NO320641B1 - Utleveringsanordning for legemiddelsuspensjon med regulert frigivelse og fremgangsmate for fremstilling derav - Google Patents

Info

Publication number

NO320641B1

NO320641B1 NO19972880A NO972880A NO320641B1 NO 320641 B1 NO320641 B1 NO 320641B1 NO 19972880 A NO19972880 A NO 19972880A NO 972880 A NO972880 A NO 972880A NO 320641 B1 NO320641 B1 NO 320641B1

Authority

NO

Norway

Prior art keywords

core

polymer

hydration

coating

layer

Prior art date

1994-12-22

Links

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• 239000003814 drug Substances 0.000 title claims description 45
• 229940079593 drug Drugs 0.000 title claims description 42
• 238000000034 method Methods 0.000 title claims description 11
• 238000013270 controlled release Methods 0.000 title claims description 4
• 229920000642 polymer Polymers 0.000 claims abstract description 100
• 230000036571 hydration Effects 0.000 claims abstract description 62
• 238000006703 hydration reaction Methods 0.000 claims abstract description 62
• 238000000576 coating method Methods 0.000 claims abstract description 52
• 239000011248 coating agent Substances 0.000 claims abstract description 51
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• -1 allyl ethers Chemical class 0.000 claims description 14
• 238000004519 manufacturing process Methods 0.000 claims description 14
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• 239000013543 active substance Substances 0.000 claims description 11
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• 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
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• 229960004844 lovastatin Drugs 0.000 claims description 8
• PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 8
• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 8
• 239000000463 material Substances 0.000 claims description 8
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• WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 5
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• DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 5
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• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
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• CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
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• UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
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• 229960002965 pravastatin Drugs 0.000 claims description 2
• 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
• 235000000346 sugar Nutrition 0.000 claims description 2
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• DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
• 239000001856 Ethyl cellulose Substances 0.000 claims 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
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• 235000019325 ethyl cellulose Nutrition 0.000 claims 1
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
• 238000010952 in-situ formation Methods 0.000 claims 1
• TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
• IVQVTRZCAXVNSG-UHFFFAOYSA-M sodium;prop-2-enoate;prop-2-enoic acid Chemical group [Na+].OC(=O)C=C.[O-]C(=O)C=C IVQVTRZCAXVNSG-UHFFFAOYSA-M 0.000 claims 1
• 238000012384 transportation and delivery Methods 0.000 abstract description 12
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