304741T patent/DE60304741T2/de not_active Expired - Lifetime
- 2003-12-05 PL PL377530A patent/PL216530B1/pl unknown
-
2005
- 2005-05-30 IL IL168882A patent/IL168882A/en not_active IP Right Cessation
- 2005-06-02 ZA ZA200504533A patent/ZA200504533B/en unknown
- 2005-06-23 IS IS7911A patent/IS2282B/is unknown
- 2005-07-04 HR HRP20050617AA patent/HRP20050617B1/hr not_active IP Right Cessation
- 2005-07-05 NO NO20053302A patent/NO330392B1/no not_active IP Right Cessation
-
2006
- 2006-07-03 CY CY20061100913T patent/CY1105699T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7280929B2 (ja) | Ｇｌｐ－１受容体アゴニスト作用を持つピラゾロピリジン誘導体 | |
| US20070027118A1 (en) | Novel compounds of amino sulfonyl derivatives | |
| US9468635B2 (en) | Fused ring compound for use as mineralocorticoid receptor antagonist | |
| AU2011279909A1 (en) | Bifunctional rho kinase inhibitor compounds, composition and use | |
| US20070072914A1 (en) | N-(pyridin-2-yl)-sulfonamide derivatives | |
| US11407729B2 (en) | Quinoline and quinazoline compounds and methods of use thereof | |
| US10717727B2 (en) | Pyridinium compounds | |
| CA3161590A1 (en) | Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use | |
| US6077841A (en) | 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction | |
| NO330392B1 (no) | Imidazolderivater med affinitet for alfa 2-reseptoraktivitet og anvendelser derav, samt farmasoytisk preparat omfattende imidazolderivat | |
| ITMI991452A1 (it) | Antagonisti selettivi per i recettori m2 con struttura 5h-dibenzo b,fazepinica | |
| EP0210025A2 (en) | 5-Substituted-6-aminopyrimidine derivatives, composition and uses | |
| US8580808B2 (en) | Filamin A-binding anti-inflammatory analgesic | |
| ZA200505957B (en) | Triazole compounds useful in therapy | |
| AU2003302622B2 (en) | Imidazol derivatives having affinity for alpha 2 receptors activity | |
| US11884627B2 (en) | Compounds and compositions for treating conditions associated with LPA receptor activity | |
| JP6691127B2 (ja) | ヘテロシクリルアルキン誘導体およびそれらのｍＧｌｕＲ５受容体のモジュレーターとしての使用 | |
| US4507304A (en) | Use of 6-amino-5-pyrimidinecarbonitrile derivatives as cardiotonic agents | |
| NZ751725B2 (en) | Pyrazolopyridine derivative having glp-1 receptor agonist effect | |
| WO2023076237A1 (en) | Compounds as glp-1r agonists | |
| US20230355638A1 (en) | Cyclopentathiophene Carboxamide Derivatives as Platelet Activating Factor Receptor Antagonists | |
| WO2024112895A1 (en) | Compounds and compositions for treating conditions associated with lpa receptor activity | |
| PT1511735E (pt) | Compostos imidazólicos e sua utilização enquanto ligantes receptores alfa-2 adrenérgicos | |
| MXPA00009090A (en) | 1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as nmda receptor antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |