NO311026B1 - Benzoxazinforbindelser, mellomprodukter for fremstilling av forbindelsene, anvendelse av forbindelsene samt farmasoytiskepreparater inneholdende disse og fremgangsmater for fremstillingav mellomprodukter og sluttprodukt - Google Patents
Benzoxazinforbindelser, mellomprodukter for fremstilling av forbindelsene, anvendelse av forbindelsene samt farmasoytiskepreparater inneholdende disse og fremgangsmater for fremstillingav mellomprodukter og sluttprodukt Download PDFInfo
- Publication number
- NO311026B1 NO311026B1 NO19982071A NO982071A NO311026B1 NO 311026 B1 NO311026 B1 NO 311026B1 NO 19982071 A NO19982071 A NO 19982071A NO 982071 A NO982071 A NO 982071A NO 311026 B1 NO311026 B1 NO 311026B1
- Authority
- NO
- Norway
- Prior art keywords
- dihydro
- oxo
- ethyl
- benzoxazine
- phenoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 299
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- MMQAIAGSZFXZCR-UHFFFAOYSA-N tert-butyl N-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-N-[2-[4-[2-[7-nitro-4-[(4-nitrophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]carbamate Chemical compound C(C)(C)(C)OC(=O)N(C(=NC(=O)OC(C)(C)C)N)CCC1=CC=C(OCCC2OC3=C(N(C2=O)CC2=CC=C(C=C2)[N+](=O)[O-])C=CC(=C3)[N+](=O)[O-])C=C1 MMQAIAGSZFXZCR-UHFFFAOYSA-N 0.000 description 1
- MLYADCZFSCNTPI-UHFFFAOYSA-N tert-butyl N-[[4-[2-[4-[(3-chlorophenyl)methyl]-7-nitro-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]methyl]-N-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate Chemical compound CC(C)(C)OC(=O)NC(=N)N(CC1=CC=C(C=C1)OCCC2C(=O)N(C3=C(O2)C=C(C=C3)[N+](=O)[O-])CC4=CC(=CC=C4)Cl)C(=O)OC(C)(C)C MLYADCZFSCNTPI-UHFFFAOYSA-N 0.000 description 1
- OWIZBOBVXITREP-UHFFFAOYSA-N tert-butyl n-[2-(3-hydroxyphenyl)ethyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCC1=CC=CC(O)=C1 OWIZBOBVXITREP-UHFFFAOYSA-N 0.000 description 1
- KHOCNFQXJBSMCF-UHFFFAOYSA-N tert-butyl n-[2-[3-[2-[4-[(2-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCC1=CC=CC(OCCC2C(N(CC=3C(=CC=CC=3)Cl)C3=CC=CC=C3O2)=O)=C1 KHOCNFQXJBSMCF-UHFFFAOYSA-N 0.000 description 1
- GCXQEUTYDPTACB-UHFFFAOYSA-N tert-butyl n-[2-[4-[2-[4-[(3-aminophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]-n-[n'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate Chemical compound C1=CC(CCN(C(N)=NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=C(N)C=CC=2)C2=CC=CC=C2O1 GCXQEUTYDPTACB-UHFFFAOYSA-N 0.000 description 1
- CFVINJXWBFIPPP-UHFFFAOYSA-N tert-butyl n-[2-[4-[2-[4-[(3-chlorophenyl)methyl]-7-nitro-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]carbamate Chemical compound C1=CC(CCNC(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=C(Cl)C=CC=2)C2=CC=C([N+]([O-])=O)C=C2O1 CFVINJXWBFIPPP-UHFFFAOYSA-N 0.000 description 1
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- UQJXXWHAJKRDKY-UHFFFAOYSA-N tert-butyl n-[[(2-methylpropan-2-yl)oxycarbonylamino]-methylsulfanylmethylidene]carbamate Chemical compound CC(C)(C)OC(=O)NC(SC)=NC(=O)OC(C)(C)C UQJXXWHAJKRDKY-UHFFFAOYSA-N 0.000 description 1
- KNXDPHRLFWPRDY-UHFFFAOYSA-N tert-butyl n-[[3-[2-[4-[(2-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=CC(OCCC2C(N(CC=3C(=CC=CC=3)Cl)C3=CC=CC=C3O2)=O)=C1 KNXDPHRLFWPRDY-UHFFFAOYSA-N 0.000 description 1
- KGTCKCGTXRCHKT-UHFFFAOYSA-N tert-butyl n-[[4-[2-[4-[(2-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]methyl]carbamate Chemical compound C1=CC(CNC(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C(=CC=CC=2)Cl)C2=CC=CC=C2O1 KGTCKCGTXRCHKT-UHFFFAOYSA-N 0.000 description 1
- CQUVCDGFVDUOEL-UHFFFAOYSA-N tert-butyl n-[[4-[2-[4-[(3-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]methyl]carbamate Chemical compound C1=CC(CNC(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=C(Cl)C=CC=2)C2=CC=CC=C2O1 CQUVCDGFVDUOEL-UHFFFAOYSA-N 0.000 description 1
- YKQJUCYFYFVRHF-UHFFFAOYSA-N tert-butyl n-[[4-[2-[4-[(4-chlorophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]methyl]carbamate Chemical compound C1=CC(CNC(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=CC(Cl)=CC=2)C2=CC=CC=C2O1 YKQJUCYFYFVRHF-UHFFFAOYSA-N 0.000 description 1
- DWHLBQLUUHGNJA-UHFFFAOYSA-N tert-butyl n-[n'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-n-[2-[4-[2-[4-[(3-nitrophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]carbamate Chemical compound C1=CC(CCN(C(N)=NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=C(C=CC=2)[N+]([O-])=O)C2=CC=CC=C2O1 DWHLBQLUUHGNJA-UHFFFAOYSA-N 0.000 description 1
- OYGBGPRSGWJJPX-UHFFFAOYSA-N tert-butyl n-[n'-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-n-[2-[4-[2-[7-nitro-4-[(3-nitrophenyl)methyl]-3-oxo-1,4-benzoxazin-2-yl]ethoxy]phenyl]ethyl]carbamate Chemical compound C1=CC(CCN(C(N)=NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)=CC=C1OCCC1C(=O)N(CC=2C=C(C=CC=2)[N+]([O-])=O)C2=CC=C([N+]([O-])=O)C=C2O1 OYGBGPRSGWJJPX-UHFFFAOYSA-N 0.000 description 1
- XJAUKGFBFJVWTL-UHFFFAOYSA-N tert-butyl n-[n'-[(4-hydroxyphenyl)methyl]-n-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate Chemical compound CC(C)(C)OC(=O)NC(NC(=O)OC(C)(C)C)=NCC1=CC=C(O)C=C1 XJAUKGFBFJVWTL-UHFFFAOYSA-N 0.000 description 1
- RVQAYMAWAJMDJN-UHFFFAOYSA-N tert-butyl n-benzyl-n-(4-hydroxyphenyl)carbamate Chemical compound C=1C=C(O)C=CC=1N(C(=O)OC(C)(C)C)CC1=CC=CC=C1 RVQAYMAWAJMDJN-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/553,188 US5696117A (en) | 1995-11-07 | 1995-11-07 | Benzoxazine antimicrobial agents |
PCT/US1996/016669 WO1997017333A1 (en) | 1995-11-07 | 1996-10-17 | Benzoxazine antimicrobial agents |
Publications (3)
Publication Number | Publication Date |
---|---|
NO982071D0 NO982071D0 (no) | 1998-05-06 |
NO982071L NO982071L (no) | 1998-06-05 |
NO311026B1 true NO311026B1 (no) | 2001-10-01 |
Family
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NO19982071A NO311026B1 (no) | 1995-11-07 | 1998-05-06 | Benzoxazinforbindelser, mellomprodukter for fremstilling av forbindelsene, anvendelse av forbindelsene samt farmasoytiskepreparater inneholdende disse og fremgangsmater for fremstillingav mellomprodukter og sluttprodukt |
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US (2) | US5696117A (hu) |
EP (1) | EP0869949B1 (hu) |
JP (1) | JP2000500134A (hu) |
KR (1) | KR100503910B1 (hu) |
AR (1) | AR004706A1 (hu) |
AT (1) | ATE229944T1 (hu) |
AU (1) | AU720743B2 (hu) |
BR (1) | BR9611400A (hu) |
CZ (1) | CZ137998A3 (hu) |
DE (1) | DE69625515T2 (hu) |
DK (1) | DK0869949T3 (hu) |
ES (1) | ES2188795T3 (hu) |
HU (1) | HUP9901184A3 (hu) |
IL (1) | IL124337A (hu) |
MX (1) | MX9803650A (hu) |
MY (1) | MY128650A (hu) |
NO (1) | NO311026B1 (hu) |
NZ (1) | NZ321251A (hu) |
PL (1) | PL189987B1 (hu) |
RU (1) | RU2191179C2 (hu) |
SK (2) | SK285388B6 (hu) |
TW (1) | TW536537B (hu) |
WO (1) | WO1997017333A1 (hu) |
ZA (1) | ZA969326B (hu) |
Families Citing this family (27)
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BR9812770A (pt) | 1997-10-27 | 2000-12-12 | Reddy Research Foundation | Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos |
US6265401B1 (en) * | 1997-10-27 | 2001-07-24 | Reddy-Cheminor, Inc. | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
AU3406599A (en) * | 1998-04-09 | 1999-11-01 | Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin | Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis |
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
AU6762400A (en) * | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
WO2001087860A2 (en) * | 2000-05-12 | 2001-11-22 | Ortho-Mcneil Pharmaceutical, Inc. | Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment |
AU2001261503A1 (en) * | 2000-05-12 | 2001-11-26 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators |
PT1280784E (pt) | 2000-05-12 | 2007-09-03 | Ortho Mcneil Pharm Inc | 4h-benzo [1,4] oxazin-3-onas biologicamente activas. |
US6908908B2 (en) | 2000-05-12 | 2005-06-21 | Ortho-Mcneil Pharmaceutical, Inc. | Biologically active 4H-benzo [1,4] oxazin-3-ones |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US20050266575A1 (en) * | 2004-05-27 | 2005-12-01 | Mayo Kevin H | Pharmacophores for nociceptin, methods of obtaining and using in screening for nociceptin mimics |
WO2006082495A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Peroxisome proliferator activated receptor modulators |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
EP1985297A1 (en) * | 2006-01-27 | 2008-10-29 | Japan Tobacco, Inc. | Carboxylic acid compound and use thereof |
US20070197512A1 (en) * | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
TWI385161B (zh) | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
JP5099814B2 (ja) * | 2006-02-02 | 2012-12-19 | 田辺三菱製薬株式会社 | 含窒素複素二環式化合物 |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
TWI410410B (zh) | 2007-08-10 | 2013-10-01 | Ono Pharmaceutical Co | Phenylacetic acid compounds |
DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
CA2757729A1 (en) * | 2009-04-14 | 2010-10-21 | Masanori Kai | Haloalkylsulfonanilide derivative |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
US9493452B2 (en) | 2011-03-24 | 2016-11-15 | Southern Methodist University | Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors |
US8669363B2 (en) | 2011-03-24 | 2014-03-11 | Southern Methodist University | Quinoxaline compounds and derivatives |
WO2013142831A1 (en) | 2012-03-23 | 2013-09-26 | Southern Methodist University | Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors |
GB2533925A (en) * | 2014-12-31 | 2016-07-13 | Univ Bath | Antimicrobial compounds, compositions and methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3635956A (en) * | 1968-03-01 | 1972-01-18 | Squibb & Sons Inc | Benzothiazines related compounds derivatives and salts thereof |
US3725403A (en) * | 1970-10-20 | 1973-04-03 | Squibb & Sons Inc | Benzothiazine derivatives |
JPS5547006B2 (hu) * | 1973-04-04 | 1980-11-27 | ||
FR2588868B1 (fr) * | 1985-10-21 | 1988-11-10 | Negma Laboratoires | Acyl-7 benzoxazinones et leurs derives, procede pour les obtenir et compositions pharmaceutiques les contenant |
EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
DE4304806A1 (de) * | 1993-02-17 | 1994-08-18 | Kali Chemie Pharma Gmbh | 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
-
1995
- 1995-11-07 US US08/553,188 patent/US5696117A/en not_active Expired - Lifetime
-
1996
- 1996-10-17 SK SK1033-2002A patent/SK285388B6/sk not_active IP Right Cessation
- 1996-10-17 NZ NZ321251A patent/NZ321251A/en unknown
- 1996-10-17 PL PL96326704A patent/PL189987B1/pl not_active IP Right Cessation
- 1996-10-17 DK DK96936648T patent/DK0869949T3/da active
- 1996-10-17 ES ES96936648T patent/ES2188795T3/es not_active Expired - Lifetime
- 1996-10-17 JP JP9518188A patent/JP2000500134A/ja not_active Ceased
- 1996-10-17 HU HU9901184A patent/HUP9901184A3/hu unknown
- 1996-10-17 AU AU74519/96A patent/AU720743B2/en not_active Ceased
- 1996-10-17 BR BR9611400-2A patent/BR9611400A/pt not_active IP Right Cessation
- 1996-10-17 CZ CZ981379A patent/CZ137998A3/cs unknown
- 1996-10-17 AT AT96936648T patent/ATE229944T1/de not_active IP Right Cessation
- 1996-10-17 DE DE69625515T patent/DE69625515T2/de not_active Expired - Fee Related
- 1996-10-17 SK SK597-98A patent/SK283888B6/sk not_active IP Right Cessation
- 1996-10-17 IL IL12433796A patent/IL124337A/en not_active IP Right Cessation
- 1996-10-17 WO PCT/US1996/016669 patent/WO1997017333A1/en not_active Application Discontinuation
- 1996-10-17 KR KR10-1998-0703405A patent/KR100503910B1/ko not_active IP Right Cessation
- 1996-10-17 EP EP96936648A patent/EP0869949B1/en not_active Expired - Lifetime
- 1996-10-17 RU RU98110572/04A patent/RU2191179C2/ru not_active IP Right Cessation
- 1996-11-06 ZA ZA9609326A patent/ZA969326B/xx unknown
- 1996-11-06 AR ARP960105075A patent/AR004706A1/es active IP Right Grant
- 1996-11-07 MY MYPI96004648A patent/MY128650A/en unknown
- 1996-11-25 TW TW085114485A patent/TW536537B/zh not_active IP Right Cessation
-
1997
- 1997-07-23 US US08/899,235 patent/US5854242A/en not_active Expired - Lifetime
-
1998
- 1998-05-06 NO NO19982071A patent/NO311026B1/no not_active IP Right Cessation
- 1998-05-07 MX MX9803650A patent/MX9803650A/es not_active IP Right Cessation
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