NO314144B1 - Arylsubstituerte piperaziner anvendelige ved behandling av benign prostatisk hyperplasi samt farmasöytisk preparat og mellomprodukter - Google Patents
Arylsubstituerte piperaziner anvendelige ved behandling av benign prostatisk hyperplasi samt farmasöytisk preparat og mellomprodukter Download PDFInfo
- Publication number
- NO314144B1 NO314144B1 NO19995518A NO995518A NO314144B1 NO 314144 B1 NO314144 B1 NO 314144B1 NO 19995518 A NO19995518 A NO 19995518A NO 995518 A NO995518 A NO 995518A NO 314144 B1 NO314144 B1 NO 314144B1
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- Norway
- Prior art keywords
- compound
- alkyl
- compounds
- propyloxyphenyl
- iso
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4623697P | 1997-05-12 | 1997-05-12 | |
| PCT/US1998/009023 WO1998051298A1 (fr) | 1997-05-12 | 1998-05-08 | Piperazines a substitution aryle utiles dans le traitement de l'adenome prostatique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995518D0 NO995518D0 (no) | 1999-11-11 |
| NO995518L NO995518L (no) | 2000-01-11 |
| NO314144B1 true NO314144B1 (no) | 2003-02-03 |
Family
ID=21942353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995518A NO314144B1 (no) | 1997-05-12 | 1999-11-11 | Arylsubstituerte piperaziner anvendelige ved behandling av benign prostatisk hyperplasi samt farmasöytisk preparat og mellomprodukter |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US6071915A (fr) |
| EP (1) | EP0984777B1 (fr) |
| JP (1) | JP4189867B2 (fr) |
| KR (1) | KR100440755B1 (fr) |
| CN (3) | CN1149081C (fr) |
| AP (1) | AP1349A (fr) |
| AR (1) | AR012686A1 (fr) |
| AT (1) | ATE250033T1 (fr) |
| AU (1) | AU7366998A (fr) |
| BR (1) | BR9809804A (fr) |
| CA (1) | CA2289987C (fr) |
| CZ (1) | CZ298217B6 (fr) |
| DE (1) | DE69818255T2 (fr) |
| DK (1) | DK0984777T3 (fr) |
| EA (1) | EA001904B1 (fr) |
| ES (1) | ES2206928T3 (fr) |
| HK (1) | HK1024630A1 (fr) |
| HU (1) | HUP0100048A3 (fr) |
| IL (1) | IL132836A0 (fr) |
| MY (2) | MY127385A (fr) |
| NO (1) | NO314144B1 (fr) |
| NZ (1) | NZ500992A (fr) |
| PL (1) | PL192596B1 (fr) |
| PT (1) | PT984777E (fr) |
| TR (1) | TR199902971T2 (fr) |
| TW (1) | TW512146B (fr) |
| WO (1) | WO1998051298A1 (fr) |
| ZA (1) | ZA983968B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2768055A1 (fr) * | 1997-09-11 | 1999-03-12 | Synthelabo | Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie |
| ZA991319B (en) | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
| EP1346983A3 (fr) * | 1998-02-20 | 2003-12-03 | Ortho-Mcneil Pharmaceutical, Inc. | Phthalimido-arylpiperazines utiles dans le traitement de l'hyperplasie prostatique bénigne en tant qu'antagonistes du récepteur alpha 1A |
| TW536538B (en) | 1998-02-20 | 2003-06-11 | Ortho Mcneil Pharm Inc | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
| AU2001290743A1 (en) * | 2000-09-14 | 2002-03-26 | Ortho-Mcneil Pharmaceutical, Inc. | Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide |
| PL362210A1 (en) | 2000-11-30 | 2004-10-18 | Ranbaxy Laboratories Limited | 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a);1-adrenoceptor blockers |
| US20090312344A1 (en) * | 2004-05-31 | 2009-12-17 | Mohammad Salman | Arylpiperazine derivatives as adrenergic receptor antagonists |
| WO2006092710A1 (fr) * | 2005-03-02 | 2006-09-08 | Ranbaxy Laboratories Limited | Metabolites de la 2-{3-[4-(2-isopropoxyphenyl)piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione |
| WO2007029156A2 (fr) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Derives d'isoindoledione comme antagonistes de recepteurs adrenergiques |
| CN102391169B (zh) * | 2011-10-17 | 2015-10-28 | 上海化学试剂研究所 | N-(5-甲氧基-3-吲哚乙基)-4-取代苯基哌嗪-1-乙酰胺的制备方法 |
| CN103387531A (zh) * | 2012-05-10 | 2013-11-13 | 广州医学院 | 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用 |
| CN103980195A (zh) * | 2014-04-28 | 2014-08-13 | 广州医科大学 | 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069336A (en) * | 1976-02-25 | 1978-01-17 | Chemisches Laboratorium Fritz-Walter Lange Gmbh & Co Kg | (2-oxo-pyrrolidines)-acetic hydrazides |
| JPS5955878A (ja) | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| AU1475583A (en) * | 1983-04-27 | 1984-11-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted picolinic acids, processes for their preparation,their use and medicaments containing them |
| JPS62135464A (ja) * | 1985-12-10 | 1987-06-18 | Nippon Kayaku Co Ltd | フエニルピペラジン誘導体 |
| GB8703749D0 (en) | 1987-02-18 | 1987-03-25 | Sandoz Ltd | Piperazinecarboxylic acid |
| US5254552A (en) * | 1988-05-24 | 1993-10-19 | American Home Products Corporation | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
| HRP930210A2 (en) * | 1992-02-25 | 1995-06-30 | Recordati Chem Pharm | Heterobicyclic compounds and pharmaceutical preparations containing them |
| FR2692894B1 (fr) * | 1992-06-24 | 1994-10-14 | Irceba | Aryl-1-(o-alcoxy-phényl-4-pipérazinyl-1)-2, 3- ou 4-alcanols, leur procédé de préparation et leur utilisation pour la préparation de médicaments. |
| US5403847A (en) * | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| US5807856A (en) * | 1995-11-15 | 1998-09-15 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonist |
| EP0881235A1 (fr) * | 1997-05-26 | 1998-12-02 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles |
| US6063785A (en) * | 1999-02-17 | 2000-05-16 | Ortho-Mcneil Pharmaceutical Inc. | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
| TW536538B (en) * | 1998-02-20 | 2003-06-11 | Ortho Mcneil Pharm Inc | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia |
| ZA991315B (en) * | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
-
1998
- 1998-05-08 NZ NZ500992A patent/NZ500992A/xx unknown
- 1998-05-08 PT PT98920950T patent/PT984777E/pt unknown
- 1998-05-08 CN CNB988049112A patent/CN1149081C/zh not_active Expired - Fee Related
- 1998-05-08 DE DE69818255T patent/DE69818255T2/de not_active Expired - Fee Related
- 1998-05-08 DK DK98920950T patent/DK0984777T3/da active
- 1998-05-08 EP EP98920950A patent/EP0984777B1/fr not_active Expired - Lifetime
- 1998-05-08 CN CNB2003101029013A patent/CN1269807C/zh not_active Expired - Fee Related
- 1998-05-08 BR BR9809804-7A patent/BR9809804A/pt active Search and Examination
- 1998-05-08 KR KR10-1999-7010460A patent/KR100440755B1/ko not_active IP Right Cessation
- 1998-05-08 CA CA002289987A patent/CA2289987C/fr not_active Expired - Fee Related
- 1998-05-08 HU HU0100048A patent/HUP0100048A3/hu unknown
- 1998-05-08 EA EA199900928A patent/EA001904B1/ru not_active IP Right Cessation
- 1998-05-08 ES ES98920950T patent/ES2206928T3/es not_active Expired - Lifetime
- 1998-05-08 WO PCT/US1998/009023 patent/WO1998051298A1/fr active IP Right Grant
- 1998-05-08 JP JP54927698A patent/JP4189867B2/ja not_active Expired - Fee Related
- 1998-05-08 CN CNA031070485A patent/CN1515556A/zh active Pending
- 1998-05-08 AU AU73669/98A patent/AU7366998A/en not_active Abandoned
- 1998-05-08 US US09/074,789 patent/US6071915A/en not_active Expired - Lifetime
- 1998-05-08 PL PL342518A patent/PL192596B1/pl not_active IP Right Cessation
- 1998-05-08 TR TR1999/02971T patent/TR199902971T2/xx unknown
- 1998-05-08 AP APAP/P/1999/001684A patent/AP1349A/en active
- 1998-05-08 IL IL13283698A patent/IL132836A0/xx not_active IP Right Cessation
- 1998-05-08 AT AT98920950T patent/ATE250033T1/de not_active IP Right Cessation
- 1998-05-08 CZ CZ0399799A patent/CZ298217B6/cs not_active IP Right Cessation
- 1998-05-09 MY MYPI20041438A patent/MY127385A/en unknown
- 1998-05-09 MY MYPI98002108A patent/MY122095A/en unknown
- 1998-05-11 ZA ZA9803968A patent/ZA983968B/xx unknown
- 1998-05-11 AR ARP980102181A patent/AR012686A1/es active IP Right Grant
- 1998-08-12 TW TW087107253A patent/TW512146B/zh not_active IP Right Cessation
-
1999
- 1999-11-11 NO NO19995518A patent/NO314144B1/no not_active IP Right Cessation
-
2000
- 2000-03-15 US US09/526,224 patent/US6890921B1/en not_active Expired - Lifetime
- 2000-06-12 US US09/591,814 patent/US6593474B1/en not_active Expired - Lifetime
- 2000-06-29 HK HK00103972A patent/HK1024630A1/xx not_active IP Right Cessation
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2003
- 2003-06-02 US US10/452,255 patent/US20030220493A1/en not_active Abandoned
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