NO327047B1 - Fremgangsmate for fremstilling av monoklonalt antistoff, monoklonalt antistoff og farmasoytisk blanding - Google Patents
Fremgangsmate for fremstilling av monoklonalt antistoff, monoklonalt antistoff og farmasoytisk blanding Download PDFInfo
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- NO327047B1 NO327047B1 NO19975714A NO975714A NO327047B1 NO 327047 B1 NO327047 B1 NO 327047B1 NO 19975714 A NO19975714 A NO 19975714A NO 975714 A NO975714 A NO 975714A NO 327047 B1 NO327047 B1 NO 327047B1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- 235000020183 skimmed milk Nutrition 0.000 description 1
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- 235000015921 sodium selenite Nutrition 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96203465 | 1996-12-06 | ||
| EP97201972 | 1997-06-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975714D0 NO975714D0 (no) | 1997-12-05 |
| NO975714L NO975714L (no) | 1998-06-08 |
| NO327047B1 true NO327047B1 (no) | 2009-04-14 |
Family
ID=26143410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975714A NO327047B1 (no) | 1996-12-06 | 1997-12-05 | Fremgangsmate for fremstilling av monoklonalt antistoff, monoklonalt antistoff og farmasoytisk blanding |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6020170A (de) |
| EP (1) | EP0856520B1 (de) |
| JP (1) | JPH10179160A (de) |
| KR (1) | KR100543053B1 (de) |
| AT (1) | ATE322507T1 (de) |
| AU (1) | AU733165B2 (de) |
| BR (1) | BR9706236A (de) |
| CA (1) | CA2221682C (de) |
| DE (1) | DE69735621T2 (de) |
| DK (1) | DK0856520T3 (de) |
| ES (1) | ES2262170T3 (de) |
| HU (1) | HUP9702359A3 (de) |
| IL (1) | IL122233A (de) |
| NO (1) | NO327047B1 (de) |
| NZ (1) | NZ329314A (de) |
| PL (1) | PL193821B1 (de) |
| PT (1) | PT856520E (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1258539C (zh) * | 1998-12-22 | 2006-06-07 | 雷文生物技术公司 | 用于产生特定类型细胞的代表性单克隆抗体的组合物及方法 |
| SE9902817D0 (sv) | 1999-07-30 | 1999-07-30 | A & Science Invest Ab | A method for selective electrofusion of at least two fusion partners having cell-like membranes |
| KR20020047245A (ko) * | 1999-10-18 | 2002-06-21 | 에프.지.엠. 헤르만스 ; 이.에이치. 리링크 | 면역요법에 사용하기 위한 수정 펩티드 및 펩티드모방체 |
| US6541225B1 (en) | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
| JP2004506901A (ja) | 2000-08-14 | 2004-03-04 | アクゾ・ノベル・エヌ・ベー | 特異的なｍｈｃ−ペプチド複合体に対する抗体の使用 |
| IL160000A0 (en) | 2001-07-24 | 2004-06-20 | Univ Yale | Methods, compositions and kits relating to chitinases and chitinase-like molecules and imflammatory disease |
| US7018819B2 (en) * | 2001-11-30 | 2006-03-28 | Cellectricon Ab | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof |
| CN100347296C (zh) * | 2003-03-28 | 2007-11-07 | 财团法人富山县新世纪产业机构 | 使用单个抗原特异性b淋巴细胞制备产生抗原特异性抗体的杂交瘤的方法以及单克隆抗体的制备方法 |
| AU2004286198C1 (en) | 2003-08-18 | 2011-02-24 | Medimmune, Llc | Humanization of antibodies |
| US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| US20050214297A1 (en) * | 2004-02-25 | 2005-09-29 | Medimmune, Inc. | Methods and compositions relating to chitinases and chitinase-like molecules and modulation of osteoclasts |
| EP1844073A1 (de) * | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Verfahren zur erzeugung von sequenzen der variablen domäne von antikörpern mit schweren ketten |
| JP5153613B2 (ja) | 2005-03-18 | 2013-02-27 | メディミューン，エルエルシー | 抗体のフレームワーク・シャッフル |
| AU2006261920A1 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Llc | Antibody formulations having optimized aggregation and fragmentation profiles |
| US20070071746A1 (en) * | 2005-08-31 | 2007-03-29 | Medimmune, Inc. | C/CLP antagonists and methods of use thereof |
| DK2926780T3 (en) * | 2008-01-09 | 2018-12-10 | Alcon Lensx Inc | Tissue Fragmentation Using Laser Photodispersion |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| WO2019105864A1 (en) | 2017-11-30 | 2019-06-06 | F. Hoffmann-La Roche Ag | B-cell cultivation method |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4550086A (en) * | 1983-02-16 | 1985-10-29 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies that recognize human T cells |
| EP0255547A1 (de) * | 1986-07-29 | 1988-02-10 | Kishimoto, Tadamitsu, Prof. | Monoklonale Antikörper spezifisch gegen Oberflächen-IgE-Rezeptor, sowie Hybrid-Zellinien zur Herstellung und Verwendung dieser Antikörper |
| US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| US5766947A (en) * | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
| US5162223A (en) * | 1989-02-17 | 1992-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Resources | Hybridomas and resulting monoclonal antibodies directed against antigens of Bordetella pertussis |
| US5473051A (en) * | 1990-07-19 | 1995-12-05 | The Scripps Research Institute | Inhibition of Mac-1 receptor binding to fibrinogen using D30 homologs |
| ES2103770T3 (es) * | 1990-11-26 | 1997-10-01 | Akzo Nobel Nv | Procedimiento de produccion de anticuerpos monoclonales. |
| CA2250166A1 (en) * | 1996-03-28 | 1997-10-02 | The Johns Hopkins University | Soluble divalent and multivalent heterodimeric analogs of proteins |
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1997
- 1997-11-18 IL IL12223397A patent/IL122233A/en not_active IP Right Cessation
- 1997-11-25 CA CA2221682A patent/CA2221682C/en not_active Expired - Fee Related
- 1997-11-27 JP JP9363807A patent/JPH10179160A/ja active Pending
- 1997-12-02 ES ES97203769T patent/ES2262170T3/es not_active Expired - Lifetime
- 1997-12-02 DE DE69735621T patent/DE69735621T2/de not_active Expired - Lifetime
- 1997-12-02 AT AT97203769T patent/ATE322507T1/de not_active IP Right Cessation
- 1997-12-02 DK DK97203769T patent/DK0856520T3/da active
- 1997-12-02 PT PT97203769T patent/PT856520E/pt unknown
- 1997-12-02 EP EP97203769A patent/EP0856520B1/de not_active Expired - Lifetime
- 1997-12-03 NZ NZ329314A patent/NZ329314A/xx unknown
- 1997-12-04 BR BR9706236A patent/BR9706236A/pt active Search and Examination
- 1997-12-05 AU AU46908/97A patent/AU733165B2/en not_active Ceased
- 1997-12-05 KR KR1019970066848A patent/KR100543053B1/ko not_active IP Right Cessation
- 1997-12-05 HU HU9702359A patent/HUP9702359A3/hu unknown
- 1997-12-05 NO NO19975714A patent/NO327047B1/no not_active IP Right Cessation
- 1997-12-05 PL PL323572A patent/PL193821B1/pl not_active IP Right Cessation
- 1997-12-05 US US08/985,898 patent/US6020170A/en not_active Expired - Lifetime
-
1999
- 1999-09-27 US US09/405,745 patent/US6392020B1/en not_active Expired - Lifetime
-
2001
- 2001-11-01 US US09/985,065 patent/US20020143150A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9702359A3 (en) | 2001-11-28 |
| DE69735621T2 (de) | 2006-08-24 |
| KR19980063909A (ko) | 1998-10-07 |
| MX9709446A (es) | 1998-07-31 |
| ATE322507T1 (de) | 2006-04-15 |
| PL323572A1 (en) | 1998-06-08 |
| US6392020B1 (en) | 2002-05-21 |
| IL122233A0 (en) | 1998-04-05 |
| NO975714L (no) | 1998-06-08 |
| PT856520E (pt) | 2006-08-31 |
| KR100543053B1 (ko) | 2006-06-13 |
| AU733165B2 (en) | 2001-05-10 |
| US20020143150A1 (en) | 2002-10-03 |
| HUP9702359A2 (hu) | 1998-09-28 |
| CA2221682A1 (en) | 1998-06-06 |
| ES2262170T3 (es) | 2006-11-16 |
| CA2221682C (en) | 2011-10-18 |
| NO975714D0 (no) | 1997-12-05 |
| EP0856520B1 (de) | 2006-04-05 |
| US6020170A (en) | 2000-02-01 |
| JPH10179160A (ja) | 1998-07-07 |
| EP0856520A1 (de) | 1998-08-05 |
| HU9702359D0 (en) | 1998-03-02 |
| PL193821B1 (pl) | 2007-03-30 |
| AU4690897A (en) | 1998-06-11 |
| DK0856520T3 (da) | 2006-07-31 |
| BR9706236A (pt) | 1999-05-04 |
| NZ329314A (en) | 1999-02-25 |
| DE69735621D1 (de) | 2006-05-18 |
| IL122233A (en) | 2001-04-30 |
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