NO313865B1 - Mikrovesikler, vandig dispersjon inneholdende disse, fremgangsmÕte for fremstilling av et kontrastmiddel,kontrastmidler samt et sett av reagenser - Google Patents
Mikrovesikler, vandig dispersjon inneholdende disse, fremgangsmÕte for fremstilling av et kontrastmiddel,kontrastmidler samt et sett av reagenser Download PDFInfo
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- NO313865B1 NO313865B1 NO19991688A NO991688A NO313865B1 NO 313865 B1 NO313865 B1 NO 313865B1 NO 19991688 A NO19991688 A NO 19991688A NO 991688 A NO991688 A NO 991688A NO 313865 B1 NO313865 B1 NO 313865B1
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- Prior art keywords
- gas
- microvesicles
- hyperpolarized
- gases
- mri
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicinal Preparation (AREA)
- Soft Magnetic Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97810563 | 1997-08-12 | ||
| PCT/IB1998/001227 WO1999007415A1 (en) | 1997-08-12 | 1998-08-11 | Administrable compositions and methods for magnetic resonance imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991688D0 NO991688D0 (no) | 1999-04-09 |
| NO991688L NO991688L (no) | 1999-06-09 |
| NO313865B1 true NO313865B1 (no) | 2002-12-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991688A NO313865B1 (no) | 1997-08-12 | 1999-04-09 | Mikrovesikler, vandig dispersjon inneholdende disse, fremgangsmÕte for fremstilling av et kontrastmiddel,kontrastmidler samt et sett av reagenser |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6042809A (de) |
| EP (1) | EP0968000B1 (de) |
| JP (1) | JP4317270B2 (de) |
| CN (1) | CN1103605C (de) |
| AT (1) | ATE252916T1 (de) |
| AU (1) | AU726115C (de) |
| CA (1) | CA2268324C (de) |
| DE (1) | DE69819309T2 (de) |
| ES (1) | ES2209167T3 (de) |
| IL (1) | IL129173A (de) |
| NO (1) | NO313865B1 (de) |
| WO (1) | WO1999007415A1 (de) |
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| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| CA2250401A1 (en) * | 1996-03-29 | 1997-10-09 | Thomas Budinger | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| EP1066537A1 (de) | 1998-03-18 | 2001-01-10 | Magnetic Imaging Technologies Inc. | Magnetresonanzverfahren zur abbildung von lungen- und herzgefässen und zur beurteilung des blutflusses unter verwendung von gelöstem 129xe |
| US6128918A (en) * | 1998-07-30 | 2000-10-10 | Medi-Physics, Inc. | Containers for hyperpolarized gases and associated methods |
| EP1090250A1 (de) | 1998-06-17 | 2001-04-11 | Medi-Physics, Inc. | Transportvorrichtung für hyperpolarisiertes gas und deren transportverfahren |
| US6423387B1 (en) | 1998-06-17 | 2002-07-23 | Medi-Physics, Inc. | Resilient containers for hyperpolarized gases and associated methods |
| US6159444A (en) * | 1998-09-11 | 2000-12-12 | The Regents Of The University Of California | NMR/MRI with hyperpolarized gas and high Tc SQUID |
| EP1118009A1 (de) * | 1998-09-28 | 2001-07-25 | Nycomed Imaging As | Verfahren der magnetresonanzbildgebung |
| US6237363B1 (en) | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6286319B1 (en) | 1998-09-30 | 2001-09-11 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6284222B1 (en) * | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| AU4686899A (en) | 1999-02-23 | 2000-09-14 | Medi-Physics, Inc. | Portable system for monitoring the polarization level of a hyperpolarized gas during transport |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| US6308705B1 (en) * | 1999-12-21 | 2001-10-30 | Siemens Aktiengesellschaft | Integrated lung therapy method |
| JP2003526437A (ja) * | 2000-03-13 | 2003-09-09 | メディ−フィジックス・インコーポレイテッド | ガス状過分極１２９Ｘｅの直接注射を使用する診断処置並びに関連するシステムおよび生成物 |
| JP2004515263A (ja) | 2000-07-13 | 2004-05-27 | メディ−フィジックス・インコーポレイテッド | １２９Ｘｅスペクトル法特有の化学シフトを用いて、病変をインビボで検出する診断法 |
| US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
| US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
| US6652833B2 (en) * | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
| US7179450B2 (en) | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| CA2418229A1 (en) * | 2002-05-16 | 2003-11-16 | Rohan Dharmakumar | Microbubble construct for sensitivity enhanced mr manometry |
| NO20022960D0 (no) | 2002-06-19 | 2002-06-19 | Medinnova Sf | Apparat og metode for intubasjonsovervåkning |
| GB0218868D0 (en) | 2002-08-14 | 2002-09-25 | Nasir Muhammed A | Improved airway management device |
| US20040167400A1 (en) * | 2002-11-27 | 2004-08-26 | Accuimage Diagnostics Corp. | Method and apparatus for improving a virtual colonoscopy and A CT angiography |
| US20050025710A1 (en) * | 2003-07-29 | 2005-02-03 | Michel Schneider | Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging |
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| EP1940475A4 (de) * | 2005-09-28 | 2010-05-26 | Harvard College | Hyperpolarisierte feste materialien mit langen spin-erholungszeiten zur verwendung als bildgebende mittel in der magnetresonanztomographie |
| WO2007070466A2 (en) * | 2005-12-10 | 2007-06-21 | The President And Fellows Of Harvard College | In situ hyperpolarization of imaging agents |
| EP1984757A4 (de) * | 2006-01-11 | 2009-11-04 | Harvard College | Ex-vivo-hyperpolarisation von abbildungsmitteln |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| CA2643306C (en) | 2006-02-21 | 2016-05-03 | Millikelvin Technologies Llc | Hyperpolarization methods, systems and compositions |
| GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| US20100092390A1 (en) * | 2008-10-09 | 2010-04-15 | President And Fellows Of Harvard College | Methods for Making Particles Having Long Spin-Lattice Relaxation Times |
| JP2013180956A (ja) * | 2012-02-29 | 2013-09-12 | Sunstar Engineering Inc | 殺菌剤組成物 |
| US20140288411A1 (en) * | 2013-03-12 | 2014-09-25 | The Regents Of The University Of California | Gas vesicle magnetic resonance imaging contrast agents and methods of using the same |
| CN103807598B (zh) * | 2014-03-04 | 2016-06-01 | 合肥工业大学 | 一种储存成像气体的储气装置 |
| CN103815907B (zh) * | 2014-03-04 | 2016-04-06 | 合肥工业大学 | 用于人体呼吸系统检测成像的成像气体及其储气装置 |
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| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
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| CA2250401A1 (en) * | 1996-03-29 | 1997-10-09 | Thomas Budinger | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| US5694934A (en) * | 1996-04-17 | 1997-12-09 | Beth Israel Hospital | MR studies in which a paramagnetic gas is administered to a living patient |
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1998
- 1998-08-11 DE DE69819309T patent/DE69819309T2/de not_active Expired - Lifetime
- 1998-08-11 CA CA002268324A patent/CA2268324C/en not_active Expired - Fee Related
- 1998-08-11 ES ES98935248T patent/ES2209167T3/es not_active Expired - Lifetime
- 1998-08-11 CN CN98801143A patent/CN1103605C/zh not_active Expired - Fee Related
- 1998-08-11 EP EP98935248A patent/EP0968000B1/de not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2001501977A (ja) | 2001-02-13 |
| DE69819309T2 (de) | 2004-07-15 |
| WO1999007415A1 (en) | 1999-02-18 |
| EP0968000B1 (de) | 2003-10-29 |
| AU726115B2 (en) | 2000-11-02 |
| CA2268324A1 (en) | 1999-02-18 |
| CN1236323A (zh) | 1999-11-24 |
| IL129173A0 (en) | 2000-02-17 |
| NO991688L (no) | 1999-06-09 |
| US6042809A (en) | 2000-03-28 |
| DE69819309D1 (de) | 2003-12-04 |
| IL129173A (en) | 2002-03-10 |
| ATE252916T1 (de) | 2003-11-15 |
| CA2268324C (en) | 2007-06-12 |
| ES2209167T3 (es) | 2004-06-16 |
| JP4317270B2 (ja) | 2009-08-19 |
| NO991688D0 (no) | 1999-04-09 |
| AU8458798A (en) | 1999-03-01 |
| AU726115C (en) | 2001-12-20 |
| EP0968000A1 (de) | 2000-01-05 |
| CN1103605C (zh) | 2003-03-26 |
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