NO321007B1 - Anvendelse av en H+,KC-ATPase-inhibitor og et glukokortikoid ved behandlingen av Widals syndrom og nesepolypper, samt en farmasoytisk formulering som innbefatter en H+,K+-ATPase-inhibitor og et glukokortikoid - Google Patents
Anvendelse av en H+,KC-ATPase-inhibitor og et glukokortikoid ved behandlingen av Widals syndrom og nesepolypper, samt en farmasoytisk formulering som innbefatter en H+,K+-ATPase-inhibitor og et glukokortikoid Download PDFInfo
- Publication number
- NO321007B1 NO321007B1 NO19991619A NO991619A NO321007B1 NO 321007 B1 NO321007 B1 NO 321007B1 NO 19991619 A NO19991619 A NO 19991619A NO 991619 A NO991619 A NO 991619A NO 321007 B1 NO321007 B1 NO 321007B1
- Authority
- NO
- Norway
- Prior art keywords
- glucocorticoid
- atpase inhibitor
- pharmaceutical formulation
- treatment
- alkyl
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims description 22
- 239000003862 glucocorticoid Substances 0.000 title claims description 16
- 208000000592 Nasal Polyps Diseases 0.000 title claims description 15
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 title claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 11
- 229940121819 ATPase inhibitor Drugs 0.000 title claims description 10
- 208000033309 Analgesic asthma syndrome Diseases 0.000 title claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 10
- 159000000011 group IA salts Chemical class 0.000 claims description 9
- 239000003112 inhibitor Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 6
- 229960004436 budesonide Drugs 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 4
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 3
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- 239000000203 mixture Substances 0.000 claims description 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 2
- 125000004414 alkyl thio group Chemical group 0.000 claims description 2
- 125000005466 alkylenyl group Chemical group 0.000 claims description 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 2
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- 125000004438 haloalkoxy group Chemical group 0.000 claims description 2
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- 230000007935 neutral effect Effects 0.000 claims description 2
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
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- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 14
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- 239000002253 acid Substances 0.000 description 4
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- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
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- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9603725A SE9603725D0 (sv) | 1996-10-11 | 1996-10-11 | New teatment |
| PCT/SE1997/001651 WO1998016228A1 (en) | 1996-10-11 | 1997-10-01 | USE OF AN H+, K+-ATPase INHIBITOR IN THE TREATMENT OF NASAL POLYPS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991619L NO991619L (no) | 1999-04-06 |
| NO991619D0 NO991619D0 (no) | 1999-04-06 |
| NO321007B1 true NO321007B1 (no) | 2006-02-27 |
Family
ID=20404214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991619A NO321007B1 (no) | 1996-10-11 | 1999-04-06 | Anvendelse av en H+,KC-ATPase-inhibitor og et glukokortikoid ved behandlingen av Widals syndrom og nesepolypper, samt en farmasoytisk formulering som innbefatter en H+,K+-ATPase-inhibitor og et glukokortikoid |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP0946175B1 (ja) |
| JP (1) | JP4100713B2 (ja) |
| KR (1) | KR100510812B1 (ja) |
| CN (1) | CN1146416C (ja) |
| AR (1) | AR008886A1 (ja) |
| AT (1) | ATE230597T1 (ja) |
| AU (1) | AU738310B2 (ja) |
| BR (1) | BR9711896A (ja) |
| CA (1) | CA2268305C (ja) |
| CZ (1) | CZ298799B6 (ja) |
| DE (1) | DE69718347T2 (ja) |
| DK (1) | DK0946175T3 (ja) |
| EE (1) | EE04043B1 (ja) |
| ES (1) | ES2188995T3 (ja) |
| HK (1) | HK1022848A1 (ja) |
| HU (1) | HUP0000036A3 (ja) |
| ID (1) | ID23692A (ja) |
| IL (1) | IL129324A0 (ja) |
| IS (1) | IS1930B (ja) |
| MY (1) | MY117918A (ja) |
| NO (1) | NO321007B1 (ja) |
| NZ (1) | NZ334786A (ja) |
| PL (1) | PL190902B1 (ja) |
| PT (1) | PT946175E (ja) |
| RS (1) | RS49599B (ja) |
| RU (1) | RU2197966C2 (ja) |
| SA (1) | SA97180641B1 (ja) |
| SE (1) | SE9603725D0 (ja) |
| SK (1) | SK284252B6 (ja) |
| TR (1) | TR199900770T2 (ja) |
| TW (1) | TW568784B (ja) |
| UA (1) | UA59374C2 (ja) |
| WO (1) | WO1998016228A1 (ja) |
| ZA (1) | ZA978842B (ja) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| TR200100560T2 (tr) | 1998-08-18 | 2002-05-21 | The Regents Of The University Of California | EGF-R Antagonistlerinin uygulanmasıyla nefes yolunda mukus üretiminin önlenmesi |
| US6846799B1 (en) * | 1998-08-18 | 2005-01-25 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| US7354894B2 (en) | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| AU2002342917A1 (en) * | 2001-11-19 | 2003-06-10 | Altana Pharma Ag | Reversible proton pump inhibitors for the treatment of airway disorders |
| PL370839A1 (en) * | 2002-03-14 | 2005-05-30 | Altana Pharma Ag | Use of proton pump inhibitors for the treatment of airway disorders |
| CN1652822A (zh) * | 2002-05-07 | 2005-08-10 | 奥坦纳医药公司 | 用于治疗气道病症的可逆质子泵抑制剂和气道治疗剂的新组合 |
| WO2003094968A2 (en) * | 2002-05-07 | 2003-11-20 | Altana Pharma Ag | Combination of a proton pump inhibitor and a respiratory agent for the treatment of respiratory diseases |
| FR2845915B1 (fr) * | 2002-10-21 | 2006-06-23 | Negma Gild | Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien |
| PT1572217E (pt) | 2002-12-12 | 2008-11-28 | Nycomed Gmbh | Medicamento combinado de r,r-formoterol e ciclesonida |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| PL1670482T5 (pl) | 2003-09-16 | 2022-10-03 | Covis Pharma Gmbh | Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CN104408249B (zh) * | 2014-11-24 | 2017-09-26 | 广州供电局有限公司 | 单芯电缆导体热性参数的确定方法及系统 |
| KR101974504B1 (ko) * | 2017-04-10 | 2019-05-03 | 재단법인 아산사회복지재단 | 호산구성 비용종 동물모델 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1429184A (en) * | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| GB1571629A (en) * | 1977-11-30 | 1980-07-16 | Fisons Ltd | Pharmaceutical compositions containing beclomethasone dipropionate |
-
1996
- 1996-10-11 SE SE9603725A patent/SE9603725D0/xx unknown
-
1997
- 1997-01-10 UA UA99042004A patent/UA59374C2/uk unknown
- 1997-10-01 RS YUP-163/99A patent/RS49599B/sr unknown
- 1997-10-01 SK SK384-99A patent/SK284252B6/sk unknown
- 1997-10-01 WO PCT/SE1997/001651 patent/WO1998016228A1/en active IP Right Grant
- 1997-10-01 RU RU99109596/14A patent/RU2197966C2/ru not_active IP Right Cessation
- 1997-10-01 NZ NZ334786A patent/NZ334786A/xx unknown
- 1997-10-01 IL IL12932497A patent/IL129324A0/xx not_active IP Right Cessation
- 1997-10-01 EE EEP199900118A patent/EE04043B1/xx not_active IP Right Cessation
- 1997-10-01 JP JP51824698A patent/JP4100713B2/ja not_active Expired - Fee Related
- 1997-10-01 AT AT97945135T patent/ATE230597T1/de not_active IP Right Cessation
- 1997-10-01 CN CNB971985847A patent/CN1146416C/zh not_active Expired - Fee Related
- 1997-10-01 BR BR9711896A patent/BR9711896A/pt not_active Application Discontinuation
- 1997-10-01 CZ CZ0122999A patent/CZ298799B6/cs not_active IP Right Cessation
- 1997-10-01 DK DK97945135T patent/DK0946175T3/da active
- 1997-10-01 HU HU0000036A patent/HUP0000036A3/hu unknown
- 1997-10-01 PL PL332692A patent/PL190902B1/pl not_active IP Right Cessation
- 1997-10-01 PT PT97945135T patent/PT946175E/pt unknown
- 1997-10-01 TR TR1999/00770T patent/TR199900770T2/xx unknown
- 1997-10-01 EP EP97945135A patent/EP0946175B1/en not_active Expired - Lifetime
- 1997-10-01 AU AU46409/97A patent/AU738310B2/en not_active Ceased
- 1997-10-01 ES ES97945135T patent/ES2188995T3/es not_active Expired - Lifetime
- 1997-10-01 ID IDW990139D patent/ID23692A/id unknown
- 1997-10-01 DE DE69718347T patent/DE69718347T2/de not_active Expired - Fee Related
- 1997-10-01 CA CA002268305A patent/CA2268305C/en not_active Expired - Fee Related
- 1997-10-01 KR KR10-1999-7003115A patent/KR100510812B1/ko not_active IP Right Cessation
- 1997-10-02 ZA ZA9708842A patent/ZA978842B/xx unknown
- 1997-10-07 TW TW086114622A patent/TW568784B/zh not_active IP Right Cessation
- 1997-10-07 MY MYPI97004697A patent/MY117918A/en unknown
- 1997-10-08 AR ARP970104655A patent/AR008886A1/es unknown
- 1997-11-23 SA SA97180641A patent/SA97180641B1/ar unknown
-
1999
- 1999-04-06 NO NO19991619A patent/NO321007B1/no unknown
- 1999-04-08 IS IS5021A patent/IS1930B/is unknown
-
2000
- 2000-04-03 HK HK00102015A patent/HK1022848A1/xx not_active IP Right Cessation
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