NO314664B1 - Polyamid-oligonukleotid derivater, fremgangsmåte for fremstilling av polyamid-oligonukleotid derivater, farmasöytisk middel oggenprobeanalyse - Google Patents
Polyamid-oligonukleotid derivater, fremgangsmåte for fremstilling av polyamid-oligonukleotid derivater, farmasöytisk middel oggenprobeanalyse Download PDFInfo
- Publication number
- NO314664B1 NO314664B1 NO19950955A NO950955A NO314664B1 NO 314664 B1 NO314664 B1 NO 314664B1 NO 19950955 A NO19950955 A NO 19950955A NO 950955 A NO950955 A NO 950955A NO 314664 B1 NO314664 B1 NO 314664B1
- Authority
- NO
- Norway
- Prior art keywords
- dna
- formula
- pna
- polyamide
- alkyl
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- 108091034117 Oligonucleotide Proteins 0.000 title claims abstract description 79
- 239000004952 Polyamide Substances 0.000 title claims abstract description 42
- 229920002647 polyamide Polymers 0.000 title claims abstract description 42
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4408528A DE4408528A1 (de) | 1994-03-14 | 1994-03-14 | Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung |
Publications (3)
Publication Number | Publication Date |
---|---|
NO950955D0 NO950955D0 (no) | 1995-03-13 |
NO950955L NO950955L (no) | 1995-09-15 |
NO314664B1 true NO314664B1 (no) | 2003-04-28 |
Family
ID=6512694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19950955A NO314664B1 (no) | 1994-03-14 | 1995-03-13 | Polyamid-oligonukleotid derivater, fremgangsmåte for fremstilling av polyamid-oligonukleotid derivater, farmasöytisk middel oggenprobeanalyse |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP1113021B1 (da) |
JP (1) | JP4620810B2 (da) |
KR (1) | KR100416864B1 (da) |
CN (1) | CN100379756C (da) |
AT (2) | ATE335760T1 (da) |
AU (1) | AU698210B2 (da) |
CA (1) | CA2144475C (da) |
DE (3) | DE4408528A1 (da) |
DK (2) | DK0672677T3 (da) |
ES (2) | ES2269239T3 (da) |
FI (2) | FI117135B (da) |
HK (2) | HK1038568A1 (da) |
NO (1) | NO314664B1 (da) |
PT (2) | PT672677E (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6710164B1 (en) | 1993-11-22 | 2004-03-23 | Peter E. Nielsen | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
DE4438918A1 (de) * | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
DE19502912A1 (de) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilisierte Oligonucleotide |
DE59607750D1 (de) * | 1995-03-13 | 2001-10-31 | Aventis Pharma Gmbh | Phosphonomonoesternnukleinsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE19532553A1 (de) * | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
GB2324534B (en) * | 1996-01-06 | 2000-05-10 | Danbiosyst Uk | Composition for delivery of nucleic acid to a cell |
ES2221942T3 (es) * | 1996-05-24 | 2005-01-16 | Aventis Pharma Deutschland Gmbh | Reactivo y metodo para inhibir la expresion de n-ras. |
WO1997045115A1 (en) * | 1996-05-31 | 1997-12-04 | Trophix Pharmaceuticals, Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
US6191165B1 (en) | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
DE69734783T2 (de) * | 1996-07-24 | 2006-08-17 | Buchardt, Dorte | Peptidnukleinsäuren mit erhöhter bindungsaffinität, sequenzspezifität und löslichkeit |
DE19637339A1 (de) * | 1996-09-13 | 1998-03-19 | Hoechst Ag | Verfahren zur Amplifikation von Nukleinsäuren |
EP2341058A3 (en) | 1997-09-12 | 2011-11-23 | Exiqon A/S | Oligonucleotide Analogues |
WO1999034014A2 (en) * | 1997-12-23 | 1999-07-08 | Roche Diagnostics Gmbh | A method for the determination of a nucleic acid |
US5952202A (en) * | 1998-03-26 | 1999-09-14 | The Perkin Elmer Corporation | Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification |
DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
US6316230B1 (en) | 1999-08-13 | 2001-11-13 | Applera Corporation | Polymerase extension at 3′ terminus of PNA-DNA chimera |
US7205105B2 (en) | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
DE10019135A1 (de) | 2000-04-18 | 2001-10-31 | Aventis Pharma Gmbh | Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung |
US7348146B2 (en) | 2003-10-02 | 2008-03-25 | Epoch Biosciences, Inc. | Single nucleotide polymorphism analysis of highly polymorphic target sequences |
CA2542768A1 (en) | 2003-10-28 | 2005-05-12 | Epoch Biosciences, Inc. | Fluorescent probes for dna detection by hybridization with improved sensitivity and low background |
DE102006034319A1 (de) * | 2006-07-21 | 2008-01-31 | Ugichem Gmbh | Chirale mit Phosponsäurester- oder Phosphonsäure- substituierte Verbindungen |
EP2781523A1 (en) | 2013-03-18 | 2014-09-24 | Miltenyi Biotec GmbH | Lipophilic oligonucleotide analogs |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3856406T2 (de) * | 1987-10-28 | 2000-10-19 | Florey Howard Inst | Oligonucleotid-polyamid konjugate |
WO1993024511A1 (en) * | 1992-05-29 | 1993-12-09 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
US5138045A (en) * | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
IL104461A (en) * | 1992-01-22 | 2001-05-20 | Hoechst Ag | Analogs of oligonucleotide, their preparation and pharmaceutical preparations containing them |
US5646261A (en) * | 1992-01-22 | 1997-07-08 | Hoechst Aktiengesellschaft | 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use |
-
1994
- 1994-03-14 DE DE4408528A patent/DE4408528A1/de not_active Withdrawn
-
1995
- 1995-03-08 EP EP01104012A patent/EP1113021B1/de not_active Expired - Lifetime
- 1995-03-08 DK DK95103332T patent/DK0672677T3/da active
- 1995-03-08 PT PT95103332T patent/PT672677E/pt unknown
- 1995-03-08 DK DK01104012T patent/DK1113021T3/da active
- 1995-03-08 EP EP95103332A patent/EP0672677B1/de not_active Expired - Lifetime
- 1995-03-08 AT AT01104012T patent/ATE335760T1/de active
- 1995-03-08 DE DE59511061T patent/DE59511061D1/de not_active Expired - Lifetime
- 1995-03-08 PT PT01104012T patent/PT1113021E/pt unknown
- 1995-03-08 AT AT95103332T patent/ATE220070T1/de active
- 1995-03-08 DE DE59510252T patent/DE59510252D1/de not_active Expired - Lifetime
- 1995-03-08 ES ES01104012T patent/ES2269239T3/es not_active Expired - Lifetime
- 1995-03-08 ES ES95103332T patent/ES2179080T3/es not_active Expired - Lifetime
- 1995-03-10 FI FI951132A patent/FI117135B/fi not_active IP Right Cessation
- 1995-03-10 AU AU14798/95A patent/AU698210B2/en not_active Ceased
- 1995-03-13 CN CNB951029460A patent/CN100379756C/zh not_active Expired - Lifetime
- 1995-03-13 NO NO19950955A patent/NO314664B1/no not_active IP Right Cessation
- 1995-03-13 CA CA2144475A patent/CA2144475C/en not_active Expired - Fee Related
- 1995-03-14 JP JP05464495A patent/JP4620810B2/ja not_active Expired - Fee Related
- 1995-03-14 KR KR1019950005676A patent/KR100416864B1/ko not_active IP Right Cessation
-
1998
- 1998-12-11 HK HK01109203A patent/HK1038568A1/xx not_active IP Right Cessation
- 1998-12-11 HK HK98113225A patent/HK1012003A1/xx not_active IP Right Cessation
-
2005
- 2005-10-24 FI FI20051072A patent/FI117939B/fi not_active IP Right Cessation
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