NO312416B1 - Sulfonsyre- eller sulfonylamino-N-(heteroaralkyl)- azaheterocyklylamidforbindelser - Google Patents

Info

Publication number

NO312416B1

NO312416B1 NO19992853A NO992853A NO312416B1 NO 312416 B1 NO312416 B1 NO 312416B1 NO 19992853 A NO19992853 A NO 19992853A NO 992853 A NO992853 A NO 992853A NO 312416 B1 NO312416 B1 NO 312416B1

Authority

NO

Norway

Prior art keywords

sulfonic acid

oxopyrrolidin

ylmethyl

methoxynaphthalene

chloro

Prior art date

1996-12-13

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• 150000001875 compounds Chemical class 0.000 title claims description 369
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 title description 2
• 125000004475 heteroaralkyl group Chemical group 0.000 title 1
• 150000003839 salts Chemical class 0.000 claims description 48
• 229910052739 hydrogen Inorganic materials 0.000 claims description 47
• 229910052757 nitrogen Inorganic materials 0.000 claims description 47
• 108010074860 Factor Xa Proteins 0.000 claims description 33
• 230000000694 effects Effects 0.000 claims description 27
• -1 dihydroquinolyl Chemical group 0.000 claims description 26
• 239000003146 anticoagulant agent Substances 0.000 claims description 23
• 208000007536 Thrombosis Diseases 0.000 claims description 19
• 230000015572 biosynthetic process Effects 0.000 claims description 17
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
• 238000002560 therapeutic procedure Methods 0.000 claims description 14
• 230000002792 vascular Effects 0.000 claims description 12
• 238000011282 treatment Methods 0.000 claims description 11
• 210000001367 artery Anatomy 0.000 claims description 10
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
• 239000001257 hydrogen Substances 0.000 claims description 9
• 210000003462 vein Anatomy 0.000 claims description 9
• 230000001154 acute effect Effects 0.000 claims description 8
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
• 208000035475 disorder Diseases 0.000 claims description 7
• 206010000891 acute myocardial infarction Diseases 0.000 claims description 6
• 238000007887 coronary angioplasty Methods 0.000 claims description 6
• 229910052736 halogen Inorganic materials 0.000 claims description 6
• VFHQLCGAUYJSRP-FERBBOLQSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC3=CC=C4C=CN=C(C4=C3)N)=CC2=C1 VFHQLCGAUYJSRP-FERBBOLQSA-N 0.000 claims description 6
• WNQJRFJOLDUOFH-FERBBOLQSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-6-chloro-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C(Cl)C=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC3=CC=C4C=CN=C(C4=C3)N)=CC2=C1 WNQJRFJOLDUOFH-FERBBOLQSA-N 0.000 claims description 6
• MMPKCFIXJKMLPC-FTBISJDPSA-N n-[(3s)-1-[(2-aminoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC(N)=NC2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 MMPKCFIXJKMLPC-FTBISJDPSA-N 0.000 claims description 6
• 230000001575 pathological effect Effects 0.000 claims description 6
• 230000002093 peripheral effect Effects 0.000 claims description 6
• 125000005493 quinolyl group Chemical group 0.000 claims description 6
• ZGIAFQOCODFJFG-FERBBOLQSA-N 6-chloro-n-[(3s)-1-[(1,6-diaminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C(Cl)C=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC3=CC4=C(N)N=CC=C4C=C3N)=CC2=C1 ZGIAFQOCODFJFG-FERBBOLQSA-N 0.000 claims description 5
• GNSUPVVLHBGDAU-QHCPKHFHSA-N 7-methoxy-n-[(3s)-2-oxo-1-[(2-oxo-1h-quinolin-6-yl)methyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide Chemical compound N1=C(O)C=CC2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 GNSUPVVLHBGDAU-QHCPKHFHSA-N 0.000 claims description 5
• WJDBPMVSXWUXAW-DEOSSOPVSA-N 7-methoxy-n-methyl-n-[(3s)-2-oxo-1-[(2-oxo-1h-quinolin-5-yl)methyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide Chemical compound N1C(=O)C=CC2=C1C=CC=C2CN(C1=O)CC[C@@H]1N(C)S(=O)(=O)C1=CC2=CC(OC)=CC=C2C=C1 WJDBPMVSXWUXAW-DEOSSOPVSA-N 0.000 claims description 5
• 206010053567 Coagulopathies Diseases 0.000 claims description 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
• 206010028980 Neoplasm Diseases 0.000 claims description 5
• 201000011510 cancer Diseases 0.000 claims description 5
• 125000005945 imidazopyridyl group Chemical group 0.000 claims description 5
• 230000002401 inhibitory effect Effects 0.000 claims description 5
• 125000005956 isoquinolyl group Chemical group 0.000 claims description 5
• CVQMJHHVBFGTFG-BQAIUKQQSA-N n-[(3s)-1-[(1,6-diaminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical group OC(=O)C(F)(F)F.N1=CC=C2C=C(N)C(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC2=C1N CVQMJHHVBFGTFG-BQAIUKQQSA-N 0.000 claims description 5
• VCVKZPRYRNNAHF-FYZYNONXSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-5-pyridin-3-ylthiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N([C@H]1CCN(C1=O)CC1=CC=C2C=CN=C(C2=C1)N)S(=O)(=O)C(S1)=CC=C1C1=CC=CN=C1 VCVKZPRYRNNAHF-FYZYNONXSA-N 0.000 claims description 5
• CDIMXWPYBBXLPZ-FYZYNONXSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-5-pyridin-4-ylthiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N([C@H]1CCN(C1=O)CC1=CC=C2C=CN=C(C2=C1)N)S(=O)(=O)C(S1)=CC=C1C1=CC=NC=C1 CDIMXWPYBBXLPZ-FYZYNONXSA-N 0.000 claims description 5
• XQYHQVFBDDWDCG-BQAIUKQQSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CN=C(N)C2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 XQYHQVFBDDWDCG-BQAIUKQQSA-N 0.000 claims description 5
• SEYWMQRAUGNBSI-LMOVPXPDSA-N n-[(3s)-1-[(2-aminoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-6-chloro-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C(Cl)C=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC=3C=CC4=CC=C(N=C4C=3)N)=CC2=C1 SEYWMQRAUGNBSI-LMOVPXPDSA-N 0.000 claims description 5
• KHZHBQZHEIZBHY-FYZYNONXSA-N n-[(3s)-1-[(4-aminoquinolin-6-yl)methyl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC3=CC=C4N=CC=C(C4=C3)N)=CC2=C1 KHZHBQZHEIZBHY-FYZYNONXSA-N 0.000 claims description 5
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 125000006085 pyrrolopyridyl group Chemical group 0.000 claims description 5
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 5
• 208000037803 restenosis Diseases 0.000 claims description 5
• 230000002537 thrombolytic effect Effects 0.000 claims description 5
• 210000005166 vasculature Anatomy 0.000 claims description 5
• DCVXLCIPWIKDJU-BOXHHOBZSA-N 7-methoxy-n-[(3s)-2-oxo-1-(1h-pyrrolo[3,2-b]pyridin-2-ylmethyl)pyrrolidin-3-yl]naphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC=C2NC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC2=N1 DCVXLCIPWIKDJU-BOXHHOBZSA-N 0.000 claims description 4
• JAEKEOJFYOBMBH-DEOSSOPVSA-N 7-methoxy-n-methyl-n-[(3s)-2-oxo-1-[(2-oxo-1h-quinolin-7-yl)methyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide Chemical compound C1=CC(=O)NC2=CC(CN3CC[C@@H](C3=O)N(C)S(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 JAEKEOJFYOBMBH-DEOSSOPVSA-N 0.000 claims description 4
• 206010002388 Angina unstable Diseases 0.000 claims description 4
• 208000005189 Embolism Diseases 0.000 claims description 4
• 206010022562 Intermittent claudication Diseases 0.000 claims description 4
• 208000010378 Pulmonary Embolism Diseases 0.000 claims description 4
• 206010040070 Septic Shock Diseases 0.000 claims description 4
• 208000006011 Stroke Diseases 0.000 claims description 4
• 208000001435 Thromboembolism Diseases 0.000 claims description 4
• 208000032109 Transient ischaemic attack Diseases 0.000 claims description 4
• 208000007814 Unstable Angina Diseases 0.000 claims description 4
• 208000036142 Viral infection Diseases 0.000 claims description 4
• 230000003187 abdominal effect Effects 0.000 claims description 4
• 230000002159 abnormal effect Effects 0.000 claims description 4
• 208000015294 blood coagulation disease Diseases 0.000 claims description 4
• 229910052799 carbon Inorganic materials 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 238000001631 haemodialysis Methods 0.000 claims description 4
• 230000000322 hemodialysis Effects 0.000 claims description 4
• 238000002513 implantation Methods 0.000 claims description 4
• 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 4
• 208000021156 intermittent vascular claudication Diseases 0.000 claims description 4
• 210000003127 knee Anatomy 0.000 claims description 4
• 230000007774 longterm Effects 0.000 claims description 4
• 210000003141 lower extremity Anatomy 0.000 claims description 4
• XQYHQVFBDDWDCG-GNAFDRTKSA-N n-[(3r)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CN=C(N)C2=CC(CN3CC[C@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 XQYHQVFBDDWDCG-GNAFDRTKSA-N 0.000 claims description 4
• MGBXCZRURZLLGG-BOXHHOBZSA-N n-[(3s)-1-(3h-benzimidazol-5-ylmethyl)-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=C2NC=NC2=CC(CN2CC[C@@H](C2=O)NS(=O)(=O)C=2C=CC3=CC=C(C=C3C=2)OC)=C1 MGBXCZRURZLLGG-BOXHHOBZSA-N 0.000 claims description 4
• HZBSKFFTPFUHBU-BQAIUKQQSA-N n-[(3s)-1-[(1-amino-6-methoxyisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;hydrochloride Chemical compound Cl.N1=CC=C2C=C(OC)C(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC2=C1N HZBSKFFTPFUHBU-BQAIUKQQSA-N 0.000 claims description 4
• QTMHKYIZBVUMKD-QHCPKHFHSA-N n-[(3s)-1-[(2-aminoquinolin-6-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide Chemical compound N1=C(N)C=CC2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 QTMHKYIZBVUMKD-QHCPKHFHSA-N 0.000 claims description 4
• QFZAMTBGXXFFQX-LMOVPXPDSA-N n-[(3s)-1-[(2-aminoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC=C2SC(S(=O)(=O)N[C@H]3CCN(C3=O)CC=3C=CC4=CC=C(N=C4C=3)N)=CC2=C1 QFZAMTBGXXFFQX-LMOVPXPDSA-N 0.000 claims description 4
• PXHFGDWQPIVXFA-BQAIUKQQSA-N n-[(3s)-1-[(4-aminoquinazolin-6-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxy-n-methylnaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N1=CN=C(N)C2=CC(CN3CC[C@@H](C3=O)N(C)S(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 PXHFGDWQPIVXFA-BQAIUKQQSA-N 0.000 claims description 4
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 4
• 230000036303 septic shock Effects 0.000 claims description 4
• 238000001356 surgical procedure Methods 0.000 claims description 4
• 230000009885 systemic effect Effects 0.000 claims description 4
• 201000010875 transient cerebral ischemia Diseases 0.000 claims description 4
• 230000009385 viral infection Effects 0.000 claims description 4
• RROZPQBCANKSJH-GXKRWWSZSA-N (3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-3-(methylamino)pyrrolidin-2-one 7-methoxynaphthalene-2-sulfonic acid 2,2,2-trifluoroacetic acid Chemical compound CN[C@@H](CCN1CC2=CC=C(C=CN=C3N)C3=C2)C1=O.COC1=CC=C(C=CC(S(O)(=O)=O)=C2)C2=C1.OC(C(F)(F)F)=O RROZPQBCANKSJH-GXKRWWSZSA-N 0.000 claims description 3
• IJZYUSAXPDDIKX-HNNXBMFYSA-N 6-chloro-n-[(3s)-1-(furo[3,2-b]pyridin-2-ylmethyl)-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide Chemical compound C1=CC=C2OC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC2=N1 IJZYUSAXPDDIKX-HNNXBMFYSA-N 0.000 claims description 3
• ROMBXSYEYVFYBT-INIZCTEOSA-N 6-chloro-n-[(3s)-1-[(4-chloro-1h-pyrrolo[3,2-c]pyridin-2-yl)methyl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide Chemical compound N1=CC=C2NC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC2=C1Cl ROMBXSYEYVFYBT-INIZCTEOSA-N 0.000 claims description 3
• FCKLLRUYGATBJZ-NTISSMGPSA-N 6-chloro-n-[(3s)-2-oxo-1-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=NC=C2NC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC2=C1 FCKLLRUYGATBJZ-NTISSMGPSA-N 0.000 claims description 3
• MOPNSDIFLDWQAX-NTISSMGPSA-N 6-chloro-n-[(3s)-2-oxo-1-(1h-pyrrolo[3,2-b]pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CC=C2NC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC2=N1 MOPNSDIFLDWQAX-NTISSMGPSA-N 0.000 claims description 3
• CKARHIGQRRNVFD-UHFFFAOYSA-N 7-methoxynaphthalene-2-sulfonic acid Chemical compound C1=CC(S(O)(=O)=O)=CC2=CC(OC)=CC=C21 CKARHIGQRRNVFD-UHFFFAOYSA-N 0.000 claims description 3
• 210000005249 arterial vasculature Anatomy 0.000 claims description 3
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• CHHOGAXEDDUADQ-BQAIUKQQSA-N n-[(3s)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;hydrochloride Chemical compound Cl.C1=CN=C(N)C2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=C21 CHHOGAXEDDUADQ-BQAIUKQQSA-N 0.000 claims description 3
• DTFIQFNBTJDSPN-BQAIUKQQSA-N n-[(3s)-1-[(2-aminoquinolin-5-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.NC1=CC=C2C(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC=CC2=N1 DTFIQFNBTJDSPN-BQAIUKQQSA-N 0.000 claims description 3
• CEPIVQSUYSIUSV-FYZYNONXSA-N n-[(3s)-1-[(4-aminothieno[2,3-d]pyrimidin-6-yl)methyl]-2-oxopyrrolidin-3-yl]-7-methoxynaphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N1=CN=C2SC(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC2=C1N CEPIVQSUYSIUSV-FYZYNONXSA-N 0.000 claims description 3
• KJCAMNRIQLAECW-UTLKBRERSA-N n-[(3s)-2-oxo-1-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.C1=CC=C2SC(S(=O)(=O)N[C@@H]3C(N(CC3)CC=3NC4=CN=CC=C4C=3)=O)=CC2=N1 KJCAMNRIQLAECW-UTLKBRERSA-N 0.000 claims description 3
• NILRJQHBKCPZCU-FYZYNONXSA-N 6-chloro-n-[(3s)-2-oxo-1-(1,2,3,4-tetrahydroisoquinolin-7-ylmethyl)pyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1CNCC2=CC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC=C21 NILRJQHBKCPZCU-FYZYNONXSA-N 0.000 claims description 2
• GHJCYBFDKTZELP-KRWDZBQOSA-N 6-chloro-n-[(3s)-2-oxo-1-(1h-pyrrolo[3,2-c]pyridin-2-ylmethyl)pyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide Chemical compound N1=CC=C2NC(CN3CC[C@@H](C3=O)NS(=O)(=O)C3=CC4=CC=C(C=C4S3)Cl)=CC2=C1 GHJCYBFDKTZELP-KRWDZBQOSA-N 0.000 claims description 2
• WFPXVTGXHWCEQC-JIDHJSLPSA-N 7-methoxy-n-[(3s)-1-[(6-methoxyisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.N1=CC=C2C=C(OC)C(CN3CC[C@@H](C3=O)NS(=O)(=O)C=3C=CC4=CC=C(C=C4C=3)OC)=CC2=C1 WFPXVTGXHWCEQC-JIDHJSLPSA-N 0.000 claims description 2
• VARXSWARIPTRNM-BDQAORGHSA-N 7-methoxy-n-[(3s)-2-oxo-1-[(7-oxo-6h-thieno[2,3-c]pyridin-3-yl)methyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1=CNC(=O)C2=C1C(CN1CC[C@@H](C1=O)NS(=O)(=O)C=1C=CC3=CC=C(C=C3C=1)OC)=CS2 VARXSWARIPTRNM-BDQAORGHSA-N 0.000 claims description 2
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