NO311762B1 - Tetracykliske forbindelser som dopaminagonister - Google Patents
Tetracykliske forbindelser som dopaminagonister Download PDFInfo
- Publication number
- NO311762B1 NO311762B1 NO19953957A NO953957A NO311762B1 NO 311762 B1 NO311762 B1 NO 311762B1 NO 19953957 A NO19953957 A NO 19953957A NO 953957 A NO953957 A NO 953957A NO 311762 B1 NO311762 B1 NO 311762B1
- Authority
- NO
- Norway
- Prior art keywords
- trans
- phenanthrene
- hexahydro
- cyclopenta
- aza
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 189
- 239000003136 dopamine receptor stimulating agent Substances 0.000 title description 18
- 229940052760 dopamine agonists Drugs 0.000 title description 10
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 101
- 229960003638 dopamine Drugs 0.000 claims abstract description 50
- 238000011282 treatment Methods 0.000 claims abstract description 24
- 230000000926 neurological effect Effects 0.000 claims abstract description 7
- 208000011117 substance-related disease Diseases 0.000 claims abstract description 7
- 201000009032 substance abuse Diseases 0.000 claims abstract description 6
- 231100000736 substance abuse Toxicity 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 32
- 229940079593 drug Drugs 0.000 claims description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 208000035475 disorder Diseases 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- REHAKLRYABHSQJ-KBXCAEBGSA-N chembl39230 Chemical compound OC1=C(O)C=C2[C@@H]3C(C=C(S4)CCC)=C4CN[C@H]3CCC2=C1 REHAKLRYABHSQJ-KBXCAEBGSA-N 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- JRQAGZUTSLOUSW-SCLBCKFNSA-N chembl290438 Chemical compound OC1=C(O)C=C2[C@@H]3C(C=C(S4)C(C)(C)C)=C4CN[C@H]3CCC2=C1 JRQAGZUTSLOUSW-SCLBCKFNSA-N 0.000 claims description 12
- OHQFGIVFMUFZJP-BLLLJJGKSA-N chembl289283 Chemical compound OC1=C(O)C=C2[C@@H]3C(C=C(S4)C)=C4CN[C@H]3CCC2=C1 OHQFGIVFMUFZJP-BLLLJJGKSA-N 0.000 claims description 11
- 230000003291 dopaminomimetic effect Effects 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- OXIMNPYYZPJDBV-SUMWQHHRSA-N chembl296993 Chemical compound OC1=C(O)C=C2[C@@H]3C(C=C(S4)CC)=C4CN[C@H]3CCC2=C1 OXIMNPYYZPJDBV-SUMWQHHRSA-N 0.000 claims description 8
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 7
- KTEBZVJGMARTOQ-PGRDOPGGSA-N [(1R,10S)-4-acetyloxy-15-propyl-14-thia-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-2,4,6,13(17),15-pentaen-5-yl] acetate Chemical compound CC(=O)OC1=C(OC(C)=O)C=C2[C@@H]3C(C=C(S4)CCC)=C4CN[C@H]3CCC2=C1 KTEBZVJGMARTOQ-PGRDOPGGSA-N 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 7
- 125000004122 cyclic group Chemical group 0.000 claims description 7
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- 238000002360 preparation method Methods 0.000 claims description 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 3
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- PVEFEIWVJKUCLJ-UHFFFAOYSA-N sulfuric acid;toluene Chemical compound OS(O)(=O)=O.CC1=CC=CC=C1 PVEFEIWVJKUCLJ-UHFFFAOYSA-N 0.000 description 1
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- SJXLNIDKIYXLBL-UHFFFAOYSA-N tricyclohexylborane Chemical compound C1CCCCC1B(C1CCCCC1)C1CCCCC1 SJXLNIDKIYXLBL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4342493A | 1993-04-06 | 1993-04-06 | |
| US20998294A | 1994-03-17 | 1994-03-17 | |
| PCT/US1994/002894 WO1994022858A1 (fr) | 1993-04-06 | 1994-03-18 | Composes tetracycliques agonistes de la dopamine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO953957D0 NO953957D0 (no) | 1995-10-05 |
| NO953957L NO953957L (no) | 1995-11-21 |
| NO311762B1 true NO311762B1 (no) | 2002-01-21 |
Family
ID=26720416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19953957A NO311762B1 (no) | 1993-04-06 | 1995-10-05 | Tetracykliske forbindelser som dopaminagonister |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5597832A (fr) |
| EP (1) | EP0690863B1 (fr) |
| JP (1) | JP2710695B2 (fr) |
| KR (1) | KR100383342B1 (fr) |
| CN (1) | CN1046723C (fr) |
| AT (1) | ATE233765T1 (fr) |
| AU (1) | AU677842B2 (fr) |
| BR (1) | BR9405972A (fr) |
| DE (1) | DE69432217T2 (fr) |
| DK (1) | DK0690863T3 (fr) |
| ES (1) | ES2193158T3 (fr) |
| FI (1) | FI954738A (fr) |
| NO (1) | NO311762B1 (fr) |
| PT (1) | PT690863E (fr) |
| WO (1) | WO1994022858A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5659037A (en) * | 1994-08-18 | 1997-08-19 | Abbott Laboratories | Process for preparing chiral tetracyclic dopaminergic compounds |
| US5668141A (en) * | 1996-04-02 | 1997-09-16 | Abbott Laboratories | Trans-2,6-,3,6-and 4,6-diaza-5,6,6a,7,8,12b-hexahydrobenzo[c]phenanthrene compounds as dopamine agonists |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| CA2323889A1 (fr) * | 1997-03-12 | 1998-09-17 | Robert W. Esmond | Procede de traitement ou de prevention de la maladie d'alzheimer |
| US6193954B1 (en) | 1997-03-21 | 2001-02-27 | Abbott Laboratories | Formulations for pulmonary delivery of dopamine agonists |
| WO1999017803A1 (fr) | 1997-10-03 | 1999-04-15 | Cary Medical Corporation | Composition de traitement de la dependance a la nicotine contenant un antagoniste du recepteur a la nicotine et medicament antidepresseur ou anxiolytique |
| US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
| GB9828861D0 (en) * | 1998-12-31 | 1999-02-17 | Danbiosyst Uk | Compositions |
| US5969159A (en) * | 1999-02-16 | 1999-10-19 | Great Lakes Chemical Corporation | Synthesis of cyclopentyl 2-thienyl ketone tiletamine and tiletamine acid addition salts such as tiletamine hydrochloride |
| US6147226A (en) * | 1999-02-16 | 2000-11-14 | Great Lakes Chemical Corporation | Synthesis of cyclopentyl 2-thienyl ketone, tiletamine and tiletamine acid addition salts, such as tiletamine hydrochloride |
| US6638929B2 (en) * | 1999-12-29 | 2003-10-28 | Wyeth | Tricyclic protein kinase inhibitors |
| AU8339301A (en) * | 2000-08-16 | 2002-02-25 | Upjohn Co | Compounds for the treatment of addictive disorders |
| DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
| US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
| DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| EP1480647B1 (fr) * | 2002-02-15 | 2008-09-03 | Darpharma, INC. | Promedicaments a base de monoester et de diester a substitution asymetrique des agonistes des recepteurs d1 de la dopamine |
| EP1626703A2 (fr) * | 2003-05-22 | 2006-02-22 | Yeda Research And Development Co. Ltd. | Dopamine et ses agonistes et antagonistes pour moduler l'activite suppressive de lymphocytes t regulateurs de cd4+cd25+ |
| WO2005055920A2 (fr) * | 2003-12-09 | 2005-06-23 | Yeda Research And Development Co. Ltd. | Compositions et methodes de traitement de troubles psychiatriques |
| JP2007516292A (ja) * | 2003-12-23 | 2007-06-21 | ダーファーマ，インコーポレイテッド | ドーパミン受容体結合化合物の共投与 |
| WO2007098462A2 (fr) * | 2006-02-21 | 2007-08-30 | Purdue Research Foundation | Synthèse et méthodes d'utilisation de chroménoisoquinolines trans-fusionnées |
| JP5734957B2 (ja) | 2009-04-21 | 2015-06-17 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ドーパミンレセプターのオクタヒドロベンゾイソキノリンモジュレーター及びその使用 |
| EP2822936B1 (fr) | 2012-03-07 | 2021-09-08 | The McLean Hospital Corporation | Dérivés d'aminoquinoléine et leurs utilisations |
| CN103387583B (zh) * | 2012-05-09 | 2018-04-13 | 中国科学院上海药物研究所 | 二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用 |
| RU2537170C1 (ru) * | 2013-11-20 | 2014-12-27 | Войсковая Часть 41598 | Средство профилактики церебральной формы острой лучевой болезни |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2691024A (en) * | 1952-05-26 | 1954-10-05 | Schenley Ind Inc | Dihydropyrrolo-(3.2-c) quinoline derivatives |
| US3541100A (en) * | 1967-12-14 | 1970-11-17 | American Cyanamid Co | Benzheteroazolo(2,3-a)isoquinolium salts |
| GB1379387A (en) * | 1970-12-11 | 1975-01-02 | Agfa Gevaert | Photoconductive recording materials |
| US3943137A (en) * | 1973-07-09 | 1976-03-09 | University Of Kansas Endowment Association | Acronycine derivatives |
| NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| US4282227A (en) * | 1980-05-22 | 1981-08-04 | Smithkline Corporation | Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines |
| US4340600A (en) * | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| US5047536A (en) * | 1989-03-17 | 1991-09-10 | Purdue Research Foundation | Hexahydrobenzo(A)phenanthridine compounds |
| JP3476193B2 (ja) * | 1992-05-26 | 2003-12-10 | パーデュー・リサーチ・ファウンデーション | 置換ヘキサヒドロベンゾ〔α〕フェナンスリジン類 |
-
1994
- 1994-03-18 DE DE69432217T patent/DE69432217T2/de not_active Expired - Lifetime
- 1994-03-18 EP EP94912799A patent/EP0690863B1/fr not_active Expired - Lifetime
- 1994-03-18 CN CN94192241A patent/CN1046723C/zh not_active Expired - Lifetime
- 1994-03-18 ES ES94912799T patent/ES2193158T3/es not_active Expired - Lifetime
- 1994-03-18 WO PCT/US1994/002894 patent/WO1994022858A1/fr active IP Right Grant
- 1994-03-18 AU AU65203/94A patent/AU677842B2/en not_active Expired
- 1994-03-18 DK DK94912799T patent/DK0690863T3/da active
- 1994-03-18 BR BR9405972A patent/BR9405972A/pt not_active Application Discontinuation
- 1994-03-18 PT PT94912799T patent/PT690863E/pt unknown
- 1994-03-18 AT AT94912799T patent/ATE233765T1/de active
- 1994-03-18 KR KR1019950704355A patent/KR100383342B1/ko not_active IP Right Cessation
- 1994-03-18 JP JP6522116A patent/JP2710695B2/ja not_active Expired - Lifetime
- 1994-11-10 US US08/337,348 patent/US5597832A/en not_active Expired - Lifetime
-
1995
- 1995-10-05 NO NO19953957A patent/NO311762B1/no not_active IP Right Cessation
- 1995-10-05 FI FI954738A patent/FI954738A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1046723C (zh) | 1999-11-24 |
| JP2710695B2 (ja) | 1998-02-10 |
| NO953957L (no) | 1995-11-21 |
| KR100383342B1 (ko) | 2003-08-25 |
| DE69432217T2 (de) | 2004-04-08 |
| ES2193158T3 (es) | 2003-11-01 |
| US5597832A (en) | 1997-01-28 |
| EP0690863A1 (fr) | 1996-01-10 |
| CN1124489A (zh) | 1996-06-12 |
| FI954738A0 (fi) | 1995-10-05 |
| WO1994022858A1 (fr) | 1994-10-13 |
| DE69432217D1 (de) | 2003-04-10 |
| KR960701870A (ko) | 1996-03-28 |
| DK0690863T3 (da) | 2003-06-30 |
| ATE233765T1 (de) | 2003-03-15 |
| AU677842B2 (en) | 1997-05-08 |
| BR9405972A (pt) | 1995-12-12 |
| AU6520394A (en) | 1994-10-24 |
| NO953957D0 (no) | 1995-10-05 |
| FI954738A (fi) | 1995-12-05 |
| EP0690863A4 (fr) | 1995-11-07 |
| JPH08508487A (ja) | 1996-09-10 |
| EP0690863B1 (fr) | 2003-03-05 |
| PT690863E (pt) | 2003-07-31 |
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| Date | Code | Title | Description |
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| MK1K | Patent expired |