NO317825B1 - Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat - Google Patents
Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat Download PDFInfo
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- NO317825B1 NO317825B1 NO19980518A NO980518A NO317825B1 NO 317825 B1 NO317825 B1 NO 317825B1 NO 19980518 A NO19980518 A NO 19980518A NO 980518 A NO980518 A NO 980518A NO 317825 B1 NO317825 B1 NO 317825B1
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- alkyl
- aryl
- defined above
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- XYKIUTSFQGXHOW-UHFFFAOYSA-N propan-2-one;toluene Chemical compound CC(C)=O.CC1=CC=CC=C1 XYKIUTSFQGXHOW-UHFFFAOYSA-N 0.000 description 1
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- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
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- 125000005033 thiopyranyl group Chemical group 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9516349.9A GB9516349D0 (en) | 1995-08-09 | 1995-08-09 | Aza-anthracyclinone derivatives |
| PCT/EP1996/003237 WO1997006165A1 (fr) | 1995-08-09 | 1996-07-23 | Derives d'aza-anthracyclinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO980518D0 NO980518D0 (no) | 1998-02-06 |
| NO980518L NO980518L (no) | 1998-03-31 |
| NO317825B1 true NO317825B1 (no) | 2004-12-13 |
Family
ID=10779013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19980518A NO317825B1 (no) | 1995-08-09 | 1998-02-06 | Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5985887A (fr) |
| EP (1) | EP0843675B1 (fr) |
| JP (1) | JPH11510500A (fr) |
| KR (1) | KR100449580B1 (fr) |
| CN (1) | CN1063178C (fr) |
| AR (1) | AR010200A1 (fr) |
| AT (1) | ATE225347T1 (fr) |
| CA (1) | CA2227984C (fr) |
| DE (1) | DE69624122T2 (fr) |
| DK (1) | DK0843675T3 (fr) |
| ES (1) | ES2184885T3 (fr) |
| GB (1) | GB9516349D0 (fr) |
| IL (1) | IL123000A (fr) |
| NO (1) | NO317825B1 (fr) |
| NZ (1) | NZ315609A (fr) |
| PL (1) | PL185305B1 (fr) |
| PT (1) | PT843675E (fr) |
| RU (1) | RU2159245C2 (fr) |
| TW (1) | TW327170B (fr) |
| UA (1) | UA48983C2 (fr) |
| WO (1) | WO1997006165A1 (fr) |
| ZA (1) | ZA966665B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9701628D0 (en) * | 1997-01-27 | 1997-03-19 | Pharmacia & Upjohn Spa | Imino-aza-anthracyclinone derivatives |
| GB9805080D0 (en) | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Amino anthracyclinone derivatives |
| GB9805082D0 (en) * | 1998-03-10 | 1998-05-06 | Pharmacia & Upjohn Spa | Heterocyclyl anthracyclinone derivatives |
| US7053191B2 (en) * | 2003-05-21 | 2006-05-30 | Solux Corporation | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
| US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US8846882B2 (en) | 2011-04-29 | 2014-09-30 | Synbias Pharma Ag | Method of producing 4-demethoxydaunorubicin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110289A (en) * | 1993-08-06 | 1998-01-04 | Policlinico San Matteo Istitut | Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
-
1995
- 1995-08-09 GB GBGB9516349.9A patent/GB9516349D0/en active Pending
-
1996
- 1996-07-23 PT PT96927580T patent/PT843675E/pt unknown
- 1996-07-23 KR KR10-1998-0700943A patent/KR100449580B1/ko not_active IP Right Cessation
- 1996-07-23 DE DE69624122T patent/DE69624122T2/de not_active Expired - Fee Related
- 1996-07-23 US US09/000,496 patent/US5985887A/en not_active Expired - Fee Related
- 1996-07-23 CA CA002227984A patent/CA2227984C/fr not_active Expired - Fee Related
- 1996-07-23 WO PCT/EP1996/003237 patent/WO1997006165A1/fr active IP Right Grant
- 1996-07-23 RU RU98103795/04A patent/RU2159245C2/ru not_active IP Right Cessation
- 1996-07-23 UA UA98031098A patent/UA48983C2/uk unknown
- 1996-07-23 NZ NZ315609A patent/NZ315609A/xx unknown
- 1996-07-23 DK DK96927580T patent/DK0843675T3/da active
- 1996-07-23 ES ES96927580T patent/ES2184885T3/es not_active Expired - Lifetime
- 1996-07-23 IL IL12300096A patent/IL123000A/xx not_active IP Right Cessation
- 1996-07-23 AT AT96927580T patent/ATE225347T1/de not_active IP Right Cessation
- 1996-07-23 EP EP96927580A patent/EP0843675B1/fr not_active Expired - Lifetime
- 1996-07-23 PL PL96324892A patent/PL185305B1/pl not_active IP Right Cessation
- 1996-07-23 JP JP9508066A patent/JPH11510500A/ja not_active Withdrawn
- 1996-07-23 CN CN96196586A patent/CN1063178C/zh not_active Expired - Fee Related
- 1996-07-27 TW TW085109190A patent/TW327170B/zh active
- 1996-08-06 ZA ZA966665A patent/ZA966665B/xx unknown
- 1996-08-07 AR ARP960103903A patent/AR010200A1/es active IP Right Grant
-
1998
- 1998-02-06 NO NO19980518A patent/NO317825B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL123000A0 (en) | 1998-08-16 |
| CA2227984C (fr) | 2006-07-11 |
| AU712411B2 (en) | 1999-11-04 |
| RU2159245C2 (ru) | 2000-11-20 |
| DK0843675T3 (da) | 2003-02-10 |
| NZ315609A (en) | 1999-11-29 |
| PL324892A1 (en) | 1998-06-22 |
| EP0843675B1 (fr) | 2002-10-02 |
| AR010200A1 (es) | 2000-06-07 |
| MX9801045A (es) | 1998-10-31 |
| KR100449580B1 (ko) | 2004-12-03 |
| WO1997006165A1 (fr) | 1997-02-20 |
| ATE225347T1 (de) | 2002-10-15 |
| PL185305B1 (pl) | 2003-04-30 |
| IL123000A (en) | 2000-10-31 |
| TW327170B (en) | 1998-02-21 |
| CN1194646A (zh) | 1998-09-30 |
| US5985887A (en) | 1999-11-16 |
| PT843675E (pt) | 2002-12-31 |
| AU6735996A (en) | 1997-03-05 |
| KR19990036275A (ko) | 1999-05-25 |
| ZA966665B (en) | 1997-05-12 |
| NO980518L (no) | 1998-03-31 |
| JPH11510500A (ja) | 1999-09-14 |
| NO980518D0 (no) | 1998-02-06 |
| CA2227984A1 (fr) | 1997-02-20 |
| EP0843675A1 (fr) | 1998-05-27 |
| ES2184885T3 (es) | 2003-04-16 |
| GB9516349D0 (en) | 1995-10-11 |
| DE69624122D1 (de) | 2002-11-07 |
| CN1063178C (zh) | 2001-03-14 |
| UA48983C2 (uk) | 2002-09-16 |
| DE69624122T2 (de) | 2003-03-20 |
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