NO319266B1 - Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner. - Google Patents

Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner. Download PDF

Info

Publication number
NO319266B1
NO319266B1 NO19964965A NO964965A NO319266B1 NO 319266 B1 NO319266 B1 NO 319266B1 NO 19964965 A NO19964965 A NO 19964965A NO 964965 A NO964965 A NO 964965A NO 319266 B1 NO319266 B1 NO 319266B1
Authority
NO
Norway
Prior art keywords
protein
pro
factor
stated
protease
Prior art date
Application number
NO19964965A
Other languages
English (en)
Norwegian (no)
Other versions
NO964965D0 (no
NO964965L (no
Inventor
Artur Mitterer
Friedrich Dorner
Johann Eibl
Bernhard Fischer
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of NO964965D0 publication Critical patent/NO964965D0/no
Publication of NO964965L publication Critical patent/NO964965L/no
Publication of NO319266B1 publication Critical patent/NO319266B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6429Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6432Coagulation factor Xa (3.4.21.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21005Thrombin (3.4.21.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21006Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO19964965A 1995-11-24 1996-11-22 Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner. NO319266B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0192795A AT404597B (de) 1995-11-24 1995-11-24 Verfahren zur herstellung von proteinen

Publications (3)

Publication Number Publication Date
NO964965D0 NO964965D0 (no) 1996-11-22
NO964965L NO964965L (no) 1997-05-26
NO319266B1 true NO319266B1 (no) 2005-07-11

Family

ID=3524033

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19964965A NO319266B1 (no) 1995-11-24 1996-11-22 Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner.

Country Status (7)

Country Link
US (1) US6010844A (ja)
EP (1) EP0776969B1 (ja)
JP (1) JP4180671B2 (ja)
AT (2) AT404597B (ja)
CA (1) CA2190802C (ja)
DE (1) DE59611093D1 (ja)
NO (1) NO319266B1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATA159597A (de) * 1997-09-19 2000-09-15 Immuno Ag Präparat zur behandlung von blutgerinnungsstörungen
US7560622B2 (en) * 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
US6830917B2 (en) 2001-12-10 2004-12-14 Baxter Healthcare S.A. Method of isolation and purification of trypsin from pronase protease and use thereof
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CA2558811A1 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
JP2012050386A (ja) * 2010-09-01 2012-03-15 Kaneka Corp 2種類以上の多孔質充填剤を充填するカラム
JP2012050387A (ja) * 2010-09-01 2012-03-15 Kaneka Corp 2種類以上の分子を多孔質担体に固定化する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2000887A1 (en) * 1988-11-01 1990-05-01 Cecilia S.L. Ku Thromboresistant materials and methods for making same
US5053453A (en) * 1988-11-01 1991-10-01 Baxter International Inc. Thromboresistant materials and methods for making same
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
CA2024598A1 (en) * 1989-09-05 1991-03-06 Sau-Chi B. Yan Method for activating protein c
US5296352A (en) * 1990-10-02 1994-03-22 Ciba-Geigy Corporation Monoclonal antibodies directed against complexes formed by thrombin and hirudin
AT398079B (de) 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AT396937B (de) * 1992-04-06 1993-12-27 Immuno Ag Verfahren zur aktivierung von blutgerinnungsfaktoren
AT397390B (de) * 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen

Also Published As

Publication number Publication date
US6010844A (en) 2000-01-04
DE59611093D1 (de) 2004-10-28
NO964965D0 (no) 1996-11-22
JP4180671B2 (ja) 2008-11-12
NO964965L (no) 1997-05-26
CA2190802C (en) 2008-02-12
EP0776969A3 (de) 1999-06-02
EP0776969B1 (de) 2004-09-22
ATA192795A (de) 1998-05-15
JPH09183794A (ja) 1997-07-15
CA2190802A1 (en) 1997-05-25
EP0776969A2 (de) 1997-06-04
AT404597B (de) 1998-12-28
ATE277169T1 (de) 2004-10-15

Similar Documents

Publication Publication Date Title
Radcliffe et al. Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII
Jesty et al. The mechanism of activation of factor X: kinetic control of alternative pathways leading to the formation of activated factor X
Mann [13] Prothrombin
US5304372A (en) Process for preparing a human thrombin concentrate intended for therapeutic use
DK176090B1 (da) Fremgangsmåde til oprensning af proteiner
AU677309B2 (en) Purification of factor VII
Zhang et al. Role of the hexapeptide disulfide loop present in the. gamma.-carboxyglutamic acid domain of human protein C in its activation properties and in the in vitro anticoagulant activity of activated protein C
Bortoleto et al. Purification, characterization and crystallization of Jararacussin-I, a fibrinogen-clotting enzyme isolated from the venom of Bothrops jararacussu
NO319266B1 (no) Fremgangsmate ved fremstilling og utvinning av proteiner fra pro-proteiner i ett fremgangsmatetrinn samt anvendelse av fremgangsmaten til fremstilling av proteiner.
Kawabata et al. A microsomal endopeptidase from liver with substrate specificity for processing proproteins such as the vitamin K-dependent proteins of plasma.
DK147408B (da) Fremgangsmaade til udvinding af thrombinagtige enzymer fra slangegifte eller slangegiftfraktioner
JP2832129B2 (ja) 酵素的分解によるタンパク質の切断方法およびその利用方法
JP2723445B2 (ja) 血液凝固因子を活性化する方法
Leonardi et al. Two coagulation factor X activators from Vipera a. ammodytes venom with potential to treat patients with dysfunctional factors IXa or VIIa
Iwasaki et al. Purification and Characterization of a Coagulant Enzyme, Okinaxobin I, from the Venom of Trimeresums okinavensis (Himehabu Snake) Which Releases Fibrinopeptide B
IE903212A1 (en) Method for activating protein c
Samel et al. Metalloproteinase with factor X activating and fibrinogenolytic activities from Vipera berus berus venom
Rabiet et al. Activation of prothrombin Barcelona evidence for active high molecular weight intermediates
Taby et al. Inhibition of activated protein C by aprotinin and the use of the insolubilized inhibitor for its purification
Kumar et al. Specific molecular interaction sites on factor VII involved in factor X activation
Sakai et al. Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine
Nakagaki et al. Isolation and characterization of a protein C activator from tropical moccasin venom
Dode et al. Characterization of a proteolytically modified form of human prothrombin
AU4311893A (en) Purification of kringle containing proteins, and especially t-pa
Mollerup et al. The use of RP‐HPLC for measuring activation and cleavage of rFVIIA during purification

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAXALTA INCORPORATED, CH

MK1K Patent expired