NO328053B1 - Kondenserte pyridazinderivatforbindelser og legemidler inneholdene forbindelsene som den aktive bestanddel - Google Patents
Kondenserte pyridazinderivatforbindelser og legemidler inneholdene forbindelsene som den aktive bestanddel Download PDFInfo
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- NO328053B1 NO328053B1 NO20043429A NO20043429A NO328053B1 NO 328053 B1 NO328053 B1 NO 328053B1 NO 20043429 A NO20043429 A NO 20043429A NO 20043429 A NO20043429 A NO 20043429A NO 328053 B1 NO328053 B1 NO 328053B1
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- methanol
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 490
- -1 pyridazine derivative compounds Chemical class 0.000 title claims description 69
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- 229940079593 drug Drugs 0.000 title claims description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 76
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- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims abstract description 6
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- 125000000217 alkyl group Chemical group 0.000 claims description 61
- 229920006395 saturated elastomer Polymers 0.000 claims description 49
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
- 125000002947 alkylene group Chemical group 0.000 claims description 39
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 24
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 20
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 3
- LKTOXLNLOJCDJD-UHFFFAOYSA-N 4-(2-morpholin-4-ylethyl)-5,6,7,8-tetrahydro-2h-phthalazin-1-one Chemical compound C1=2CCCCC=2C(=O)NN=C1CCN1CCOCC1 LKTOXLNLOJCDJD-UHFFFAOYSA-N 0.000 claims description 3
- SXTXREBNFQTGFW-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)-5,6,7,8-tetrahydro-2h-phthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C1=NNC(=O)C2=C1CCCC2 SXTXREBNFQTGFW-UHFFFAOYSA-N 0.000 claims description 3
- ZBKYQCOYVUNRQU-UHFFFAOYSA-N 4-(3-aminophenyl)-6,7-dihydro-2h-[1,4]thiazino[4,3-d][1,2,4]triazin-1-one Chemical compound NC1=CC=CC(C=2N3CCSC=C3C(=O)NN=2)=C1 ZBKYQCOYVUNRQU-UHFFFAOYSA-N 0.000 claims description 3
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- CUDDJOKEASSPCM-UHFFFAOYSA-N 4-(4-bromophenyl)-5,6,7,8-tetrahydro-2h-phthalazin-1-one Chemical compound C1=CC(Br)=CC=C1C1=NNC(=O)C2=C1CCCC2 CUDDJOKEASSPCM-UHFFFAOYSA-N 0.000 claims description 3
- NAFRJSXRUUAWKI-UHFFFAOYSA-N 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-2h-phthalazin-1-one Chemical compound C1=CC(Cl)=CC=C1C1=NNC(=O)C2=C1CCCC2 NAFRJSXRUUAWKI-UHFFFAOYSA-N 0.000 claims description 3
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- YPVZTHKKFYLGOU-UHFFFAOYSA-N tert-butyl 2-(4-oxo-5,6,7,8-tetrahydro-3h-phthalazin-1-yl)acetate Chemical compound C1CCCC2=C1C(=O)NN=C2CC(=O)OC(C)(C)C YPVZTHKKFYLGOU-UHFFFAOYSA-N 0.000 claims description 3
- 125000004953 trihalomethyl group Chemical group 0.000 claims description 3
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- MYOXVGZOZKHOQV-UHFFFAOYSA-N 4-[2-(4-methyl-1,4-diazepan-1-yl)ethyl]-5,6,7,8-tetrahydro-2h-phthalazin-1-one Chemical compound C1CN(C)CCCN1CCC1=NNC(=O)C2=C1CCCC2 MYOXVGZOZKHOQV-UHFFFAOYSA-N 0.000 claims description 2
- JUBYMZFORNUWCT-UHFFFAOYSA-N 8-(4-aminophenyl)-2,3,4,6-tetrahydro-1h-pyrido[2,3-d]pyridazin-5-one Chemical compound C1=CC(N)=CC=C1C1=NNC(=O)C2=C1NCCC2 JUBYMZFORNUWCT-UHFFFAOYSA-N 0.000 claims description 2
- UKHGAQUAXGCEDY-UHFFFAOYSA-N 8-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-2,3,4,6-tetrahydro-1h-pyrido[2,3-d]pyridazin-5-one Chemical compound C1=2NCCCC=2C(=O)NN=C1CCN(CC1)CCN1C1CCCCC1 UKHGAQUAXGCEDY-UHFFFAOYSA-N 0.000 claims description 2
- LFFRGCOLHZZSFN-UHFFFAOYSA-N 8-[2-(4-cyclopentylpiperazin-1-yl)ethyl]-2,3,4,6-tetrahydro-1h-pyrido[2,3-d]pyridazin-5-one Chemical compound C1=2NCCCC=2C(=O)NN=C1CCN(CC1)CCN1C1CCCC1 LFFRGCOLHZZSFN-UHFFFAOYSA-N 0.000 claims description 2
- RXTZUTJKNUQPNF-UHFFFAOYSA-N 8-[2-(4-ethylpiperazin-1-yl)ethyl]-2,3,4,6-tetrahydro-1h-pyrido[2,3-d]pyridazin-5-one Chemical compound C1CN(CC)CCN1CCC1=NNC(=O)C2=C1NCCC2 RXTZUTJKNUQPNF-UHFFFAOYSA-N 0.000 claims description 2
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- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 2
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- IFSPHGLITYOEDI-UHFFFAOYSA-N 8-[4-(diethylaminomethyl)phenyl]-2,3,4,6-tetrahydro-1h-pyrido[2,3-d]pyridazin-5-one Chemical compound C1=CC(CN(CC)CC)=CC=C1C1=NNC(=O)C2=C1NCCC2 IFSPHGLITYOEDI-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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JP2002042259 | 2002-02-19 | ||
JP2002199673 | 2002-07-09 | ||
PCT/JP2003/001694 WO2003070707A1 (fr) | 2002-02-19 | 2003-02-18 | Composes condenses derives de la pyridazine et medicaments contenant lesdits composes comme ingredients actifs |
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NO328053B1 true NO328053B1 (no) | 2009-11-16 |
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NO20043429A NO328053B1 (no) | 2002-02-19 | 2004-08-17 | Kondenserte pyridazinderivatforbindelser og legemidler inneholdene forbindelsene som den aktive bestanddel |
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JP (2) | JP3843454B2 (es) |
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CN105646497B (zh) * | 2016-02-01 | 2019-06-04 | 南京格亚医药科技有限公司 | 吡咯并三嗪酮衍生物 |
CA3096127A1 (en) | 2017-04-28 | 2018-11-01 | Akribes Biomedical Gmbh | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
GB201913030D0 (en) | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
US20230017948A1 (en) | 2019-11-25 | 2023-01-19 | The Research Foundation For The State University Of New York | Combination therapy using fabp5 inhibitors with taxanes for treatment of cancer |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE555319A (es) | 1956-03-21 | 1900-01-01 | ||
US3095355A (en) | 1961-10-12 | 1963-06-25 | Revlon | Aerosol composition |
DE3302021A1 (de) | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung |
FR2647676A1 (fr) | 1989-06-05 | 1990-12-07 | Union Pharma Scient Appl | Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase |
SK283270B6 (sk) | 1997-01-15 | 2003-04-01 | Altana Pharma Ag | Ftalazinóny, farmaceutické prostriedky s ich obsahom a ich použitie |
AU3076700A (en) * | 1999-01-26 | 2000-08-18 | Ono Pharmaceutical Co. Ltd. | 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient |
AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
-
2003
- 2003-02-18 EP EP03705265A patent/EP1477175B1/en not_active Expired - Lifetime
- 2003-02-18 BR BR0307780-2A patent/BR0307780A/pt not_active IP Right Cessation
- 2003-02-18 DE DE60336890T patent/DE60336890D1/de not_active Expired - Lifetime
- 2003-02-18 AT AT03705265T patent/ATE507207T1/de not_active IP Right Cessation
- 2003-02-18 IL IL16356203A patent/IL163562A0/xx unknown
- 2003-02-18 KR KR1020047012806A patent/KR100663147B1/ko not_active IP Right Cessation
- 2003-02-18 CN CNB038084597A patent/CN100348587C/zh not_active Expired - Fee Related
- 2003-02-18 EP EP10178316A patent/EP2281818A1/en not_active Withdrawn
- 2003-02-18 MX MXPA04008014A patent/MXPA04008014A/es active IP Right Grant
- 2003-02-18 CA CA002476406A patent/CA2476406A1/en not_active Abandoned
- 2003-02-18 JP JP2003569614A patent/JP3843454B2/ja not_active Expired - Fee Related
- 2003-02-18 AU AU2003211381A patent/AU2003211381B9/en not_active Ceased
- 2003-02-18 NZ NZ534712A patent/NZ534712A/en not_active IP Right Cessation
- 2003-02-18 US US10/505,012 patent/US7402580B2/en not_active Expired - Fee Related
- 2003-02-18 WO PCT/JP2003/001694 patent/WO2003070707A1/ja active Application Filing
- 2003-02-18 PL PL03372171A patent/PL372171A1/xx not_active Application Discontinuation
- 2003-02-18 RU RU2004127932/04A patent/RU2292337C2/ru not_active IP Right Cessation
- 2003-02-19 TW TW092103373A patent/TW200306836A/zh unknown
-
2004
- 2004-08-17 NO NO20043429A patent/NO328053B1/no not_active IP Right Cessation
-
2008
- 2008-06-11 US US12/137,267 patent/US20080261947A1/en not_active Abandoned
-
2010
- 2010-05-20 JP JP2010115956A patent/JP2010209106A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2010209106A (ja) | 2010-09-24 |
US20080261947A1 (en) | 2008-10-23 |
KR20040085199A (ko) | 2004-10-07 |
IL163562A0 (en) | 2005-12-18 |
TW200306836A (en) | 2003-12-01 |
AU2003211381B9 (en) | 2009-07-30 |
NZ534712A (en) | 2006-11-30 |
EP1477175A4 (en) | 2006-03-22 |
RU2292337C2 (ru) | 2007-01-27 |
KR100663147B1 (ko) | 2007-02-28 |
BR0307780A (pt) | 2004-12-28 |
DE60336890D1 (de) | 2011-06-09 |
NO20043429L (no) | 2004-11-19 |
CN1646499A (zh) | 2005-07-27 |
CA2476406A1 (en) | 2003-08-28 |
JPWO2003070707A1 (ja) | 2005-06-09 |
RU2004127932A (ru) | 2005-05-27 |
WO2003070707A1 (fr) | 2003-08-28 |
EP2281818A1 (en) | 2011-02-09 |
US7402580B2 (en) | 2008-07-22 |
EP1477175A1 (en) | 2004-11-17 |
AU2003211381A1 (en) | 2003-09-09 |
EP1477175B1 (en) | 2011-04-27 |
ATE507207T1 (de) | 2011-05-15 |
AU2003211381B2 (en) | 2009-03-05 |
MXPA04008014A (es) | 2004-11-26 |
US20050085476A1 (en) | 2005-04-21 |
PL372171A1 (en) | 2005-07-11 |
JP3843454B2 (ja) | 2006-11-08 |
CN100348587C (zh) | 2007-11-14 |
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