NO323155B1 - Makrofagaktiverende faktorer avledet fra klonet vitamin D-bindingsprotein - Google Patents

Makrofagaktiverende faktorer avledet fra klonet vitamin D-bindingsprotein Download PDF

Info

Publication number
NO323155B1
NO323155B1 NO19975771A NO975771A NO323155B1 NO 323155 B1 NO323155 B1 NO 323155B1 NO 19975771 A NO19975771 A NO 19975771A NO 975771 A NO975771 A NO 975771A NO 323155 B1 NO323155 B1 NO 323155B1
Authority
NO
Norway
Prior art keywords
cloned
protein
cancer
cells
macrophage
Prior art date
Application number
NO19975771A
Other languages
English (en)
Norwegian (no)
Other versions
NO975771D0 (no
NO975771L (no
Inventor
Nobuto Yamamoto
Original Assignee
Nobuto Yamamoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/478,121 external-priority patent/US5620846A/en
Application filed by Nobuto Yamamoto filed Critical Nobuto Yamamoto
Publication of NO975771D0 publication Critical patent/NO975771D0/no
Publication of NO975771L publication Critical patent/NO975771L/no
Publication of NO323155B1 publication Critical patent/NO323155B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/57IFN-gamma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049Alpha-N-acetylgalactosaminidase (3.2.1.49)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • G01N33/56988HIV or HTLV
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16HIV-1, HIV-2
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function
    • Y10S436/813Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
NO19975771A 1995-06-07 1997-12-08 Makrofagaktiverende faktorer avledet fra klonet vitamin D-bindingsprotein NO323155B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/478,121 US5620846A (en) 1995-06-07 1995-06-07 Diagnostic and prognostic indices for cancer and aids
US08/618,485 US6410269B1 (en) 1995-06-07 1996-03-19 Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
PCT/US1996/008867 WO1996040903A1 (fr) 1995-06-07 1996-06-05 Facteurs d'activation de macrophages derives de la proteine de liaison de vitamine d clonee

Publications (3)

Publication Number Publication Date
NO975771D0 NO975771D0 (no) 1997-12-08
NO975771L NO975771L (no) 1998-01-30
NO323155B1 true NO323155B1 (no) 2007-01-08

Family

ID=27045792

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19975771A NO323155B1 (no) 1995-06-07 1997-12-08 Makrofagaktiverende faktorer avledet fra klonet vitamin D-bindingsprotein

Country Status (12)

Country Link
US (3) US6410269B1 (fr)
EP (3) EP1443112A3 (fr)
JP (1) JPH11511962A (fr)
CN (2) CN1510147A (fr)
AT (1) ATE307885T1 (fr)
AU (1) AU6253596A (fr)
BR (1) BR9609072A (fr)
CA (1) CA2223940A1 (fr)
DE (2) DE69635346T4 (fr)
ES (1) ES2252756T3 (fr)
NO (1) NO323155B1 (fr)
WO (1) WO1996040903A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985545A (en) * 1996-03-19 1999-11-16 Yamamoto; Nobuto Diagnostic and prognostic ELISA assays of serum α-N-acetylgalactosaminidase for AIDS
AU6137801A (en) * 2000-05-09 2001-11-20 Childrens Medical Center Method and composition for the treatment of angiogenesis
US6846642B2 (en) * 2000-09-07 2005-01-25 The Brigham And Women's Hospital, Inc. Methods of detecting cancer based on prostasin
US20050009120A1 (en) * 2000-09-07 2005-01-13 The Brigham And Women's Hospital, Inc. Methods of detecting ovarian cancer based on osteopontin
AU2002246849A1 (en) * 2000-11-09 2002-08-06 Northeastern Ohio Universities College Of Medicine Agents and methods for promoting bone growth
AU2001297571A1 (en) * 2000-11-30 2002-10-03 Matritech, Inc. Detection and treatment of prostate cancer
US7112408B2 (en) * 2001-06-08 2006-09-26 The Brigham And Women's Hospital, Inc. Detection of ovarian cancer based upon alpha-haptoglobin levels
US6806355B2 (en) 2001-08-14 2004-10-19 Statens Serum Institut Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product
US7288383B2 (en) * 2003-01-15 2007-10-30 The Brigham And Women's Hospital, Inc. Eosinophil-derived neurotoxin as a marker for ovarian cancer
WO2005087793A2 (fr) 2004-02-05 2005-09-22 The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University Compositions immunostimulatrices et leurs utilisations
US20050186577A1 (en) * 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
US8178649B2 (en) 2004-12-07 2012-05-15 Arizona Biomedical Research Commission Immunostimulatory compositions and uses thereof
US7838497B2 (en) 2006-12-13 2010-11-23 Susavion Biosciences, Inc. Pro-angiogenic peptides
US7811995B2 (en) 2006-12-13 2010-10-12 Susavion Biosciences, Inc. Therapeutic and diagnostic peptides
US8460697B2 (en) 2006-12-13 2013-06-11 Susavion Biosciences, Inc. Pro-angiogenic peptides and uses thereof
US8496942B2 (en) 2006-12-13 2013-07-30 Susavion Biosciences, Inc. Therapeutic peptides and uses thereof
USRE46425E1 (en) 2006-12-13 2017-06-06 Susavion Biosciences, Inc. Pro-angiogenic peptides and uses thereof
AU2010289901A1 (en) * 2009-08-22 2012-03-15 Charles Knezevich Tumoricidal, bactericidal, or viricidal macrophage activation
EP2612921B1 (fr) 2010-09-03 2016-11-02 Morita Pharmaceutical Ind., Ltd. Procédé de production d'une nouvelle gc globuline dégalactosylée
CA2832487A1 (fr) * 2011-04-07 2012-10-11 Efranat Ltd. Facteur d'activation des macrophages pour des compositions pharmaceutiques
EP2561879A1 (fr) 2011-08-23 2013-02-27 Protea Biopharma N.V. Facteur d'activation de macrophage à utiliser dans le traitement du syndrome de fatigue chronique (SFC) et maladies et troubles liés au SFC
WO2013130953A2 (fr) * 2012-03-01 2013-09-06 The Trustees Of Columbia University In The City Of New York Biomarqueurs associés à l'autisme et leurs utilisations
EP2687264A1 (fr) 2012-07-17 2014-01-22 Protea Biopharma N.V. Facteur d'activation de macrophages pour le traitement de l'endométriose
WO2014113641A1 (fr) * 2013-01-18 2014-07-24 Kline Ellis Régime de glycosidase sélective pour la programmation immunitaire et le traitement du cancer
CN105530950A (zh) * 2013-06-09 2016-04-27 艾弗兰纳特有限公司 包含Gc-巨噬细胞活化因子的组合物及其用途
AT518622A1 (de) * 2016-04-21 2017-11-15 Hg Pharma Gmbh Dimerer Komplex aus selektiv deglycosyliertem Vitamin D bindenden Protein (GcMAF) und Cholecalciferol (Calciol) und Verfahren zu dessen Herstellung
CN106577294B (zh) * 2016-12-24 2018-08-24 河南中医药大学 一种姬玉露的离体快速繁殖方法
US20210198307A1 (en) * 2017-12-15 2021-07-01 Foundation For Biomedical Research And Innovation At Kobe Method for producing active gcmaf
WO2022124331A1 (fr) 2020-12-08 2022-06-16 再生ファーマ株式会社 Activateur de macrophages

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177001A (en) 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated mammalian vitamin D-binding protein to a potent macrophage activating factor
US5326749A (en) 1989-11-20 1994-07-05 Nobuto Yamamoto Macrophage activating factor from vitamin D binding protein
US5177002A (en) * 1989-11-20 1993-01-05 Nobuto Yamamoto In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor
US5516657A (en) * 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
US5652352A (en) * 1994-03-31 1997-07-29 Amgen Inc. Afamin: a human serum albumin-like gene

Also Published As

Publication number Publication date
EP1340815A3 (fr) 2003-09-17
NO975771D0 (no) 1997-12-08
EP1340815A2 (fr) 2003-09-03
DE69635346T4 (de) 2007-11-08
CN1510147A (zh) 2004-07-07
EP0837932A1 (fr) 1998-04-29
ATE307885T1 (de) 2005-11-15
JPH11511962A (ja) 1999-10-19
ES2252756T3 (es) 2006-05-16
US5712104A (en) 1998-01-27
EP1443112A3 (fr) 2004-11-03
DE69635346D1 (de) 2005-12-01
CN1191567A (zh) 1998-08-26
BR9609072A (pt) 2000-10-24
NO975771L (no) 1998-01-30
EP0837932A4 (fr) 2001-02-28
WO1996040903A1 (fr) 1996-12-19
CA2223940A1 (fr) 1996-12-19
CN1174097C (zh) 2004-11-03
AU6253596A (en) 1996-12-30
US20020055140A1 (en) 2002-05-09
EP0837932B1 (fr) 2005-10-26
US6410269B1 (en) 2002-06-25
EP1443112A2 (fr) 2004-08-04
DE69635346T2 (de) 2006-07-27

Similar Documents

Publication Publication Date Title
NO323155B1 (no) Makrofagaktiverende faktorer avledet fra klonet vitamin D-bindingsprotein
Culp et al. Regulated expression allows high level production and secretion of HIV-1 gp120 envelope glycoprotein in Drosophila Schneider cells
Amagai et al. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus.
RU2179034C2 (ru) ЛЕЧЕНИЕ В СЛУЧАЕ ДЕФИЦИТА α-ГАЛАКТОЗИДАЗЫ А
US7718428B2 (en) Myeloid colony stimulating factor and uses thereof
Kido et al. Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus
Naim et al. The pro region of human intestinal lactase-phlorizin hydrolase.
JP2000508894A (ja) 細胞外/上皮増殖因子hcaba58x
US6165794A (en) Suppression of proteolytic activity by dysfunctional protease formation
WO2002033094A1 (fr) Anticorps inhibant l'activite vplf
AU731911B2 (en) Use of a polypeptide as cellular receptor for adenoviruses
US20060014143A1 (en) Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis
RU2198218C2 (ru) СПОСОБ КЛОНИРОВАНИЯ СВЯЗЫВАЮЩЕГО ВИТАМИН D3 БЕЛКА (БЕЛКА Gc), СПОСОБ ПОЛУЧЕНИЯ КЛОНИРОВАННОГО ФАКТОРА АКТИВАЦИИ МАКРОФАГОВ, ФАКТОР АКТИВАЦИИ МАКРОФАГОВ (ВАРИАНТЫ), АДЪЮВАНТ (ВАРИАНТЫ), КЛОНИРОВАННЫЙ СВЯЗЫВАЮЩИЙ ВИТАМИН D3 БЕЛОК (Gc-БЕЛОК), КЛОНИРОВАННЫЙ ДОМЕН III СВЯЗЫВАЮЩЕГО ВИТАМИН D3 БЕЛКА (ВАРИАНТЫ)
WO1996014863A9 (fr) Suppression de l'activite proteolytique par formation de protease dysfonctionnelle
Fan et al. Purification and characterization of a recombinant human thyroid peroxidase expressed in insect cells
AU784155B2 (en) Myeloid colony stimulating factor and uses thereof
KR19990022316A (ko) 형질전환 성장 인자 알파 hi
CA2336406A1 (fr) Galectine 11
Yang et al. Demonstration of the interaction of transforming growth factor beta 2 and type X collagen using a modified tandem affinity purification tag
AU2012227349B2 (en) Therapy for alpha-galactosidase A deficiency
JP2001017188A (ja) 新規なvegf/pdgf様因子
CN110016482A (zh) Ldlr突变体的外泌体及制备方法与制备高脂血症药物的应用
JPH09124510A (ja) Fasリガンドの遊離抑制剤及び抑制方法
JP2003000247A (ja) トランスフォーミング増殖因子αHII
CA2402839A1 (fr) Galectine 11

Legal Events

Date Code Title Description
CB Opposition filed (par. 26,5 patents act)

Opponent name: NOBUTO YAMAMOTO, 1040 66TH AVENUE, PHILADELPHIA, P

Effective date: 20070913

MM1K Lapsed by not paying the annual fees