NO321966B1 - Anvendelse av et kontrastmiddel for fremstilling av et diagnostisk middel for overvaking av bildekontrast under intervensjonsterapi. - Google Patents

Anvendelse av et kontrastmiddel for fremstilling av et diagnostisk middel for overvaking av bildekontrast under intervensjonsterapi. Download PDF

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Publication number
NO321966B1
NO321966B1 NO20001707A NO20001707A NO321966B1 NO 321966 B1 NO321966 B1 NO 321966B1 NO 20001707 A NO20001707 A NO 20001707A NO 20001707 A NO20001707 A NO 20001707A NO 321966 B1 NO321966 B1 NO 321966B1
Authority
NO
Norway
Prior art keywords
tissue
use according
contrast agent
contrast
state
Prior art date
Application number
NO20001707A
Other languages
English (en)
Norwegian (no)
Other versions
NO20001707L (no
NO20001707D0 (no
Inventor
Stephen O Dunham
Randall B Lauffer
Original Assignee
Epix Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharm Inc filed Critical Epix Pharm Inc
Publication of NO20001707D0 publication Critical patent/NO20001707D0/no
Publication of NO20001707L publication Critical patent/NO20001707L/no
Publication of NO321966B1 publication Critical patent/NO321966B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052Small organic molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
NO20001707A 1997-10-02 2000-04-03 Anvendelse av et kontrastmiddel for fremstilling av et diagnostisk middel for overvaking av bildekontrast under intervensjonsterapi. NO321966B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94298997A 1997-10-02 1997-10-02
PCT/US1998/020182 WO1999017809A2 (en) 1997-10-02 1998-09-24 Contrast-enhanced diagnostic imaging method for monitoring interventional therapies

Publications (3)

Publication Number Publication Date
NO20001707D0 NO20001707D0 (no) 2000-04-03
NO20001707L NO20001707L (no) 2000-05-31
NO321966B1 true NO321966B1 (no) 2006-07-31

Family

ID=25478927

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001707A NO321966B1 (no) 1997-10-02 2000-04-03 Anvendelse av et kontrastmiddel for fremstilling av et diagnostisk middel for overvaking av bildekontrast under intervensjonsterapi.

Country Status (20)

Country Link
US (2) US6861045B1 (de)
EP (1) EP1019094B1 (de)
JP (2) JP2001518523A (de)
KR (1) KR20010030854A (de)
AT (1) ATE254479T1 (de)
AU (1) AU742438C (de)
BR (1) BR9812716A (de)
CA (1) CA2303426C (de)
DE (1) DE69819925T2 (de)
DK (1) DK1019094T3 (de)
ES (1) ES2206996T3 (de)
HK (1) HK1030744A1 (de)
HU (1) HUP0101245A3 (de)
IL (1) IL134985A0 (de)
IS (1) IS2041B (de)
NO (1) NO321966B1 (de)
NZ (1) NZ503402A (de)
PT (1) PT1019094E (de)
SK (1) SK4842000A3 (de)
WO (1) WO1999017809A2 (de)

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US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
ATE254479T1 (de) * 1997-10-02 2003-12-15 Epix Medical Inc Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung
US6167297A (en) * 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
JP2003514601A (ja) 1999-11-22 2003-04-22 エピックス メディカル, インコーポレイテッド 性的反応の画像化
EP1251876A2 (de) * 2000-01-22 2002-10-30 Epix Medical, Inc. Kernspinnresonanzbildgebunng mit kontrastmittelprodrogen die durch enzymatische spaltung activiert werden
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US7186797B2 (en) * 2001-08-10 2007-03-06 Epix Pharmaceuticals, Inc. Polypeptide conjugates with extended circulating half-lives
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP2301587B1 (de) 2002-03-01 2014-06-25 Dyax Corp. KDR- und VEGF/KDR-bindende Peptide sowie ihre Verwendung bei der Diagnose und Therapie
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US20050064045A1 (en) * 2003-09-18 2005-03-24 Sheng-Ping Zhong Injectable therapeutic formulations
US7585492B2 (en) 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
EP1747026A1 (de) * 2004-05-18 2007-01-31 Siemens Aktiengesellschaft Biomolekulare kontrastmittel zur kontrolle der strahlentherapie mit protonen oder ionenstrahlen
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2007063454A1 (en) * 2005-11-29 2007-06-07 Koninklijke Philips Electronics N.V. Distinguishing bound and unbound contrast agents using magnetic resonance
WO2007073792A1 (de) * 2005-12-19 2007-07-05 Bayer Schering Pharma Aktiengesellschaft Verfahren zur herstellung von 4,4-diphenylcyclohexanol
CA2660717A1 (en) * 2006-08-17 2008-02-21 Epix Pharmaceuticals, Inc. Methods for lymph system imaging
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
US20100092389A1 (en) * 2008-10-10 2010-04-15 The General Hospital Corporation Detection of atherosclerosis using indocyanine green
US9423480B2 (en) * 2008-10-27 2016-08-23 The University Of Western Ontario System and method for magnetic resonance imaging
EP2408790A1 (de) 2009-03-19 2012-01-25 Wyeth LLC Verfahren zur herstellung von [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)- en-2-yl)ethyl]phosphonsäure und vorstufen davon
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
WO2011095898A1 (en) 2010-02-02 2011-08-11 Koninklijke Philips Electronics N.V. Functional imaging
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
WO2014165990A1 (en) 2013-04-08 2014-10-16 Sunnybrook Research Institute System and method for imaging biomarkers indicative of cardiac thermal ablation lesions
JP2015087167A (ja) * 2013-10-29 2015-05-07 キヤノン株式会社 画像処理方法、画像処理システム
US10314648B2 (en) 2013-12-13 2019-06-11 The Trustees of the Universoty of Pennsylvania Coaxial ablation probe and method and system for real-time monitoring of ablation therapy
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
WO2016149404A1 (en) 2015-03-16 2016-09-22 California Institute Of Technology Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en) 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
US10383590B2 (en) 2015-09-28 2019-08-20 General Electric Company Methods and systems for adaptive scan control
EP3519425B1 (de) 2016-09-29 2024-02-28 Indi Molecular, Inc. Zusammensetzungen zum nachweis, zur hemmung und zur bildgebung von indolamin 2,3-dioxygenase 1 (ido1) und verfahren zur herstellung und verwendung davon
EP3535278A4 (de) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Verfahren zur jodierung von biomolekülen
EP3638687A1 (de) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US20190370956A1 (en) 2018-05-30 2019-12-05 General Electric Company Contrast imaging system and method
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)

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US5250285A (en) 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5094848A (en) 1989-06-30 1992-03-10 Neorx Corporation Cleavable diphosphate and amidated diphosphate linkers
IT1269839B (it) 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
CA2539215A1 (en) 1995-02-01 1996-08-08 Epix Pharmaceuticals, Inc. Diagnostic imaging contrast agents with extended blood retention
DE19529512C2 (de) 1995-08-10 2000-11-23 Siemens Ag Verfahren zur Phasenkontrast-MR-Angiographie und Anordnung zur Durchführung des Verfahrens
DE19543785A1 (de) 1995-11-24 1997-05-28 Philips Patentverwaltung MR-Verfahren und Anordnung zur Durchführung des Verfahrens
PT907379E (pt) * 1996-04-01 2004-09-30 Epix Medical Inc Agentes de contraste bioactivados para imagiologia de diagnostico
IT1283650B1 (it) 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US5919967A (en) 1997-04-11 1999-07-06 Epix Medical, Inc. Process for synthesizing phosphodiesters
ATE254479T1 (de) * 1997-10-02 2003-12-15 Epix Medical Inc Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung
IT1304501B1 (it) 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Also Published As

Publication number Publication date
AU9668698A (en) 1999-04-27
US20050118103A1 (en) 2005-06-02
NZ503402A (en) 2002-03-01
DE69819925D1 (de) 2003-12-24
PT1019094E (pt) 2004-03-31
IL134985A0 (en) 2001-05-20
WO1999017809A3 (en) 1999-05-20
HUP0101245A3 (en) 2003-10-28
DE69819925T2 (de) 2004-09-02
CA2303426A1 (en) 1999-04-15
US7175829B2 (en) 2007-02-13
ATE254479T1 (de) 2003-12-15
JP2001518523A (ja) 2001-10-16
SK4842000A3 (en) 2000-11-07
JP2006077020A (ja) 2006-03-23
IS5399A (is) 2000-03-10
NO20001707L (no) 2000-05-31
ES2206996T3 (es) 2004-05-16
AU742438C (en) 2003-05-22
HK1030744A1 (en) 2001-05-18
IS2041B (is) 2005-09-15
EP1019094A2 (de) 2000-07-19
BR9812716A (pt) 2000-08-22
HUP0101245A2 (hu) 2001-08-28
WO1999017809A2 (en) 1999-04-15
KR20010030854A (ko) 2001-04-16
US6861045B1 (en) 2005-03-01
CA2303426C (en) 2008-09-23
DK1019094T3 (da) 2004-02-16
NO20001707D0 (no) 2000-04-03
AU742438B2 (en) 2002-01-03
EP1019094B1 (de) 2003-11-19

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