NO319163B1 - Transdermalt terapeutisk system som forhindrer misbruk - Google Patents
Transdermalt terapeutisk system som forhindrer misbruk Download PDFInfo
- Publication number
- NO319163B1 NO319163B1 NO20001492A NO20001492A NO319163B1 NO 319163 B1 NO319163 B1 NO 319163B1 NO 20001492 A NO20001492 A NO 20001492A NO 20001492 A NO20001492 A NO 20001492A NO 319163 B1 NO319163 B1 NO 319163B1
- Authority
- NO
- Norway
- Prior art keywords
- substance
- layer
- tts according
- active substance
- requirements
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 11
- 239000000126 substance Substances 0.000 claims description 29
- 239000013543 active substance Substances 0.000 claims description 19
- 235000019640 taste Nutrition 0.000 claims description 9
- 210000000214 mouth Anatomy 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000004925 denaturation Methods 0.000 claims description 3
- 230000036425 denaturation Effects 0.000 claims description 3
- 229940100640 transdermal system Drugs 0.000 claims description 3
- MXYUKLILVYORSK-UHFFFAOYSA-N (+/-)-allo-lobeline Natural products C1CCC(CC(=O)C=2C=CC=CC=2)N(C)C1CC(O)C1=CC=CC=C1 MXYUKLILVYORSK-UHFFFAOYSA-N 0.000 claims description 2
- MXYUKLILVYORSK-HBMCJLEFSA-N (-)-lobeline Chemical compound C1([C@@H](O)C[C@H]2N([C@H](CCC2)CC(=O)C=2C=CC=CC=2)C)=CC=CC=C1 MXYUKLILVYORSK-HBMCJLEFSA-N 0.000 claims description 2
- 241000189429 Angostura Species 0.000 claims description 2
- 235000001258 Cinchona calisaya Nutrition 0.000 claims description 2
- 206010013911 Dysgeusia Diseases 0.000 claims description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 2
- 206010028813 Nausea Diseases 0.000 claims description 2
- 241000779819 Syncarpia glomulifera Species 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 239000003613 bile acid Substances 0.000 claims description 2
- 235000019658 bitter taste Nutrition 0.000 claims description 2
- 229960001948 caffeine Drugs 0.000 claims description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims description 2
- 230000007794 irritation Effects 0.000 claims description 2
- 229960002339 lobeline Drugs 0.000 claims description 2
- 229930013610 lobeline Natural products 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000004400 mucous membrane Anatomy 0.000 claims description 2
- 230000008693 nausea Effects 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 239000001739 pinus spp. Substances 0.000 claims description 2
- 229960000948 quinine Drugs 0.000 claims description 2
- 235000018553 tannin Nutrition 0.000 claims description 2
- 229920001864 tannin Polymers 0.000 claims description 2
- 239000001648 tannin Substances 0.000 claims description 2
- 229940111630 tea tree oil Drugs 0.000 claims description 2
- 239000010677 tea tree oil Substances 0.000 claims description 2
- 229940036248 turpentine Drugs 0.000 claims description 2
- 239000010410 layer Substances 0.000 claims 12
- 239000011247 coating layer Substances 0.000 claims 2
- 244000207543 Euphorbia heterophylla Species 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000001055 chewing effect Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940124326 anaesthetic agent Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000011928 denatured alcohol Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19743484A DE19743484C1 (de) | 1997-10-01 | 1997-10-01 | Transdermales therapeutisches System mit Schutz vor oraler Applikation und Verfahren zum Schutz einer Person vor Kontamination infolge unzulässiger oraler Applikation toxischer Inhaltsstoffe eines transdermalen therapeutischen Systems |
| PCT/EP1998/005955 WO1999016428A1 (de) | 1997-10-01 | 1998-09-18 | Verfahren zur vermeidung des missbrauchs eines transdermalen therapeutischen systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20001492D0 NO20001492D0 (no) | 2000-03-22 |
| NO20001492L NO20001492L (no) | 2000-03-22 |
| NO319163B1 true NO319163B1 (no) | 2005-06-27 |
Family
ID=7844345
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001492A NO319163B1 (no) | 1997-10-01 | 2000-03-22 | Transdermalt terapeutisk system som forhindrer misbruk |
| NO20001691A NO20001691D0 (no) | 1997-10-01 | 2000-03-31 | Barnesikker pakning for trykkfølsomme produkter som ogsÕ har relativt stor overflate, slik som transdermale terapeutiske systemer (TTS) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001691A NO20001691D0 (no) | 1997-10-01 | 2000-03-31 | Barnesikker pakning for trykkfølsomme produkter som ogsÕ har relativt stor overflate, slik som transdermale terapeutiske systemer (TTS) |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1019032B1 (da) |
| JP (2) | JP4755338B2 (da) |
| KR (1) | KR100552102B1 (da) |
| AT (1) | ATE228356T1 (da) |
| AU (1) | AU759609B2 (da) |
| CA (1) | CA2305432C (da) |
| DE (2) | DE19743484C1 (da) |
| DK (1) | DK1019032T3 (da) |
| ES (1) | ES2188021T3 (da) |
| HK (1) | HK1029919A1 (da) |
| HU (1) | HU226644B1 (da) |
| ID (1) | ID24333A (da) |
| IL (1) | IL134479A (da) |
| MY (1) | MY116425A (da) |
| NO (2) | NO319163B1 (da) |
| NZ (1) | NZ503643A (da) |
| PL (1) | PL193066B1 (da) |
| PT (1) | PT1019032E (da) |
| SK (1) | SK3332000A3 (da) |
| TR (1) | TR200000461T2 (da) |
| TW (1) | TW431894B (da) |
| WO (1) | WO1999016428A1 (da) |
| ZA (1) | ZA988904B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19743484C1 (de) * | 1997-10-01 | 1999-01-28 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Schutz vor oraler Applikation und Verfahren zum Schutz einer Person vor Kontamination infolge unzulässiger oraler Applikation toxischer Inhaltsstoffe eines transdermalen therapeutischen Systems |
| GB0026137D0 (en) * | 2000-10-25 | 2000-12-13 | Euro Celtique Sa | Transdermal dosage form |
| US7867511B2 (en) * | 2004-01-23 | 2011-01-11 | Travanti Pharma Inc. | Abuse potential reduction in abusable substance dosage form |
| DE102004019916A1 (de) * | 2004-04-21 | 2005-11-17 | Grünenthal GmbH | Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster |
| WO2020079948A1 (ja) * | 2018-10-17 | 2020-04-23 | 日榮新化株式会社 | 粘着シート及びその製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804164D0 (en) * | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
| US5149538A (en) * | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
| DE4342174C1 (de) * | 1993-12-10 | 1995-05-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung |
| DE19743484C1 (de) * | 1997-10-01 | 1999-01-28 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Schutz vor oraler Applikation und Verfahren zum Schutz einer Person vor Kontamination infolge unzulässiger oraler Applikation toxischer Inhaltsstoffe eines transdermalen therapeutischen Systems |
-
1997
- 1997-10-01 DE DE19743484A patent/DE19743484C1/de not_active Expired - Fee Related
-
1998
- 1998-09-18 ES ES98950053T patent/ES2188021T3/es not_active Expired - Lifetime
- 1998-09-18 PL PL339736A patent/PL193066B1/pl not_active IP Right Cessation
- 1998-09-18 DK DK98950053T patent/DK1019032T3/da active
- 1998-09-18 AT AT98950053T patent/ATE228356T1/de active
- 1998-09-18 IL IL13447998A patent/IL134479A/xx not_active IP Right Cessation
- 1998-09-18 JP JP2000513566A patent/JP4755338B2/ja not_active Expired - Lifetime
- 1998-09-18 ID IDW20000399A patent/ID24333A/id unknown
- 1998-09-18 SK SK333-2000A patent/SK3332000A3/sk unknown
- 1998-09-18 DE DE59806468T patent/DE59806468D1/de not_active Expired - Lifetime
- 1998-09-18 TR TR2000/00461T patent/TR200000461T2/xx unknown
- 1998-09-18 WO PCT/EP1998/005955 patent/WO1999016428A1/de active IP Right Grant
- 1998-09-18 PT PT98950053T patent/PT1019032E/pt unknown
- 1998-09-18 HU HU0003476A patent/HU226644B1/hu not_active IP Right Cessation
- 1998-09-18 EP EP98950053A patent/EP1019032B1/de not_active Expired - Lifetime
- 1998-09-18 NZ NZ503643A patent/NZ503643A/en not_active IP Right Cessation
- 1998-09-18 AU AU96265/98A patent/AU759609B2/en not_active Ceased
- 1998-09-18 KR KR1020007003579A patent/KR100552102B1/ko not_active IP Right Cessation
- 1998-09-18 CA CA002305432A patent/CA2305432C/en not_active Expired - Lifetime
- 1998-09-25 TW TW087115939A patent/TW431894B/zh not_active IP Right Cessation
- 1998-09-29 MY MYPI98004449A patent/MY116425A/en unknown
- 1998-09-30 ZA ZA988904A patent/ZA988904B/xx unknown
-
2000
- 2000-03-22 NO NO20001492A patent/NO319163B1/no not_active IP Right Cessation
- 2000-03-31 NO NO20001691A patent/NO20001691D0/no not_active Application Discontinuation
-
2001
- 2001-01-15 HK HK01100389A patent/HK1029919A1/xx not_active IP Right Cessation
-
2008
- 2008-08-20 JP JP2008212077A patent/JP2009035561A/ja active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |