NO317825B1 - Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat - Google Patents

Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat Download PDF

Info

Publication number
NO317825B1
NO317825B1 NO19980518A NO980518A NO317825B1 NO 317825 B1 NO317825 B1 NO 317825B1 NO 19980518 A NO19980518 A NO 19980518A NO 980518 A NO980518 A NO 980518A NO 317825 B1 NO317825 B1 NO 317825B1
Authority
NO
Norway
Prior art keywords
group
formula
alkyl
aryl
defined above
Prior art date
Application number
NO19980518A
Other languages
English (en)
Norwegian (no)
Other versions
NO980518L (no
NO980518D0 (no
Inventor
Antonino Suarato
Michele Caruso
Tiziano Bandiera
Jacqueline Lansen
Daniela Fiardi
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO980518D0 publication Critical patent/NO980518D0/no
Publication of NO980518L publication Critical patent/NO980518L/no
Publication of NO317825B1 publication Critical patent/NO317825B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO19980518A 1995-08-09 1998-02-06 Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat NO317825B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9516349.9A GB9516349D0 (en) 1995-08-09 1995-08-09 Aza-anthracyclinone derivatives
PCT/EP1996/003237 WO1997006165A1 (fr) 1995-08-09 1996-07-23 Derives d'aza-anthracyclinone

Publications (3)

Publication Number Publication Date
NO980518D0 NO980518D0 (no) 1998-02-06
NO980518L NO980518L (no) 1998-03-31
NO317825B1 true NO317825B1 (no) 2004-12-13

Family

ID=10779013

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980518A NO317825B1 (no) 1995-08-09 1998-02-06 Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat

Country Status (22)

Country Link
US (1) US5985887A (fr)
EP (1) EP0843675B1 (fr)
JP (1) JPH11510500A (fr)
KR (1) KR100449580B1 (fr)
CN (1) CN1063178C (fr)
AR (1) AR010200A1 (fr)
AT (1) ATE225347T1 (fr)
CA (1) CA2227984C (fr)
DE (1) DE69624122T2 (fr)
DK (1) DK0843675T3 (fr)
ES (1) ES2184885T3 (fr)
GB (1) GB9516349D0 (fr)
IL (1) IL123000A (fr)
NO (1) NO317825B1 (fr)
NZ (1) NZ315609A (fr)
PL (1) PL185305B1 (fr)
PT (1) PT843675E (fr)
RU (1) RU2159245C2 (fr)
TW (1) TW327170B (fr)
UA (1) UA48983C2 (fr)
WO (1) WO1997006165A1 (fr)
ZA (1) ZA966665B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701628D0 (en) * 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives
GB9805080D0 (en) 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Amino anthracyclinone derivatives
GB9805082D0 (en) * 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Heterocyclyl anthracyclinone derivatives
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110289A (en) * 1993-08-06 1998-01-04 Policlinico San Matteo Istitut Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives

Also Published As

Publication number Publication date
CA2227984C (fr) 2006-07-11
EP0843675B1 (fr) 2002-10-02
ATE225347T1 (de) 2002-10-15
IL123000A (en) 2000-10-31
ES2184885T3 (es) 2003-04-16
ZA966665B (en) 1997-05-12
CN1194646A (zh) 1998-09-30
AR010200A1 (es) 2000-06-07
EP0843675A1 (fr) 1998-05-27
IL123000A0 (en) 1998-08-16
CN1063178C (zh) 2001-03-14
KR19990036275A (ko) 1999-05-25
UA48983C2 (uk) 2002-09-16
AU712411B2 (en) 1999-11-04
JPH11510500A (ja) 1999-09-14
GB9516349D0 (en) 1995-10-11
DE69624122T2 (de) 2003-03-20
NO980518L (no) 1998-03-31
DK0843675T3 (da) 2003-02-10
US5985887A (en) 1999-11-16
DE69624122D1 (de) 2002-11-07
PL324892A1 (en) 1998-06-22
WO1997006165A1 (fr) 1997-02-20
CA2227984A1 (fr) 1997-02-20
KR100449580B1 (ko) 2004-12-03
TW327170B (en) 1998-02-21
PT843675E (pt) 2002-12-31
NZ315609A (en) 1999-11-29
MX9801045A (es) 1998-10-31
PL185305B1 (pl) 2003-04-30
RU2159245C2 (ru) 2000-11-20
NO980518D0 (no) 1998-02-06
AU6735996A (en) 1997-03-05

Similar Documents

Publication Publication Date Title
US5731313A (en) Use of anthracyclinone derivatives in amyloidosis
WO1996004895A9 (fr) Derives d&#39;anthracyclinone et leur utilisation dans le traitement de l&#39;amylose
US5744454A (en) Anthracycline derivatives
NO317825B1 (no) Aza-antracyklinonderivater, fremgangsmate for fremstilling derav, anvendelse av forbindelsene samt farmasoytisk preparat
US6194422B1 (en) Anthracycline derivatives
EP0910415B1 (fr) Derives d&#39;anthracycline et d&#39;anthracyclinone marques par du fluor
MXPA98001045A (es) Derivados de aza-antraciclinona
AU712411C (en) Aza-anthracyclinone derivatives
AU755754B2 (en) Amino anthracyclinone derivatives and their use in the treatment of amyloidosis
MXPA99006881A (en) Imino-aza-anthracyclinone derivatives for the treatment of amyloidosis